{"title":"Aminophylline","description":"Aminophylline is a medication used primarily as a bronchodilator to treat symptoms of asthma, chronic bronchitis, and other lung diseases such as chronic obstructive pulmonary disease (COPD). It works by relaxing the muscles of the airways, thereby increasing airflow to the lungs. Aminophylline is a complex of theophylline with ethylenediamine, which improves its solubility and absorption. In some cases, it is also used in critical care settings to manage apnea in premature infants. Its use requires monitoring of blood levels due to a narrow therapeutic index and potential side effects.","products":[{"product_id":"aminophylline-for-injection-bronchodilator-500mg-single-dose-vial-20-ml-x-25-tray","title":"Aminophylline for Injection 500 mg Single-dose Vial 20 mL x 25\/Tray (Rx)","description":"\u003cp\u003eAminophylline for Injection 500 mg is a bronchodilator used to relieve symptoms of asthma, chronic obstructive pulmonary disease (COPD), and other respiratory conditions involving bronchospasm. It aids in relaxing the smooth muscles of the airways, enhancing airflow and easing breathing difficulties during acute exacerbations. Administered intravenously, Aminophylline is effective in hospital settings for rapid intervention in severe asthma attacks or COPD flare-ups, providing quick relief from respiratory distress and improving oxygenation in critical situations.\u003c\/p\u003e\n\u003cp\u003eAminophylline for Injection by Pfizer Injectables is a bronchodilator used to treat symptoms of asthma, chronic bronchitis, emphysema, and other obstructive lung diseases. This formulation is suitable for intravenous administration, offering quick relief in acute respiratory conditions. Each single-dose vial contains 500 mg of aminophylline in a 20 mL solution, and the product is packaged in a tray of 25 vials.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eActive Ingredient:\u003c\/strong\u003e Aminophylline (a compound of theophylline and ethylenediamine)\u003cbr\u003e\u003cstrong\u003eConcentration: \u003c\/strong\u003e25 mg\/mL\u003cbr\u003e\u003cstrong\u003eVolume: \u003c\/strong\u003e20 mL per vial\u003cbr\u003e\u003cstrong\u003ePackaging: \u003c\/strong\u003eTray of 25 single-dose vials\u003cbr\u003e\u003cstrong\u003eAdministration Route: \u003c\/strong\u003eIntravenous (IV)\u003cbr\u003e\u003cstrong\u003eIndications:\u003c\/strong\u003e Used for the treatment of acute exacerbations of asthma, chronic obstructive pulmonary disease (COPD), and other situations requiring bronchodilation to ease breathing difficulties.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAminophylline works as a bronchodilator by relaxing the smooth muscles in the bronchial airways and pulmonary blood vessels. It inhibits phosphodiesterase enzymes, leading to increased intracellular cyclic AMP levels. This elevation results in bronchodilation, decreased airway reactivity, and some reduction in inflammation. Additionally, it has mild diuretic effects and can stimulate the central nervous system and cardiac muscles.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTherapeutic Monitoring:\u003c\/strong\u003e Serum theophylline levels should be monitored to maintain them within the therapeutic range and avoid toxicity.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular Effects:\u003c\/strong\u003e Can induce arrhythmias and palpitations, especially in those with pre-existing heart conditions.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eSeizure Risk: Lowers the seizure threshold, posing risks if levels become toxic.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrug Interactions: \u003c\/strong\u003ePossible interactions with drugs like cimetidine, erythromycin, and fluoroquinolones, which may affect the metabolism of aminophylline.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdjustment in Special Populations\u003c\/strong\u003e: Caution is required for patients with liver disease, heart failure, or hypothyroidism as these conditions may alter drug metabolism.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eSide Effects\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eAminophylline can cause several side effects, and the dosage needs careful titration and monitoring:\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCommon Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eNausea\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eVomiting\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eHeadache\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eInsomnia\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eNervousness or restlessness\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSerious Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCardiac arrhythmias\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eSeizures\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eSevere hypotension\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eGastrointestinal disturbances, including bleeding\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eClose monitoring by healthcare professionals is essential to ensure safe administration, particularly in terms of dosage and serum level monitoring. Adjustments may be needed based on patient-specific factors such as age, weight, overall health, and concurrent medications. Regular evaluation helps mitigate potential risks, ensuring effective and safe treatment outcomes.\u003cbr\u003e\u003c\/p\u003e","brand":"Pfizer Injectables","offers":[{"title":"Default Title","offer_id":39961603080264,"sku":"00409-5922-01","price":575.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Aminophylline-for-Injection-Bronchodilator-500mg--Pfizer.jpg?v=1687180195"},{"product_id":"aminophylline-for-injection-bronchodilator-250mg-single-dose-vial-10-ml-x-25-tray","title":"Aminophylline for Injection 250 mg Single-dose Vial 10 mL x 25\/Tray (Rx)","description":"\u003cp\u003eAminophylline for Injection 250 mg is a bronchodilator used to treat and manage symptoms of asthma, chronic obstructive pulmonary disease (COPD), and other lung diseases associated with bronchospasm. It works by relaxing the muscles around the airways, improving breathing and airflow in patients experiencing difficulty in breathing. Aminophylline is typically administered intravenously in hospital settings for acute asthma attacks or severe COPD exacerbations, ensuring rapid action to relieve respiratory distress.\u003c\/p\u003e\n\u003cp\u003eAminophylline for Injection by Pfizer Injectables is a bronchodilator used primarily to treat and prevent symptoms of asthma, chronic bronchitis, emphysema, and other lung diseases. It is available in the form of a 250 mg single-dose vial, with a volume of 10 mL per vial. Packaged in a tray of 25 vials, this formulation is intended for intravenous administration to provide rapid relief in acute respiratory emergencies.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eActive Ingredient:\u003c\/strong\u003e Aminophylline (a complex of theophylline and ethylenediamine)\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e 25 mg\/mL\u003cbr\u003e\u003cstrong\u003eVolume: \u003c\/strong\u003e10 mL per vial\u003cbr\u003e\u003cstrong\u003ePackaging: \u003c\/strong\u003eTray containing 25 single-dose vials\u003cbr\u003e\u003cstrong\u003eRoute of Administration:\u003c\/strong\u003e Intravenous (IV)\u003cbr\u003e\u003cstrong\u003eIndications:\u003c\/strong\u003e Primarily used for the treatment of acute asthma attacks, chronic obstructive pulmonary disease (COPD), and other situations requiring bronchodilation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAminophylline works by relaxing the smooth muscles of the bronchial airways and pulmonary blood vessels. It does this by inhibiting phosphodiesterase enzymes, leading to an increase in cyclic AMP levels in the cells. The elevated cAMP helps in relaxing the tracheal and bronchial muscles while decreasing airway reactivity and inflammation. Additionally, aminophylline has mild diuretic effects and central nervous system stimulation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTherapeutic Monitoring:\u003c\/strong\u003e Regular monitoring of serum theophylline levels is essential to avoid toxicity, as the therapeutic range is narrow.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular Effects:\u003c\/strong\u003e Can cause arrhythmias and palpitations, particularly in patients with pre-existing heart conditions.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSeizure Risk:\u003c\/strong\u003e May lower the seizure threshold, especially at supra-therapeutic levels.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrug Interactions:\u003c\/strong\u003e Aminophylline can interact with various drugs, including cimetidine, fluoroquinolones, and certain anticonvulsants, affecting its metabolism.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConditions:\u003c\/strong\u003e Caution is advised in patients with hepatic impairment, heart failure, or hypothyroidism, as these conditions might alter the drug's pharmacokinetics.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eSide Effects\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eWhile effective, aminophylline may cause side effects, particularly if serum levels are not properly monitored or if the patient has contraindicating factors:\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCommon Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eNausea\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eVomiting\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eHeadache\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eInsomnia\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eNervousness or tremors\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSerious Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCardiac arrhythmias\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eSeizures\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eSevere hypotension\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eGastrointestinal hemorrhage\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003ePatients receiving aminophylline must be closely monitored by healthcare professionals to ensure therapeutic levels are maintained and side effects are minimized. Regular assessment of drug levels, especially during dose adjustments, is critical to avoid toxic effects. Patient-specific factors such as age, weight, and comorbid conditions should guide dosing and monitoring strategies.\u003cbr\u003e\u003c\/p\u003e","brand":"Pfizer Injectables","offers":[{"title":"Default Title","offer_id":39961603375176,"sku":"00409-5921-01","price":849.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Aminophylline-for-Injection-Bronchodilator-500mg-Single-dose-Vial-10-mL.jpg?v=1687180952"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/collections\/Aminophylline.jpg?v=1727973491","url":"https:\/\/www.mountainside-medical.com\/collections\/aminophylline\/pfizer-injectables+doctor-only.oembed","provider":"Mountainside Medical","version":"1.0","type":"link"}