{"title":"Sulfamethoxazole and Trimethoprim","description":"\u003ch1\u003eSulfamethoxazole\/Trimethoprim (Co-trimoxazole)\u003c\/h1\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism:\u003c\/strong\u003e Sulfamethoxazole\/trimethoprim (SMX\/TMP, co-trimoxazole; brand names Bactrim, Septra) is a fixed 5:1 combination of a sulfonamide (sulfamethoxazole) and a dihydrofolate reductase inhibitor (trimethoprim). Together they block two sequential steps in bacterial folate synthesis: SMX (a PABA analogue) inhibits dihydropteroate synthase, and TMP inhibits dihydrofolate reductase. This synergistic blockade is often \u003cstrong\u003ebactericidal\u003c\/strong\u003e rather than merely bacteriostatic.. Both components are well absorbed orally, achieve good tissue and cerebrospinal fluid levels, and are eliminated by the kidneys. The TMP\/SMX ratio is usually 1:5 by weight (e.g. 80 mg TMP + 400 mg SMX, or double-strength tablets 160\/800 mg).\u003c\/p\u003e\n\u003ch2\u003eUses\u003c\/h2\u003e\n\u003cp\u003eSMX\/TMP has very broad antibacterial coverage (many Gram-positive and Gram-negative pathogens) and multiple clinical uses. It is a first-line or alternative therapy for:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eUrinary tract infections (UTIs):\u003c\/strong\u003e e.g. cystitis, pyelonephritis, and chronic bacterial prostatitis. It is also used for suppression of recurrent UTIs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRespiratory infections:\u003c\/strong\u003e such as acute otitis media and bacterial bronchitis. (It is not effective for viral infections like colds or flu.)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGastrointestinal infections:\u003c\/strong\u003e including traveler’s diarrhea, shigellosis (bacillary dysentery), \u003cem\u003eVibrio cholerae\u003c\/em\u003e, \u003cem\u003eCampylobacter\u003c\/em\u003e, etc.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePneumocystis jirovecii pneumonia (PCP):\u003c\/strong\u003e SMX\/TMP is the \u003cem\u003edrug of choice\u003c\/em\u003e for treatment \u003cem\u003eand prophylaxis\u003c\/em\u003e of PCP in immunocompromised patients (HIV\/AIDS, cancer, transplant).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin\/soft tissue infections:\u003c\/strong\u003e It covers community-associated MRSA and other skin infections caused by susceptible strains.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eOther important uses include therapy or prophylaxis of certain opportunistic\/parasitic infections: e.g. \u003cem\u003eCyclospora\u003c\/em\u003e, \u003cem\u003eCystoisospora\u003c\/em\u003e and \u003cem\u003eToxoplasma gondii\u003c\/em\u003e enteritis, and mild nocardiosis. It also has activity against \u003cem\u003eNocardia\u003c\/em\u003e and \u003cem\u003eListeria\u003c\/em\u003e (used when these organisms are identified).\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003e\u003cem\u003eSMX\/TMP effectively treats many infections, especially UTIs, PCP prophylaxis, and resistant skin or GI pathogens\u003c\/em\u003e\u003c\/span\u003e.\u003c\/p\u003e\n\u003ch2\u003eForms and Dosing\u003c\/h2\u003e\n\u003cp\u003eSMX\/TMP is available \u003cstrong\u003eorally\u003c\/strong\u003e (tablets and suspension) and \u003cstrong\u003eintravenously\u003c\/strong\u003e (IV) for severe infections.. Common oral strengths are \u003cem\u003esingle-strength\u003c\/em\u003e (SMX 400 mg\/ TMP 80 mg) and \u003cem\u003edouble-strength\u003c\/em\u003e (SMX 800 mg\/ TMP 160 mg) tablets. A typical adult dose for uncomplicated UTI is one double-strength tablet twice daily (5–14 days). For PCP treatment, much higher doses are used (e.g. TMP 15–20 mg\/kg\/day, often given as multiple DS tablets every 6–8 hours, or IV equivalent). Chronic suppressive doses (e.g. one tablet daily or a few times per week) may be used for prophylaxis of recurrent UTIs or PCP. Dosage must be adjusted in renal impairment (TMP\/SMX is renally cleared) and in infants\/small children by weight.\u003c\/p\u003e\n\u003cp\u003eAdults swallow tablets with plenty of water (to reduce crystalluria risk). Adequate hydration is advised during therapy. (The suspension form allows pediatric dosing.) The 1:5 dosing ratio (TMP:SMX) should always be maintained; do \u003cstrong\u003enot\u003c\/strong\u003e alter the tablet ratio. IV SMX\/TMP is used when patients cannot take oral drugs or in life-threatening infections.\u003c\/p\u003e\n\u003ch2\u003eSide Effects and Adverse Reactions\u003c\/h2\u003e\n\u003cp\u003eAs with other sulfa drugs, adverse effects of SMX\/TMP can affect multiple organ systems:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGastrointestinal:\u003c\/strong\u003e Nausea, vomiting, anorexia, diarrhea and abdominal pain are common. Take with food if intolerable.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin reactions:\u003c\/strong\u003e Rash, itching and photosensitivity are frequent. Sulfa hypersensitivity can rarely cause severe reactions like Stevens–Johnson syndrome\/toxic epidermal necrolysis (blistering, peeling skin). Patients with HIV\/AIDS have especially high rates of dermatologic and other reactions..\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHematologic:\u003c\/strong\u003e Bone marrow suppression may occur. SMX\/TMP can cause pancytopenia (anemia, leukopenia, thrombocytopenia) and notably \u003cem\u003emacrocytic anemia\u003c\/em\u003e due to folate antagonism. Folate or folinic acid supplementation may be needed for prolonged therapy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eElectrolyte:\u003c\/strong\u003e Trimethoprim acts like a potassium‐sparing diuretic; it can \u003cstrong\u003eraise serum potassium\u003c\/strong\u003e, sometimes to dangerous levels. Monitor electrolytes during high-dose or long-term use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRenal:\u003c\/strong\u003e Interstitial nephritis is a potential effect of sulfonamides. Trimethoprim also yields a reversible rise in serum creatinine (by inhibiting its tubular secretion) even without true GFR decline. Kidney function should be monitored, especially in elderly or dehydrated patients. Crystalluria and obstruction can occur if dehydrated (drink fluids).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOther:\u003c\/strong\u003e Headache, dizziness, and fatigue are reported. Rarely, hepatic necrosis and drug-induced aseptic meningitis have been described. Transient hyperbilirubinemia and elevated LFTs can occur.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cem\u003eMost side effects are related to sulfonamide toxicity. Nausea and rash are the most common. Patients on high-dose therapy (especially HIV patients) should be monitored closely.\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003ch2\u003ePrecautions and Contraindications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSulfa allergy:\u003c\/strong\u003e Contraindicated in patients with a known allergy to sulfonamides. A history of severe sulfa reaction (e.g. SJS) is an absolute contraindication.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAge:\u003c\/strong\u003e Avoid in infants \u0026lt;2 months old (risk of kernicterus). (SMX displaces bilirubin.) Pediatric use is acceptable for ≥2 months with appropriate dosing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePregnancy\/Breastfeeding:\u003c\/strong\u003e Avoid during first trimester (neural tube defect risk) and near term (kernicterus risk). Sulfonamides cross the placenta and may cause fetal harm; if used in pregnancy, folate supplementation is recommended. Breastfeeding is usually discouraged (sulfamethoxazole is excreted in milk).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRenal\/Hepatic impairment:\u003c\/strong\u003e Use with caution in renal or liver dysfunction. Dose reduction is required for renal insufficiency. Avoid in severe renal failure unless necessary (risk of accumulation\/toxicity).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBlood disorders:\u003c\/strong\u003e Use cautiously in patients with folate deficiency or blood dyscrasias (anemia, neutropenia). Baseline CBC and periodic monitoring are prudent for long courses.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrug interactions:\u003c\/strong\u003e SMX\/TMP \u003cstrong\u003einhibits CYP2C9\u003c\/strong\u003e and other pathways. It potentiates warfarin (increased INR\/bleeding risk) and phenytoin\/methotrexate levels. It enhances the hypoglycemic effect of sulfonylureas. Check drug levels\/INR when coadministered.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHydration:\u003c\/strong\u003e Ensure adequate fluids to prevent crystalluria. Clamp IV lines if needed.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOther caution:\u003c\/strong\u003e Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency may risk hemolysis with sulfonamides (exercise caution).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSummary\u003c\/h2\u003e\n\u003cp\u003eSulfamethoxazole\/trimethoprim (co-trimoxazole) is a broad-spectrum antibiotic combination that blocks bacterial folate synthesis in two steps. Its spectrum covers many Gram-positive and Gram-negative bacteria (including some MRSA) and certain protozoa\/fungi. Clinically, it is widely used for UTIs, PCP pneumonia (prophylaxis and treatment), respiratory and GI infections, and resistant organisms. Therapy is usually oral (DS tablets or suspension) but IV formulations exist for severe cases. Patients must be monitored for classic sulfonamide toxicities: GI upset, rash, hematologic suppression, renal effects, and hyperkalemia. Use is contraindicated in sulfa-allergic individuals and should be avoided in neonates and pregnancy due to fetal risks. All prescribing should follow physician guidance and official guidelines for dosing and monitoring.\u003c\/p\u003e","products":[{"product_id":"sulfamethoxazole-usp-for-compounding-api","title":"Sulfamethoxazole API Powder USP For Custom Compounding","description":"\u003cp\u003eSulfamethoxazole API Powder is the purified antibiotic powder supplied to pharmaceutical manufacturers for use in preparing finished medications to treat infections. It is not for direct patient use in this raw form.\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003e\u003cstrong\u003eSulfamethoxazole API Powder\u003c\/strong\u003e is the \u003cem\u003eactive pharmaceutical ingredient\u003c\/em\u003e (API) form of the antibiotic \u003cstrong\u003esulfamethoxazole\u003c\/strong\u003e in a powdered state.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(255, 42, 0);\"\u003e\u003cstrong\u003eShips in 2-4 business days.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eSulfamethoxazole USP for Compounding (API) is an antibiotic used in the preparation of customized medications to treat bacterial infections. It belongs to the class of sulfonamide antibiotics and works by inhibiting the synthesis of folic acid, which is crucial for bacterial growth and replication. Sulfamethoxazole is commonly used in combination with trimethoprim to enhance antibacterial effectiveness and is used to treat a variety of infections, including urinary tract infections, respiratory infections, and certain types of gastrointestinal infections. Compounded formulations allow for tailored dosing and specific combinations to suit individual patient needs.\u003c\/p\u003e\n\u003cp\u003eSulfamethoxazole is a broad-spectrum antibiotic medication that is used for compounding to treat various bacterial infections. It works by stopping the growth and multiplication of bacteria, thereby treating and preventing infections. It is commonly used to treat urinary tract infections, ear infections, respiratory infections, and skin infections. Sulfamethoxazole is not effective against viral infections. When used for compounding, it is often combined with another antibiotic, such as trimethoprim, to create a more potent and effective treatment for bacterial infections.\u003c\/p\u003e\n\u003cp\u003eSulfamethoxazole USP is an active pharmaceutical ingredient (API) commonly used in the treatment of various bacterial infections. It belongs to the class of sulfa drugs and works by stopping the growth and reproduction of the bacteria.\u003cbr\u003e\u003cbr\u003eSulfamethoxazole acts by inhibiting the production of folic acid, which is essential for the bacteria to survive and reproduce. This leads to the death of the bacteria and helps in treating the infection.\u003cbr\u003e\u003cbr\u003eThe USP designation signifies that the drug meets strict quality standards set by the United States Pharmacopeia, ensuring its safety, potency, and purity.\u003cbr\u003e\u003cbr\u003eSulfamethoxazole USP is frequently used in combination with trimethoprim (another antibiotic) and is known commercially as co-trimoxazole or TMP-SMZ. It is commonly prescribed for urinary tract infections, respiratory tract infections, skin and soft tissue infections, and other types of infections.\u003cbr\u003e\u003cbr\u003eSulfamethoxazole USP is available in various forms such as tablets, suspension, and injectable solution. It is often prescribed in combination with other antibiotics to increase its effectiveness against different types of bacteria.\u003cbr\u003e\u003cbr\u003eAs with all medications, sulfamethoxazole USP may cause side effects such as nausea, diarrhea, and allergic reactions. It is important to follow the prescribed dosage and instructions from a healthcare provider when taking this medication.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number: 54182-58-0\u003cbr\u003e\u003c\/strong\u003e\u003c\/p\u003e","brand":"Mountainside Medical","offers":[{"title":"500 g","offer_id":40079537799240,"sku":"0261-08","price":145.0,"currency_code":"USD","in_stock":true},{"title":"1 Kg","offer_id":40079537832008,"sku":"0261-09","price":225.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Sulfamethoxazole-USP-For-Compounding-_API.jpg?v=1707245301"},{"product_id":"sulfamethoxazole-and-trimethoprim-200-mg-40-mg-per-5-ml-oral-suspension-473-ml","title":"Sulfamethoxazole and Trimethoprim 200 mg \/40 mg Per 5 mL Oral Suspension 473 mL (RX)","description":"\u003cp\u003eSulfamethoxazole and Trimethoprim 200 mg \/40 mg Per 5 mL Oral Suspension 473 mL is a prescription medication used to treat bacterial infections. It contains a combination of two antibiotics, sulfamethoxazole and trimethoprim, which work together to kill the bacteria causing the infection. This suspension form of the medication contains 200 mg of sulfamethoxazole and 40 mg of trimethoprim per 5 mL, with a total volume of 473 mL per bottle. It is usually taken by mouth every 12 hours for a certain number of days, as directed by a doctor.\u003c\/p\u003e\n\u003cp\u003eSulfamethoxazole and Trimethoprim 200 mg\/40 mg per 5 mL Oral Suspension is an antibiotic medication used to treat bacterial infections such as urinary tract infections, middle ear infections, bronchitis, and traveler's diarrhea. It works by stopping the growth of bacteria that cause infections. It is a combination of two antibiotics, sulfamethoxazole and trimethoprim, which work together to increase their effectiveness against a wider range of bacteria. This medication is only effective for treating bacterial infections and will not work for viral infections. It is usually prescribed by a doctor and should not be used without a prescription.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow to use Sulfamethoxazole and Trimethoprim Oral Suspension?\u003c\/strong\u003e\u003cbr\u003e1. Read the medication label: Before using Sulfamethoxazole and Trimethoprim 200 mg\/40 mg per 5 mL oral suspension, carefully read the label of the medication bottle. This will provide important information such as the dosage, storage instructions, and possible side effects.\u003cbr\u003e2. Measure the correct dosage: Use a measuring device such as a special dose-measuring cup or spoon to accurately measure the prescribed dose. Do not use a household spoon as it may not provide the correct dosage.\u003cbr\u003e3. Shake the bottle well: Before using the oral suspension, shake the bottle well to ensure an even distribution of the medication.\u003cbr\u003e4. Administer the medication: Sulfamethoxazole and Trimethoprim oral suspension can be taken with or without food. Use the measuring device to pour the prescribed amount of medication into the patient's mouth. Do not mix the suspension with other liquids.\u003cbr\u003e5. Finish the prescribed course of treatment: It is important to finish the prescribed course of treatment, even if symptoms improve, to ensure the infection is completely cleared. Do not stop taking the medication unless directed by a doctor.\u003cbr\u003e6. Store the medication properly: Keep the medication in a cool, dry place away from direct sunlight and out of the reach of children. Discard any remaining medication after the prescribed duration of treatment.\u003cbr\u003e7. Follow your doctor's instructions: Follow your doctor's instructions closely, as they may prescribe a different dosage or frequency of Sulfamethoxazole and Trimethoprim oral suspension depending on the severity and type of infection. If you miss a dose, take it as soon as you remember. If it is close to the time for the next dose, skip the missed dose and continue with the regular dosing schedule.\u003cbr\u003e8. Watch for side effects: Like any medication, Sulfamethoxazole and Trimethoprim oral suspension may cause side effects such as nausea, vomiting, diarrhea, and allergic reactions. If you experience any severe side effects, seek medical attention immediately.\u003cbr\u003e9. Do not use with certain medications: Inform your doctor of any other medications, supplements, or herbal remedies you are currently taking or plan to take during your Sulfamethoxazole and Trimethoprim treatment. Some medications may interact with Sulfamethoxazole and Trimethoprim and cause adverse effects.\u003cbr\u003e10. Complete follow-up appointments: Once you have completed the prescribed course of treatment, follow up with your doctor to ensure the infection has cleared. In case of any lingering symptoms, inform your doctor immediately. Do not take any additional medications without consulting your doctor.\u003c\/p\u003e","brand":"Aurobindo Pharma USA","offers":[{"title":"Default Title","offer_id":40082708201544,"sku":"65862-0496-47","price":67.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Sulfamethoxazole-and-Trimethoprim-200-mg-40-mg-Per-5-mL-Oral-Suspension.jpg?v=1721837919"},{"product_id":"sulfamethoxazole-and-trimethoprim-injection-multiple-dose-vial-30-ml-rx","title":"Sulfamethoxazole and Trimethoprim Injection Multiple-Dose Vial 30 mL (RX)","description":"\u003ch4\u003ePowerful IV Antibiotic for Bacterial Infections \u0026amp; Sepsis\u003c\/h4\u003e\n\u003cp\u003e\u003cspan class=\"EcDrQ pdMy8\"\u003e\u003cstrong\u003eSulfamethoxazole and Trimethoprim Injection Multiple-Dose Vial 30 mL by Somerset Therapeutics\u003c\/strong\u003e delivers fast-acting, hospital-grade broad-spectrum infection treatment for both adults and pediatric patients. As a potent IV antibiotic combination—also known as Co-Trimoxazole or IV Bactrim—this clinician-trusted solution effectively treats serious urinary tract infections (UTIs), respiratory tract infections, Pneumocystis jirovecii pneumonia (PCP), sepsis, skin and soft tissue infections, and more. The 30 mL multiple-dose vial offers flexible dosing and proven efficacy against a wide array of susceptible bacteria, making it an essential for hospitals, ICUs, and infection control programs.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eUses and Indications\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eSulfamethoxazole and Trimethoprim Injection is indicated for:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eSerious urinary tract infections (UTIs) requiring IV therapy\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRespiratory tract infections\u003c\/strong\u003e (bronchitis, pneumonia, particularly PCP in immunosuppressed patients)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePneumocystis jirovecii pneumonia (PCP)\u003c\/strong\u003e—prophylaxis and treatment in HIV\/AIDS, transplant, or immunocompromised individuals\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eSepsis and bacteremia\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eShigellosis and other severe GI tract infections\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eSkin and soft tissue infections\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eAlternative treatment for patients unable to take oral antibiotics\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eNot indicated for viral infections. Use only under physician direction.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eKey Benefits\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBroad-Spectrum Antibacterial Power:\u003c\/strong\u003e Combines two powerful agents (sulfamethoxazole + trimethoprim) for superior coverage against Gram-positive and Gram-negative pathogens.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIV Administration for Serious Infections:\u003c\/strong\u003e Rapid and reliable therapy for severe infections where oral antibiotics are inadequate.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlexible Dosing:\u003c\/strong\u003e 30 mL multiple-dose vial allows for individualized dosing in adults and pediatric patients.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTrusted for PCP Prophylaxis and Treatment:\u003c\/strong\u003e Go-to first-line therapy for \u003cstrong\u003ePneumocystis jirovecii (carinii) pneumonia\u003c\/strong\u003e in immunocompromised patients.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClinician’s Choice:\u003c\/strong\u003e Efficacy proven in complex and hospital-acquired infections—often used in ICU, surgical, and transplant patients.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFDA-Approved Quality:\u003c\/strong\u003e Manufactured to strict quality standards by Somerset Therapeutics.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBrand:\u003c\/strong\u003e Somerset Therapeutics\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActive Ingredients:\u003c\/strong\u003e Sulfamethoxazole and Trimethoprim\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStrength:\u003c\/strong\u003e (typically 80 mg\/mL sulfamethoxazole + 16 mg\/mL trimethoprim per mL – verify per product insert)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVolume:\u003c\/strong\u003e 30 mL multiple-dose vial\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNDC:\u003c\/strong\u003e 70069-0363-01\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRoute:\u003c\/strong\u003e Intravenous (IV) infusion only\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Sterile solution for injection\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eHow It Works\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eThis combination antibiotic \u003cstrong\u003einhibits two consecutive steps in bacterial folate synthesis\u003c\/strong\u003e, maximizing bacterial kill and reducing the risk of resistance. Its dual mechanism makes it highly effective for a variety of complicated and resistant infections.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eWho Should Use This Product?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eEmergency rooms, ICUs, and hospital inpatient settings\u003c\/strong\u003e treating life-threatening bacterial infections\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTransplant teams and infectious disease specialists\u003c\/strong\u003e needing PCP prophylaxis\/treatment for immunocompromised patients\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eClinicians managing UTI, sepsis, or pneumonia where oral route is not possible\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003ePediatric or adult patients requiring IV therapy as prescribed by a healthcare professional\u003c\/strong\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eNot for:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePatients with allergy to sulfa drugs or trimethoprim\u003c\/li\u003e\n\u003cli\u003eIndividuals with severe liver\/kidney disease without specialist oversight\u003c\/li\u003e\n\u003cli\u003ePatients with history of blood disorders related to folate deficiency\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003ePossible Side Effects\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eNausea, vomiting, or loss of appetite\u003c\/li\u003e\n\u003cli\u003eRash or skin reactions\u003c\/li\u003e\n\u003cli\u003eIncrease in potassium levels\u003c\/li\u003e\n\u003cli\u003eKidney function changes\u003c\/li\u003e\n\u003cli\u003eAnemia, leukopenia, or thrombocytopenia (rare)\u003c\/li\u003e\n\u003cli\u003ePhlebitis at site of infusion\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003eSerious Side Effects (Seek Immediate Medical Help):\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003eSevere allergic reaction (anaphylaxis)\u003c\/li\u003e\n\u003cli\u003eStevens-Johnson syndrome or toxic epidermal necrolysis\u003c\/li\u003e\n\u003cli\u003eSevere or persistent diarrhea (C. difficile–associated)\u003c\/li\u003e\n\u003cli\u003eBlood disorders or renal impairment\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eImportant Safety \u0026amp; Drug Interaction Information\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrug Interactions:\u003c\/strong\u003e May interact with warfarin, ACE inhibitors, methotrexate, diuretics, and other drugs affecting kidney or blood function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMonitoring:\u003c\/strong\u003e Regular blood counts and kidney\/liver function tests recommended during therapy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUse in Pregnancy:\u003c\/strong\u003e Not advised unless clearly needed—consult infectious disease specialist.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eFAQs\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eHow is it administered?\u003c\/strong\u003e By slow intravenous infusion, typically over 60–90 minutes, in a hospital or clinical setting.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy use multiple-dose vials?\u003c\/strong\u003e Allows for repeated, accurate dosing for multi-day, multi-patient use in busy hospital environments.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIs this the same as Bactrim IV?\u003c\/strong\u003e Yes, it is the generic equivalent and often referred to in clinical guidelines as IV Bactrim or co-trimoxazole injection.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eOrder Sulfamethoxazole and Trimethoprim Injection Multiple-Dose Vial 30 mL by Somerset Therapeutics Now!\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eFor serious, hospital-acquired, and resistant infections, trust \u003cstrong\u003eSulfamethoxazole and Trimethoprim Injection 30 mL by Somerset Therapeutics.\u003c\/strong\u003e \u003cstrong\u003eOrder today\u003c\/strong\u003e for reliable, broad-spectrum infection control and consistent hospital supply—backed by clinical excellence and FDA approval.\u003c\/p\u003e","brand":"Somerset Therapeutics","offers":[{"title":"Default Title","offer_id":40093869539400,"sku":"70069-0363-01","price":64.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Sulfamethoxazole-and-Trimethoprim-Injection-Multiple-Dose-Somerset-Therapeutics.jpg?v=1770816003"},{"product_id":"sulfamethoxazole-and-trimethoprim-800mg-160-mg-double-strength-tablets-100-bottle-rx","title":"Sulfamethoxazole and Trimethoprim 800mg\/160 mg Double Strength Tablets 100\/Bottle (RX)","description":"\u003cp\u003eSulfamethoxazole and Trimethoprim 800mg\/160mg tablets are an antibiotic combination used to treat a variety of bacterial infections. Commonly prescribed for urinary tract infections (UTIs), respiratory infections, and gastrointestinal infections, this medication works by inhibiting bacterial growth. It is also effective against certain types of pneumonia and other infections caused by susceptible bacteria. Consistent use as directed by a healthcare provider is crucial for effective treatment and preventing antibiotic resistance.\u003c\/p\u003e\n\u003cp\u003eSulfamethoxazole and Trimethoprim DS Tablets combine two potent antibacterial agents in double-strength formulation, meticulously produced by Aurobindo Pharma USA. This synergistic antibiotic blend is formulated for the effective treatment of a variety of bacterial infections, delivering enhanced efficacy in a convenient, dual-action dosage. Each bottle contains 100 double-strength tablets, ensuring an optimal supply for prescribed regimens. Designed to tackle infections with precision, these tablets represent Aurobindo Pharma's commitment to quality and patient care.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Details and Features:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eActive Ingredients:\u003c\/strong\u003e Sulfamethoxazole 800 mg, Trimethoprim 160 mg per tablet\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e Double-strength oral tablets\u003cbr\u003e\u003cstrong\u003eQuantity: \u003c\/strong\u003e100 tablets per bottle, ideal for therapeutic consistency and adherence\u003cbr\u003e\u003cstrong\u003eIndications:\u003c\/strong\u003e Effective against urinary tract infections, respiratory infections, gastrointestinal infections, and various other bacterial infections where the use of a broad-spectrum antibiotic is required\u003cbr\u003e\u003cstrong\u003ePackaging: \u003c\/strong\u003eSecurely sealed to ensure product integrity and stability to the end user\u003cbr\u003e\u003cstrong\u003eTherapeutic Class:\u003c\/strong\u003e Antibiotic combination providing broad bacterial spectrum coverage\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirections for Use:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e1. Dosage:\u003c\/strong\u003e Follow the dosing instructions prescribed by your healthcare provider, typically one tablet every 12 hours. The duration can vary based on the infection and clinical response.\u003cbr\u003e\u003cstrong\u003e2. Administration:\u003c\/strong\u003e Tablets should be taken orally with a full glass of water. Ensure adequate hydration during the course of treatment to prevent crystalluria.\u003cbr\u003e\u003cstrong\u003e3. Meal Consideration:\u003c\/strong\u003e This medication can be taken with or without food. However, taking it with meals may reduce the risk of stomach upset.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMechanism of Action:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eSulfamethoxazole and trimethoprim work synergistically by blocking sequential steps in bacterial folic acid synthesis:\u003c\/em\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSulfamethoxazole:\u003c\/strong\u003e Inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTrimethoprim:\u003c\/strong\u003e Inhibits dihydrofolate reductase, preventing conversion of dihydrofolic acid to tetrahydrofolic acid.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThis dual inhibition effectively halts bacterial growth, providing a potent bacteriostatic effect.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eSide Effects:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eWhile generally well-tolerated, some patients may experience side effects including:\u003c\/em\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eNausea or vomiting\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eRash or skin reactions\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eLoss of appetite or stomach pain\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eFatigue or headaches\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSevere side effects may include allergic reactions, unanticipated bruising\/bleeding, persistent sore throat, or signs of a severe skin reaction. Seek medical advice if these occur.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarnings:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypersensitivity:\u003c\/strong\u003e Contraindicated in individuals with a history of allergy to sulfonamides or trimethoprim.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePregnancy and Lactation:\u003c\/strong\u003e Use only if clearly needed during pregnancy and after assessing the benefit-risk ratio during breastfeeding.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBlood Disorders:\u003c\/strong\u003e Exercise caution in patients with pre-existing blood dyscrasias or G6PD deficiency.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRenal\/Hepatic Impairment:\u003c\/strong\u003e Monitor kidney and liver function regularly during therapy in vulnerable patients.\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrug Interactions:\u003c\/strong\u003e Can interact with warfarin and certain antihyperglycemics, adjusting therapy as necessary.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eFor comprehensive bacterial infection management, trust Sulfamethoxazole and Trimethoprim DS by Aurobindo Pharma USA, exemplifying reliability in pharmaceutical excellence.\u003c\/p\u003e","brand":"Aurobindo Pharma USA","offers":[{"title":"Default Title","offer_id":40350567006280,"sku":"65862-0420-01","price":21.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Sulfamethoxazole-and-Trimethoprim-800mg_160-mg-Double-Strength-Tablets-by-Aurobindo-NDC-65862-0420-01.jpg?v=1766249332"},{"product_id":"sulfamethoxazole-and-trimethoprim-800mg-160mg-double-strength-100-tablets-rx","title":"Sulfamethoxazole and Trimethoprim 800mg\/160mg Double Strength 100 Tablets (Rx)","description":"\u003ch2\u003ePrescription Strength Antibiotic – Trusted Solution for Bacterial Infections!\u003c\/h2\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003e\u003cstrong\u003eSulfamethoxazole and Trimethoprim 800mg\/160mg Double Strength Tablets USP, 100 Count by Rising Pharmaceuticals\u003c\/strong\u003e is a top-rated, FDA-approved, broad-spectrum prescription antibiotic combination designed to treat a wide range of bacterial infections. Known also as \u003cstrong\u003eSMX-TMP DS\u003c\/strong\u003e or \u003cstrong\u003eBactrim DS (generic)\u003c\/strong\u003e, this medication is clinically trusted for its dual-action effectiveness and rapid symptom relief. Perfect for both outpatient and hospital settings, this double-strength tablet pack offers physician-recommended, high quality infection care.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003eWhat Are Sulfamethoxazole and Trimethoprim 800mg\/160mg Tablets?\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eSulfamethoxazole and Trimethoprim\u003c\/strong\u003e, also known as \u003cstrong\u003eco-trimoxazole\u003c\/strong\u003e, is a combination antibiotic medication. The “double strength” (DS) tablet contains 800mg of sulfamethoxazole and 160mg of trimethoprim. Typically, these tablets are supplied in bottles or packs of 100 for prescription use.\u003c\/p\u003e\n\u003ch2\u003e\n\u003cstrong\u003eUse\u003c\/strong\u003es\u003c\/h2\u003e\n\u003cp\u003eSulfamethoxazole and trimethoprim tablets are used to treat a variety of \u003cstrong\u003ebacterial infections\u003c\/strong\u003e, such as:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eUrinary tract infections (UTIs)\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRespiratory infections:\u003c\/strong\u003e e.g. acute exacerbations of chronic bronchitis, pneumonia (including \u003cem\u003ePneumocystis jirovecii\u003c\/em\u003e pneumonia in people with HIV\/AIDS)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGastrointestinal infections:\u003c\/strong\u003e e.g. traveler’s diarrhea, shigellosis\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin and soft tissue infections\u003c\/strong\u003e (such as some forms of MRSA)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEar infections\u003c\/strong\u003e (acute otitis media)\u003c\/li\u003e\n\u003cli\u003e\u003cstrong\u003eCertain types of prostatitis\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrevention and treatment of \u003cem\u003ePneumocystis\u003c\/em\u003e pneumonia\u003c\/strong\u003e (PCP) in immunocompromised patients\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eNOTE:\u003c\/strong\u003e This combination is \u003cstrong\u003enot effective against viral or fungal infections\u003c\/strong\u003e.\u003c\/p\u003e\n\u003ch3\u003eOrder Sulfamethoxazole and Trimethoprim 800mg\/160mg DS Tablets, 100 Count\u003c\/h3\u003e\n\u003cp\u003eGet rapid, reliable relief from bacterial infections with this leading prescription antibiotic. \u003cstrong\u003eOrder now for FDA-approved, doctor-trusted infection therapy.\u003c\/strong\u003e\u003c\/p\u003e","brand":"Rising Pharmaceuticals","offers":[{"title":"Default Title","offer_id":53357185073520,"sku":"57237-0233-01P","price":16.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Sulfamethoxazole-and-Trimethoprim-800mg-160mg-Double-Strength.jpg?v=1773055866"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/collections\/Sulfamethoxazole.jpg?v=1775480736","url":"https:\/\/www.mountainside-medical.com\/collections\/sulfamethoxazole\/somerset-therapeutics+trimethoprim+treat-pneumonia.oembed","provider":"Mountainside Medical","version":"1.0","type":"link"}