{"product_id":"papaverine-hydrochloride-injection-60-mg-2ml-oryza-pharmaceutical-72516-0024-10","title":"Papaverine Hydrochloride Injection 60 mg\/2mL Single Dose Vials 2 mL x 10\/Box (RX)","description":"\u003ch1\u003eVasodilator \u0026amp; Smooth Muscle Relaxant\u003c\/h1\u003e\n\u003cp\u003ePapaverine Hydrochloride 60mg\/2mL is a \u003cstrong\u003eprescription-strength injectable medication\u003c\/strong\u003e formulated to relax smooth muscles and dilate blood vessels. Each sterile 2 mL single-dose vial contains \u003cstrong\u003e60 mg of Papaverine HCl\u003c\/strong\u003e (30 mg\/mL), providing a ready-to-use injectable solution. Administered only by healthcare professionals (intramuscularly or via slow IV infusion), Papaverine injection is used to \u003cstrong\u003eimprove circulation and relieve muscle spasms\u003c\/strong\u003e in various medical conditions. Its potent vasodilator action makes it ideal for treating \u003cstrong\u003eerectile dysfunction (ED)\u003c\/strong\u003e, \u003cstrong\u003eperipheral and cerebral vascular spasms\u003c\/strong\u003e, and \u003cstrong\u003evisceral smooth muscle cramps\u003c\/strong\u003e.\u003c\/p\u003e\n\u003ch2\u003eUses\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePowerful Vasodilator \u0026amp; Spasmolytic:\u003c\/strong\u003e Papaverine directly relaxes smooth muscles in blood vessels and organs, increasing circulation. It is classified as a \u003cstrong\u003edirect-acting vasodilator\u003c\/strong\u003e (benzylisoquinoline alkaloid).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIndicated for ED and Vascular Disorders:\u003c\/strong\u003e Clinically used to treat male ED by increasing penile blood flow, and to relieve arterial spasms in peripheral vascular disease, Raynaud’s phenomenon, and cerebral vasospasm. It can also ease \u003cstrong\u003evisceral muscle spasms\u003c\/strong\u003e in the gastrointestinal or biliary tract.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIntracavernosal Injection Therapy:\u003c\/strong\u003e For erectile dysfunction, Papaverine is often injected directly into the penis (intracavernosal) – sometimes in combination with phentolamine or prostaglandin – to induce a firm erection. Unlike oral ED drugs, this method works locally and can be effective when other treatments fail.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSingle-Dose Sterile Vials:\u003c\/strong\u003e Each glass ampoule contains a clear, colorless solution of Papaverine HCl. The amber-colored 2 mL vial ensures drug stability. Being single-use, it minimizes contamination – simply dispose after one injection.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdministration:\u003c\/strong\u003e Supplied in ready-to-use injectable form. Papaverine is given via \u003cstrong\u003eintramuscular (IM) or slow intravenous (IV)\u003c\/strong\u003e injection. It \u003cstrong\u003emust be injected slowly\u003c\/strong\u003e (over 1–2 minutes) to avoid rapid drops in blood pressure or heart arrhythmias. All doses and frequency are determined by a doctor based on the patient’s condition.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrescription Only:\u003c\/strong\u003e This medication requires a doctor’s prescription and oversight. It should \u003cem\u003enever\u003c\/em\u003e be self-administered without proper training. Under supervision, Papaverine can be an effective therapy for improving circulation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eComposition \u0026amp; Formulation\u003c\/h2\u003e\n\u003cp\u003eEach 2 mL ampoule of Papaverine Injection contains:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eActive ingredient:\u003c\/strong\u003e 60 mg Papaverine Hydrochloride (30 mg per 1 mL). Papaverine is a vasodilating smooth-muscle relaxant derived synthetically or from opium.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExcipients:\u003c\/strong\u003e Includes 0.45 mg disodium EDTA per ampoule as a stabilizer. The solution is sterile, pyrogen-free, and preservative-free.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e A clear, colorless injectable solution in an amber glass ampoule. The 2 mL single-dose format ensures accurate dosing and sterility.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eHow It Works (Mechanism of Action)\u003c\/h2\u003e\n\u003cp\u003ePapaverine’s primary action is \u003cstrong\u003edirect spasmolysis of smooth muscle\u003c\/strong\u003e. It works by inhibiting the contractility of vascular and visceral muscles, leading to vessel dilation and muscle relaxation. Key points of its mechanism:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVasodilation:\u003c\/strong\u003e Papaverine acts most strongly on arterial smooth muscle. It relaxes coronary, cerebral, pulmonary and peripheral arteries, markedly increasing blood flow to these regions. For example, dilation of penile arteries enables erection, while relaxation of cerebral vessels can improve brain perfusion.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSmooth Muscle Relaxation:\u003c\/strong\u003e Beyond vessels, Papaverine relaxes \u003cstrong\u003ebronchial, gastrointestinal, ureteral, and biliary\u003c\/strong\u003e smooth muscle. This helps relieve spasms in the intestines or biliary tract (e.g. intestinal cramp or gallbladder colic).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiac Effects:\u003c\/strong\u003e It also mildly depresses cardiac excitability and prolongs myocardial refractory period. Although no longer first-line for heart issues, it has been used in certain arrhythmias and angina when other drugs are unsuitable.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnhanced Collateral Flow:\u003c\/strong\u003e In cases of arterial blockage, Papaverine may reduce reflex vasoconstriction in collateral vessels, improving blood supply to ischemic tissues.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThrough these actions, Papaverine injection helps \u003cstrong\u003eincrease oxygen delivery and relieve pain related to spasms\u003c\/strong\u003e. Its combined vasodilator and spasmolytic effects make it valuable in circulatory disorders and muscle cramp conditions.\u003c\/p\u003e\n\u003ch2\u003eIndications and Benefits\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eErectile Dysfunction (ED):\u003c\/strong\u003e Papaverine 60mg injection is an established therapy for ED. By relaxing penile smooth muscle, it enhances penile blood flow and induces an erection usable for sexual intercourse. It is especially helpful when oral ED medications are ineffective or contraindicated. In practice, one 2 mL dose is injected into the penis under medical supervision. Many men experience firmer erections and improved sexual performance without systemic side effects of oral drugs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeripheral Vascular Disease (PVD):\u003c\/strong\u003e In conditions like peripheral artery disease or Raynaud’s phenomenon, narrowed arteries reduce limb blood flow. Papaverine injection relaxes these peripheral arteries, improving circulation to the arms and legs. Patients often report relief from symptoms like leg cramps, numbness, or cold extremities after therapy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCerebral Arterial Spasm:\u003c\/strong\u003e Papaverine can be used to counteract cerebral vasospasm (e.g., after subarachnoid hemorrhage or head injury). By dilating cerebral arteries, it helps restore brain perfusion. In neurosurgery settings, Papaverine infusion has been used to prevent or treat arterial spasms, potentially reducing stroke risk.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVisceral Spasms:\u003c\/strong\u003e Smooth muscle cramps in the gastrointestinal (GI) tract, bile ducts or ureters can cause severe pain. Papaverine’s action on GI and biliary smooth muscle means it can relieve such spasms. For instance, in biliary colic or intestinal cramping (colitis, irritable bowel), Papaverine injection or infusion provides muscular relaxation and pain relief.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOther Uses:\u003c\/strong\u003e Historically, Papaverine was trialed in angina and hypertension, though it is now superseded by better drugs. It has utility in certain heart rhythm disorders by relaxing cardiac muscle. Its broad smooth-muscle relaxant effect also means it can be used off-label for conditions involving involuntary muscle contractions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eDosage \u0026amp; Administration\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRoute:\u003c\/strong\u003e Papaverine comes as a ready-to-inject solution. It is administered by a doctor or trained nurse via \u003cstrong\u003eintramuscular (IM)\u003c\/strong\u003e or \u003cstrong\u003eslow intravenous (IV)\u003c\/strong\u003e injection. For erectile dysfunction, it is injected \u003cstrong\u003eintracavernosally\u003c\/strong\u003e into the penis (often with local anesthesia).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTypical Dose:\u003c\/strong\u003e A single 2 mL vial (60 mg) is a common dose. The exact regimen (frequency and duration) is determined by the prescribing physician based on the indication. For ED therapy, injections are often given 1–3 times per week as needed. For vascular or spasm uses, a single injection or infusion may be done daily or every few days as prescribed.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInjection Technique:\u003c\/strong\u003e Always inject \u003cstrong\u003eslowly\u003c\/strong\u003e over 1–2 minutes to avoid cardiovascular side effects. Rapid IV injection can cause serious arrhythmias or respiratory arrest, so careful administration is critical. After injection, the patient should be monitored briefly for any immediate reactions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdministration Setting:\u003c\/strong\u003e Because of the risk of cardiovascular effects and the need for sterility, Papaverine injection \u003cstrong\u003emust only be used under medical supervision\u003c\/strong\u003e. It is not a self-injectable medication. Patients should lie down or sit during injection to reduce risk of fainting from hypotension.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrecautions:\u003c\/strong\u003e Prior to administration, the doctor will review the patient’s health history. Inform your healthcare provider about any heart conditions (arrhythmias, heart block), blood pressure issues, liver problems, or other medications. Those conditions may require dose adjustments or extra monitoring.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eStorage \u0026amp; Handling\u003c\/h2\u003e\n\u003cp\u003eEach ampoule is single-use. Store Papaverine Injection vials at room temperature \u003cstrong\u003ebelow 30 °C\u003c\/strong\u003e, away from direct sunlight. Do not freeze. Keep the ampoules in the original box until use to protect from light. After opening, do not save any leftover; dispose of used vials properly. Always check the solution before use – it should be clear and free of particles. If the ampoule is damaged or the solution is discolored, do not use it.\u003c\/p\u003e\n\u003ch2\u003eSide Effects \u0026amp; Precautions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eCommon Side Effects (IV\/IM use)\u003c\/strong\u003e – Patients may experience mild to moderate side effects due to vasodilation or muscle relaxation. These include: nausea, headache, flushing of the face, sweating, abdominal discomfort, mild hypotension (low blood pressure), dizziness, and local injection site irritation. Usually these symptoms are transient.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCardiovascular Risks\u003c\/strong\u003e – Because Papaverine lowers vascular resistance, it can \u003cstrong\u003edrop blood pressure\u003c\/strong\u003e. Rapid IV injection especially risks serious arrhythmias or cardiac events. For safety, infusion should be very slow and the patient monitored. In rare cases, IV use has caused arrhythmias, apnea, or thrombophlebitis at the injection site.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eED Therapy Risks\u003c\/strong\u003e – With penile injection, the most concerning risk is \u003cstrong\u003epriapism\u003c\/strong\u003e: a prolonged, painful erection lasting \u0026gt;4 hours. Patients must be counseled to seek immediate medical help if an erection persists, as this is an emergency. Long-term intracavernosal use can also rarely lead to fibrosis (scar tissue) in the penis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrecautions:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cem\u003eHeart Conditions:\u003c\/em\u003e Contraindicated in complete heart block or severe bradycardia. Use with caution in any patient with conduction disorders or on antiarrhythmic drugs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cem\u003eBlood Pressure:\u003c\/em\u003e Patients on antihypertensives or those prone to hypotension should be monitored closely, as Papaverine can amplify blood pressure-lowering effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cem\u003eOther Medications:\u003c\/em\u003e Inform your doctor of all drugs you take; interactions are possible. For example, combining with other vasodilators or nitrates could cause excessive hypotension.\u003c\/li\u003e\n\u003cli\u003e\n\u003cem\u003eAllergy:\u003c\/em\u003e Do not use if allergic to papaverine or opium derivatives.\u003c\/li\u003e\n\u003cli\u003e\n\u003cem\u003ePregnancy \u0026amp; Breastfeeding:\u003c\/em\u003e Classified \u003cstrong\u003ePregnancy Category C\u003c\/strong\u003e. Use only if clearly needed and if benefits outweigh risks. It is excreted in breast milk, so nursing mothers should exercise caution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cem\u003eDependence:\u003c\/em\u003e Long-term use can cause drug dependence. Use only for the prescribed duration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cem\u003eSide Effects Management:\u003c\/em\u003e Dizziness or drowsiness may occur; avoid driving or operating machinery until you know how Papaverine affects you. Drink water if feeling faint. Report severe symptoms (chest pain, irregular heartbeat, severe nausea) to a doctor immediately.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003eIn summary, Papaverine 60mg\/2mL single-dose injection is a \u003cstrong\u003epharmacy-grade medication\u003c\/strong\u003e with strong vasodilatory and antispasmodic action. Under medical supervision, it provides targeted relief for circulation and muscle spasm disorders. Always use it exactly as directed by your healthcare provider to maximize benefits and minimize risks.\u003c\/span\u003e\u003c\/p\u003e","brand":"Oryza Pharmaceuticals","offers":[{"title":"Default Title","offer_id":53871120023920,"sku":"72516-0024-10","price":465.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Papaverine-Hydrochloride-Injection-60-mg-Muscle-Relaxant.jpg?v=1780665007","url":"https:\/\/www.mountainside-medical.com\/products\/papaverine-hydrochloride-injection-60-mg-2ml-oryza-pharmaceutical-72516-0024-10","provider":"Mountainside Medical","version":"1.0","type":"link"}