{"product_id":"recothrom-thrombin-topical-recombinant-5000-units-lyophilized-powder-for-solution-rx","title":"Recothrom Thrombin Topical (Recombinant) 5000 Units Kit (Topical Coagulant) (RX)","description":"\u003ch1\u003eRecothrom Thrombin Topical (Recombinant) 5000 IU Kit – Topical Coagulant\u003c\/h1\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003eRecothrom is a \u003cstrong\u003erecombinant human thrombin\u003c\/strong\u003e product (by Baxter) supplied as a sterile kit for topical hemostasis in surgery. It contains lyophilized thrombin powder that is reconstituted with saline before use. Recothrom is indicated to \u003cstrong\u003eaid hemostasis in capillary\/small-vessel bleeding\u003c\/strong\u003e when conventional methods (sutures, ligatures, cautery, etc.) are ineffective or impractical. It is approved for use in adults and pediatric patients ≥1 month old, and can be used with an absorbable gelatin sponge for added effectiveness. As a recombinant product, it contains \u003cstrong\u003eno human- or animal-derived additives\u003c\/strong\u003e (reducing infection or allergy risk).\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eKit Contents\u003c\/h2\u003e\n\u003cp\u003eEach 5,000-unit Recothrom kit includes all components needed to prepare and apply the thrombin solution:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eThrombin vial:\u003c\/strong\u003e 5000 IU of sterile, lyophilized recombinant thrombin powder (single-use vial).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiluent syringe:\u003c\/strong\u003e 5 mL pre-filled with sterile 0.9% sodium chloride (saline).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTransfer device:\u003c\/strong\u003e A sterile needle-free vial adapter (transfer device).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTransfer syringe:\u003c\/strong\u003e A sterile 5 mL empty syringe for withdrawing the reconstituted solution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSyringe label:\u003c\/strong\u003e An adhesive label marked “For topical use only – DO NOT INJECT”.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAll items are sterile and for single use. (For example, a product listing notes: “One single-use vial containing 5000 IU… one 5-mL prefilled diluent syringe, one sterile needle-free transfer device, one sterile 5-mL empty syringe, and one syringe label”.\u003c\/p\u003e\n\u003ch2\u003ePreparation and Administration\u003c\/h2\u003e\n\u003cp\u003eTo prepare Recothrom, add the entire 5 mL saline diluent to the thrombin vial. This yields a \u003cstrong\u003e1000 IU\/mL\u003c\/strong\u003e thrombin solution (5,000 IU in 5 mL) once fully dissolved. Gently swirl until the powder is completely dissolved. Withdraw the reconstituted solution into the transfer syringe.\u003c\/p\u003e\n\u003cp\u003eApply the Recothrom solution \u003cstrong\u003edirectly to the bleeding tissue\u003c\/strong\u003e. The official instructions state: “Apply RECOTHROM solution with absorbable gelatin sponge or RECOTHROM Spray Applicator Kit directly to the bleeding site surface”. In practice, the surgeon may pour or spray the solution onto a collagen\/gelfoam sponge and press it onto the oozing tissue, or use a dedicated spray pump. The required volume depends on the size of the bleeding area. The solution remains active for up to 24 hours at room temperature after mixing, allowing flexibility during long procedures.\u003c\/p\u003e\n\u003ch2\u003eIndications\u003c\/h2\u003e\n\u003cp\u003eRecothrom is indicated for \u003cstrong\u003eminor capillary or venule bleeding (oozing)\u003c\/strong\u003e during surgery. Specifically, it “aids hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible and control of bleeding by standard surgical techniques (such as suture, ligature, or cautery) is ineffective or impractical”. It is used in a variety of surgical specialties (cardiac, vascular, orthopedic, general, etc.) whenever this level of bleeding control is needed. The product label notes it may be used in conjunction with an absorbable gelatin sponge (USP) to enhance clotting. (It is \u003cstrong\u003enot\u003c\/strong\u003e intended for major arterial bleeds or use as an injection.)\u003c\/p\u003e\n\u003ch2\u003eSafety and Precautions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eTopical use only – do not inject.\u003c\/strong\u003e Recothrom must never be injected intravenously. The labeling explicitly warns “For topical use only. DO NOT INJECT.”. Intravenous injection of thrombin can cause dangerous thrombosis if the product enters the bloodstream. Recothrom should not be used to control massive or brisk arterial bleeding; it is meant for low‐pressure oozing.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAllergies:\u003c\/strong\u003e Do not use in patients with a known hypersensitivity to Recothrom or any component of the kit, including hamster ovary cell proteins used in its manufacture. Hypersensitivity reactions (including anaphylaxis) have been reported.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSide effects:\u003c\/strong\u003e In clinical trials, the most common adverse events were thromboses or embolic events (up to ~6% incidence), reflecting the need for careful topical use. Formation of antibodies to Recothrom itself was very rare: \u0026lt;1% of patients developed antibodies, and none neutralized human thrombin. (This low immunogenicity is an advantage of the recombinant product – only ~1.5% on Recothrom developed antibodies vs. ~21.5% on bovine thrombin in one study.)\u003c\/p\u003e\n\u003ch2\u003eAdditional Notes\u003c\/h2\u003e\n\u003cp\u003eRecothrom is supplied by prescription (Rx) and is one of Baxter’s adjunctive hemostatic agents. Because it is recombinant, it avoids animal\/human plasma components, minimizing the risk of viral transmission or anti-bovine antibody reactions. Baxter reports that about 95% of Recothrom-treated surgical sites reached hemostasis within 10 minutes (comparable to bovine thrombin), demonstrating its efficacy for stopping minor bleeding quickly.\u003c\/p\u003e","brand":"Baxter Recothrom","offers":[{"title":"Default Title","offer_id":53793278034288,"sku":"00338-0322-01","price":135.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Recothrom-Thrombin-Kit.jpg?v=1779287056","url":"https:\/\/www.mountainside-medical.com\/products\/recothrom-thrombin-topical-recombinant-5000-units-lyophilized-powder-for-solution-rx","provider":"Mountainside Medical","version":"1.0","type":"link"}