{"product_id":"mepivacaine-hcl-3-plain-1-7-ml-local-anesthetic-cartridge","title":"Mepivacaine Hydrochloride 3% Plain 1.7 mL Local Anesthetic Cartridge 50\/Box (RX)","description":"\u003ch1\u003eMepivacaine HCl 3% Plain 1.7 mL Anesthetic Cartridge\u003c\/h1\u003e\n\u003cp\u003eMepivacaine HCl 3% Plain (1.7 mL) is a potent amide-type local anesthetic supplied in a dental cartridge. Each carpule contains 3% mepivacaine hydrochloride (30 mg\/mL) at approximately 51 mg per 1.7 mL dose. It provides rapid-onset, intermediate-duration anesthesia (typically about 2–2.5 hours of pulpal block) without added vasoconstrictor. As a \u003cstrong\u003eplain (no-epinephrine)\u003c\/strong\u003e formulation, it’s ideal for patients in whom epinephrine is contraindicated. Mepivacaine works by blocking the generation and conduction of nerve impulses – it raises the threshold for electrical excitation in nerve fibers and slows the rate of rise of the action potential. In practice, this means sensory signals (especially pain) cannot be transmitted to the brain, achieving effective numbness for dental and minor surgical procedures.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eKey Features:\u003c\/strong\u003e Each cartridge (tan band) contains 3% mepivacaine HCl in 1.7 mL. No vasoconstrictor (plain). Fast onset (on par or faster than many lidocaine solutions. Duration ~2–2.5 hours of pulpal anesthesia. Packaged 50 cartridges\/box.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eINDICATIONS:\u003c\/strong\u003e Mepivacaine HCl 3% is used for local anesthesia by infiltration or nerve block in dentistry and oral surgery. It is suitable for restorative work, periodontal procedures, endodontics (root canals), minor oral surgery, and for any dental patient requiring anesthesia (especially cardiac or hyperthyroid patients) without added epinephrine.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eOnset \u0026amp; Duration:\u003c\/strong\u003e Compared to lidocaine, 3% mepivacaine (plain) generally produces a faster onset of pulpal anesthesia. Clinical studies show mepivacaine’s anesthesia sets in quicker than 2% lidocaine with epinephrine and provides comparable pain control. Mepivacaine’s duration (about 2–3 hours) covers most routine dental procedures.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eMechanism of Action\u003c\/h2\u003e\n\u003cp\u003eMepivacaine is an amide local anesthetic that \u003cstrong\u003eblocks nerve conduction\u003c\/strong\u003e. It inhibits voltage-gated sodium channels in nerve membranes, increasing the excitation threshold and slowing impulse propagation. This blockade prevents nerve fibers from transmitting pain signals. Clinically, sensory loss typically follows the order: pain is lost first, followed by temperature, touch, and finally pressure. In effect, mepivacaine produces reversible numbness of the targeted area. (This mechanism is similar to other local anesthetics like lidocaine.)\u003c\/p\u003e\n\u003ch2\u003eMepivacaine vs Lidocaine\u003c\/h2\u003e\n\u003cp\u003eWhen comparing mepivacaine to lidocaine, mepivacaine (especially in 3% plain form) often has a \u003cstrong\u003efaster onset\u003c\/strong\u003e while maintaining similar anesthetic efficacy. In one meta-analysis, 3% plain mepivacaine provided a significantly shorter onset of pulpal anesthesia than 2% lidocaine with epinephrine. Both drugs produce comparable anesthesia, but mepivacaine’s lack of vasodilating effect means it can be used without epinephrine and still achieve adequate duration. Mepivacaine also tends to cause less tachycardia than epinephrine-containing solutions, making it advantageous for cardiac-compromised patients. In short, \u003cstrong\u003emepivacaine vs lidocaine\u003c\/strong\u003e: mepivacaine’s onset is equal or faster, and it offers a safe alternative when epinephrine is not desired.\u003c\/p\u003e\n\u003ch2\u003eDosage Guidelines (Mepivacaine dosage)\u003c\/h2\u003e\n\u003cp\u003eDosage of mepivacaine is weight- and procedure-dependent. Each cartridge (1.7 mL of 3%) contains ~51 mg mepivacaine. Professional guidelines recommend a maximum of about \u003cstrong\u003e6.6 mg\/kg\u003c\/strong\u003e (up to ~400 mg) for healthy adults. For example, an adult patient (70 kg) could receive up to ~460 mg mepivacaine (roughly 9 cartridges) in total, though in practice dentists use the minimum effective dose. Clinicians calculate the needed dose by number of carpules (one carpule = 51 mg). Since this product is preservative-free, multiple cartridges can be given without concern for preservatives. (Always follow standard dosing protocols and patient monitoring.)\u003c\/p\u003e\n\u003ch2\u003eBrand Names \u0026amp; Synonyms\u003c\/h2\u003e\n\u003cp\u003eMepivacaine is sold under various brand names. Common \u003cstrong\u003emepivacaine brand names\u003c\/strong\u003e include \u003cstrong\u003eCarbocaine\u003c\/strong\u003e (Pfizer), \u003cstrong\u003ePolocaine\u003c\/strong\u003e (injection solution, including Polocaine-MPF which is preservative-free), \u003cstrong\u003eScandonest\u003c\/strong\u003e (3% plain), and \u003cstrong\u003eIsocaine\u003c\/strong\u003e. On dental labels and charts, mepivacaine (3% plain) is often tan-colored. These brands all contain the same active ingredient (mepivacaine HCl) and offer 3% concentrations similar to the Henry Schein cartridge. (For instance, Carbocaine 3% is a well-known equivalent to this product.)\u003c\/p\u003e\n\u003ch2\u003eSide Effects \u0026amp; Precautions (Mepivacaine side effects)\u003c\/h2\u003e\n\u003cp\u003eWhen used correctly for local anesthesia, mepivacaine is generally safe. Common side effects (\u003cstrong\u003emepivacaine side effects\u003c\/strong\u003e) are usually mild and result from systemic absorption:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCentral Nervous System:\u003c\/strong\u003e Patients may experience transient nervousness, dizziness, headache, or tremors. Feeling of restlessness, anxiety, or even depression (drowsiness) can occur at higher doses.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSensory:\u003c\/strong\u003e Some report blurred vision or ringing in the ears (tinnitus) during or after injection. These effects are typically short-lived.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular:\u003c\/strong\u003e Rarely, large doses can cause CNS excitatory symptoms (tremors, convulsions) followed by CNS depression and cardiovascular changes. Toxic levels depress cardiac conduction, potentially causing bradycardia or arrhythmias. However, these severe events are very uncommon when doses stay within guidelines.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAllergic reactions:\u003c\/strong\u003e True allergy to amide anesthetics like mepivacaine is extremely rare. In sensitive individuals, allergic signs (hives, swelling) would warrant stopping use. This 3% plain formulation contains no sulfite preservative or vasopressor, minimizing allergenic risk.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePrecautions:\u003c\/strong\u003e Use only when local anesthesia is indicated, and aspirate carefully to avoid intravascular injection. Monitor patient vitals during use. Mepivacaine should be administered by qualified practitioners.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNote:\u003c\/strong\u003e This cartridge product is for professional use in medical\/dental settings only. Always follow institutional protocols for anesthesia administration.\u003c\/p\u003e","brand":"Henry Schein","offers":[{"title":"Default Title","offer_id":53902991294832,"sku":"02A0003","price":89.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Mepivacaine-HCl-3_-Plain-1-7-mL-Anesthetic-Cartridge.jpg?v=1781271675","url":"https:\/\/www.mountainside-medical.com\/products\/mepivacaine-hcl-3-plain-1-7-ml-local-anesthetic-cartridge","provider":"Mountainside Medical","version":"1.0","type":"link"}