{"product_id":"dimenhydrinate-injection-50mg-ml-mdv-1-ml-x-25-tray","title":"Dimenhydrinate Injection 50 mg\/mL Multiple Dose Vials 1 mL x 25\/Tray","description":"\u003ch1\u003eDimenhydrinate Injection (50 mg\/mL, 1 mL MDV) – Fast-Acting Anti-Nausea Therapy\u003c\/h1\u003e\n\u003cp\u003e\u003cstrong\u003eDimenhydrinate Injection\u003c\/strong\u003e is a potent prescription antiemetic supplied in a 1 mL multi-dose vial (MDV) at 50 mg per mL. It delivers rapid relief from severe nausea, vomiting, dizziness, and vertigo, especially related to \u003cstrong\u003emotion sickness\u003c\/strong\u003e and other vestibular disorders. Each vial contains dimenhydrinate (an 8-chlorotheophylline salt of diphenhydramine) in a sterile solution with propylene glycol and a 5% benzyl alcohol preservative. Because it is an injection formulation (IM\/IV), it acts faster than oral equivalents and is used when immediate effect or an alternative to oral therapy is needed. As with any powerful medication, Dimenhydrinate Injection is \u003cstrong\u003eRx-only\u003c\/strong\u003e and should be used under medical supervision (see Usage \u0026amp; Precautions below).\u003c\/p\u003e\n\u003ch2\u003eKey Features \u0026amp; Benefits\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFast antiemetic action:\u003c\/strong\u003e Delivers 50 mg dimenhydrinate per mL directly into the bloodstream, quickly blocking nausea\/vomiting pathways.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMotion sickness \u0026amp; vertigo relief:\u003c\/strong\u003e Clinically indicated for prevention\/treatment of \u003cstrong\u003enausea, vomiting, or vertigo of motion sickness\u003c\/strong\u003e. Also used for symptomatic relief in vestibular disorders (e.g. Meniere’s disease)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIM\/IV administration:\u003c\/strong\u003e Usable by intramuscular or intravenous injection. Particularly useful in hospital\/emergency settings when oral meds are not practical.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMulti-dose vial (MDV):\u003c\/strong\u003e Contains 25 × 1 mL vials with preservative. Benzyl alcohol (5%) allows multiple withdrawals – however, note that benzyl alcohol \u003cstrong\u003eshould not\u003c\/strong\u003e be used in newborns or very low-birth-weight infants (risk of “gasping syndrome”).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProven antihistamine formula:\u003c\/strong\u003e Dimenhydrinate’s combination of an H1-antihistamine and stimulant (diphenhydramine + 8-chlorotheophylline) effectively dampens inner-ear (labyrinthine) signals that trigger emesis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePhysician-directed use:\u003c\/strong\u003e As a prescription product (Category: Abbreviated NDA, Rx-only), it must be prescribed by a qualified healthcare professional. Dose and frequency are adjusted per patient condition.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSafety notes:\u003c\/strong\u003e Contains \u003cstrong\u003ebenzyl alcohol preservative (5%)\u003c\/strong\u003e– caution in children. Pregnancy Category B. May cause sedation\/drowsiness – advise patients \u003cstrong\u003enot to drive or operate machinery\u003c\/strong\u003e after administration and to avoid alcohol or other CNS depressants.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eIndications \u0026amp; Uses\u003c\/h2\u003e\n\u003cp\u003eDimenhydrinate Injection is \u003cstrong\u003eindicated\u003c\/strong\u003e for prevention and treatment of severe nausea, vomiting, and vertigo \u003cem\u003edue to motion sickness.\u003c\/em\u003e This includes “sea-sickness”, “car-sickness”, air travel nausea, or any travel-related labyrinth irritation. In practice, it is also used for \u003cstrong\u003evestibular disorders\u003c\/strong\u003e – for example, acute vertigo attacks in Meniere’s disease or inner-ear inflammation. By tranquilizing the vestibular nerve signals, it halts the emetic impulse at its source. It works more quickly than oral Dramamine, making it ideal for emergency rooms or pre-emptive dosing (e.g. prior to prolonged travel).\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cem\u003ePreventive dosing:\u003c\/em\u003e For motion sickness, clinicians often administer the first injection \u003cstrong\u003e30–60 minutes before travel\u003c\/strong\u003e to pre-empt nausea.\u003c\/li\u003e\n\u003cli\u003e\n\u003cem\u003eTreatment:\u003c\/em\u003e If symptoms start, one injection (50–100 mg) can stop vomiting and allow comfort. Note that injectable dimenhydrinate \u003cstrong\u003etypically works within minutes\u003c\/strong\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNote:\u003c\/strong\u003e Since this is a potent prescription drug, it should only be given under medical guidance. (It is an antihistamine on the WHO essential medicines list for antiemesis.)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eMechanism of Action\u003c\/h2\u003e\n\u003cp\u003eDimenhydrinate is an \u003cstrong\u003eantihistamine (H1-blocker)\u003c\/strong\u003e with anticholinergic properties. It specifically depresses “hyperstimulated labyrinthine function” in the inner ear, which is a key trigger for motion-induced vomiting. Although the exact antiemetic mechanism isn’t fully known, dimenhydrinate’s central action blocks histamine signals to the brain’s vomiting center. In short, it soothes the vestibular system and reduces dizziness by stabilizing neural firing in the balance pathways. The 8-chlorotheophylline part slightly counteracts sedation of diphenhydramine, but patients still typically feel drowsy.\u003c\/p\u003e\n\u003ch2\u003eDosage \u0026amp; Administration\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eAdults – IM\/IV:\u003c\/strong\u003e The usual adult dose is \u003cstrong\u003e50–100 mg\u003c\/strong\u003e (1–2 mL) by intramuscular (IM) or slow intravenous (IV) injection every 4–6 hours as needed. Do \u003cstrong\u003enot exceed 400 mg\/day\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIntramuscular:\u003c\/strong\u003e Inject 50–100 mg into a large muscle (e.g. hip or thigh). IM route is commonly used in ER settings.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIntravenous (IV):\u003c\/strong\u003e \u003cem\u003eDilute before use.\u003c\/em\u003e Mix the dose (e.g. 50 mg) in at least 10 mL of 0.9% NaCl, then inject \u003cstrong\u003eslowly\u003c\/strong\u003e (over ~2 minutes). Rapid IV push can cause hypotension or irritation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOnset \u0026amp; Duration:\u003c\/strong\u003e IM injection typically acts within 15–30 minutes; IV onset is faster (minutes). Effects last about 4–6 hours per dose.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePediatrics:\u003c\/strong\u003e Dimenhydrinate injection is \u003cstrong\u003econtraindicated in neonates\u003c\/strong\u003e (due to benzyl alcohol and immature metabolism) and generally \u003cem\u003enot recommended\u003c\/em\u003e for infants. For children over ~2 years, pediatric dosing is weight-based: ~1.25 mg\/kg (37.5 mg\/m²) IM up to 4 times daily (max ~300 mg\/day). Always dose a child under physician supervision.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdministration Tips:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eUse a new sterile syringe\/needle for each injection.\u003c\/li\u003e\n\u003cli\u003eCheck the vial's integrity and expiration.\u003c\/li\u003e\n\u003cli\u003eSwab vial top with alcohol before drawing up.\u003c\/li\u003e\n\u003cli\u003e\u003cem\u003eIM injections should be given deep in the muscle.\u003c\/em\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cem\u003eIV injections must be diluted and given slowly†.\u003c\/em\u003e\u003c\/li\u003e\n\u003cli\u003eMonitor blood pressure and sedation level after injection.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eSafety \u0026amp; Precautions\u003c\/h2\u003e\n\u003cp\u003eDimenhydrinate has a well-established safety profile when used correctly, but \u003cstrong\u003ewarnings\u003c\/strong\u003e include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypersensitivity:\u003c\/strong\u003e Do \u003cstrong\u003enot\u003c\/strong\u003e give to anyone with known hypersensitivity to dimenhydrinate, diphenhydramine, or benzyl alcohol. Cases of allergic reaction (rash, itching, anaphylaxis) have been reported.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeonates\/Infants:\u003c\/strong\u003e Contraindicated in newborns and premature infants due to benzyl alcohol preservative risk (“gasping syndrome”). Use extreme caution in nursing mothers (small amounts pass into milk.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCNS Effects:\u003c\/strong\u003e Dimenhydrinate causes \u003cstrong\u003edrowsiness\u003c\/strong\u003e in most patients. Patients should be warned \u003cstrong\u003enot to drive, operate machinery\u003c\/strong\u003e, or consume alcohol while under its influence. Concurrent use with other CNS depressants (alcohol, sedatives) can greatly increase drowsiness.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnticholinergic Risks:\u003c\/strong\u003e Avoid or use cautiously in patients with narrow-angle glaucoma, enlarged prostate (urinary retention), asthma, severe heart disease, or GI obstruction. These conditions can be worsened by anticholinergic side effects (e.g. increased eye pressure or bladder issues).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular:\u003c\/strong\u003e Overdose or rapid IV push may precipitate hypotension (especially in hypovolemic patients). Monitor vital signs if given IV.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePregnancy:\u003c\/strong\u003e Category B. Animal studies show no fetal harm, but no controlled trials exist in pregnant women. Use \u003cstrong\u003eonly if clearly needed\u003c\/strong\u003e; consult obstetrician.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBreastfeeding:\u003c\/strong\u003e Dimenhydrinate passes into breast milk. If the injection is necessary, consider discontinuing nursing temporarily.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAlways inform the patient’s healthcare team of all medications and conditions. Disclose any existing medical issues before administration. Follow hospital protocols for IV antiemetic administration.\u003c\/p\u003e\n\u003ch2\u003eSide Effects \u0026amp; Adverse Reactions\u003c\/h2\u003e\n\u003cp\u003eLike all drugs, Dimenhydrinate injection can cause side effects. The \u003cstrong\u003emost common\u003c\/strong\u003e reaction is \u003cstrong\u003edrowsiness\/sedation\u003c\/strong\u003e. Dizziness often accompanies this. Other reported effects include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCNS:\u003c\/strong\u003e headache, nervousness, restlessness or paradoxical excitement (especially in children), insomnia. Rarely, confusion or seizures in overdose.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnticholinergic:\u003c\/strong\u003e dry mouth, nose and throat, blurred vision, urinary retention or difficulty urinating. (These stem from the antihistamine’s drying effects.)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiac:\u003c\/strong\u003e tachycardia (fast heartbeat), palpitation. Rarely bradycardia or hypotension if quickly injected.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRespiratory:\u003c\/strong\u003e thickened bronchial secretions, respiratory depression (especially if overdosed).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGI:\u003c\/strong\u003e epigastric distress, heartburn.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic:\u003c\/strong\u003e skin rash, itching.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIf severe side effects occur (e.g. extreme drowsiness, confusion, rapid heart rate, breathing problems), seek medical attention immediately. Overdose can be life-threatening, particularly in children.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eConsult a physician or poison control center for guidance if overdose is suspected.\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eStorage \u0026amp; Handling\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store Dimenhydrinate Injection at \u003cstrong\u003e20–25 °C (68–77 °F)\u003c\/strong\u003e – controlled room temperature. Do \u003cstrong\u003enot freeze\u003c\/strong\u003e. Keep the vials in their original box away from light.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStability:\u003c\/strong\u003e Use each opened vial within the manufacturer’s recommended time once punctured (the benzyl alcohol preservative provides some safety for multi-dose use – follow local policy, typically discard after 28 days).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHandling:\u003c\/strong\u003e Use aseptic technique when withdrawing from the vial. Do not use if the solution is discolored or contains particulate matter.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDisposal:\u003c\/strong\u003e Dispose of used syringes and any unused drug per biohazard regulations.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eComposition (per 1 mL)\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eActive Ingredient:\u003c\/strong\u003e 50 mg Dimenhydrinate (8-chlorotheophylline salt of diphenhydramine).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInactive Ingredients:\u003c\/strong\u003e Propylene glycol (50%), Benzyl alcohol (5%, preservative), Water for Injection, with pH adjusted by sodium hydroxide\/hydrochloric acid.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNote:\u003c\/strong\u003e The presence of benzyl alcohol means this \u003cstrong\u003eMDV is for multiple uses\u003c\/strong\u003e under proper precautions\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This description is for informational\/educational purposes only and is \u003cem\u003enot\u003c\/em\u003e medical advice. Always administer dimenhydrinate injections according to a licensed healthcare provider’s instructions and institutional protocols. Patients should be counseled on the risks, benefits, and alternatives before use.\u003c\/span\u003e\u003c\/p\u003e","brand":"Fresenius Kabi","offers":[{"title":"Default Title","offer_id":53871036596592,"sku":"63323-0366-01","price":560.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Dimenhydrinate-Injection-50-mg-mL-Multiple-Dose-Vials-1-mL.jpg?v=1780663150","url":"https:\/\/www.mountainside-medical.com\/products\/dimenhydrinate-injection-50mg-ml-mdv-1-ml-x-25-tray","provider":"Mountainside Medical","version":"1.0","type":"link"}