{"title":"Marcaine","description":"Marcaine injections, containing the active ingredient bupivacaine, are local anesthetics used for pain management and surgical procedures. They work by blocking nerve signals in a specific area, providing effective pain relief. Commonly used in dentistry, orthopedic surgery, and childbirth, Marcaine offers prolonged anesthesia compared to other agents. Its targeted application ensures focused pain control, making it ideal for both minor and major procedures. Safety and dosage must be professionally managed.","products":[{"product_id":"marcaine-bupivacaine-hydrochloride-for-injection-75mg-10ml-10-vials","title":"Marcaine (Bupivacaine Hydrochloride) 0.75% Injection 10 mL Vials, 10\/pack (Rx)","description":"\u003cp\u003eMarcaine (Bupivacaine Hydrochloride) 0.75% Injection is a local anesthetic used to provide long-lasting pain relief during surgical, dental, and obstetric procedures. It works by blocking nerve signals in specific areas of the body, preventing the sensation of pain. Marcaine is particularly effective for regional anesthesia techniques such as epidurals, nerve blocks, and spinal anesthesia, making it ideal for managing pain in complex procedures, labor and delivery, and postoperative recovery.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActive Ingredient: Bupivacaine Hydrochloride\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eConcentration: 0.75% (7.5 mg\/mL)\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eVolume: 10 mL per vial\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003ePackaging: 10 vials per pack\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eFormulation: Sterile solution for injection\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eUsage: Used for local or regional anesthesia during surgeries, dental procedures, or chronic pain management.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eManufacturer: Pfizer Injectables\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBupivacaine works by binding to and inhibiting voltage-gated sodium channels on nerve cells. This action blocks nerve impulse generation and propagation, thereby providing a local anesthetic effect. Bupivacaine has a longer duration of action compared to other local anesthetics, making it particularly useful for prolonged surgical procedures or pain relief.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular Risks:\u003c\/strong\u003e Potential for cardiovascular complications including hypotension and arrhythmias; use with caution in patients with cardiovascular disease.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCentral Nervous System Effects:\u003c\/strong\u003e Risk of central nervous system toxicity, including seizures, especially if administered intravascularly.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic Reactions:\u003c\/strong\u003e Rare potential for hypersensitivity reactions; contraindicated in patients with known allergies to amide-type anesthetics.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePregnancy: \u003c\/strong\u003eShould be used cautiously in obstetric anesthesia due to potential effects on the mother and fetus.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInjection Technique: \u003c\/strong\u003eMust be meticulously administered to avoid accidental intravascular injection.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContraindications:\u003c\/strong\u003e Avoid use in intravenous regional anesthesia (Bier block).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSide Effects\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCommon Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eLocal irritation at the injection site\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eDizziness\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eNausea or vomiting\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eSensations of tingling or numbness\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSerious Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular:\u003c\/strong\u003e Arrhythmias, bradycardia, cardiac arrest\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCNS Toxicity: Seizures,\u003c\/strong\u003e confusion, nervousness\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRespiratory distress:\u003c\/strong\u003e Difficulty breathing in severe cases\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic Reactions:\u003c\/strong\u003e Urticaria, rash, or anaphylactic reactions\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eAdministration and Monitoring\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMarcaine should be administered by healthcare professionals experienced with regional anesthesia and the management of potential complications. Continuous monitoring of the patient's cardiovascular and respiratory status is advised during administration. Emergency resuscitative equipment and medications should be immediately available in case of adverse reactions. Dosage should be tailored to the individual needs of the patient and the specific procedure being performed, taking special care in patients with underlying health conditions that may influence their reaction to the drug.\u003cbr\u003e\u003c\/p\u003e","brand":"Pfizer Injectables","offers":[{"title":"Default Title","offer_id":39615355453512,"sku":"00409-1582-10","price":102.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Marcaine-_Bupivacaine-Hydrochloride_-0.75_-Injection-Tary-of-10-Vials.jpg?v=1730725255"},{"product_id":"marcaine-bupivacaine-hydrochloride-with-epinephrine-1-200-000-for-injection-0-25-multi-dose-50ml-vial","title":"Marcaine (Bupivacaine Hydrochloride) 125 mg\/50 mL with Epinephrine 1:200,000 Injection 0.25% Multi-Dose 50mL Vial (Rx)","description":"\u003cp\u003eMarcaine (Bupivacaine Hydrochloride) 125 mg\/50 mL with Epinephrine 1:200,000 is used for local anesthesia and pain management during surgical, dental, and obstetric procedures. The addition of epinephrine prolongs the anesthetic effect by constricting blood vessels, minimizing bleeding, and reducing the rate of systemic absorption. This formulation provides prolonged muscle relaxation and sensory blockade, making it suitable for procedures requiring extended anesthesia. Bupivacaine is preferred for its long-lasting effects, ensuring effective patient comfort and control over pain during and post-procedure.\u003c\/p\u003e\n\u003cp\u003eMarcaine (Bupivacaine Hydrochloride) with Epinephrine Injection is a long-lasting local anesthetic formulation designed for producing regional anesthesia or nerve block during surgical, dental, or diagnostic procedures. This specific formulation combines Bupivacaine, a potent amide-type anesthetic, with Epinephrine to extend the duration of anesthetic action by reducing local blood flow.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKey Features\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eActive Ingredients: \u003c\/strong\u003eThe formulation contains 125 mg of Bupivacaine Hydrochloride per 50 mL and Epinephrine at a concentration of 1:200,000, providing effective anesthesia with prolonged action.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e This 0.25% solution offers a balanced potency suitable for a wide range of medical applications, ensuring effective nerve blockade while minimizing potential toxicity.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpinephrine Addition:\u003c\/strong\u003e The inclusion of Epinephrine helps to constrict blood vessels at the site of administration, thereby prolonging the anesthetic effect of Bupivacaine and reducing systemic absorption, which enhances the action and safety profile.\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMulti-Dose Vial:\u003c\/strong\u003e Packaged in a 50 mL multi-dose vial, it allows for multiple uses from the same vial when sterile technique is employed, making it a convenient cost-effective option for clinical settings.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eUsage and Application\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegional Anesthesia:\u003c\/strong\u003e Ideal for procedures where localized numbness is required, such as surgeries involving extremities, where spinal or epidural anesthesia may be applied.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNerve Block:\u003c\/strong\u003e Used in various nerve blocks to manage pain during and after surgical procedures.\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpidural Anesthesia:\u003c\/strong\u003e Can be utilized in epidural blocks, especially when combined with analgesics for labor pain management.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSafety and Precautions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eContraindications\u003c\/strong\u003e: Marcaine should not be used in patients with a known hypersensitivity to local anesthetics of the amide type or any component of the formulation.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMonitoring:\u003c\/strong\u003e Continuous monitoring of cardiovascular and respiratory functions is recommended during administration due to potential systemic effects.\u003cbr\u003e\u003cstrong\u003e\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHandling:\u003c\/strong\u003e Multi-dose vials should be handled under sterile conditions to prevent contamination.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eStorage Information\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage Conditions\u003c\/strong\u003e: Store at controlled room temperature and protect from light to maintain the stability of the formulation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eManufacturer Information\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBrand:\u003c\/strong\u003e Manufactured by Pfizer Injectables, a globally recognized leader in pharmaceutical solutions ensuring stringent quality control and reliability.\u003c\/p\u003e\n\u003cp\u003eMarcaine with Epinephrine provides a reliable and effective anesthetic solution for a wide range of medical procedures, ensuring safety and efficacy in local anesthesia practices.\u003c\/p\u003e","brand":"Pfizer Injectables","offers":[{"title":"Default Title","offer_id":39726135935048,"sku":"00409-1752-50","price":38.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Marcaine-_Bupivacaine-Hydrochloride_-125-mg-50-mL-with-Epinephrine.jpg?v=1742840295"},{"product_id":"marcaine-spinal-bupivacaine-hydrochloride-0-75-in-dextrose-injection-2-ml-x-10-single-dose-ampules","title":"Marcaine Spinal (bupivacaine hydrochloride 0.75% in dextrose injection) 2 mL x 10 Single-Dose Ampules","description":"\u003cp\u003eMarcaine Spinal (bupivacaine hydrochloride 0.75% in dextrose injection) is used for spinal anesthesia to provide prolonged pain relief during lower abdominal, pelvic, or lower limb surgeries. This local anesthetic works by blocking nerve impulses, leading to the temporary loss of sensation and motor function in the lower body. The inclusion of dextrose allows for a hyperbaric solution, which helps in precise control and distribution of the anesthetic effect in the spinal column, ensuring effective anesthesia for surgical procedures.\u003c\/p\u003e\n\u003cp\u003eMarcaine Spinal (Bupivacaine Hydrochloride 0.75% in Dextrose Injection) is a local anesthetic solution designed for spinal anesthesia. It is primarily used for surgical procedures requiring lower abdominal, pelvic, and lower extremity anesthesia. The formulation includes dextrose, which helps ensure proper distribution in the cerebrospinal fluid. This product is supplied by Pfizer Injectables in single-dose ampules, with each ampule containing 2 mL of the solution, packaged in boxes of 10.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eActive Ingredient:\u003c\/strong\u003e Bupivacaine Hydrochloride\u003cbr\u003e\u003cstrong\u003eConcentration\u003c\/strong\u003e: 0.75%\u003cbr\u003e\u003cstrong\u003eDextrose Inclusion\u003c\/strong\u003e: Facilitates specific gravity and distribution in the spinal column\u003cbr\u003e\u003cstrong\u003eVolume\u003c\/strong\u003e: 2 mL per ampule\u003cbr\u003e\u003cstrong\u003ePackaging:\u003c\/strong\u003e 10 single-dose ampules per box\u003cbr\u003e\u003cstrong\u003eUsage:\u003c\/strong\u003e Intended for intrathecal (spinal) injection to induce regional anesthesia\u003cbr\u003e\u003cstrong\u003eManufacturer:\u003c\/strong\u003e Pfizer Injectables\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBupivacaine acts as a long-acting local anesthetic by blocking sodium ion channels in nerve fibers. This blockade inhibits the initiation and conduction of nerve impulses, producing loss of sensation or motor function at the targeted spinal regions. The presence of dextrose aids in the spread of the anesthetic in the cerebrospinal fluid by creating a hyperbaric solution, optimizing the anesthetic effects specific to the site of administration.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular Risks:\u003c\/strong\u003e May cause significant cardiovascular effects, including hypotension and bradycardia. Monitor vital signs closely after administration.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCentral Nervous System Effects:\u003c\/strong\u003e Serious CNS toxicity (e.g., seizures) can occur with systemic absorption or excessive dosages.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePregnancy:\u003c\/strong\u003e While used in obstetric anesthesia, careful consideration and dosing are necessary to minimize risks to the mother and fetus.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContraindications:\u003c\/strong\u003e Not suitable for patients with known hypersensitivity to bupivacaine or other amide-type anesthetics, as well as those with severe mental health disturbances, especially from hypercarbia or hypoxia.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eSide Effects\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCommon Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHypotension\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eNausea or vomiting\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eBradycardia\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eHeadache\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSerious Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular:\u003c\/strong\u003e Severe hypotension, arrhythmias, or cardiac arrest\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCNS\u003c\/strong\u003e: Seizures or prolonged numbness beyond the target area\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRespiratory:\u003c\/strong\u003e Respiratory depression when anesthetic spreads too high (rare in properly managed doses)\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic reactions:\u003c\/strong\u003e Although rare, include skin reactions or anaphylaxis\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eAdministration and Monitoring\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMarcaine Spinal should be administered by trained healthcare professionals experienced in spinal anesthesia techniques. Thorough patient evaluation and preparedness to manage potential adverse reactions are crucial. Continuous monitoring of blood pressure, heart rate, and respiratory status is necessary following administration. The dose should be carefully selected based on the patient's age, body mass, and overall health status, as well as the type and duration of the surgical procedure. Emergency equipment and drugs for resuscitation should be readily available prior to its use.\u003cbr\u003e\u003c\/p\u003e","brand":"Pfizer Injectables","offers":[{"title":"Default Title","offer_id":39929890832456,"sku":"00409-1761-10","price":129.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/products\/Marcaine-Spinal-_bupivacaine-hydrochloride-0.75.jpg?v=1681742563"},{"product_id":"bupivacaine-hydrochloride-0-5-injection-sdv-preservative-free-30-ml","title":"Bupivacaine Hydrochloride 0.5% Injection SDV, Preservative Free 30 mL by Hikma (Rx)","description":"\u003cp\u003eBupivacaine Hydrochloride 0.5% Injection is a high-quality, preservative-free local anesthetic solution designed for surgical anesthesia and pain management. With its trusted formulation, this injection offers reliable onset and extended duration of action, making it an essential choice for healthcare professionals.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eUsage:\u003c\/strong\u003e Bupivacaine is primarily used for local or regional anesthesia in various surgical procedures. It is suitable for peripheral nerve blocks, epidural anesthesia, and sympathetic nerve blocks, providing effective pain relief during and after operations.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDosage:\u003c\/strong\u003e The dosage of Bupivacaine Hydrochloride depends on the procedure, the specific requirements of the patient, and the method of administration. It should be administered by a trained healthcare professional. Consultation with relevant medical guidelines or a specialist is recommended to determine the appropriate dosing.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCDC Guidelines:\u003c\/strong\u003e While the CDC provides overarching guidelines for the use of anesthetics in clinical settings, it emphasizes the importance of adhering to aseptic techniques and monitoring patient vitals during administration to prevent complications. Always follow institutional protocols and national guidelines when using anesthetics.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 0.5% Bupivacaine Hydrochloride\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePackaging:\u003c\/strong\u003e Single-Dose Vial (SDV)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVolume:\u003c\/strong\u003e 30 mL\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePreservative-Free:\u003c\/strong\u003e Minimizes the risk of hypersensitivity reactions\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSterile Formulation:\u003c\/strong\u003e Ensures patient safety and efficacy\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExtended Duration:\u003c\/strong\u003e Offers prolonged anesthesia suitable for lengthy procedures\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action:\u003c\/strong\u003e Bupivacaine works by inhibiting sodium ion influx through nerve cell membranes. This blocks nerve impulse transmission, effectively preventing the sensation of pain without causing significant motor blockade at lower concentrations.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections for Use:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eInspect the vial for particulate matter and discoloration before use.\u003c\/li\u003e\n\u003cli\u003eAdminister using sterile equipment.\u003c\/li\u003e\n\u003cli\u003eAdhere to the prescribed technique for the selected mode of anesthesia.\u003c\/li\u003e\n\u003cli\u003eMonitor patient's vitals and response continuously during the procedure.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFor professional use only.\u003c\/li\u003e\n\u003cli\u003eNot intended for intravenous (IV) administration.\u003c\/li\u003e\n\u003cli\u003eExercise caution in patients with cardiovascular disease or liver dysfunction.\u003c\/li\u003e\n\u003cli\u003eMay cause central nervous system and cardiovascular adverse reactions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSide Effects:\u003c\/strong\u003e Some patients may experience side effects, including:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHypotension\u003c\/li\u003e\n\u003cli\u003eDizziness\u003c\/li\u003e\n\u003cli\u003eNausea\u003c\/li\u003e\n\u003cli\u003eBradycardia\u003c\/li\u003e\n\u003cli\u003eAllergic reactions In the event of adverse effects, discontinue use and provide appropriate medical intervention.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eBupivacaine Hydrochloride 0.5% Injection SDV by Hikma Injectables delivers reliable anesthesia with precision, safety, and efficiency, upholding the highest standards of patient care.\u003c\/em\u003e\u003c\/p\u003e","brand":"Hikma Injectables","offers":[{"title":"Default Title","offer_id":52232481440112,"sku":"70594-0118-01","price":5.1,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Bupivacaine-HCL-Injection-0_5_percent-by-Pfizer.jpg?v=1730809829"},{"product_id":"bupivacaine-0-5-injection-50-mg-per-10-ml-x-25-vials","title":"Bupivacaine 0.5% Injection 50 mg Per 10 ml x 25 Vials (RX)","description":"\u003ch1\u003eBupivacaine 0.5% Injection (50 mg per 10 mL)\u003c\/h1\u003e\n\u003cp\u003eBupivacaine is a potent amide-type local anesthetic used by clinicians for regional anesthesia. Each mL of a 0.5% solution contains 5 mg of bupivacaine (so a 10 mL vial has 50 mg). It blocks nerve impulse conduction by binding to open voltage-gated sodium channels in nerve membranes, stabilizing their inactive state and preventing depolarization. Bupivacaine has a relatively slow onset (often 10–20 minutes for operative anesthesia) but a \u003cstrong\u003elong duration\u003c\/strong\u003e of action (several hours of sensory and motor block) compared to shorter-acting agents.\u003c\/p\u003e\n\u003ch2\u003eUses\u003c\/h2\u003e\n\u003cp\u003eBupivacaine 0.5% injection (with or without added epinephrine) is used to produce \u003cstrong\u003eregional anesthesia or analgesia\u003c\/strong\u003e for various procedures. Indications include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSurgical anesthesia:\u003c\/strong\u003e infiltration or field block for surgery (especially when prolonged anesthesia is needed), and peripheral nerve blocks for procedures on limbs or torso.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpidural and caudal blocks:\u003c\/strong\u003e labor\/delivery pain relief and postoperative analgesia (e.g. epidural anesthesia during obstetrical or orthopedic procedures). (Only preservative-free drug should be used in epidural\/caudal space.)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiagnostic\/therapeutic nerve blocks:\u003c\/strong\u003e e.g. sympathetic blocks, neck or ganglion blocks that require long-duration anesthetic effect.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eObstetrical anesthesia:\u003c\/strong\u003e Bupivacaine 0.5% (often diluted) is commonly used in epidural labor analgesia. It provides visceral and somatic block for Cesarean delivery or labor.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eNot indicated:\u003c\/strong\u003e This formulation should \u003cstrong\u003enever be given by spinal (intrathecal)\u003c\/strong\u003e injection (Intrathecal bupivacaine is given in special hyperbaric preparations at different concentrations.) It is used only by trained personnel, not for routine outpatient or self-administration.\u003c\/p\u003e\n\u003ch2\u003eDosage and Administration\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eAdministration route:\u003c\/strong\u003e Bupivacaine 0.5% is given by injection, typically \u003cstrong\u003eslowly\u003c\/strong\u003e and in controlled increments. Aspirate before injecting to avoid intravascular administration. Monitor blood pressure and ECG during injection due to systemic effects. Always use the appropriate dose and formulation (e.g. preservative-free for neuraxial use).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eTypical dosing:\u003c\/strong\u003e The dose depends on patient size, site, and block technique. Each mL contains 5 mg of drug. A single 10 mL vial (50 mg) is often used for minor blocks. For larger blocks or epidurals, volumes of 10–20 mL (50–100 mg) may be given. For example, epidural anesthesia often uses 10–20 mL of 0.5% (50–100 mg) for a moderate-to-complete motor block. Peripheral nerve blocks may use smaller volumes (e.g. 5–10 mL, 25–50 mg) to cover a nerve distribution. In obstetrics, continuous epidural or infusion techniques use more dilute solutions (e.g. 0.125–0.25% with opioids) rather than 0.5%.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eMaximum dose:\u003c\/strong\u003e Because of systemic toxicity risk, total dose limits must be observed. For an average adult, single-dose bupivacaine generally should \u003cstrong\u003enot exceed ~150–175 mg\u003c\/strong\u003e (about 30–35 mL of 0.5%). (This is roughly 2–2.5 mg\/kg for a 70-kg patient.) If epinephrine is added, slightly higher maximal doses (up to ~3 mg\/kg) are sometimes tolerated. Repeated injections (if needed) are usually given no more frequently than every 3–4 hours, with a 24-hour total not exceeding ~400 mg. In all cases, dose must be tailored to patient factors (age, weight, comorbidities) and monitored closely.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial techniques:\u003c\/strong\u003e Before performing labor epidurals or major blocks, clinicians often administer a \u003cstrong\u003etest dose\u003c\/strong\u003e (e.g. 3 mL of 0.5% solution with epinephrine) to check for inadvertent intrathecal or intravascular placement. (This formulation without epinephrine would not contain epinephrine, but the principle of slow injection and monitoring still applies.)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSide Effects and Safety\u003c\/h2\u003e\n\u003cp\u003eBecause bupivacaine is a \u003cstrong\u003epotent anesthetic\u003c\/strong\u003e, side effects stem from both its local action and potential systemic absorption:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eCNS effects (LAST – Local Anesthetic Systemic Toxicity):\u003c\/strong\u003e Early warning signs of toxicity include central nervous system symptoms: circumoral numbness, tinnitus, blurred vision, dizziness, lightheadedness, tingling, or tremors. If plasma levels get high (e.g. from rapid IV injection or excessive dose), seizures (tonic-clonic convulsions) can occur. Importantly, bupivacaine can cause \u003cem\u003eimmediate cardiotoxicity\u003c\/em\u003e without warning by CNS signs.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eCardiovascular effects:\u003c\/strong\u003e Bupivacaine is notably cardiotoxic at higher concentrations. Overdose or intravascular injection may cause severe cardiac arrhythmias. Reported signs include \u003cstrong\u003ebradycardia\u003c\/strong\u003e, conduction blocks (AV block), ventricular arrhythmias, and even cardiac arrest. In obstetric cases, there are rare reports of cardiovascular collapse during epidural use. Hypotension and reflex tachycardia can occur as a sympathetic block effect, especially with larger volume epidurals. (If epinephrine is present, careful with underlying heart conditions.)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eAllergic reactions:\u003c\/strong\u003e True IgE-mediated allergy to bupivacaine is extremely rare. Bupivacaine contains no ester groups and has low cross-reactivity; most “allergy” is actually to preservatives\/sulfites (in epinephrine vials). Standard contraindications include any history of hypersensitivity to amide local anesthetics or to any formulation component. If a rash, swelling, or anaphylactic reaction occurs after injection, treatment must be stopped and appropriate care given.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eNeurotoxicity:\u003c\/strong\u003e High spinal or epidural blocks can cause prolonged neurological effects. Care must be taken not to inject intrathecally (spinal) unless using the proper formulation. Post-LP syndrome or nerve injury can occur if technique is improper. Repeated intra-articular infusions of local anesthetics (e.g. pain pumps in shoulder joints) have been linked to cartilage damage (chondrolysis), although a single injection is generally safe.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eOthers:\u003c\/strong\u003e Bupivacaine can induce methemoglobinemia (rarely), so watch for cyanosis\/dark blood if given high doses intravenously or to infants. Large epidural blocks can cause respiratory depression if very high neuraxial block occurs (e.g. diaphragmatic weakness). Nausea, vomiting, urinary retention, and fever have been reported with epidural use.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eMonitoring:\u003c\/strong\u003e Because of these risks, bupivacaine injections are given only by experienced providers with resuscitation equipment at hand. Vital signs (blood pressure, heart rate, ECG, oxygen saturation) are monitored. If any symptoms of toxicity arise, injection is stopped. Intravenous lipid emulsion (lipid rescue) is a treatment for severe LAST (cardiac arrest) in case it occurs.\u003c\/p\u003e\n\u003ch2\u003ePrecautions and Contraindications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eContraindicated uses:\u003c\/strong\u003e Do \u003cem\u003enot\u003c\/em\u003e use bupivacaine 0.5% for \u003cstrong\u003eobstetric paracervical block\u003c\/strong\u003e (this technique can cause fetal bradycardia and death). Bupivacaine is also contraindicated for intravenous regional anesthesia (Bier block). Other absolute contra: known allergy to bupivacaine or related amide anesthetics. Avoid formulations containing preservatives (e.g. multi-dose vials) for epidural or spinal use.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eHepatic impairment:\u003c\/strong\u003e Bupivacaine is \u003cstrong\u003emetabolized in the liver\u003c\/strong\u003e, so patients with severe liver disease clear it more slowly. Dose reduction and careful monitoring are recommended in hepatic impairment. Excessive levels can build up with repeated dosing in such patients.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eRenal impairment:\u003c\/strong\u003e Bupivacaine and its metabolites are excreted by the kidneys. In renal failure, accumulation can occur over time; use caution and assess dosing for renal insufficiency.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eCardiovascular disease:\u003c\/strong\u003e Patients with conduction blocks, bradycardia, or severe cardiac dysfunction should receive bupivacaine only with extreme caution. Concurrent use of other cardiodepressant drugs (beta-blockers, certain calcium channel blockers, antiarrhythmics) may magnify bupivacaine’s effects. Also, because dose administration can cause hypotension, ensure patient volume is adequate before large epidural blocks.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003ePregnancy\/lactation:\u003c\/strong\u003e Bupivacaine crosses the placenta, so maternal administration can affect the fetus (fetal heart rate should be monitored in obstetric use). While widely used for labor analgesia, it should only be used when benefit outweighs risk. Bupivacaine is excreted into breast milk in small amounts; caution is advised if nursing (though a one-time block is unlikely to harm the infant significantly).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eOther drugs:\u003c\/strong\u003e Avoid mixing with other local anesthetics in the same syringe. Some drug interactions: potent CYP3A4 inhibitors (e.g. cimetidine) can raise plasma bupivacaine levels, whereas inducers (e.g. phenytoin, rifampin) can lower levels. If epinephrine is added, drugs affecting coagulation or the fetus should be considered.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSummary\u003c\/h2\u003e\n\u003cp\u003eBupivacaine 0.5% (5 mg\/mL) injection is a prescription local anesthetic given by healthcare professionals for \u003cstrong\u003elong-duration regional anesthesia\u003c\/strong\u003e. It provides several hours of numbness and muscle relaxation, making it useful for surgeries, labor epidurals, and nerve blocks. The typical adult dose is individually determined (often up to 10–20 mL for epidural blocks), with absolute maximums around 150–175 mg per single dose. Careful administration is crucial: do not inject intravenously or intrathecally. Common side effects include numbness and muscle weakness in the blocked area; serious risk comes from systemic absorption – manifesting as neurological (e.g. seizures) and cardiovascular (arrhythmias, hypotension) toxicity. Strict monitoring of vital signs and readiness to manage complications (e.g. airway, blood pressure support, intralipid) are standard practice.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImportant:\u003c\/strong\u003e Bupivacaine injection is \u003cem\u003enot\u003c\/em\u003e for patient self-use and should be used exactly as directed by an anesthesiologist or physician. Always follow the clinician’s instructions and equipment protocols when this drug is used. If any adverse symptoms (e.g. numbness beyond expected, difficulty breathing or heartbeat changes) occur during or after its use, notify medical staff immediately.\u003c\/p\u003e","brand":"Eugia US","offers":[{"title":"Default Title","offer_id":53723137704304,"sku":"55150-0169-10P","price":79.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Bupivacaine-0.5_-Injection-50-mg-Per-10-ml.jpg?v=1778165038"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/collections\/Marcaine_Injections.jpg?v=1744722864","url":"https:\/\/www.mountainside-medical.com\/collections\/marcaine.oembed?constraint=numbing-injection","provider":"Mountainside Medical","version":"1.0","type":"link"}