{"product_id":"terbinafine-250-mg-tablets-100-count-rx","title":"Terbinafine 250 mg Tablets by Bionpharma 100 Count (RX)","description":"\u003ch1\u003eTerbinafine 250 mg Tablets (Terbinafine Hydrochloride)\u003c\/h1\u003e\n\u003cp\u003eTerbinafine is a systemic antifungal in the allylamine class. It works by inhibiting fungal \u003cstrong\u003esqualene epoxidase\u003c\/strong\u003e, an enzyme needed for ergosterol synthesis in the fungal cell membrane. This causes toxic buildup of squalene and cell death. After an oral dose, terbinafine distributes into skin, hair and nails at fungicidal levels (detectable in nail for weeks after stopping). The 250 mg tablet is a prescription-only oral formulation (often marketed as Lamisil and generics) used for deep or hard-to-treat dermatophyte infections. (Terbinafine also exists as OTC topical creams\/gels for athlete’s foot and ringworm, but the tablet is reserved for severe or nail infections that require systemic therapy.)\u003c\/p\u003e\n\u003ch2\u003eUses (Indications)\u003c\/h2\u003e\n\u003cp\u003eTerbinafine tablets are indicated for \u003cstrong\u003edermatophyte fungal infections\u003c\/strong\u003e, especially:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOnychomycosis (nail fungus)\u003c\/strong\u003e – Most commonly used for toenail or fingernail infections caused by dermatophytes (e.g. \u003cem\u003eTrichophyton rubrum\u003c\/em\u003e). Oral terbinafine typically offers higher cure rates than oral azole antifungals in nail disease. It’s approved for fingernail fungus (6 weeks of therapy) and toenail fungus (12 weeks).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTinea capitis (scalp ringworm)\u003c\/strong\u003e – An oral antifungal is required for scalp infections. Terbinafine (250 mg\/day for ~6–8 weeks, weight-based in children) is effective against \u003cem\u003eTrichophyton\u003c\/em\u003e scalp infections and is often as good as griseofulvin.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCutaneous dermatophyte infections\u003c\/strong\u003e – It can treat severe or widespread tinea corporis (body), tinea cruris (jock itch), and tinea pedis (athlete’s foot), especially when topical therapy fails or infection is extensive. (For localized skin tinea, topical antifungals are usually first-line, but terbinafine tablets may be used for extensive or refractory cases.)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMiscellaneous\u003c\/strong\u003e – Terbinafine also treats \u003cem\u003eMalassezia\u003c\/em\u003e (pityriasis) and some yeast infections (e.g. \u003cem\u003eCandida\u003c\/em\u003e) off-label, though it is \u003cstrong\u003enot reliable for Candida\u003c\/strong\u003e fingernail infections. It is not effective for systemic fungal infections.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIn short, \u003cstrong\u003eterbinafine tablets\u003c\/strong\u003e are prescribed for persistent dermatophyte infections of nails and (less commonly) skin or scalp that require systemic therapy. Compared to azole antifungals, terbinafine is often preferred for nail fungus due to its fungicidal activity and tissue penetration.\u003c\/p\u003e\n\u003ch2\u003eDosage and Administration\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdults:\u003c\/strong\u003e The usual dose is \u003cstrong\u003e250 mg once daily\u003c\/strong\u003e by mouth (with a glass of water). Tablets may be taken with or without food.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNail infections (onychomycosis):\u003c\/strong\u003e Typical courses are \u003cstrong\u003e6 weeks for fingernail infections\u003c\/strong\u003e or \u003cstrong\u003e12 weeks for toenail infections\u003c\/strong\u003e. (Sustained cure occurs only after the nail regrows, so clinical benefit may appear months after treatment.) Therapy is sometimes extended or repeated if needed.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eScalp infection (tinea capitis):\u003c\/strong\u003e 250 mg once daily for ~6 weeks (children’s dose based on weight, typically 125–250 mg\/day). (Capitis requires oral therapy; terbinfine is an alternative to griseofulvin.)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin infections:\u003c\/strong\u003e Generally shorter courses (often 2–4 weeks) are sufficient. For example, general tinea corporis is often treated ~4 weeks, tinea cruris (groin) ~2–4 weeks, and tinea pedis (feet) ~2–6 weeks. Duration varies by severity and site.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecial populations:\u003c\/strong\u003e In severe renal impairment (CrCl ≤50 mL\/min), a reduced dose (e.g. 125 mg once daily) may be used. No adjustment is usually needed for mild renal dysfunction. Terbinafine is \u003cstrong\u003enot recommended\u003c\/strong\u003e for patients with significant liver disease.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eAdministration tips:\u003c\/strong\u003e Swallow the tablet whole with water. (A granule formulation is available for children \u0026lt;18 years). Complete the full prescribed course even if symptoms improve, to ensure eradication. Follow-up (e.g. nail evaluation) is usually done weeks to months after therapy.\u003c\/p\u003e\n\u003ch2\u003eSide Effects and Safety\u003c\/h2\u003e\n\u003cp\u003eTerbinafine is generally well tolerated, but patients should be aware of common side effects and rare serious reactions.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eCommon adverse effects:\u003c\/strong\u003e Gastrointestinal symptoms (e.g. nausea, dyspepsia, diarrhea) and headache are frequent. Other common effects include skin reactions (rash, itching) and mild fatigue. A notorious side effect is \u003cem\u003etaste disturbance\u003c\/em\u003e (dysgeusia) – some patients experience reduced or altered taste (and sometimes smell) that usually resolves weeks after stopping, but can be prolonged. (On rare occasion taste loss has led to weight loss if severe.) Mild dizziness or vertigo is also reported.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eRare but serious effects:\u003c\/strong\u003e Hepatotoxicity is the most concerning. Terbinafine can cause liver enzyme elevations and, very rarely, severe cholestatic hepatitis or liver failure. Cases of fatal or life-threatening liver injury have been reported, often in patients with other health issues. For this reason, \u003cstrong\u003eterbinafine is usually avoided in anyone with preexisting chronic liver disease\u003c\/strong\u003e; baseline liver function tests (AST\/ALT) are recommended, and therapy should be stopped if any signs of hepatic injury occur (e.g. dark urine, jaundice, persistent nausea).\u003c\/p\u003e\n\u003cp\u003eBlood cell abnormalities are uncommon but documented. Transient lymphocyte drops, neutropenia or thrombocytopenia have occurred. Rare reports of agranulocytosis or pancytopenia have emerged; patients on long courses (\u0026gt;6 weeks) may have periodic blood counts checked. Terbinafine has also been reported to trigger or worsen systemic or cutaneous \u003cstrong\u003elupus erythematosus\u003c\/strong\u003e in rare cases, and very rarely severe skin reactions (Stevens-Johnson syndrome\/toxic epidermal necrolysis) have been reported.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eOther effects:\u003c\/strong\u003e Allergic reactions (hives, angioedema, anaphylaxis) are possible in sensitive individuals. Patients have reported changes in vision (blurry or altered color perception) in isolated cases. Hepatic or renal dosing changes may be needed in elderly or organ-impaired patients.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIf any severe adverse signs appear during treatment — especially symptoms of liver inflammation (jaundice, dark urine), unexplained fever\/rash\/swollen lymph nodes, or major mood changes — discontinue terbinafine and seek medical care. Discuss any troublesome side effects with your doctor.\u003c\/p\u003e\n\u003ch2\u003ePrecautions and Interactions\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eLiver and blood monitoring:\u003c\/strong\u003e Because of rare hepatotoxicity, liver enzymes should be checked before starting therapy and monitored during prolonged treatment. Do not prescribe if AST\/ALT are elevated or if active liver disease is present. If signs of liver injury occur, stop the drug immediately. Patients with neutropenia or immunodeficiency should have periodic CBCs if on long-term terbinafine.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eDrug interactions:\u003c\/strong\u003e Terbinafine is metabolized by and moderately inhibits CYP450 enzymes (especially CYP2D6) in the liver. This can raise blood levels of certain medications. For example, terbinafine can increase levels of some anti‐arrhythmic drugs and antidepressants (tricyclics, SSRIs, MAO inhibitors) that are CYP2D6 substrates. Notably, it has been shown to increase desipramine levels and can interact with beta-blockers. Conversely, enzyme inducers like \u003cstrong\u003erifampin\u003c\/strong\u003e can lower terbinafine levels, while enzyme inhibitors like \u003cstrong\u003ecimetidine\u003c\/strong\u003e can raise it. Always tell your doctor all medications (prescription, OTC, supplements) you take.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eBlood thinners \/ others:\u003c\/strong\u003e Terbinafine has minimal effect on CYP2C9 or 1A2, so it generally does \u003cem\u003enot\u003c\/em\u003e significantly alter warfarin or theophylline levels. However, vitamin K levels should still be monitored if on warfarin. Contraceptive pills may be slightly less reliable; irregular menstrual bleeding has been reported.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003ePregnancy and lactation:\u003c\/strong\u003e Terbinafine is Pregnancy Category B. It is usually avoided during pregnancy unless clearly needed, and breastfeeding is not recommended while on terbinafine. Discuss risks vs. benefits with your physician if pregnant or nursing.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eChildren:\u003c\/strong\u003e Oral terbinafine tablets are \u003cstrong\u003enot approved for children \u0026lt;18 years\u003c\/strong\u003e (for those patients, use pediatric granule formulations or alternative antifungals).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eOther precautions:\u003c\/strong\u003e Patients with psoriasis or connective tissue disease should use terbinafine cautiously. If manifestations of lupus or severe connective tissue reaction appear, discontinue treatment. Avoid alcohol use during therapy if possible (to reduce liver stress). Terbinafine can cause dizziness or drowsiness in some people; they should not drive or operate machinery if affected.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eTerbinafine 250 mg tablets are a potent systemic antifungal reserved for confirmed dermatophyte infections of skin, hair or nails. The typical adult dose is one 250 mg tablet daily. For nail fungus, course lengths are months (6 weeks for fingers, 12 or more for toes). Shorter courses (2–6 weeks) treat athlete’s foot or jock itch as directed. The drug is fungicidal and highly effective against \u003cem\u003eTrichophyton\u003c\/em\u003e species. Its main benefits are clearing persistent fungal infections and improving nail quality.\u003c\/p\u003e\n\u003cp\u003eMost patients handle terbinafine well, but liver function must be monitored. Common side effects include GI upset and headache; uncommon but serious risks include liver toxicity, blood count changes, and allergic reactions. Drug interactions (especially with CYP2D6 substrates) are possible. Always inform your healthcare provider of all conditions and medications before using terbinafine.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNote:\u003c\/strong\u003e Terbinafine is a prescription medication. This summary is for educational purposes only and does not replace professional medical advice. Follow your doctor’s instructions and the product label for safe use.\u003c\/p\u003e","brand":"Bionpharma","offers":[{"title":"Default Title","offer_id":53722996441456,"sku":"69452-0351-13","price":7.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/Terbinafine-250-mg-Tablets-Bionpharma.jpg?v=1778157039","url":"https:\/\/www.mountainside-medical.com\/products\/terbinafine-250-mg-tablets-100-count-rx","provider":"Mountainside Medical","version":"1.0","type":"link"}