{"title":"Bupivacaine Injections","description":"\u003ch1\u003eBupivacaine Injections\u003c\/h1\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003eBupivacaine is a \u003cstrong\u003elong‐acting amide local anesthetic\u003c\/strong\u003e used for surgical and pain blocks (infiltration, nerve blocks, epidural, etc.). It is chemically related to lidocaine\/mepivacaine but is more lipid‐soluble and protein-bound, giving it a slower onset and much longer duration of anesthesia. Brand names include \u003cstrong\u003eMarcaine\u003c\/strong\u003e and \u003cstrong\u003eSensorcaine\u003c\/strong\u003e (bupivacaine HCl) for injections, and \u003cstrong\u003eExparel\u003c\/strong\u003e for the liposomal (extended-release) formulation. Bupivacaine works by \u003cstrong\u003eblocking voltage-gated sodium channels\u003c\/strong\u003e in nerve membranes, preventing depolarization and thus nerve impulse conduction. In clinical order, sensation lost is pain → temperature → touch → motor function\u003c\/span\u003e.\u003c\/p\u003e\n\u003ch2\u003eAvailable Strengths and Formulations\u003c\/h2\u003e\n\u003cp\u003eBupivacaine injections come in several concentrations (all as \u003cem\u003emg per mL\u003c\/em\u003e):\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan class=\"VODHU pdMy8\"\u003e\u003cstrong\u003e0.25% (2.5 mg\/mL):\u003c\/strong\u003e Provides mild anesthesia with minimal motor block. Used for minor infiltration or prolonged procedures not requiring deep muscle relaxation. (Available as Marcaine\/Sensorcaine 0.25% in 10 mL or 30 mL single-dose vials and 50 mL multi-dose vials\u003c\/span\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan class=\"VODHU pdMy8\"\u003e\u003cstrong\u003e0.5% (5 mg\/mL):\u003c\/strong\u003e The most common standard strength. Used for many peripheral nerve blocks, epidural labor analgesia, dental procedures, etc. (Available in 10 mL, 30 mL single-dose and 50 mL multi-dose vials\u003c\/span\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e0.75% (7.5 mg\/mL):\u003c\/strong\u003e A higher concentration for deeper anesthesia (e.g. surgical blocks requiring complete motor block, retrobulbar eye blocks, some epidurals). \u003cem\u003eNot\u003c\/em\u003e recommended for obstetrical epidurals due to reports of cardiotoxicity. (Sold in 10 mL and 30 mL vials; e.g. Marcaine 0.75%.)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWith epinephrine (1:200,000):\u003c\/strong\u003e Bupivacaine 0.25% and 0.5% are also available combined with epinephrine to constrict blood vessels, slow absorption, and prolong duration (e.g. Marcaine with epi 0.5% in 1:200,000). Epinephrine-containing solutions carry additional warnings (see below).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOther formulations:\u003c\/strong\u003e A \u003cstrong\u003e0.75% (7.5 mg\/mL) heavy solution with 8.25% dextrose\u003c\/strong\u003e is sold as LIDOCAINE \u003cem\u003eMarcaine™ Spinal\u003c\/em\u003e for intrathecal (spinal) anesthesia (hyperbaric block). The liposomal form, \u003cstrong\u003eExparel®\u003c\/strong\u003e, contains 1.3% bupivacaine (13.3 mg\/mL) in a slow-release formulation for post-surgical infiltration (multi-dose vial or syringe). (Exparel is FDA-approved for wound infiltration, not for nerve blocks.)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eTypical packaging sizes are \u003cstrong\u003e10 mL or 30 mL single-dose vials\u003c\/strong\u003e and \u003cstrong\u003e50 mL multi-dose vials\u003c\/strong\u003e, depending on manufacturer and strength. Each vial is colorless solution. Marcaine and Sensorcaine products are chemically identical; the “MPF” designation indicates \u003cem\u003eMethyl Paraben Free\u003c\/em\u003e (sterile preservative-free) single-dose formats.\u003c\/p\u003e\n\u003ch2\u003ePackaging and Brands\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eBrands:\u003c\/strong\u003e The most common commercial names are \u003cstrong\u003eMarcaine™\u003c\/strong\u003e (by Pfizer) and \u003cstrong\u003eSensorcaine™\u003c\/strong\u003e (by AstraZeneca\/Fresenius Kabi). Both supply bupivacaine HCl injection in the strengths above, with and without epinephrine. \u003cstrong\u003eExparel®\u003c\/strong\u003e (Pacira) is a liposomal bupivacaine (1.3%) for infiltration. Bupivacaine 0.75% with dextrose is marketed as \u003cstrong\u003eMarcain Spinal\u003c\/strong\u003e for intrathecal use (Pacira also sells non-liposomal Marcaine® Spinal heavy).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePack sizes:\u003c\/strong\u003e Typical vials are \u003cstrong\u003e10 mL or 30 mL single-dose vials\u003c\/strong\u003e or \u003cstrong\u003e50 mL multi-dose vials\u003c\/strong\u003e (for example, Marcaine 0.5% comes in 10 mL, 30 mL and 50 mL vials). The Multi-dose vials contain a preservative (methylparaben) whereas “MPF” single-dose vials do not. Each mL of solution contains only bupivacaine (and possibly epinephrine); carriers include normal saline and minimal sodium citrate (to adjust pH). Unused opened vials (without preservative) should be discarded after 24 hours.\u003c\/p\u003e\n\u003cp\u003eAll injection vials should be stored at controlled room temperature (no refrigeration needed) and protected from light. Check the expiration date—discard any solution that has changed color or clarity. Do \u003cstrong\u003enot\u003c\/strong\u003e reuse syringes or share vials between patients (risk of contamination and dosing errors).\u003c\/p\u003e\n\u003ch1\u003eMechanism of Action\u003c\/h1\u003e\n\u003cp\u003eBupivacaine works by \u003cstrong\u003ereversibly blocking voltage-gated sodium (Na⁺) channels\u003c\/strong\u003e on nerve fibers. Normally, these channels allow sodium influx to generate action potentials (nerve impulses). When bupivacaine binds inside the channel (especially when the channel is open), it prevents Na⁺ from entering, so the nerve cannot depolarize. In effect, the nerve impulse is halted and \u003cstrong\u003epain signals cannot travel to the brain\u003c\/strong\u003e, producing a localized numbness.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBecause of its chemical structure, bupivacaine is an \u003cem\u003eamide-type\u003c\/em\u003e local anesthetic (like lidocaine), which generally has lower allergy risk than ester-type anesthetics.\u003c\/li\u003e\n\u003cli\u003eBupivacaine is highly lipid-soluble (high potency) and has a relatively high pKa, so onset is somewhat slower than lidocaine but it produces a \u003cstrong\u003elong duration\u003c\/strong\u003e of anesthesia (often several hours).\u003c\/li\u003e\n\u003cli\u003eIn the heart and cardiovascular system, bupivacaine also blocks sodium (and other) channels. Due to its slow unbinding from the channel, it \u003cstrong\u003eprolongs refractory periods in cardiac muscle\u003c\/strong\u003e, which can depress cardiac conduction and cause dangerous arrhythmias if the drug reaches high blood levels. This cardiac effect underlies why bupivacaine has a \u003cstrong\u003ehigh risk of cardiotoxicity\u003c\/strong\u003e compared to other local anesthetics.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch1\u003eAdministration Routes and Uses\u003c\/h1\u003e\n\u003cp\u003eBupivacaine is administered by a healthcare professional, typically by injection in or around nerves or the spine. Common injection routes include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeripheral nerve block:\u003c\/strong\u003e Injected near a nerve or nerve plexus (e.g. brachial plexus block for arm surgery, dental nerve blocks, intercostal nerve block).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLocal infiltration:\u003c\/strong\u003e Injected into surgical wounds or tissues for postoperative analgesia (e.g. after tooth extraction, knee surgery).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpidural anesthesia\/analgesia:\u003c\/strong\u003e Injected into the epidural space of the spine (e.g. during labor or cesarean delivery, or for pain control after abdominal surgery).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpinal (subarachnoid) anesthesia:\u003c\/strong\u003e Injected into the cerebrospinal fluid (CSF) in the spinal canal for procedures like lower-limb orthopedic surgery or cesarean section.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCaudal block:\u003c\/strong\u003e A type of epidural given through the lower spine (sacral hiatus) mainly used for pediatric lower-body procedures.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eEach route and dose is chosen based on the procedure and desired duration of numbing. Bupivacaine is often formulated at 0.25%, 0.5%, or 0.75% concentrations, and can be combined with a small amount of epinephrine (a vasoconstrictor) to \u003cstrong\u003eprolong its effect\u003c\/strong\u003e and reduce systemic absorption. Whichever route is used, injections must be performed under strict sterile conditions and with monitoring, since bupivacaine’s potency and slow clearance make toxicity a serious concern.\u003c\/p\u003e\n\u003ch1\u003eEffects and Duration\u003c\/h1\u003e\n\u003cp\u003eAfter injection, bupivacaine numbs the targeted area by preventing sensory (and eventually motor) nerve signals. Patients feel \u003cstrong\u003enumb\u003c\/strong\u003e rather than sedated; consciousness is maintained. Bupivacaine has a \u003cstrong\u003eslow to intermediate onset\u003c\/strong\u003e and a \u003cstrong\u003elong duration of action\u003c\/strong\u003e relative to shorter-acting agents like lidocaine. For example, analgesia can last from several hours to up to 8–12 hours depending on dose, concentration, and use of epinephrine. Because of this long action, bupivacaine is often chosen for procedures or postoperative pain control where extended anesthesia is desired.\u003c\/p\u003e\n\u003ch1\u003eAdverse Effects and Toxicity\u003c\/h1\u003e\n\u003cp\u003eWhen used properly at recommended doses, bupivacaine provides safe local anesthesia. However, \u003cstrong\u003esystemic toxicity\u003c\/strong\u003e can occur if too much drug enters the bloodstream or is injected into highly vascular areas. Warning signs of systemic toxicity (sometimes called LAST – Local Anesthetic Systemic Toxicity) include neurologic and cardiac symptoms. Key points:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurologic effects:\u003c\/strong\u003e Early CNS symptoms can include numbness of the tongue or mouth, tinnitus (ringing in the ears), dizziness, blurred vision, and tremors. At higher blood levels, generalized central nervous system depression can occur, including convulsions (seizures), loss of consciousness, and coma.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular effects:\u003c\/strong\u003e Bupivacaine is notorious for cardiotoxicity. It can cause bradycardia, severe hypotension, conduction blocks, and fatal \u003cstrong\u003eventricular arrhythmias\u003c\/strong\u003e (e.g. ventricular tachycardia or fibrillation) due to its strong blockade of cardiac Na⁺ channels. In fact, among local anesthetics, bupivacaine has one of the highest risks of causing life-threatening cardiac complications if overdose occurs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOther effects:\u003c\/strong\u003e Allergic reactions to bupivacaine are rare (most true allergies occur with ester-type anesthetics). Other side effects can include nausea, vomiting, shivering, headache, or hypotension from sympathetic block. Methemoglobinemia (abnormal hemoglobin) is exceedingly rare with bupivacaine but has been reported.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe risk of toxicity depends on dose and site of injection. Intravenous injection (accidental intravascular injection) or injections in highly vascular areas (e.g. intercostal blocks) carry the greatest absorption risk. To minimize risk, practitioners aspirate before injecting and give fractional doses, while continuously monitoring the patient.\u003c\/p\u003e\n\u003ch1\u003eManagement of Overdose (Local Anesthetic Systemic Toxicity)\u003c\/h1\u003e\n\u003cp\u003eIf signs of bupivacaine toxicity appear (e.g. sudden seizure, severe arrhythmia), immediate treatment is critical. Guidelines recommend \u003cstrong\u003eairway support, seizure control (benzodiazepines, if needed), and cardiovascular support\u003c\/strong\u003e. A key therapy for lipophilic anaesthetic toxicity is \u003cstrong\u003eintravenous lipid emulsion\u003c\/strong\u003e (often 20% lipid infusion). Experimental and clinical data show that early administration of lipid emulsion can “rescue” patients from severe bupivacaine-induced cardiovascular collapse. Facilities using long-acting anesthetics should have lipid emulsion readily available for LAST emergencies.\u003c\/p\u003e\n\u003ch1\u003eContraindications and Precautions\u003c\/h1\u003e\n\u003cp\u003eBupivacaine injection should \u003cem\u003enot\u003c\/em\u003e be used in patients with known hypersensitivity to it or other amide anesthetics. It is also contraindicated in some specific scenarios: for example, it should not be used in \u003cstrong\u003eintravenous regional (Bier) blocks\u003c\/strong\u003e and certain obstetric blocks (paracervical blocks or high-concentration obstetric epidurals). Caution is needed in patients with severe liver disease, heart block, low blood pressure, or other conditions that reduce cardiac function, since impaired clearance or added cardiac effects increase risk. Pregnant women, children, and elderly patients require dose adjustments and monitoring.\u003c\/p\u003e\n\u003cp\u003eIn all cases, bupivacaine injections \u003cstrong\u003emust be administered by qualified healthcare professionals\u003c\/strong\u003e with proper monitoring (EKG, blood pressure, oxygen). The dose is carefully calculated (typically not exceeding ~2–3 mg\/kg total) to avoid toxicity. Patients are informed not to move the numb area until normal sensation returns, to avoid injury during anesthesia.\u003c\/p\u003e\n\u003ch1\u003eSummary\u003c\/h1\u003e\n\u003cp\u003eIn summary, \u003cstrong\u003ebupivacaine injection\u003c\/strong\u003e is a powerful long-acting local anesthetic used to produce numbness for surgeries, labor, and pain relief. It works by blocking nerve impulses and is given for epidural, spinal, and peripheral nerve blocks. Its benefits include prolonged pain control, but it carries a higher risk of serious cardiac and CNS toxicity than shorter-acting anesthetics. When used by trained clinicians in controlled doses, bupivacaine is an effective and commonly used local anesthetic. Patients receive this medication under medical supervision, and any signs of toxicity (nervousness, dizziness, metallic taste, seizures, arrhythmia) are treated immediately – often with lipid emulsion therapy and advanced cardiac life support as needed.\u003c\/p\u003e","products":[{"product_id":"marcaine-bupivacaine-hydrochloride-for-injection-75mg-10ml-10-vials","title":"Marcaine (Bupivacaine Hydrochloride) 0.75% Injection 10 mL Vials, 10\/pack (Rx)","description":"\u003cp\u003eMarcaine (Bupivacaine Hydrochloride) 0.75% Injection is a local anesthetic used to provide long-lasting pain relief during surgical, dental, and obstetric procedures. It works by blocking nerve signals in specific areas of the body, preventing the sensation of pain. Marcaine is particularly effective for regional anesthesia techniques such as epidurals, nerve blocks, and spinal anesthesia, making it ideal for managing pain in complex procedures, labor and delivery, and postoperative recovery.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActive Ingredient: Bupivacaine Hydrochloride\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eConcentration: 0.75% (7.5 mg\/mL)\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eVolume: 10 mL per vial\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003ePackaging: 10 vials per pack\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eFormulation: Sterile solution for injection\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eUsage: Used for local or regional anesthesia during surgeries, dental procedures, or chronic pain management.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eManufacturer: Pfizer Injectables\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBupivacaine works by binding to and inhibiting voltage-gated sodium channels on nerve cells. This action blocks nerve impulse generation and propagation, thereby providing a local anesthetic effect. Bupivacaine has a longer duration of action compared to other local anesthetics, making it particularly useful for prolonged surgical procedures or pain relief.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular Risks:\u003c\/strong\u003e Potential for cardiovascular complications including hypotension and arrhythmias; use with caution in patients with cardiovascular disease.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCentral Nervous System Effects:\u003c\/strong\u003e Risk of central nervous system toxicity, including seizures, especially if administered intravascularly.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic Reactions:\u003c\/strong\u003e Rare potential for hypersensitivity reactions; contraindicated in patients with known allergies to amide-type anesthetics.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePregnancy: \u003c\/strong\u003eShould be used cautiously in obstetric anesthesia due to potential effects on the mother and fetus.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInjection Technique: \u003c\/strong\u003eMust be meticulously administered to avoid accidental intravascular injection.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContraindications:\u003c\/strong\u003e Avoid use in intravenous regional anesthesia (Bier block).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSide Effects\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCommon Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eLocal irritation at the injection site\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eDizziness\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eNausea or vomiting\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eSensations of tingling or numbness\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSerious Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular:\u003c\/strong\u003e Arrhythmias, bradycardia, cardiac arrest\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCNS Toxicity: Seizures,\u003c\/strong\u003e confusion, nervousness\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRespiratory distress:\u003c\/strong\u003e Difficulty breathing in severe cases\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic Reactions:\u003c\/strong\u003e Urticaria, rash, or anaphylactic reactions\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eAdministration and Monitoring\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMarcaine should be administered by healthcare professionals experienced with regional anesthesia and the management of potential complications. Continuous monitoring of the patient's cardiovascular and respiratory status is advised during administration. Emergency resuscitative equipment and medications should be immediately available in case of adverse reactions. Dosage should be tailored to the individual needs of the patient and the specific procedure being performed, taking special care in patients with underlying health conditions that may influence their reaction to the drug.\u003cbr\u003e\u003c\/p\u003e","brand":"Pfizer Injectables","offers":[{"title":"Default Title","offer_id":39615355453512,"sku":"00409-1582-10","price":102.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Marcaine-_Bupivacaine-Hydrochloride_-0.75_-Injection-Tary-of-10-Vials.jpg?v=1730725255"},{"product_id":"bupivacaine-for-injection-0-25-50ml-x-25","title":"Bupivacaine 0.25% Injection Multiple Dose 50 mL Vials 25\/tray (Rx)","description":"\u003cp\u003eBupivacaine 0.25% for Injection Multiple Dose 50 mL is a local anesthetic used for pain management in various surgical, dental, and obstetric procedures. It works by blocking nerve impulses, providing long-lasting numbness and analgesia to targeted areas. This lower concentration is ideal for procedures requiring moderate anesthetic effects and allows for flexibility and multiple dosing in clinical settings. It is commonly used in nerve blocks, epidurals, and regional anesthesia to ensure effective pain control and patient comfort during and after procedures.\u003c\/p\u003e\n\u003cp\u003eBupivacaine 0.25% for Injection is a sterile, multiple-dose local anesthetic solution used for providing prolonged pain relief during surgical, obstetric, or other procedures requiring regional anesthesia. With its lower concentration, it is typically used in situations where prolonged sensory blockade is desired with minimal motor block. This formulation is available in 50 mL vials, packaged in trays of 25 vials by Pfizer Injectables.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVolume:\u003c\/strong\u003e 50 mL per vial\u003cbr\u003e\u003cstrong\u003ePackaging:\u003c\/strong\u003e 25 vials per tray\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e Bupivacaine Hydrochloride 0.25% (2.5 mg\/mL)\u003cbr\u003e\u003cstrong\u003eVial Type:\u003c\/strong\u003e Multiple-dose, permitting multiple withdrawals for various procedures ensuring flexibility in anesthetic management\u003cbr\u003e\u003cstrong\u003eUse: \u003c\/strong\u003eCommonly used for local infiltration, peripheral nerve blocks, and epidural anesthesia\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBupivacaine acts by blocking sodium ion channels in the axonal membrane of nerve cells. This blockade prevents the rise in membrane permeability to sodium during the action potential, effectively inhibiting neural depolarization and the propagation of nerve impulses. This leads to a reversible loss of sensory transmission and thus, localized anesthesia. Bupivacaine is particularly noted for its prolonged duration of action compared to other local anesthetics.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystemic Toxicity:\u003c\/strong\u003e Risk of CNS and cardiovascular toxicity, especially with high doses or unintended intravascular injection. Symptoms can include CNS disturbances like seizures and cardiovascular complications like arrhythmias.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProper Administration:\u003c\/strong\u003e Should only be administered by those experienced in managing regional anesthesia. Continuous monitoring is recommended during administration to prevent accidental intravascular injection.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContraindications:\u003c\/strong\u003e Not to be used in intravenous regional anesthesia (e.g., Bier Block) due to risk of cardiac arrest.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic Reactions:\u003c\/strong\u003e Patients with hypersensitivity to bupivacaine or other amide-type local anesthetics should avoid the use of this drug.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSide Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePotential side effects of Bupivacaine 0.25% may include:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eLocal Reactions\u003c\/strong\u003e: Pain, swelling, or sensitivity at the site of injection.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCNS Effects:\u003c\/strong\u003e Dizziness, drowsiness, confusion, tinnitus, or in severe cases, convulsions, particularly if toxic plasma levels are reached.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular Effects\u003c\/strong\u003e: Hypotension, bradycardia, and at toxic levels, arrhythmias or cardiac arrest.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic Reactions:\u003c\/strong\u003e Though rare, symptoms such as rash, pruritus, or more severe anaphylactic reactions may occur.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAppropriate dosing and vigilant monitoring are essential during bupivacaine administration. Healthcare providers must be prepared to manage potential side effects and should have resuscitation equipment readily available. The decision to use bupivacaine should involve careful consideration of patient-specific factors, type of procedure, and required duration of anesthesia.\u003cbr\u003e\u003c\/p\u003e","brand":"Pfizer Injectables","offers":[{"title":"Default Title","offer_id":39615365644360,"sku":"0409-1160-01","price":159.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Bupivacaine-0.25_-Injection-Vials-by-Pfizer.jpg?v=1732287327"},{"product_id":"bupivacaine-0_5-hydrochloride-injection-local-anesthesia-surgical-procedures","title":"Bupivacaine 0.5% Injection Single-Dose 10 mL Vial, 25\/tray (Rx)","description":"Bupivacaine 0.5% Injection is a widely used local anesthetic, trusted by healthcare professionals for providing long-lasting pain relief during surgical, dental, and obstetric procedures. Bupivacaine 0.5% Injection works by blocking nerve signals in the targeted area, ensuring that patients experience minimal discomfort during and after medical interventions. With its proven efficacy and safety profile, Bupivacaine 0.5% Injection is often the preferred choice for both minor and major procedures, helping to improve patient outcomes and satisfaction. For those seeking an effective and reliable local anesthesia solution, Bupivacaine 0.5% Injection is an excellent option backed by extensive clinical use and positive results.\n\u003cp\u003eBupivacaine 0.5% for Injection Single-Dose 10 mL is utilized as a local anesthetic for managing pain during surgical procedures, obstetrical procedures like epidurals, and post-operative pain management. It works by blocking nerve impulses, providing prolonged numbness, and pain relief in targeted areas. Bupivacaine is favored for its long-lasting anesthetic effects, making it suitable for lengthy operations and labor analgesia. Administered via nerve blocks, it ensures effective pain control, enhancing patient comfort and facilitating smoother surgical experiences.\u003c\/p\u003e\n\u003cp\u003eBupivacaine 0.5% for Injection is a sterile, preservative-free local anesthetic solution used for regional anesthesia. The product is designed to produce prolonged anesthesia for surgical, obstetric, or procedural interventions by blocking nerve impulses. It comes in 10 mL single-dose vials, and each tray contains 25 vials, provided by Pfizer Injectables.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVolume: \u003c\/strong\u003e10 mL per vial\u003cbr\u003e\u003cstrong\u003ePackaging: \u003c\/strong\u003e25 single-dose vials per tray\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e Bupivacaine Hydrochloride 0.5% (5 mg\/mL)\u003cbr\u003e\u003cstrong\u003ePreservative-Free:\u003c\/strong\u003e Ideal for reducing the risk of preservative-related toxicity or allergic reactions\u003cbr\u003e\u003cstrong\u003eUse:\u003c\/strong\u003e Suitable for local or regional anesthesia during a variety of surgical procedures, as well as for acute pain management\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBupivacaine acts as a local anesthetic by inhibiting sodium ion influx through voltage-gated sodium channels in neuronal membranes. This blockade prevents depolarization of the nerve cell membrane, interrupting the generation and conduction of nerve impulses responsible for sensation. As a result, there's a reversible loss of sensation in the targeted area, allowing effective pain control during procedures. Bupivacaine is known for its prolonged duration of action compared to other local anesthetics.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic Reactions:\u003c\/strong\u003e Contraindicated in patients with a known hypersensitivity to bupivacaine or other amide-type local anesthetics.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular\/CNS Toxicity:\u003c\/strong\u003e High doses or intravascular injection may result in systemic toxicity, manifesting as central nervous system (CNS) symptoms like seizures, and cardiovascular symptoms like arrhythmias. Facilities for resuscitation should be immediately available.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProper Administration:\u003c\/strong\u003e Only for use by healthcare professionals experienced in regional anesthesia techniques. Avoid intravascular injection by frequent aspiration checks.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContraindications:\u003c\/strong\u003e Not recommended for intravenous regional anesthesia (Bier Block) due to risk of cardiac arrest and death.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecial Populations:\u003c\/strong\u003e Dose adjustments may be necessary for elderly patients, those with liver disease, and others with reduced tolerance to local anesthetics.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSide Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePotential side effects associated with the use of Bupivacaine 0.5% may include:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eLocal Reactions:\u003c\/strong\u003e Pain, swelling, or irritation at the injection site.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystemic Reactions:\u003c\/strong\u003e Central nervous system reactions, such as dizziness, lightheadedness, confusion, or more severe symptoms like seizures, if toxic levels are reached.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular Effects:\u003c\/strong\u003e Hypotension, bradycardia, or heart block, particularly with high plasma levels.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRespiratory Effects\u003c\/strong\u003e: Difficulty breathing or respiratory depression, especially in higher doses affecting the thorax or cervical region.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic Reactions:\u003c\/strong\u003e Although rare, hypersensitivity reactions such as rashes or anaphylaxis can occur.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBupivacaine should always be administered with caution, adhering to appropriate dosing protocols tailored to the patient's specific condition, and it requires careful monitoring during and after administration to identify and manage potential adverse effects promptly.\u003cbr\u003e\u003c\/p\u003e","brand":"Pfizer Injectables","offers":[{"title":"Default Title","offer_id":39615370100808,"sku":"00409-1162-01","price":195.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/products\/BupivacaineHydrochlorideforInjection0.50Single-Dose10mLVialx25Vials.jpg?v=1748522379"},{"product_id":"zynrelef-kit-bupivacaine-and-meloxicam-extended-release-solution","title":"ZYNRELEF Kit (bupivacaine and meloxicam) Extended-Release Solution (Rx)","description":"\u003cp\u003eZYNRELEF is indicated in adults for soft tissue or periarticular instillation to produce postsurgical analgesia for up to 72 hours after foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.\u003c\/p\u003e\n\u003cp\u003eZYNRELEF ® (bupivacaine and meloxicam) extended-release solution is approved in adults for soft tissue or periarticular instillation to produce postsurgical analgesia for up to 72 hours after foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.\u003cbr\u003e\u003cbr\u003eZYNRELEF is the first and only extended-release dual-acting local anesthetic ™ (DALA ™) and delivers 72 hours of postoperative pain relief via a single needle-free application. It has been clinically proven to better manage pain than standard of care bupivacaine HCl solution over 72 hours and to significantly reduce opioid utilization following surgery. ZYNRELEF utilizes a novel synergistic mechanism of action that combines bupivacaine with a low dose of meloxicam to overcome the challenges of the inflammatory process at the surgical site. ZYNRELEF is formulated in Heron’s proprietary controlled-diffusion Biochronomer ® polymer for consistently regulated delivery of bupivacaine and meloxicam.\u003c\/p\u003e","brand":"Heron Therapeutics","offers":[{"title":"Default Title","offer_id":39615435538504,"sku":"47426-0503-01","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/products\/ZYNRELEF-Kit-bupivacaine-and-meloxicam-Extended-Release-Solution.jpg?v=1665758582"},{"product_id":"sensorcaine-mpf-bupivacaine-hcl-injection-0-25-30-ml-single-dose-vials-25-pack","title":"Sensorcaine MPF (Bupivacaine HCL Injection) 0.25% 30 mL Single-dose Vials - 25 Pack","description":"\u003cp\u003eSensorcaine MPF (Bupivacaine HCL Injection) 0.25% 30 mL Single-dose Vials - 25 Pack. Sensorcaine (bupivacaine HCL) is indicated for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eSensorcaine® (bupivacaine HCL) injections are sterile isotonic solutions that contain a local anesthetic agent with and without epinephrine (as bitartrate) 1:200,000 and are administered parenterally by injection.\u003cbr\u003e\u003cbr\u003eSensorcaine MPF is a sterile isotonic solution containing sodium chloride. Sensorcaine in multiple dose vials, each mL also contains 1 mg methylparaben as antiseptic preservative. The pH of these solutions is adjusted to between 4.0 and 6.5 with sodium hydroxide and\/or hydrochloric acid.\u003cbr\u003eIndications and Usage\u003cbr\u003e\u003cbr\u003eSensorcaine (bupivacaine HCL) is indicated for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures.\u003c\/p\u003e\n\u003cp\u003eNDC: 63323-0464-37\u003c\/p\u003e\n\u003cp\u003eSize: 30 mL x 25\/Tray\u003c\/p\u003e","brand":"Fresenius Kabi","offers":[{"title":"Default Title","offer_id":39641419055176,"sku":"63323-0464-37","price":275.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/products\/Sensorcaine-MPF-Bupivacaine-HCL-Injection-0.25-30-mL-Single-dose-Vials.jpg?v=1666895423"},{"product_id":"sensorcaine-mpf-bupivacaine-hcl-injection-0-75-30-ml-single-dose-vials-25-pack","title":"Sensorcaine MPF (Bupivacaine HCL Injection) 0.75% 30 mL Single-dose Vials 25\/Tray (Rx)","description":"Sensorcaine MPF (Bupivacaine HCL Injection) 0.75% 30 mL Single-dose Vials - 25 Pack. Sensorcaine (bupivacaine HCL) is indicated for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures.\u003cbr\u003e\n\u003cp\u003eSensorcaine® (bupivacaine HCL) injections are sterile isotonic solutions that contain a local anesthetic agent with and without epinephrine (as bitartrate) 1:200,000 and are administered parenterally by injection.\u003cbr\u003e\u003cbr\u003eSensorcaine MPF is a sterile isotonic solution containing sodium chloride. Sensorcaine in multiple dose vials, each mL also contains 1 mg methylparaben as antiseptic preservative. The pH of these solutions is adjusted to between 4.0 and 6.5 with sodium hydroxide and\/or hydrochloric acid.\u003cbr\u003eIndications and Usage\u003cbr\u003e\u003cbr\u003eSensorcaine (bupivacaine HCL) is indicated for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures.\u003c\/p\u003e\n\u003cp\u003eNDC: 63323-0472-37\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eSize: 30 mL x 25\/Tray\u003c\/p\u003e","brand":"Fresenius Kabi","offers":[{"title":"Default Title","offer_id":39641420169288,"sku":"63323-0472-37","price":299.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/products\/Sensorcaine-MPF-Bupivacaine-HCL-Injection-0.75.jpg?v=1666895860"},{"product_id":"sensorcaine-mpf-0-25-bupivacaine-with-epinephrine-1-200-000-multi-dose-50-ml-vials-x-25-tray","title":"Sensorcaine (Bupivacaine HCL) 0.25% with Epinephrine 1:200,000 (as bitartrate) Multi-Dose 50 mL Vials x 25\/Tray","description":"\u003cp\u003eSensorcaine® (bupivacaine HCl) injections are sterile isotonic solutions that contain a local anesthetic agent with and without epinephrine (as bitartrate) 1:200,000 and are administered parenterally by injection.\u003c\/p\u003e\n\u003cp\u003eLocal anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: (1) pain, (2) temperature, (3) touch, (4) proprioception, and (5) skeletal muscle tone.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSystemic absorption of local anesthetics produces effects on the cardiovascular and central nervous systems (CNS). At blood concentrations achieved with normal therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal. However, toxic blood concentrations depress cardiac conduction and excitability, which may lead to atrioventricular block, ventricular arrhythmias and cardiac arrest, sometimes resulting in fatalities. In addition, myocardial contractility is depressed and peripheral vasodilation occurs, leading to decreased cardiac output and arterial blood pressure. Recent clinical reports and animal research suggest that these cardiovascular changes are more likely to occur after unintended intravascular injection of bupivacaine. Therefore, incremental dosing is necessary.\u003cbr\u003e\u003c\/p\u003e","brand":"Fresenius Kabi","offers":[{"title":"Default Title","offer_id":39666969182280,"sku":"63323-0461-57","price":839.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/products\/Sensorcaine-MPF-0.25-Bupivacaine-with-Epinephrine.jpg?v=1667913115"},{"product_id":"bupivacaine-hydrochloride-for-injection-0-75-single-dose-vials-30-ml-x-25-tray","title":"Bupivacaine 0.75% for Injection Single-Dose Vials 30 mL, 25\/Tray (Rx)","description":"\u003cp\u003eBupivacaine 0.75% for Injection is a local anesthetic used to provide prolonged pain relief by blocking nerve signals during surgical, dental, or obstetric procedures, including labor and delivery. It works by numbing a specific area to inhibit sensation and reduce discomfort. Bupivacaine is particularly effective for regional anesthesia techniques like epidurals and nerve blocks, offering sustained pain management for complex procedures and postoperative recovery.\u003c\/p\u003e\n\u003cp\u003eBupivacaine 0.75% for Injection is a local anesthetic used primarily for regional anesthesia, including epidural and peripheral nerve block techniques. Offered by Pfizer Injectables, these vials are designed for single-dose use in medical settings to provide long-lasting pain relief during surgery or obstetric procedures.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eActive Ingredient: Bupivacaine Hydrochloride\u003cbr\u003eConcentration: 0.75% (7.5 mg\/mL)\u003cbr\u003eVolume: 30 mL per vial\u003cbr\u003eFormat: Single-dose vial \u003cbr\u003ePackaging: 25 vials per tray\u003cbr\u003eIndications: Suitable for surgical anesthesia, obstetrical procedures, and other interventions requiring prolonged local or regional anesthetic effect.\u003cbr\u003eManufacturer: Pfizer Injectables\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBupivacaine works by blocking sodium channels on neuronal membranes, specifically inhibiting the initiation and transmission of nerve impulses. This action results in a reversible loss of sensation, providing effective local or regional anesthesia. Compared to other local anesthetics, bupivacaine has a longer duration of action, making it suitable for procedures requiring extended anesthesia.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular Risks:\u003c\/strong\u003e There is a significant risk of cardiotoxicity, especially if inadvertently injected intravascularly. This includes the potential for arrhythmias or cardiac arrest. \u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCentral Nervous System Effects:\u003c\/strong\u003e Potential for CNS toxicity, which may present as tinnitus, seizures, or respiratory depression.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic Reactions:\u003c\/strong\u003e Though rare, patients may exhibit hypersensitivity to amide-type anesthetics.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUse in Pregnant Women: \u003c\/strong\u003eCaution is advised, particularly when used for epidural anesthesia, as it can affect maternal blood pressure and fetal wellbeing.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContraindications:\u003c\/strong\u003e Not suitable for intravenous regional anesthesia (Bier block) or in patients with any history of hypersensitivity to bupivacaine or similar drugs.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eSide Effects\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCommon Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eProlonged numbness or tingling in the area of injection\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eHypotension\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eNausea\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eDizziness or lightheadedness\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSerious Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular events:\u003c\/strong\u003e Bradycardia, hypotension, cardiac arrest\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCentral nervous system toxicity:\u003c\/strong\u003e Seizures, confusion, persistent drowsiness\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic reactions\u003c\/strong\u003e: Anaphylaxis, rash, or hives\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRespiratory depression\u003c\/strong\u003e or difficulty breathing\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eAdministration and Monitoring\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAdministration should be conducted by trained healthcare professionals familiar with anesthesia techniques and the management of potential toxicities. It is essential to monitor cardiovascular and respiratory function throughout the use of bupivacaine, especially when used in high doses or in sensitive populations. Facilities for resuscitation should be readily available when using this medication. Adjustments in dosage and careful monitoring are crucial to mitigate adverse effects, especially in patients with existing cardiac conditions or those receiving other CNS depressants.\u003cbr\u003e\u003c\/p\u003e","brand":"Pfizer Injectables","offers":[{"title":"Default Title","offer_id":39699234095176,"sku":"00409-1165-02","price":197.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/products\/Pfizer--0409-1165-02-Bupivacaine-Hydrochloride-Injection-USP.jpg?v=1669391755"},{"product_id":"marcaine-bupivacaine-hydrochloride-with-epinephrine-1-200-000-for-injection-0-25-multi-dose-50ml-vial","title":"Marcaine (Bupivacaine Hydrochloride) 125 mg\/50 mL with Epinephrine 1:200,000 Injection 0.25% Multi-Dose 50mL Vial (Rx)","description":"\u003cp\u003eMarcaine (Bupivacaine Hydrochloride) 125 mg\/50 mL with Epinephrine 1:200,000 is used for local anesthesia and pain management during surgical, dental, and obstetric procedures. The addition of epinephrine prolongs the anesthetic effect by constricting blood vessels, minimizing bleeding, and reducing the rate of systemic absorption. This formulation provides prolonged muscle relaxation and sensory blockade, making it suitable for procedures requiring extended anesthesia. Bupivacaine is preferred for its long-lasting effects, ensuring effective patient comfort and control over pain during and post-procedure.\u003c\/p\u003e\n\u003cp\u003eMarcaine (Bupivacaine Hydrochloride) with Epinephrine Injection is a long-lasting local anesthetic formulation designed for producing regional anesthesia or nerve block during surgical, dental, or diagnostic procedures. This specific formulation combines Bupivacaine, a potent amide-type anesthetic, with Epinephrine to extend the duration of anesthetic action by reducing local blood flow.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKey Features\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eActive Ingredients: \u003c\/strong\u003eThe formulation contains 125 mg of Bupivacaine Hydrochloride per 50 mL and Epinephrine at a concentration of 1:200,000, providing effective anesthesia with prolonged action.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e This 0.25% solution offers a balanced potency suitable for a wide range of medical applications, ensuring effective nerve blockade while minimizing potential toxicity.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpinephrine Addition:\u003c\/strong\u003e The inclusion of Epinephrine helps to constrict blood vessels at the site of administration, thereby prolonging the anesthetic effect of Bupivacaine and reducing systemic absorption, which enhances the action and safety profile.\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMulti-Dose Vial:\u003c\/strong\u003e Packaged in a 50 mL multi-dose vial, it allows for multiple uses from the same vial when sterile technique is employed, making it a convenient cost-effective option for clinical settings.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eUsage and Application\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegional Anesthesia:\u003c\/strong\u003e Ideal for procedures where localized numbness is required, such as surgeries involving extremities, where spinal or epidural anesthesia may be applied.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNerve Block:\u003c\/strong\u003e Used in various nerve blocks to manage pain during and after surgical procedures.\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpidural Anesthesia:\u003c\/strong\u003e Can be utilized in epidural blocks, especially when combined with analgesics for labor pain management.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSafety and Precautions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eContraindications\u003c\/strong\u003e: Marcaine should not be used in patients with a known hypersensitivity to local anesthetics of the amide type or any component of the formulation.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMonitoring:\u003c\/strong\u003e Continuous monitoring of cardiovascular and respiratory functions is recommended during administration due to potential systemic effects.\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHandling:\u003c\/strong\u003e Multi-dose vials should be handled under sterile conditions to prevent contamination.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eStorage Information\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage Conditions\u003c\/strong\u003e: Store at controlled room temperature and protect from light to maintain the stability of the formulation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eManufacturer Information\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBrand:\u003c\/strong\u003e Manufactured by Pfizer Injectables, a globally recognized leader in pharmaceutical solutions ensuring stringent quality control and reliability.\u003c\/p\u003e\n\u003cp\u003eMarcaine with Epinephrine provides a reliable and effective anesthetic solution for a wide range of medical procedures, ensuring safety and efficacy in local anesthesia practices.\u003c\/p\u003e","brand":"Pfizer Injectables","offers":[{"title":"Default Title","offer_id":39726135935048,"sku":"00409-1752-50","price":38.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Marcaine-_Bupivacaine-Hydrochloride_-125-mg-50-mL-with-Epinephrine.jpg?v=1742840295"},{"product_id":"marcaine-spinal-bupivacaine-hydrochloride-0-75-in-dextrose-injection-2-ml-x-10-single-dose-ampules","title":"Marcaine Spinal (bupivacaine hydrochloride 0.75% in dextrose injection) 2 mL x 10 Single-Dose Ampules","description":"\u003cp\u003eMarcaine Spinal (bupivacaine hydrochloride 0.75% in dextrose injection) is used for spinal anesthesia to provide prolonged pain relief during lower abdominal, pelvic, or lower limb surgeries. This local anesthetic works by blocking nerve impulses, leading to the temporary loss of sensation and motor function in the lower body. The inclusion of dextrose allows for a hyperbaric solution, which helps in precise control and distribution of the anesthetic effect in the spinal column, ensuring effective anesthesia for surgical procedures.\u003c\/p\u003e\n\u003cp\u003eMarcaine Spinal (Bupivacaine Hydrochloride 0.75% in Dextrose Injection) is a local anesthetic solution designed for spinal anesthesia. It is primarily used for surgical procedures requiring lower abdominal, pelvic, and lower extremity anesthesia. The formulation includes dextrose, which helps ensure proper distribution in the cerebrospinal fluid. This product is supplied by Pfizer Injectables in single-dose ampules, with each ampule containing 2 mL of the solution, packaged in boxes of 10.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eActive Ingredient:\u003c\/strong\u003e Bupivacaine Hydrochloride\u003cbr\u003e\u003cstrong\u003eConcentration\u003c\/strong\u003e: 0.75%\u003cbr\u003e\u003cstrong\u003eDextrose Inclusion\u003c\/strong\u003e: Facilitates specific gravity and distribution in the spinal column\u003cbr\u003e\u003cstrong\u003eVolume\u003c\/strong\u003e: 2 mL per ampule\u003cbr\u003e\u003cstrong\u003ePackaging:\u003c\/strong\u003e 10 single-dose ampules per box\u003cbr\u003e\u003cstrong\u003eUsage:\u003c\/strong\u003e Intended for intrathecal (spinal) injection to induce regional anesthesia\u003cbr\u003e\u003cstrong\u003eManufacturer:\u003c\/strong\u003e Pfizer Injectables\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBupivacaine acts as a long-acting local anesthetic by blocking sodium ion channels in nerve fibers. This blockade inhibits the initiation and conduction of nerve impulses, producing loss of sensation or motor function at the targeted spinal regions. The presence of dextrose aids in the spread of the anesthetic in the cerebrospinal fluid by creating a hyperbaric solution, optimizing the anesthetic effects specific to the site of administration.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular Risks:\u003c\/strong\u003e May cause significant cardiovascular effects, including hypotension and bradycardia. Monitor vital signs closely after administration.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCentral Nervous System Effects:\u003c\/strong\u003e Serious CNS toxicity (e.g., seizures) can occur with systemic absorption or excessive dosages.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePregnancy:\u003c\/strong\u003e While used in obstetric anesthesia, careful consideration and dosing are necessary to minimize risks to the mother and fetus.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContraindications:\u003c\/strong\u003e Not suitable for patients with known hypersensitivity to bupivacaine or other amide-type anesthetics, as well as those with severe mental health disturbances, especially from hypercarbia or hypoxia.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eSide Effects\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCommon Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHypotension\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eNausea or vomiting\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eBradycardia\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eHeadache\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSerious Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular:\u003c\/strong\u003e Severe hypotension, arrhythmias, or cardiac arrest\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCNS\u003c\/strong\u003e: Seizures or prolonged numbness beyond the target area\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRespiratory:\u003c\/strong\u003e Respiratory depression when anesthetic spreads too high (rare in properly managed doses)\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic reactions:\u003c\/strong\u003e Although rare, include skin reactions or anaphylaxis\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eAdministration and Monitoring\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMarcaine Spinal should be administered by trained healthcare professionals experienced in spinal anesthesia techniques. Thorough patient evaluation and preparedness to manage potential adverse reactions are crucial. Continuous monitoring of blood pressure, heart rate, and respiratory status is necessary following administration. The dose should be carefully selected based on the patient's age, body mass, and overall health status, as well as the type and duration of the surgical procedure. Emergency equipment and drugs for resuscitation should be readily available prior to its use.\u003cbr\u003e\u003c\/p\u003e","brand":"Pfizer Injectables","offers":[{"title":"Default Title","offer_id":39929890832456,"sku":"00409-1761-10","price":129.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/products\/Marcaine-Spinal-_bupivacaine-hydrochloride-0.75.jpg?v=1681742563"},{"product_id":"pfizer-bupivacaine-hcl-injection-0-5-single-dose-vials-30-ml-x-25-box-rx","title":"Bupivacaine HCL Injection 0.5% Single-Dose Vials 30 mL x 25\/Box by Pfizer (RX)","description":"\u003cp\u003eBupivacaine HCL Injection 0.5% is a local anesthetic used to provide prolonged pain relief during surgical, dental, and obstetrical procedures, including cesarean sections. It works by blocking nerve signals in the body, resulting in a temporary loss of sensation in the targeted area. This medication is especially useful for epidural anesthesia and peripheral nerve blocks. Due to its duration and potency, it must be administered with caution to avoid potential side effects such as cardiovascular and central nervous system complications.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eActive Ingredient:\u003c\/strong\u003e Bupivacaine Hydrochloride\u003cbr\u003e\u003cstrong\u003eConcentration\u003c\/strong\u003e: 0.5%\u003cbr\u003e\u003cstrong\u003eVolume: \u003c\/strong\u003e30 mL per vial\u003cbr\u003e\u003cstrong\u003ePackaging\u003c\/strong\u003e: 25 single-dose vials per box\u003cbr\u003e\u003cstrong\u003eRoute of Administration:\u003c\/strong\u003e Injectable, typically administered by trained healthcare professionals.\u003cbr\u003e\u003cstrong\u003eIndications\u003c\/strong\u003e: Bupivacaine is used for local or regional anesthesia or analgesia during surgery, dental procedures, and childbirth.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBupivacaine is a long-acting amide-type local anesthetic. It works by blocking sodium ion channels in nerve fibers, which inhibits the depolarization required for the propagation of nerve impulses. This blockade results in a loss of sensation in the targeted area, effectively producing local anesthesia. Its long duration of action makes it suitable for procedures that require extended anesthetic effects.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular Risk\u003c\/strong\u003e: Bupivacaine can cause cardiovascular complications, including hypotension and arrhythmias. Bupivacaine should be used cautiously in patients with cardiovascular issues.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCentral Nervous System Effects:\u003c\/strong\u003e Overdose or improper administration can lead to\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCNS toxicity, \u003c\/strong\u003echaracterized by seizures and respiratory depression.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic Reactions:\u003c\/strong\u003e Although rare, some individuals may experience allergic reactions to bupivacaine.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIntravenous Administration:\u003c\/strong\u003e Bupivacaine is not intended for intravenous regional anesthesia (IVRA or Bier block) due to the increased risk of cardiovascular collapse.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eObstetric Concerns:\u003c\/strong\u003e Use during labor should be closely monitored due to the potential for fetal bradycardia or decreased muscle tone.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eSide Effects\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eWhile bupivacaine is effective for anesthesia, it may cause certain side effects. Administration should be supervised by healthcare professionals to mitigate these risks:\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCommon Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHypotension\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eNausea\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eVomiting\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eDizziness\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSerious Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCardiovascular complications (bradycardia, arrhythmias)\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eNeurological symptoms (seizures, confusion)\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eAllergic reactions (rash, itching, anaphylaxis)\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eRespiratory depression\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003eBupivacaine HCl Injection 0.5% is a potent local anesthetic suitable for a variety of medical applications that require prolonged nerve block. It is essential that this anesthetic be used under the guidance of trained medical professionals, who are equipped to manage potential side effects or complications that arise during its use. Always follow specific dosage and administration guidelines as per the medical institution's protocols and regulatory standards.\u003cbr\u003e\u003c\/p\u003e","brand":"Pfizer Injectables","offers":[{"title":"Default Title","offer_id":39999092293704,"sku":"00409-1162-02","price":129.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Bupivacaine-HCL-Injection-0_5_percent-by-Pfizer.jpg?v=1730809829"},{"product_id":"bupivacaine-hydrochloride-injection-0-25-usp-125-mg-50-ml-multiple-dose-vial-50-ml-rx","title":"Bupivacaine Hydrochloride Injection 0.25% USP 125 mg\/50 mL Multiple Dose Vial 50 mL (RX)","description":"\u003cp\u003eBupivacaine Hydrochloride Injection 0.25% is a local anesthetic used to provide prolonged pain relief by numbing specific areas during surgical, dental, or obstetric procedures. It works by blocking nerve signals in the body, making it essential for regional anesthesia, including epidurals and nerve blocks. Bupivacaine is commonly administered in medical settings to manage pain during and after procedures, ensuring patient comfort and facilitating recovery in surgeries and childbirth.\u003c\/p\u003e\n\u003cp\u003eSomerset Therapeutics presents Bupivacaine Hydrochloride Injection 0.25% USP, a premium local anesthetic solution designed for precise pain management and surgical anesthesia. Contained in a 50 mL multiple-dose vial, this formulation delivers 125 mg of Bupivacaine Hydrochloride per vial, providing healthcare professionals with the reliability and flexibility required in diverse clinical applications, from minor surgical procedures to effective regional pain control.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eConcentration and Volume:\u003c\/strong\u003e Each vial contains 0.25% Bupivacaine Hydrochloride, equivalent to 2.5 mg\/mL, for a total of 125 mg in a 50 mL vial. This concentration ensures an effective balance between anesthetic potency and duration, making it ideal for prolonged procedures.\u003cbr\u003e\u003cstrong\u003ePackaging: \u003c\/strong\u003eOffered in multiple-dose vials, this versatile packaging supports repeated withdrawals under sterile conditions, optimizing operating room efficiency and reducing waste.\u003cbr\u003e\u003cstrong\u003eIndications:\u003c\/strong\u003e Suitable for local or regional anesthesia, including peripheral nerve blockade, infiltration anesthesia, and caudal or lumbar epidural blocks.\u003cbr\u003e\u003cstrong\u003eAdministration: \u003c\/strong\u003eAdministered via injection, tailored for the specific site and depth of anesthesia required for each individual procedure.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBupivacaine is an amide-type local anesthetic that operates by blocking sodium ion influx in nerve cells, which inhibits depolarization required for action potential initiation and propagation. This sodium channel blockade results in a reversible loss of sensation, beginning with pain, followed by temperature, touch, and finally motor functions. Bupivacaine’s unique pharmacokinetic profile ensures a prolonged duration of action, suited for surgeries that require an extensive anesthetic window.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiotoxicity Risk:\u003c\/strong\u003e High systemic levels can induce significant cardiovascular effects, including hypotension, arrhythmias, and in severe cases, cardiac arrest.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiligent monitoring is necessary,\u003c\/strong\u003e especially with higher doses.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCentral Nervous System Effects\u003c\/strong\u003e: Overdose or accidental intravascular injection may lead to central nervous system toxicity, characterized by CNS excitation, followed potentially by CNS depression.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypersensitivity Reactions:\u003c\/strong\u003e Though rare, possible allergic reactions demand pre-procedure screening for known sensitivity to amide-type anesthetics.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIntravascular Injection: \u003c\/strong\u003eAccidental intravascular administration can lead to systemic toxic reactions. Test dosages and vigilant aspiration are advisable during injections to avert inadvertent intravasal delivery.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eSide Effects:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eLocal\u003c\/strong\u003e: Prolonged numbness or tingling at the injection site, localized edema, or nerve irritation.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystemic:\u003c\/strong\u003e Dizziness, tinnitus, or metallic taste if significant systemic absorption occurs.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSevere Reactions\u003c\/strong\u003e: Hypotension, bradycardia, or convulsions in the event of systemic overdose or accidental intravenous administration.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eClinical Considerations:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDosage Precision:\u003c\/strong\u003e Careful calculation of total dose is critical, based on the patient's weight, clinical condition, and procedural requirements to minimize risk.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMonitoring: \u003c\/strong\u003eEssential to monitor cardiovascular and respiratory status throughout administration to detect early signs of adverse reactions.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePatient Evaluation\u003c\/strong\u003e: A thorough patient history, including any previous anesthetic reactions, cardiovascular health assessment, and concurrent medications, should guide the analgesic protocol.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eBupivacaine Hydrochloride Injection from Somerset Therapeutics is formulated to meet the rigorous demands of surgical anesthesia and long-duration pain relief. It demands administration by professionals skilled in local anesthetic techniques, with a keen awareness of safety protocols to optimize both efficacy and patient safety. Detailed prescribing information should be consulted to support precise clinical application.\u003c\/p\u003e","brand":"Somerset Therapeutics","offers":[{"title":"Default Title","offer_id":51668914602352,"sku":"70069-0752-01","price":6.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Bupivacaine-Hydrochloride-Injection-0.25.jpg?v=1734544490"},{"product_id":"bupivacaine-hydrochloride-0-5-injection-sdv-preservative-free-30-ml","title":"Bupivacaine Hydrochloride 0.5% Injection SDV, Preservative Free 30 mL by Hikma (Rx)","description":"\u003cp\u003eBupivacaine Hydrochloride 0.5% Injection is a high-quality, preservative-free local anesthetic solution designed for surgical anesthesia and pain management. With its trusted formulation, this injection offers reliable onset and extended duration of action, making it an essential choice for healthcare professionals.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUsage:\u003c\/strong\u003e Bupivacaine is primarily used for local or regional anesthesia in various surgical procedures. It is suitable for peripheral nerve blocks, epidural anesthesia, and sympathetic nerve blocks, providing effective pain relief during and after operations.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDosage:\u003c\/strong\u003e The dosage of Bupivacaine Hydrochloride depends on the procedure, the specific requirements of the patient, and the method of administration. It should be administered by a trained healthcare professional. Consultation with relevant medical guidelines or a specialist is recommended to determine the appropriate dosing.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCDC Guidelines:\u003c\/strong\u003e While the CDC provides overarching guidelines for the use of anesthetics in clinical settings, it emphasizes the importance of adhering to aseptic techniques and monitoring patient vitals during administration to prevent complications. Always follow institutional protocols and national guidelines when using anesthetics.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.5% Bupivacaine Hydrochloride\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePackaging:\u003c\/strong\u003e Single-Dose Vial (SDV)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVolume:\u003c\/strong\u003e 30 mL\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePreservative-Free:\u003c\/strong\u003e Minimizes the risk of hypersensitivity reactions\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSterile Formulation:\u003c\/strong\u003e Ensures patient safety and efficacy\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExtended Duration:\u003c\/strong\u003e Offers prolonged anesthesia suitable for lengthy procedures\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action:\u003c\/strong\u003e Bupivacaine works by inhibiting sodium ion influx through nerve cell membranes. This blocks nerve impulse transmission, effectively preventing the sensation of pain without causing significant motor blockade at lower concentrations.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections for Use:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eInspect the vial for particulate matter and discoloration before use.\u003c\/li\u003e\n\u003cli\u003eAdminister using sterile equipment.\u003c\/li\u003e\n\u003cli\u003eAdhere to the prescribed technique for the selected mode of anesthesia.\u003c\/li\u003e\n\u003cli\u003eMonitor patient's vitals and response continuously during the procedure.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFor professional use only.\u003c\/li\u003e\n\u003cli\u003eNot intended for intravenous (IV) administration.\u003c\/li\u003e\n\u003cli\u003eExercise caution in patients with cardiovascular disease or liver dysfunction.\u003c\/li\u003e\n\u003cli\u003eMay cause central nervous system and cardiovascular adverse reactions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSide Effects:\u003c\/strong\u003e Some patients may experience side effects, including:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHypotension\u003c\/li\u003e\n\u003cli\u003eDizziness\u003c\/li\u003e\n\u003cli\u003eNausea\u003c\/li\u003e\n\u003cli\u003eBradycardia\u003c\/li\u003e\n\u003cli\u003eAllergic reactions In the event of adverse effects, discontinue use and provide appropriate medical intervention.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eBupivacaine Hydrochloride 0.5% Injection SDV by Hikma Injectables delivers reliable anesthesia with precision, safety, and efficiency, upholding the highest standards of patient care.\u003c\/em\u003e\u003c\/p\u003e","brand":"Hikma Injectables","offers":[{"title":"Default Title","offer_id":52232481440112,"sku":"70594-0118-01","price":5.1,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Bupivacaine-HCL-Injection-0_5_percent-by-Pfizer.jpg?v=1730809829"},{"product_id":"bupivacaine-hydrochloride-injection-0-5-single-dose-vial-30-ml-nerve-block-caudal-epidural-anesthesia-rx","title":"Bupivacaine Hydrochloride Injection 0.5% Single Dose Vial 30 mL Nerve Block, Caudal \u0026 Epidural Anesthesia (RX)","description":"\u003ch3\u003eNerve Block, Caudal and Epidural Anesthesia\u003c\/h3\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003e\u003cstrong\u003eBupivacaine Hydrochloride Injection 0.5%\u003c\/strong\u003e (30 mL Single Dose Vial) is a high-quality, long-acting \u003cstrong\u003elocal anesthetic\u003c\/strong\u003e ideal for \u003cstrong\u003enerve block\u003c\/strong\u003e, \u003cstrong\u003ecaudal anesthesia\u003c\/strong\u003e, and \u003cstrong\u003eepidural anesthesia\u003c\/strong\u003e procedures. Trusted by healthcare professionals and top hospitals nationwide, this \u003cstrong\u003eprescription injectable anesthetic\u003c\/strong\u003e delivers optimal pain control during surgery, labor and delivery, dental procedures, and minor surgical interventions.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eUses:\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNerve Block anesthesia\u003c\/strong\u003e for surgical procedures on arms, legs, and torso\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpidural anesthesia\u003c\/strong\u003e for labor, delivery, or lower body surgeries\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCaudal anesthesia\u003c\/strong\u003e in pediatric and adult procedures\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLocal and regional anesthesia\u003c\/strong\u003e (infiltration and peripheral nerve blocks)\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003ePostoperative pain management\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eBenefits \u0026amp; Features:\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFast, Effective Pain Relief:\u003c\/strong\u003e Blocks nerve impulses for superior pain management during and after medical and surgical procedures.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLong-Lasting Numbing Action:\u003c\/strong\u003e Provides prolonged anesthesia, minimizing the need for repeat dosing and ensuring patient comfort.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVersatile Clinical Applications:\u003c\/strong\u003e Indicated for \u003cstrong\u003elocal, regional, caudal, and epidural anesthesia\u003c\/strong\u003e in adults and children.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSterile, Single-Use Vial:\u003c\/strong\u003e 30 mL vial ensures sterility and reduces infection risk.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTrusted Quality:\u003c\/strong\u003e Manufactured according to stringent USP and FDA standards for safety and efficacy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eWhat is Bupivacaine Hydrochloride Injection?\u003c\/h4\u003e\n\u003cp\u003eBupivacaine Hydrochloride is an \u003cstrong\u003eamino amide local anesthetic\u003c\/strong\u003e widely used for pain management in medical and surgical settings. It functions by blocking sodium channels, inhibiting nerve signal transmission, and providing robust anesthesia with minimal systemic toxicity.\u003c\/p\u003e\n\u003ch4\u003eSafety \u0026amp; Administration:\u003c\/h4\u003e\n\u003cp\u003eBupivacaine is administered only by trained healthcare professionals. Always adhere strictly to dosage recommendations and be vigilant for adverse reactions, including \u003cstrong\u003esystemic toxicity\u003c\/strong\u003e, \u003cstrong\u003ecardiac side effects\u003c\/strong\u003e, and \u003cstrong\u003eallergic reactions\u003c\/strong\u003e.\u003c\/p\u003e\n\u003ch4\u003eContraindications:\u003c\/h4\u003e\n\u003cp\u003eDo not use in patients with hypersensitivity to amide-type local anesthetics, severe heart block, or severe shock.\u003c\/p\u003e\n\u003ch4\u003eStorage:\u003c\/h4\u003e\n\u003cp\u003eStore at controlled room temperature. Keep out of reach of children.\u003c\/p\u003e\n\u003ch4\u003eFrequently Asked Questions:\u003c\/h4\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eHow long does bupivacaine last?\u003c\/strong\u003e Provides anesthesia for up to 8 hours depending on dosage and route.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eCan it be used for spinal anesthesia?\u003c\/strong\u003e Bupivacaine is indicated for various forms of regional and spinal anesthesia.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eWhat are its side effects?\u003c\/strong\u003e Main adverse reactions include hypotension, bradycardia, CNS effects, and rare allergic responses.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch3\u003e\u003cstrong\u003eOrder Bupivacaine Hydrochloride Injection 0.5% 30 mL Vial Today!\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eExperience superior pain control and optimal procedural outcomes with FDA-approved \u003cstrong\u003eBupivacaine Hydrochloride Injection\u003c\/strong\u003e. \u003cstrong\u003eBuy online\u003c\/strong\u003e for fast shipping and competitive pricing for hospitals, clinics, and surgical centers.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChoose the gold-standard in injectable anesthetics for safe, effective, and long-lasting anesthesia.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Meitheal Pharmaceutical","offers":[{"title":"Default Title","offer_id":52684442501488,"sku":"71288-0725-32","price":6.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Bupivacaine-Hydrochloride-Injection-0.5_-Single-Dose-Vial-30-mL-Nerve-Block.jpg?v=1763049400"},{"product_id":"bupivacaine-injection-0-25-single-dose-vials-30ml-preservative-free-25-box-rx","title":"Bupivacaine Injection 0.25% Single Dose Vials 30mL Preservative Free 25\/Box (RX)","description":"\u003ch2\u003eBupivacaine 0.25% Injection (30 mL Single-Dose, Preservative-Free)\u003c\/h2\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003e\u003cstrong\u003eBupivacaine injection\u003c\/strong\u003e is a \u003cstrong\u003elocal anesthetic\u003c\/strong\u003e (numbing medication) used to prevent or relieve pain during medical procedures. It belongs to the amide class of local anesthetics (chemically related to lidocaine and mepivacaine) and was first discovered in 1957. Bupivacaine works by \u003cstrong\u003eblocking nerve signals\u003c\/strong\u003e in the area where it’s injected, so that pain impulses are not transmitted to the brain. Unlike general anesthesia, it causes loss of sensation in a targeted region without making the patient unconscious.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eBupivacaine Injection Uses\u003c\/h2\u003e\n\u003cp\u003eBupivacaine is a \u003cstrong\u003elong-acting local anesthetic\u003c\/strong\u003e used to produce numbness (anesthesia or analgesia) in a specific area of the body for various medical purposes. Doctors commonly use bupivacaine 0.25% in the following ways:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eInfiltration anesthesia:\u003c\/strong\u003e Injecting the solution directly into tissues to numb a small area. For example, a surgeon might infiltrate bupivacaine around a wound or surgical incision site to provide pain relief during and after a procedure. Dental procedures or stitching of lacerations may use bupivacaine to keep the area painless for a prolonged period.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeripheral nerve blocks:\u003c\/strong\u003e Injecting near a specific nerve or bundle of nerves to block sensation from a larger region (such as an entire arm, leg, or the nerves of the chest\/abdomen). Bupivacaine’s long duration makes it ideal for nerve blocks in orthopedic surgery or for post-operative pain control; a single injection near the nerve can keep an area numb for several hours.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpidural anesthesia\/analgesia:\u003c\/strong\u003e Injecting into the \u003cstrong\u003eepidural space\u003c\/strong\u003e (around the spinal cord in the lower back) to numb the lower half of the body, often used for \u003cstrong\u003echildbirth (labor pain relief)\u003c\/strong\u003e or surgeries of the lower abdomen, pelvis, or legs. In obstetrics, dilute bupivacaine (for example 0.25% or even lower) is frequently used in epidurals to relieve pain while minimizing muscle blockade, allowing the mother to participate in delivery. Bupivacaine is also used in epidurals for major surgeries or post-surgical pain management, delivered either as single injections or continuous infusions via an epidural catheter.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpinal anesthesia:\u003c\/strong\u003e In certain cases, a form of bupivacaine can be injected into the cerebrospinal fluid (a “spinal block”) for surgeries requiring a dense block of sensation (e.g., cesarean sections or lower limb surgeries). Typically a specialized preservative-free formulation (often hyperbaric bupivacaine with dextrose) is used for spinal anesthesia. (The 0.25% solution in 30 mL vials is more often used for epidural or nerve block techniques; many spinal anesthetics use 0.75% heavy bupivacaine in small ampules.)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIn all these uses, bupivacaine causes a reversible loss of sensation. The drug’s effect generally begins within 5–15 minutes after injection (depending on the dose and proximity to the nerves) and can last \u003cstrong\u003emuch longer than shorter-acting agents\u003c\/strong\u003e – often providing \u003cstrong\u003enumbness for 2 to 6 hours or more\u003c\/strong\u003e (with higher concentrations and certain block techniques, pain relief can extend up to 8-12 hours). This prolonged action is why bupivacaine is favored for procedures where extended pain control is desired. Sometimes epinephrine (adrenaline) is added (in separate formulations of bupivacaine) to constrict blood vessels and further \u003cstrong\u003eprolong the anesthesia duration\u003c\/strong\u003e and reduce bleeding, but the \u003cstrong\u003epreservative-free 0.25% vials\u003c\/strong\u003e usually do \u003cstrong\u003enot\u003c\/strong\u003e contain epinephrine (they are plain bupivacaine solution).\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003eBupivacaine 0.25% injection (30 mL preservative-free single-dose vial) is a long-acting local anesthetic used by healthcare professionals to \u003cstrong\u003enumb specific areas\u003c\/strong\u003e for surgery, childbirth, dental work, and other procedures. It blocks nerve conduction to prevent pain, with effects that can last for several hours. This formulation’s lack of preservatives makes it safe for sensitive uses like epidural anesthesia. While highly effective for pain control, it must be administered with caution – inadvertent injection into the bloodstream or use of excessive doses can lead to serious \u003cstrong\u003ecentral nervous system and cardiovascular toxicity\u003c\/strong\u003e, so careful monitoring is required. When used properly, bupivacaine enables medical procedures to be performed pain-free and provides prolonged pain relief in the post-operative or labor setting, significantly improving patient comfort.\u003c\/span\u003e\u003c\/p\u003e","brand":"Camber Pharma","offers":[{"title":"Default Title","offer_id":53421665976688,"sku":"31722-0275-34","price":95.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Bupivacaine-Injection-0.25_-Camber.jpg?v=1774521445"},{"product_id":"bupivacaine-injection-0-5-single-dose-50mg-10ml-preservative-free-10-ml","title":"Bupivacaine Injection 0.5% Single Dose 50mg\/10ml Preservative-Free 10 ml x 10\/Box (RX)","description":"\u003ch1\u003eBupivacaine Injection 0.5% (Preservative-Free)\u003c\/h1\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003e\u003cstrong\u003eBupivacaine 0.5% Injection\u003c\/strong\u003e is a \u003cstrong\u003elocal anesthetic solution\u003c\/strong\u003e used to produce numbness (loss of sensation) in a specific area of the body. It contains \u003cstrong\u003ebupivacaine hydrochloride\u003c\/strong\u003e, a potent long-acting anesthetic of the amide class, dissolved in sterile water for injection. This formulation is \u003cstrong\u003e0.5% w\/v\u003c\/strong\u003e, meaning it has 5 mg of bupivacaine per mL; in a 10 mL vial there is a total of \u003cstrong\u003e50 mg\u003c\/strong\u003e of the drug. The product is labeled “\u003cstrong\u003eSingle Dose, Preservative-Free\u003c\/strong\u003e,” indicating that the vial is intended for one-time use and contains \u003cstrong\u003eno antimicrobial preservatives\u003c\/strong\u003e (such as parabens). Without a preservative, any unused solution must be discarded after opening to maintain sterility and safety.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eUses in Anesthesia\u003c\/h2\u003e\n\u003cp\u003eBupivacaine 0.5% is utilized by medical professionals to produce \u003cstrong\u003elocal or regional anesthesia\u003c\/strong\u003e (numbing a specific area without affecting consciousness). Common uses include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eInfiltration Anesthesia:\u003c\/strong\u003e Injecting directly into tissues to numb a small area (for example, to suture a laceration or for minor surgical procedures).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeripheral Nerve Blocks:\u003c\/strong\u003e Injecting near a specific nerve or nerve plexus to anesthetize an entire region. For instance, a brachial plexus block can numb an arm for surgery, and an intercostal nerve block can numb an area of the ribs. Bupivacaine is often chosen for nerve blocks when a longer duration of pain relief is desired.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpidural Anesthesia:\u003c\/strong\u003e Injection into the epidural space around the spinal cord (such as in the lumbar region) to block pain from an entire portion of the body. Epidural bupivacaine is commonly used for labor and delivery (obstetrical epidurals) and for surgeries of the lower limbs, abdomen, or pelvis. The 0.5% preservative-free solution is suitable for epidural use. (Higher concentrations like 0.75% are generally \u003cem\u003enot\u003c\/em\u003e used in obstetrical epidurals due to a higher risk of cardiac toxicity in pregnant patients.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCaudal and Spinal Blocks:\u003c\/strong\u003e In caudal anesthesia (a type of epidural given through the sacral canal) or spinal anesthesia (injection into the subarachnoid space), bupivacaine can provide profound numbness for surgeries below the waist. Only preservative-free, sterile solutions are used for these central neural blocks to avoid any neurotoxic additives. (Note: A specialized formulation of bupivacaine with dextrose is often used for spinal anesthesia to make it heavier than cerebrospinal fluid).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRetrobulbar Block:\u003c\/strong\u003e Injection behind the eyeball (into the retrobulbar space) to numb the eye muscles and nerves for ophthalmic procedures. Bupivacaine’s long action is useful for longer eye surgeries.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDental and Minor Surgical anesthesia:\u003c\/strong\u003e Although lidocaine is more common for dental work, bupivacaine 0.5% (often with epinephrine) is sometimes used for lengthy dental procedures or for prolonged postoperative dental pain relief due to its extended duration.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIn all these uses, bupivacaine is administered by trained healthcare providers (such as anesthesiologists, nurse anesthetists, or surgeons) in a controlled setting. The onset of numbness with bupivacaine is a bit slower (taking anywhere from 5 to 15 minutes to fully work), but the trade-off is a much longer-lasting effect compared to shorter-acting local anesthetics.\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003e\u003cem\u003eBupivacaine Injection 0.5% (50 mg\/10 mL) is a single-use, preservative-free local anesthetic solution. It is a \u003cstrong\u003elong-duration anesthetic\u003c\/strong\u003e employed for numbing specific areas during surgery or painful procedures (via infiltration, nerve blocks, or epidurals). It achieves anesthesia by blocking nerve conduction (sodium channel blockade). While extremely useful for pain control, it must be used with care to avoid systemic toxicity. The preservative-free single-dose format ensures it’s safe for sensitive applications like epidural anesthesia and minimizes the risk of adverse reactions.\u003c\/em\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"Fosun Pharma USA","offers":[{"title":"Default Title","offer_id":53421808353648,"sku":"72266-0264-10","price":46.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Bupivacaine-Injection-0.5_-Single-Dose-50mg.jpg?v=1774523988"},{"product_id":"bupivacaine-0-5-injection-50-mg-per-10-ml-x-25-vials","title":"Bupivacaine 0.5% Injection 50 mg Per 10 ml x 25 Vials (RX)","description":"\u003ch1\u003eBupivacaine 0.5% Injection (50 mg per 10 mL)\u003c\/h1\u003e\n\u003cp\u003eBupivacaine is a potent amide-type local anesthetic used by clinicians for regional anesthesia. Each mL of a 0.5% solution contains 5 mg of bupivacaine (so a 10 mL vial has 50 mg). It blocks nerve impulse conduction by binding to open voltage-gated sodium channels in nerve membranes, stabilizing their inactive state and preventing depolarization. Bupivacaine has a relatively slow onset (often 10–20 minutes for operative anesthesia) but a \u003cstrong\u003elong duration\u003c\/strong\u003e of action (several hours of sensory and motor block) compared to shorter-acting agents.\u003c\/p\u003e\n\u003ch2\u003eUses\u003c\/h2\u003e\n\u003cp\u003eBupivacaine 0.5% injection (with or without added epinephrine) is used to produce \u003cstrong\u003eregional anesthesia or analgesia\u003c\/strong\u003e for various procedures. Indications include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSurgical anesthesia:\u003c\/strong\u003e infiltration or field block for surgery (especially when prolonged anesthesia is needed), and peripheral nerve blocks for procedures on limbs or torso.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpidural and caudal blocks:\u003c\/strong\u003e labor\/delivery pain relief and postoperative analgesia (e.g. epidural anesthesia during obstetrical or orthopedic procedures). (Only preservative-free drug should be used in epidural\/caudal space.)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiagnostic\/therapeutic nerve blocks:\u003c\/strong\u003e e.g. sympathetic blocks, neck or ganglion blocks that require long-duration anesthetic effect.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eObstetrical anesthesia:\u003c\/strong\u003e Bupivacaine 0.5% (often diluted) is commonly used in epidural labor analgesia. It provides visceral and somatic block for Cesarean delivery or labor.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eNot indicated:\u003c\/strong\u003e This formulation should \u003cstrong\u003enever be given by spinal (intrathecal)\u003c\/strong\u003e injection (Intrathecal bupivacaine is given in special hyperbaric preparations at different concentrations.) It is used only by trained personnel, not for routine outpatient or self-administration.\u003c\/p\u003e\n\u003ch2\u003eDosage and Administration\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eAdministration route:\u003c\/strong\u003e Bupivacaine 0.5% is given by injection, typically \u003cstrong\u003eslowly\u003c\/strong\u003e and in controlled increments. Aspirate before injecting to avoid intravascular administration. Monitor blood pressure and ECG during injection due to systemic effects. Always use the appropriate dose and formulation (e.g. preservative-free for neuraxial use).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eTypical dosing:\u003c\/strong\u003e The dose depends on patient size, site, and block technique. Each mL contains 5 mg of drug. A single 10 mL vial (50 mg) is often used for minor blocks. For larger blocks or epidurals, volumes of 10–20 mL (50–100 mg) may be given. For example, epidural anesthesia often uses 10–20 mL of 0.5% (50–100 mg) for a moderate-to-complete motor block. Peripheral nerve blocks may use smaller volumes (e.g. 5–10 mL, 25–50 mg) to cover a nerve distribution. In obstetrics, continuous epidural or infusion techniques use more dilute solutions (e.g. 0.125–0.25% with opioids) rather than 0.5%.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eMaximum dose:\u003c\/strong\u003e Because of systemic toxicity risk, total dose limits must be observed. For an average adult, single-dose bupivacaine generally should \u003cstrong\u003enot exceed ~150–175 mg\u003c\/strong\u003e (about 30–35 mL of 0.5%). (This is roughly 2–2.5 mg\/kg for a 70-kg patient.) If epinephrine is added, slightly higher maximal doses (up to ~3 mg\/kg) are sometimes tolerated. Repeated injections (if needed) are usually given no more frequently than every 3–4 hours, with a 24-hour total not exceeding ~400 mg. In all cases, dose must be tailored to patient factors (age, weight, comorbidities) and monitored closely.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial techniques:\u003c\/strong\u003e Before performing labor epidurals or major blocks, clinicians often administer a \u003cstrong\u003etest dose\u003c\/strong\u003e (e.g. 3 mL of 0.5% solution with epinephrine) to check for inadvertent intrathecal or intravascular placement. (This formulation without epinephrine would not contain epinephrine, but the principle of slow injection and monitoring still applies.)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSide Effects and Safety\u003c\/h2\u003e\n\u003cp\u003eBecause bupivacaine is a \u003cstrong\u003epotent anesthetic\u003c\/strong\u003e, side effects stem from both its local action and potential systemic absorption:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eCNS effects (LAST – Local Anesthetic Systemic Toxicity):\u003c\/strong\u003e Early warning signs of toxicity include central nervous system symptoms: circumoral numbness, tinnitus, blurred vision, dizziness, lightheadedness, tingling, or tremors. If plasma levels get high (e.g. from rapid IV injection or excessive dose), seizures (tonic-clonic convulsions) can occur. Importantly, bupivacaine can cause \u003cem\u003eimmediate cardiotoxicity\u003c\/em\u003e without warning by CNS signs.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eCardiovascular effects:\u003c\/strong\u003e Bupivacaine is notably cardiotoxic at higher concentrations. Overdose or intravascular injection may cause severe cardiac arrhythmias. Reported signs include \u003cstrong\u003ebradycardia\u003c\/strong\u003e, conduction blocks (AV block), ventricular arrhythmias, and even cardiac arrest. In obstetric cases, there are rare reports of cardiovascular collapse during epidural use. Hypotension and reflex tachycardia can occur as a sympathetic block effect, especially with larger volume epidurals. (If epinephrine is present, careful with underlying heart conditions.)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eAllergic reactions:\u003c\/strong\u003e True IgE-mediated allergy to bupivacaine is extremely rare. Bupivacaine contains no ester groups and has low cross-reactivity; most “allergy” is actually to preservatives\/sulfites (in epinephrine vials). Standard contraindications include any history of hypersensitivity to amide local anesthetics or to any formulation component. If a rash, swelling, or anaphylactic reaction occurs after injection, treatment must be stopped and appropriate care given.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eNeurotoxicity:\u003c\/strong\u003e High spinal or epidural blocks can cause prolonged neurological effects. Care must be taken not to inject intrathecally (spinal) unless using the proper formulation. Post-LP syndrome or nerve injury can occur if technique is improper. Repeated intra-articular infusions of local anesthetics (e.g. pain pumps in shoulder joints) have been linked to cartilage damage (chondrolysis), although a single injection is generally safe.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eOthers:\u003c\/strong\u003e Bupivacaine can induce methemoglobinemia (rarely), so watch for cyanosis\/dark blood if given high doses intravenously or to infants. Large epidural blocks can cause respiratory depression if very high neuraxial block occurs (e.g. diaphragmatic weakness). Nausea, vomiting, urinary retention, and fever have been reported with epidural use.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMonitoring:\u003c\/strong\u003e Because of these risks, bupivacaine injections are given only by experienced providers with resuscitation equipment at hand. Vital signs (blood pressure, heart rate, ECG, oxygen saturation) are monitored. If any symptoms of toxicity arise, injection is stopped. Intravenous lipid emulsion (lipid rescue) is a treatment for severe LAST (cardiac arrest) in case it occurs.\u003c\/p\u003e\n\u003ch2\u003ePrecautions and Contraindications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eContraindicated uses:\u003c\/strong\u003e Do \u003cem\u003enot\u003c\/em\u003e use bupivacaine 0.5% for \u003cstrong\u003eobstetric paracervical block\u003c\/strong\u003e (this technique can cause fetal bradycardia and death). Bupivacaine is also contraindicated for intravenous regional anesthesia (Bier block). Other absolute contra: known allergy to bupivacaine or related amide anesthetics. Avoid formulations containing preservatives (e.g. multi-dose vials) for epidural or spinal use.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eHepatic impairment:\u003c\/strong\u003e Bupivacaine is \u003cstrong\u003emetabolized in the liver\u003c\/strong\u003e, so patients with severe liver disease clear it more slowly. Dose reduction and careful monitoring are recommended in hepatic impairment. Excessive levels can build up with repeated dosing in such patients.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eRenal impairment:\u003c\/strong\u003e Bupivacaine and its metabolites are excreted by the kidneys. In renal failure, accumulation can occur over time; use caution and assess dosing for renal insufficiency.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eCardiovascular disease:\u003c\/strong\u003e Patients with conduction blocks, bradycardia, or severe cardiac dysfunction should receive bupivacaine only with extreme caution. Concurrent use of other cardiodepressant drugs (beta-blockers, certain calcium channel blockers, antiarrhythmics) may magnify bupivacaine’s effects. Also, because dose administration can cause hypotension, ensure patient volume is adequate before large epidural blocks.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003ePregnancy\/lactation:\u003c\/strong\u003e Bupivacaine crosses the placenta, so maternal administration can affect the fetus (fetal heart rate should be monitored in obstetric use). While widely used for labor analgesia, it should only be used when benefit outweighs risk. Bupivacaine is excreted into breast milk in small amounts; caution is advised if nursing (though a one-time block is unlikely to harm the infant significantly).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eOther drugs:\u003c\/strong\u003e Avoid mixing with other local anesthetics in the same syringe. Some drug interactions: potent CYP3A4 inhibitors (e.g. cimetidine) can raise plasma bupivacaine levels, whereas inducers (e.g. phenytoin, rifampin) can lower levels. If epinephrine is added, drugs affecting coagulation or the fetus should be considered.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSummary\u003c\/h2\u003e\n\u003cp\u003eBupivacaine 0.5% (5 mg\/mL) injection is a prescription local anesthetic given by healthcare professionals for \u003cstrong\u003elong-duration regional anesthesia\u003c\/strong\u003e. It provides several hours of numbness and muscle relaxation, making it useful for surgeries, labor epidurals, and nerve blocks. The typical adult dose is individually determined (often up to 10–20 mL for epidural blocks), with absolute maximums around 150–175 mg per single dose. Careful administration is crucial: do not inject intravenously or intrathecally. Common side effects include numbness and muscle weakness in the blocked area; serious risk comes from systemic absorption – manifesting as neurological (e.g. seizures) and cardiovascular (arrhythmias, hypotension) toxicity. Strict monitoring of vital signs and readiness to manage complications (e.g. airway, blood pressure support, intralipid) are standard practice.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImportant:\u003c\/strong\u003e Bupivacaine injection is \u003cem\u003enot\u003c\/em\u003e for patient self-use and should be used exactly as directed by an anesthesiologist or physician. Always follow the clinician’s instructions and equipment protocols when this drug is used. If any adverse symptoms (e.g. numbness beyond expected, difficulty breathing or heartbeat changes) occur during or after its use, notify medical staff immediately.\u003c\/p\u003e","brand":"Eugia US","offers":[{"title":"Default Title","offer_id":53723137704304,"sku":"55150-0169-10P","price":79.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Bupivacaine-0.5_-Injection-50-mg-Per-10-ml.jpg?v=1778165038"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/collections\/Bupivacaine-Injections.jpg?v=1739385751","url":"https:\/\/www.mountainside-medical.com\/collections\/bupivacaine.oembed?constraint=anesthesia","provider":"Mountainside Medical","version":"1.0","type":"link"}