{"product_id":"solu-medrol-125-mg-injection-methylprednisolone-sodium-succinate","title":"Solu Medrol 125 mg Injection Methylprednisolone Sodium Succinate 2 ml Vials, 25\/Pack (RX)","description":"\u003ch1\u003eSolu-Medrol 125 mg Injection\u003c\/h1\u003e\n\u003ch1\u003e(Methylprednisolone Sodium Succinate) \u003c\/h1\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003eSolu-Medrol is a \u003cstrong\u003ewater-soluble corticosteroid injection\u003c\/strong\u003e (methylprednisolone sodium succinate) used for \u003cem\u003erapid, high-dose steroid therapy\u003c\/em\u003e. It works like cortisol (a glucocorticoid), altering gene expression to \u003cem\u003esuppress inflammation and immune responses\u003c\/em\u003e. Because it is very soluble in water, Solu-Medrol can be given \u003cstrong\u003eintravenously or intramuscularly\u003c\/strong\u003e to achieve high blood levels quick.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eUses\u003c\/h2\u003e\n\u003cp\u003eSolu-Medrol is indicated when \u003cstrong\u003eimmediate steroid effect is needed\u003c\/strong\u003e in serious conditions (often in hospitalized patients). Typical uses include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSevere allergic reactions:\u003c\/strong\u003e Anaphylaxis, severe asthma attacks, drug or transfusion reactions (when other treatments fail).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDermatologic flare-ups:\u003c\/strong\u003e Stevens–Johnson syndrome, pemphigus, severe contact dermatitis, exfoliative dermatitis, etc.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEndocrine disorders:\u003c\/strong\u003e Acute adrenal insufficiency (added as cortisol replacement), congenital adrenal hyperplasia crisis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGastrointestinal disease:\u003c\/strong\u003e To “tide over” acute flares of inflammatory bowel disease (e.g. ulcerative colitis, Crohn’s) during critical periods.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHematologic disorders:\u003c\/strong\u003e Autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura (IV use), pure red cell aplasia, or other severe blood issues.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeoplastic diseases:\u003c\/strong\u003e Adjunctive therapy for leukemias or lymphomas (palliative symptom control).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurologic\/Respiratory:\u003c\/strong\u003e Cerebral edema (from brain tumors or trauma), acute MS exacerbations, transverse myelitis, severe pulmonary diseases (sarcoidosis, acute eosinophilic pneumonia), etc.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRheumatic disorders:\u003c\/strong\u003e Acute gouty arthritis, severe rheumatoid arthritis flares, systemic lupus erythematosus, polymyalgia rheumatica, temporal arteritis, etc.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMiscellaneous:\u003c\/strong\u003e Trichinosis with neurologic involvement, tuberculous meningitis (with appropriate anti-TB drugs), etc.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003e(In practice, Solu-Medrol is reserved for life-threatening or disabling flares of inflammation. In less acute situations, oral steroids would be preferred. The above examples come from the official FDA labeling\u003c\/em\u003e.\u003c\/p\u003e\n\u003ch2\u003eAdministration and Dosage\u003c\/h2\u003e\n\u003cp\u003eSolu-Medrol 125 mg comes as a \u003cstrong\u003esterile freeze-dried powder\u003c\/strong\u003e in a single-use vial (Act-O-Vial). After reconstitution with the supplied diluent, the final solution is 40 mg\/mL (total 3.125 mL for 125 mg). The vial is intended for single use; do not mix with other medications. Use the accompanying diluent (or sterile water\/bacteriostatic saline) and inject solution into the vial to reconstitute; shake gently until dissolved.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eRoute:\u003c\/strong\u003e \u003cstrong\u003eIntravenous (IV) injection or infusion\u003c\/strong\u003e is preferred for emergencies. Intramuscular (IM) injection is an alternative if IV access is not available, but IV gives faster, more controllable dosing. \u003cstrong\u003eNever administer Solu-Medrol epidurally or into the spine\u003c\/strong\u003e, as this has caused serious neurologic injury and death.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eTypical dosing:\u003c\/strong\u003e The dose of Solu-Medrol varies by condition and severity. For \u003cstrong\u003emoderate acute flares\u003c\/strong\u003e, IV boluses of 10–40 mg are common. For \u003cstrong\u003esevere, life-threatening situations\u003c\/strong\u003e, very high doses may be used: for example, the label recommends 30 mg\/kg IV over 30 minutes (up to multi-gram doses) every 4–6 hours for 48 hours in critical acute conditions. (In practice, this might translate to 1–2 g IV in a large adult.) In asthma exacerbations, some protocols use 125 mg IV every 6 hours; others now use 40–80 mg every 6–8 hours. After initial control, therapy is usually switched to an oral steroid taper.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eDuration:\u003c\/strong\u003e High-dose IV therapy is generally limited to a few days (often 2–5 days); after that, either taper steroids or convert to oral therapy. \u003cem\u003eDo not stop abruptly\u003c\/em\u003e after prolonged high-dose use; taper gradually to allow the adrenal glands to recover.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan class=\"VODHU pdMy8\"\u003e\u003cem\u003e(Always follow a physician’s dosing regimen. The examples above are typical regimens; actual doses should be tailored to the patient and monitored.)\u003c\/em\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003eSide Effects\u003c\/h2\u003e\n\u003cp\u003eSolu-Medrol has the same side effects as other systemic corticosteroids. In general, a single 125 mg injection (or a short course) may cause transient symptoms like insomnia, mood changes, or elevated blood sugar. With repeated or long-term use, the effects become more pronounced. Common and important adverse effects include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic\/endocrine:\u003c\/strong\u003e Fluid retention and weight gain; hypertension; \u003cstrong\u003ehyperglycemia\u003c\/strong\u003e (steroid-induced high blood sugar) – diabetics need close monitoring. Cushingoid features (fat redistribution, “moon face”) can develop with ongoing therapy. Prolonged use causes adrenal insufficiency (the body’s cortisol production shuts down), so doses must be tapered gradually.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular:\u003c\/strong\u003e Corticosteroids can cause hypokalemia (low potassium) and, when given rapidly at high dose, can precipitate arrhythmias or cardiac arrest. (Notably, very fast IV injection of \u0026gt;0.5 g led to bradycardia and arrest in some cases.) Monitor blood pressure and electrolytes in at-risk patients.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmune suppression:\u003c\/strong\u003e Increased susceptibility to infection – latent infections (e.g. TB, herpes) can worsen, and new infections (bacteria, fungi, viruses) may be more severe. Avoid exposure to chickenpox or measles in susceptible individuals. Vaccines (especially live attenuated) should generally be avoided during high-dose steroid therapy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGastrointestinal:\u003c\/strong\u003e Increased appetite and potential for gastric irritation. Risk of peptic ulcer or GI bleeding is increased, particularly if used with NSAIDs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCNS\/Psychiatric:\u003c\/strong\u003e Insomnia, nervousness, headache, or euphoria can occur. Some patients experience mood swings, anxiety, or depression. Very high doses can rarely trigger “steroid psychosis” (manic or psychotic symptoms).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMusculoskeletal:\u003c\/strong\u003e Long-term use causes bone loss (osteoporosis) with fracture risk. Avascular necrosis (osteonecrosis) of femoral head is a serious risk after high-dose therapy. Myopathy (muscle weakness) can develop.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin:\u003c\/strong\u003e Easy bruising, skin thinning, acne, and delayed wound healing. Injection-site reactions (pain or burning) are common. IV Solu-Medrol can cause a transient burning or tingling sensation (especially in the perineal area) after injection.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEndocrine:\u003c\/strong\u003e Menstrual irregularities in women; suppressed growth in children with chronic use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOcular:\u003c\/strong\u003e Prolonged therapy may lead to cataracts (posterior subcapsular) and increased intraocular pressure (glaucoma). Eye exams are advised if used repeatedly.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOther:\u003c\/strong\u003e Cushingoid appearance (“moon face”), hirsutism (excess hair), sodium retention, and potassium loss. Rarely, severe allergic reaction (anaphylaxis) to injected drug components can occur.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eInjection-specific: After an IV bolus, some patients describe a warm flushing or perineal burning (short-lived). A \u003cstrong\u003e“post-injection flare”\u003c\/strong\u003e of local joint inflammation can happen if discontinuing multiple joint injections, but that’s more with joint use.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e(The list above is not exhaustive. See medication guides for full details. The cited sources list many known steroid effects\u003c\/em\u003e.\u003c\/p\u003e\n\u003ch2\u003ePrecautions and Warnings\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications:\u003c\/strong\u003e Do \u003cem\u003enot\u003c\/em\u003e use Solu-Medrol in patients with \u003cstrong\u003esystemic fungal infections\u003c\/strong\u003e or known hypersensitivity to methylprednisolone or any component (including lactose in some vials). Also contraindicated for intrathecal (spinal) administration.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eInjection safety:\u003c\/strong\u003e Only administer Solu-Medrol via approved routes (IV or IM). \u003cstrong\u003eDo not inject into the spine (epidural\/intrathecal)\u003c\/strong\u003e – this has led to strokes, paralysis, and death. If injecting into a joint or muscle, use aseptic technique.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eBenzyl alcohol:\u003c\/strong\u003e Some formulations contain benzyl alcohol as a preservative. \u003cem\u003eDo not use benzyl alcohol–preserved Solu-Medrol in neonates or pregnant women\u003c\/em\u003e, due to “gasping syndrome” (a potentially fatal neonatal metabolic acidosis). (Use preservative-free vials for infants\/children.)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eInfection risk:\u003c\/strong\u003e Avoid use in patients with untreated systemic infections (viral, bacterial, fungal, or parasitic). Be cautious if there is recent live vaccination or exposure to infectious diseases.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eGlucose monitoring:\u003c\/strong\u003e Steroids raise blood sugar; monitor diabetics closely and adjust insulin\/oral agents.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eHypertension\/Heart disease:\u003c\/strong\u003e Watch for fluid retention, hypertension, or worsening heart failure. High doses can exacerbate these conditions.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eBone and Mineral:\u003c\/strong\u003e Consider calcium\/vitamin D supplementation if long-term therapy is needed, and monitor bone density, since osteoporosis is a risk.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eAdrenal suppression:\u003c\/strong\u003e Prolonged or high-dose therapy suppresses the body’s cortisol production. If therapy exceeds a few weeks, taper gradually. In times of stress (illness, surgery), an “extra” stress dose of steroids may be required.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eEye health:\u003c\/strong\u003e Monitor for glaucoma or cataracts with repeated use.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003ePregnancy and breastfeeding:\u003c\/strong\u003e Corticosteroids can cause birth defects (cleft palate) in animals. Use in pregnancy only if the benefit justifies the risk. Infants born to mothers on steroids should be monitored for adrenal insufficiency. Methylprednisolone is excreted in breast milk; caution if nursing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003ePediatrics:\u003c\/strong\u003e Growth retardation can occur. Use lowest effective dose and monitor growth in children.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eElderly:\u003c\/strong\u003e Use with caution; older patients may be more susceptible to side effects (osteoporosis, hypertension, diabetes complications).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eDrug interactions:\u003c\/strong\u003e Steroids interact with many drugs (e.g. warfarin, NSAIDs, diuretics, vaccines). Review all medications to avoid adverse interactions.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003e(In summary, Solu-Medrol should be used under close medical supervision, with dosing individualized to the patient. Monitor vital signs, blood glucose, electrolytes, and for signs of infection or other steroid-related effects.)\u003c\/em\u003e\u003c\/p\u003e\n\u003ch2\u003eSummary\u003c\/h2\u003e\n\u003cp\u003eSolu-Medrol 125 mg is a potent injectable corticosteroid used for \u003cstrong\u003eacute, severe inflammatory or allergic conditions\u003c\/strong\u003e. It acts quickly (within 1 hour) when given IV. Clinicians use it in settings like acute asthma exacerbations, anaphylaxis, severe rheumatic flares, and other emergencies. Side effects are those of systemic steroids (weight gain, hypertension, hyperglycemia, infection risk, etc.), and it must be administered by medical professionals. All use should follow prescription guidelines and official dosing recommendations.\u003c\/p\u003e","brand":"Pfizer Injectables","offers":[{"title":"Default Title","offer_id":12194273656904,"sku":"00009-0047-22","price":379.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Solu-Medrol-125-mg-Injection-2-ml-Vials-by-Pfizer-NDC-00009-0047-22.jpg?v=1722265864","url":"https:\/\/www.mountainside-medical.com\/products\/solu-medrol-125-mg-injection-methylprednisolone-sodium-succinate","provider":"Mountainside Medical","version":"1.0","type":"link"}