{"product_id":"bortezomib-injection-3-5mg-vial-single-dose-by-somerset-pharma-rx","title":"Bortezomib Injection 3.5mg Vial, Single Dose by Somerset Pharma (RX)","description":"\u003ch1\u003eBortezomib 3.5 mg Injection (Single-Dose Vial)\u003c\/h1\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003eBortezomib is a chemotherapy drug (a \u003cstrong\u003eproteasome inhibitor\u003c\/strong\u003e) used to treat certain blood cancers. It works by blocking the 26S proteasome inside cells, preventing the breakdown of proteins that trigger cell death. Cancer cells (especially myeloma cells) cannot survive when this proteasome is inhibited, so they undergo apoptosis. Brand names include Velcade® (bortezomib for injection).\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan class=\"VODHU pdMy8\"\u003eUses: \u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003eBortezomib injection is FDA-approved for adults with multiple myeloma and mantle cell lymphoma. It is often given in combination with other chemotherapy (e.g. dexamethasone, melphalan, cyclophosphamide, etc.). It may be used as initial therapy, or for relapsed\/refractory disease after prior treatment.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eFormulation and Dosage\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Each vial contains \u003cstrong\u003e3.5 mg\u003c\/strong\u003e of bortezomib as a sterile lyophilized (freeze-dried) powder. There are no preservatives, so each vial is \u003cstrong\u003esingle-use only\u003c\/strong\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e The powder must be dissolved in 0.9% sodium chloride (sterile saline) before injection. For \u003cstrong\u003eintravenous (IV)\u003c\/strong\u003e administration, add \u003cstrong\u003e3.5 mL\u003c\/strong\u003e saline to the 3.5 mg vial (yielding 1.0 mg\/mL). For \u003cstrong\u003esubcutaneous (SC)\u003c\/strong\u003e (under-the-skin) use, add \u003cstrong\u003e1.4 mL\u003c\/strong\u003e saline (yielding 2.5 mg\/mL). Gently mix to dissolve (do \u003cstrong\u003enot shake vigorously\u003c\/strong\u003e). Use the reconstituted solution \u003cstrong\u003eimmediately\u003c\/strong\u003e (the drug has no preservative) and discard any unused portion within about \u003cstrong\u003e8 hours\u003c\/strong\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003e\u003cspan class=\"VODHU pdMy8\"\u003eDosage:\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003eThe typical \u003cstrong\u003estarting dose\u003c\/strong\u003e is \u003cstrong\u003e1.3 mg\/m²\u003c\/strong\u003e of body surface area, given as either a rapid IV push (3–5 seconds) or an SC injection. Treatment schedules vary, but a common regimen is twice weekly on days 1, 4, 8, and 11 of a 21-day cycle, followed by a 10-day rest. Dose adjustments may be needed for patients with liver impairment or other factors. Your doctor will calculate the exact dose and schedule; do not change the dose on your own.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan class=\"VODHU pdMy8\"\u003eAdministration: \u003c\/span\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003eBortezomib is given only by healthcare professionals in a clinic or hospital. Do not attempt to self-inject unless specifically trained. It can be given into a peripheral vein or via a central line. Rotating injection sites (for SC) can help reduce local irritation. Since IV and SC concentrations differ, double-check the preparation before giving any dose. Important: Bortezomib must never be administered intrathecally (into the spine) – this is contraindicated and can be fatal.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eSide Effects and Precautions\u003c\/h2\u003e\n\u003cp\u003eBortezomib has several potential side effects. Some of the most common (occurring in ≥20% of patients) include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGastrointestinal:\u003c\/strong\u003e Nausea, vomiting, diarrhea or constipation are very common. Your doctor may prescribe anti-nausea or anti-diarrheal medications if needed. Staying hydrated and eating small frequent meals can help manage these effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBlood Cell Counts:\u003c\/strong\u003e Bortezomib suppresses bone marrow. You may develop \u003cstrong\u003ethrombocytopenia\u003c\/strong\u003e (low platelets) or \u003cstrong\u003eneutropenia\u003c\/strong\u003e (low white cells). This raises the risk of bleeding or infection. \u003cstrong\u003eRegular blood tests (CBC)\u003c\/strong\u003e are required before each dose to monitor your counts. Notify your provider if you see unusual bruising, bleeding, or signs of infection (fever, sore throat).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuropathy (Nerve Effects):\u003c\/strong\u003e Many patients experience \u003cstrong\u003eperipheral neuropathy\u003c\/strong\u003e – tingling, numbness or burning in the hands and feet. This can cause pain or weakness, and may worsen if not addressed. Report any new numbness, tingling, or difficulty walking to your doctor promptly. In severe cases, the dose may need to be reduced or delayed. Ask your doctor about strategies to protect your nerves (such as avoiding extreme cold or drugs that worsen neuropathy).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFatigue and General:\u003c\/strong\u003e Tiredness, weakness, loss of appetite, fever, and rash are also fairly common. Rest when needed. Over-the-counter pain relievers (as recommended by your doctor) or cool showers may help with fatigue or fever.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypotension and Dizziness:\u003c\/strong\u003e Bortezomib can cause low blood pressure. If you feel dizzy when standing, get up slowly and drink plenty of fluids. Patients on blood pressure medication or who become dehydrated should be cautious.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHerpes Zoster (Shingles):\u003c\/strong\u003e Bortezomib significantly increases the risk of shingles (reactivation of herpes zoster). In clinical trials, 6–11% of bortezomib-treated patients developed shingles. Your doctor will likely prescribe antiviral medication (e.g. acyclovir) to prevent this. \u003cstrong\u003eDiscuss antiviral prophylaxis with your provider\u003c\/strong\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSerious Warnings:\u003c\/strong\u003e Though less common, bortezomib can cause serious problems. These include heart failure or heart damage, severe lung problems, and a rare brain condition called Posterior Reversible Encephalopathy Syndrome (PRES), which involves headaches, vision changes, or seizures. Always report any chest pain, sudden shortness of breath, severe headache, confusion, or other alarming symptoms immediately. Bortezomib may also cause birth defects – effective birth control is essential for both men and women during treatment.\u003c\/p\u003e\n\u003ch2\u003eMonitoring and Follow-Up\u003c\/h2\u003e\n\u003cp\u003eYour healthcare team will monitor you closely during bortezomib therapy:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eLaboratory Tests:\u003c\/strong\u003e Blood counts and liver function tests are checked before each dose. Your doctor may also monitor blood glucose if you have diabetes. If blood counts fall too low, the doctor may delay or reduce the next dose.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhysical Exams:\u003c\/strong\u003e Numbness in the hands\/feet is checked, blood pressure is measured regularly. Tell your doctor about any new, worsening, or unusual symptoms (numbness, bleeding, rash, severe nausea, mood changes, etc.).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMedications:\u003c\/strong\u003e Review all your medicines with the doctor – some drugs can interact with bortezomib. For example, strong CYP3A4 inhibitors (like certain antifungals or antibiotics) or inducers (like rifampin) can alter bortezomib levels. Also inform your doctor about any herbal supplements or over-the-counter products.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVaccination\/Prophylaxis:\u003c\/strong\u003e Because bortezomib weakens the immune system, expect to avoid live vaccines during treatment. Annual flu shots (inactivated vaccine) and pneumonia vaccines are often recommended before starting therapy. Antiviral prophylaxis (as mentioned) and sometimes Pneumocystis pneumonia prophylaxis may be given.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eStorage and Handling\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBefore Use:\u003c\/strong\u003e Store unopened vials at \u003cstrong\u003eroom temperature\u003c\/strong\u003e (68–77°F\/20–25°C) in the original carton, protected from light. Avoid excessive heat or freezing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAfter Reconstitution:\u003c\/strong\u003e Once mixed with saline, bortezomib solution should be kept at room temperature and used within \u003cstrong\u003e8 hours\u003c\/strong\u003e. It may be stored at up to 77°F (25°C) in the vial or syringe during that time. Do \u003cstrong\u003enot freeze\u003c\/strong\u003e the reconstituted solution and \u003cstrong\u003edo not use after 8 hours\u003c\/strong\u003e. Discard any remaining solution after a single patient use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrecautions:\u003c\/strong\u003e Handle the drug carefully (wear gloves) and dispose of needles\/syringes safely. Keep all chemotherapy agents out of reach of children and pets.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003ePatient Tips and Key Advice\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrevent Nausea \u0026amp; Diarrhea:\u003c\/strong\u003e Eat small, bland meals and sip clear liquids. Take prescribed anti-nausea pills or antidiarrheal meds as directed. Staying hydrated (water, electrolyte drinks) helps reduce dizziness and gastrointestinal upset.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eManage Neuropathy:\u003c\/strong\u003e Let your doctor know immediately if you feel burning, tingling, or loss of feeling in hands or feet. Use non-slip slippers and handrails to prevent falls. Protect your hands\/feet from extreme temperatures and avoid alcohol, which can worsen nerve symptoms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMonitor Blood Sugar:\u003c\/strong\u003e If you have diabetes, check your blood glucose more often. Bortezomib can affect blood sugar control. Your diabetes medicines may need adjustment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStay Active (Safely):\u003c\/strong\u003e Light exercise (walking, stretching) can help combat fatigue and nerve symptoms, but listen to your body. Rest when you feel very tired.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrevent Infections:\u003c\/strong\u003e Practice good hand hygiene and avoid crowds or sick people. Report fever, cough, or any sign of infection right away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvoid Pregnancy:\u003c\/strong\u003e Use effective birth control during treatment and for the advised period afterward. Bortezomib can cause fetal harm. Men should also use condoms to avoid fathering a pregnancy on treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAsk About Prophylaxis:\u003c\/strong\u003e Remind your doctor to prescribe antiviral medication to prevent shingles. If you haven’t had chickenpox or shingles before, you may discuss vaccines with your doctor prior to therapy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDo Not Share Doses:\u003c\/strong\u003e Each vial is for one patient and one use. Never use leftover drug on another day or another person.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReport Reactions:\u003c\/strong\u003e Immediately tell your provider if you have a sudden rash, trouble breathing, severe back pain, or any allergic symptoms after the injection. Emergency care is needed for these.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eArrange Support:\u003c\/strong\u003e Because bortezomib can cause fatigue or dizziness, plan to have someone drive you home after treatment if you feel lightheaded.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAlways follow your healthcare team’s instructions exactly. Keep all appointments and lab tests, and communicate any concerns. This information is a general guide; your doctor and pharmacist will give you detailed counseling tailored to your health needs.\u003c\/p\u003e","brand":"Somerset Therapeutics","offers":[{"title":"Default Title","offer_id":53715938050416,"sku":"70069-0836-01","price":22.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Bortezomib-for-Injection-3_5-gram-somerset.jpg?v=1777985942","url":"https:\/\/www.mountainside-medical.com\/products\/bortezomib-injection-3-5mg-vial-single-dose-by-somerset-pharma-rx","provider":"Mountainside Medical","version":"1.0","type":"link"}