{"title":"Metoprolol Tartrate","description":"\u003cp\u003eMetoprolol tartrate is a medication that belongs to a class of drugs called beta-blockers. It is primarily used to treat high blood pressure, chest pain (angina), and heart failure. Metoprolol tartrate is also used to prevent future heart attacks in people who have already had one. Metoprolol tartrate works by slowing down the heart rate and reducing the force of heart contractions. This helps to improve blood flow and decrease the workload on the heart, which can help to lower blood pressure and improve heart function. Additionally, it may also be used to prevent migraine headaches and to manage symptoms of anxiety.\u003c\/p\u003e","products":[{"product_id":"metoprolol-tartrate-for-injection-5-ml-single-dose-vials-10-box","title":"Metoprolol Tartrate Injection 5 mg\/ml Vials 10\/Box Pfizer Hospira (Rx)","description":"\u003cp\u003eMetoprolol Tartrate for Injection is used primarily to manage acute episodes of hypertension and to control heart rate in patients experiencing tachycardia or other arrhythmias. It is a beta-blocker that works by blocking beta-adrenergic receptors, reducing heart rate, cardiac output, and blood pressure. This formulation is particularly useful in emergency settings, such as after a heart attack, to reduce the heart's workload and oxygen demand. Administered intravenously, it offers rapid action in stabilizing cardiac conditions.\u003c\/p\u003e\n\u003cp\u003eMetoprolol Tartrate Injection is a beta-blocker medication provided by Pfizer Injectables, intended for intravenous use. It is primarily used for the rapid control of heart rate and blood pressure in acute settings, such as during a myocardial infarction (heart attack) or to manage arrhythmias and severe hypertension. The formulation is available in single-dose vials of 5 mL, and each box contains 10 vials. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDetails and Features\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eActive Ingredient:\u003c\/strong\u003e Metoprolol Tartrate\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e Usually formulated to provide a specified amount of metoprolol tartrate per mL (check specific packaging for precise details).\u003cbr\u003e\u003cstrong\u003eVolume: \u003c\/strong\u003e5 mL per vial\u003cbr\u003e\u003cstrong\u003ePackaging:\u003c\/strong\u003e 10 single-dose vials per box\u003cbr\u003e\u003cstrong\u003eAdministration Route:\u003c\/strong\u003e Intravenous (IV) injection\u003cbr\u003e\u003cstrong\u003eIndications:\u003c\/strong\u003e Rapid treatment of acute myocardial infarction, control of heart rate in tachyarrhythmias (like atrial fibrillation or flutter), acute hypertension, and in certain cases, stable heart failure as adjunct therapy.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMetoprolol Tartrate is a selective beta-1 adrenergic receptor blocker, primarily affecting cardiac tissues. By inhibiting the action of catecholamines (such as adrenaline) on beta-1 receptors, metoprolol reduces heart rate, cardiac output, and blood pressure. It decreases myocardial oxygen demand by lowering heart rate and contractility, which is particularly beneficial during heart attacks as it helps minimize heart muscle damage. Additionally, it can decrease electrical activity in the heart, helping to manage arrhythmias.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHeart Block and Bradycardia:\u003c\/strong\u003e Contraindicated in patients with significant bradycardia or advanced heart block unless a pacemaker is in place.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypotension:\u003c\/strong\u003e Use caution in patients with low blood pressure, as it can further decrease blood pressure.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAsthma and COPD:\u003c\/strong\u003e Although selective, beta-blockers can affect beta-2 receptors at higher doses, potentially exacerbating bronchospasms in susceptible individuals.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAcute Heart Failure:\u003c\/strong\u003e Initiation or dosage increments in acute heart failure should be done cautiously, as beta-blockers can initially cause worsening symptoms.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAbrupt Withdrawal:\u003c\/strong\u003e Sudden discontinuation can lead to rebound tachycardia, hypertension, or even precipitate angina or myocardial infarction. Dosing should typically be tapered.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eSide Effects\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eWhile metoprolol tartrate is effective, it can have side effects, especially when used acutely and intravenously:\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCommon Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFatigue or lethargy\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eDizziness or lightheadedness\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eBradycardia (slow heart rate)\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eHypotension\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSerious Side Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSevere bradycardia or heart block\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eHeart failure exacerbation\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eBronchospasm in individuals with a history of respiratory disorders\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eCardiogenic shock in susceptible patients\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eOther Considerations:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMonitoring: \u003c\/strong\u003eDuring administration, continuous monitoring of cardiac function (heart rate, ECG) and blood pressure is advisable. Adjustments to dose or infusion rate may be necessary based on the patient's response.\u003cbr\u003e\u003cstrong\u003eDrug Interactions:\u003c\/strong\u003e Metoprolol may interact with other medications, such as other antihypertensives, antiarrhythmics, and certain antidepressants, necessitating a comprehensive medication review.\u003c\/p\u003e\n\u003cp\u003eMetoprolol Tartrate for Injection is a potent medication used in critical care and emergency settings, offering rapid management of cardiovascular conditions when oral administration is not feasible. Its use should be overseen by healthcare professionals to ensure safe administration and effective therapeutic outcomes.\u003cbr\u003e\u003c\/p\u003e","brand":"Pfizer Injectables","offers":[{"title":"Default Title","offer_id":39957428404296,"sku":"00409-1778-05","price":49.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Metoprolol-Tartrate-Injection-5-mg-Pfizer-Hospira.jpg?v=1766080840"},{"product_id":"metoprolol-tartrate-usp-for-compounding-api","title":"Metoprolol Tartrate API Powder USP For Compounding","description":"\u003ch1\u003eMetoprolol Tartrate API\u003c\/h1\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003eMetoprolol tartrate is a \u003cstrong\u003ecardioselective β₁-adrenergic blocker\u003c\/strong\u003e (beta‐blocker) salt used in cardiovascular therapy. In its active pharmaceutical ingredient form, it appears as a \u003cstrong\u003ewhite, crystalline powder\u003c\/strong\u003e (molecular weight ≈684.82 g\/mol)\u003c\/span\u003e. \u003cspan class=\"VODHU pdMy8\"\u003eThe powder is very soluble in water (also soluble in organic solvents like methylene chloride and alcohol). (According to USP, it is not hygroscopic but is light-sensitive, so should be stored protected from strong light\u003c\/span\u003e.\u003c\/p\u003e\n\u003cp\u003eMetoprolol Tartrate USP For Compounding (API) is a beta-blocker used primarily for managing cardiovascular conditions, including hypertension (high blood pressure), angina (chest pain), and arrhythmias (irregular heartbeats). By blocking beta-adrenergic receptors in the heart, it reduces heart rate, cardiac output, and blood pressure, thereby decreasing the heart's oxygen demand and improving heart health. This active pharmaceutical ingredient is essential for creating customized formulations that cater to individual patient needs, ensuring precise dosing and optimal therapeutic outcomes. It plays a crucial role in cardiovascular health, blood pressure management, and prevention of heart disease complications.\u003c\/p\u003e\n\u003cp\u003eMetoprolol tartrate USP is an active pharmaceutical ingredient (API) used in the manufacturing of prescription medications for the treatment of high blood pressure, angina, and heart failure. It belongs to a class of drugs known as beta-blockers, which work by blocking the effects of adrenaline on the heart and blood vessels. This helps to lower blood pressure, improve blood flow, and reduce strain on the heart. Metoprolol tartrate USP comes in the form of tablets or injections and is commonly used in combination with other medications to treat various cardiovascular conditions. \u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action:\u003c\/strong\u003e Metoprolol selectively antagonizes β₁‐adrenergic receptors primarily in heart muscle. This leads to \u003cstrong\u003ereduced heart rate (negative chronotropy), decreased myocardial contractility (negative inotropy), and lower cardiac output\u003c\/strong\u003e, thereby lowering blood pressure and myocardial oxygen demand. In hypertension, additional mechanisms include central sympatholysis and reduced renin release. At higher plasma levels, metoprolol can also block β₂ receptors in bronchial and vascular smooth muscle, so selectivity is dose-dependent. Unlike some beta-blockers, metoprolol has no intrinsic sympathomimetic activity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIndications\/Uses:\u003c\/strong\u003e Metoprolol tartrate is indicated for \u003cstrong\u003ehypertension, chronic stable angina pectoris, and the management of acute myocardial infarction (to reduce mortality when used with IV therapy)\u003c\/strong\u003e. It improves survival following heart attacks and is part of post-MI therapy. It is also used (often off-label) for certain arrhythmias (e.g. supraventricular tachycardia), congestive heart failure (as part of combination therapy), hyperthyroidism (symptom control), and migraine prophylaxis. Lowering blood pressure with metoprolol (alone or in combination) reduces risks of stroke and myocardial infarction.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdministration and Dosing:\u003c\/strong\u003e Metoprolol tartrate is administered orally. Immediate-release tablets (commonly 25, 50, 100 mg) are usually taken in \u003cstrong\u003e1–2 divided doses per day\u003c\/strong\u003e. A typical starting dose for hypertension or angina in adults is around \u003cstrong\u003e50–100 mg per day\u003c\/strong\u003e, often given as 25–50 mg twice daily. Doses may be titrated up (sometimes to 200–400 mg\/day in resistant cases). (For example, one source recommends 100 mg\/day as a starting dose for hypertension.) In myocardial infarction, IV metoprolol can be given as needed under monitoring, followed by oral dosing (often 50 mg every 6 hours). The duration of action of a metoprolol dose is dose-dependent (50% effect loss in ~3–6 hours), so immediate-release tartrate often requires twice-daily dosing. (By contrast, metoprolol succinate is an extended-release once-daily formulation; tartrate and succinate salts are not interchangeable.)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePharmacokinetics:\u003c\/strong\u003e Metoprolol is well absorbed (≈50% bioavailability after a single dose, increasing with repeated dosing and has a \u003cstrong\u003ehalf-life of about 3–7 hours\u003c\/strong\u003e. It is extensively metabolized by the liver (CYP2D6 and CYP3A4), resulting in inactive metabolites; only about 10–20% of a dose is excreted unchanged in urine. Because of first-pass metabolism, blood levels can vary; dosing should be individualized. It is only ~12% protein-bound. Metoprolol crosses the placenta (pregnancy category C) and is present in breast milk, though it appears relatively safe in nursing mothers.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSide Effects:\u003c\/strong\u003e Common side effects arise from excess β₁-blockade: \u003cstrong\u003ebradycardia\u003c\/strong\u003e, \u003cstrong\u003ehypotension\u003c\/strong\u003e, \u003cstrong\u003edizziness\/lightheadedness\u003c\/strong\u003e (especially upon standing), \u003cstrong\u003efatigue\u003c\/strong\u003e, \u003cstrong\u003eheadache\u003c\/strong\u003e, and \u003cstrong\u003egastrointestinal upset\u003c\/strong\u003e (nausea, diarrhea) are frequently reported. Patients may experience \u003cstrong\u003ecold extremities\u003c\/strong\u003e or \u003cstrong\u003eperipheral vasoconstriction\u003c\/strong\u003e, and some (especially men) report \u003cstrong\u003esexual dysfunction\u003c\/strong\u003e (decreased libido\/impotence). Central nervous system effects like \u003cstrong\u003edepression\u003c\/strong\u003e, vivid dreams or insomnia can occur. Because of slowed heart rate, exercise tolerance may decrease and chest heaviness can paradoxically worsen if dosage is too high or withdrawn suddenly. In asthmatic\/COPD patients, broncho-constriction (wheezing) is possible because high doses block β₂- receptors. Severe side effects (uncommon) include profound bradyarrhythmias or heart block, heart failure exacerbation, and severe hypotension. Overdose can lead to life-threatening bradycardia, hypotension, bronchospasm and cardiogenic shock.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications \u0026amp; Precautions:\u003c\/strong\u003e Metoprolol tartrate should not be used in patients with \u003cstrong\u003esevere sinus bradycardia\u003c\/strong\u003e, \u003cstrong\u003e2nd or 3rd degree AV block\u003c\/strong\u003e (unless paced), \u003cstrong\u003esick sinus syndrome\u003c\/strong\u003e, \u003cstrong\u003ecardiogenic shock\u003c\/strong\u003e, or \u003cstrong\u003edecompensated heart failure\u003c\/strong\u003e. Caution is required in patients with asthma or chronic pulmonary disease (risk of bronchospasm) and in markedly slow heart rhythms or hypotension. In pheochromocytoma, β-blockers must be given only after adequate α-blockade, to avoid unopposed α-adrenergic hypertension. In diabetics, metoprolol can mask tachycardia and other adrenergic symptoms of hypoglycemia. It also masks hyperthyroid symptoms, so thyroid storm risk is increased on abrupt withdrawal. Patients should be warned \u003cstrong\u003enot to stop metoprolol suddenly\u003c\/strong\u003e; abrupt withdrawal can precipitate angina, arrhythmias, or myocardial infarction, especially in ischemic heart disease. Other cautions: use lower doses in the elderly or those with liver impairment, and monitor electrolytes in heart failure. Metoprolol can interact with other antihypertensives (additive effects) and with CYP2D6 inhibitors (which can raise metoprolol levels).\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFormulations:\u003c\/strong\u003e Metoprolol tartrate oral tablets are available in multiple strengths (25–100 mg). Tablets contain inert fillers (lactose, cellulose, etc.) and colorants. No injectable tartrate is commonly used; injectable metoprolol as a solution is usually the succinate form. For manufacturing, bulk metoprolol tartrate API is made to USP standards (white, crystalline, odorless powder). It is stable at room temperature (15–25 °C). (By contrast, metoprolol succinate is the extended-release salt used in long-acting tablets.) While tartrate (Lopressor) and succinate (Toprol-XL) are chemically related, they are not bioequivalent – dosing regimens differ.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKey Points:\u003c\/strong\u003e Metoprolol tartrate is a commonly prescribed β₁-selective blocker for \u003cem\u003ehypertension, angina, and post-MI management\u003c\/em\u003e. It lowers heart rate and blood pressure by blocking cardiac β₁ receptors. It must be dosed carefully (often twice daily for the tartrate salt) and tapered slowly on discontinuation. Main risks include bradycardia, hypotension, and bronchospasm; serious effects are uncommon with proper monitoring. As with all drugs, use according to guidelines and monitor the patient for therapeutic response and adverse effects.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eThis overview is based on standard pharmaceutical references and FDA-approved labeling for metoprolol tartrate. For complete prescribing information, consult official drug monographs.\u003c\/em\u003e\u003c\/p\u003e","brand":"Mountainside Medical","offers":[{"title":"25 g","offer_id":40078746681416,"sku":"0578-04","price":74.0,"currency_code":"USD","in_stock":true},{"title":"100 g","offer_id":40078746714184,"sku":"0578-05","price":260.0,"currency_code":"USD","in_stock":true},{"title":"500 g","offer_id":40078746746952,"sku":"0578-08","price":795.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Metoprolol-Tartrate-USP-For-Compounding-_API.jpg?v=1706727341"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/collections\/Metoprolol_Tartrate.jpg?v=1718638037","url":"https:\/\/www.mountainside-medical.com\/collections\/metoprolol-tartrate\/api-powder.oembed","provider":"Mountainside Medical","version":"1.0","type":"link"}