{"product_id":"vizz-eye-drop-aceclidine-1-44-ophthalmic-solution","title":"VIZZ Eye Drop Aceclidine 1.44% Ophthalmic Solution 0.25% x 25\/Box","description":"\u003ch1\u003eVIZZ™ Eye Drop – Aceclidine 1.44% Ophthalmic Solution\u003c\/h1\u003e\n\u003cp\u003eVIZZ is a prescription \u003cstrong\u003eophthalmic solution\u003c\/strong\u003e by Lenz Therapeutics, specifically formulated to treat \u003cstrong\u003epresbyopia\u003c\/strong\u003e – the age-related decline in near vision. It is the first FDA-approved \u003cstrong\u003eonce-daily eye drop\u003c\/strong\u003e (aceclidine 1.44%) shown to improve close-up vision in adults. VIZZ works as a potent \u003cstrong\u003echolinergic muscarinic agonist\u003c\/strong\u003e (miotic) that contracts the iris sphincter muscle, creating a “\u003cstrong\u003epinhole effect\u003c\/strong\u003e” to extend the eye’s depth-of-focus. In clinical studies, a single dose of VIZZ produced clear near vision for up to \u003cstrong\u003e10 hours\u003c\/strong\u003e, providing a convenient, non-surgical alternative to reading glasses or bifocals for tasks like reading, computer use, or smartphone navigation.\u003c\/p\u003e\n\u003ch2\u003eUses and Applications\u003c\/h2\u003e\n\u003cp\u003eVIZZ is indicated for \u003cstrong\u003epresbyopia\u003c\/strong\u003e – the common condition where adults gradually lose the ability to focus on close objects. By sharpening the eye’s focusing power, VIZZ helps adults regain clear \u003cstrong\u003enear vision\u003c\/strong\u003e for up to 10 hours with each \u003cstrong\u003eonce-daily\u003c\/strong\u003e dose. Typical uses include reading, sewing, cooking, writing, and other close-up activities. It is ideal for patients seeking to reduce their dependency on reading glasses or multifocal eyewear. VIZZ does \u003cem\u003enot\u003c\/em\u003e treat or prevent other eye conditions (e.g. glaucoma, cataracts, or age-related macular degeneration) – its sole application is improving \u003cstrong\u003eblurry near vision\u003c\/strong\u003e due to presbyopia.\u003c\/p\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eActive Ingredient:\u003c\/strong\u003e Aceclidine Hydrochloride, 1.44% w\/v (14.4 mg\/mL). Aceclidine is the only active drug in this solution, acting as a pupil-selective cholinergic agonist.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormulation:\u003c\/strong\u003e Sterile, preservative-free ophthalmic solution (clear to slightly yellow liquid). Each single-dose vial contains 1.44% Aceclidine in 0.25 mL sterile solution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePackaging:\u003c\/strong\u003e Comes in a carton of \u003cstrong\u003e25 single-use vials\u003c\/strong\u003e. The vials are organized as 5 blister packs of 5 vials (each vial = 0.25 mL). Each vial is sealed for one-time use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store unopened vials at room temperature away from direct light. Discard each vial after a single use to maintain sterility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eManufacturer:\u003c\/strong\u003e Lenz Therapeutics, Inc. (FDA-approved July 2025). NDC: 84226-100-21 (each box contains 25 × 0.25 mL vials).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eHow to Use\u003c\/h2\u003e\n\u003cp\u003eUse VIZZ exactly as directed by your eye doctor. Follow these steps for administration:\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrepare your eye:\u003c\/strong\u003e Wash hands thoroughly. Remove contact lenses and ensure eyes are clean. Contact lenses may be reinserted at least 10 minutes after dosing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOpen a vial:\u003c\/strong\u003e Twist and remove the top of a single-use 0.25 mL vial to expose the dropper. Do not squeeze the vial tip to avoid aerosolizing the solution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInstill first drop:\u003c\/strong\u003e Tilt head back slightly, look upward, and gently pull down the lower eyelid with a clean finger. Holding the vial just above the eye, instill one drop into the lower conjunctival sac of \u003cem\u003eeach eye\u003c\/em\u003e. Avoid touching your eye, eyelid, or eyelashes with the vial tip to prevent contamination.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWait and instill second drop:\u003c\/strong\u003e Close your eyes or blink 1–2 times. Wait \u003cstrong\u003e2 minutes\u003c\/strong\u003e, then repeat the instillation of \u003cstrong\u003eone more drop in each eye from the same vial\u003c\/strong\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiscard vial:\u003c\/strong\u003e After administering the second drop, discard the opened vial immediately. \u003cstrong\u003eDo not reuse\u003c\/strong\u003e vials.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAftercare:\u003c\/strong\u003e Blink or gently move eyes to distribute the medication. Wait another 10 minutes before putting contact lenses back in. If you accidentally miss instilling a drop or flush out the drop, do not double up doses – just resume normal dosing the next day.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMultiple eye medications:\u003c\/strong\u003e If you also use other ophthalmic drops (e.g. artificial tears or glaucoma medications), administer them at least \u003cstrong\u003e5 minutes apart\u003c\/strong\u003e to avoid wash-out.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eFollow your doctor’s instructions for the timing of daily dosing (typically morning for all-day effectiveness). Only one VIZZ dose should be used per day. Each box contains 25 doses (use one vial per day, discard after use).\u003c\/p\u003e\n\u003ch2\u003eDosage and Administration\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecommended Dose:\u003c\/strong\u003e One drop in each eye, then a second drop in each eye (for two drops per eye total), once daily This dosing (two drops per eye) has been shown effective; do not use more than instructed.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFrequency:\u003c\/strong\u003e VIZZ is a \u003cem\u003eonce-daily\u003c\/em\u003e treatment. Do not exceed one dose every 24 hours. If a dose is missed, skip it (do not double up the next day).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecial Populations:\u003c\/strong\u003e VIZZ is approved for adults with presbyopia. Safety and efficacy in children have not been established. Use in pregnancy or breastfeeding should be considered only if clearly needed; consult your doctor about risks.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdministration Tips:\u003c\/strong\u003e Do not let the vial tip touch your eye or surrounding area. Dispose of the empty vial immediately after use to avoid contamination.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAlways follow the dosing schedule prescribed by your eye care provider. Use exactly as directed and do not change the schedule or dosage without consulting your doctor.\u003c\/p\u003e\n\u003ch2\u003eDrug Interactions\u003c\/h2\u003e\n\u003cp\u003eNo clinically significant drug-drug interactions with VIZZ have been identified. Because VIZZ is applied topically with minimal systemic absorption, routine systemic interactions are unlikely. However:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIf you use multiple \u003cstrong\u003eophthalmic medications\u003c\/strong\u003e (e.g. for dry eye, glaucoma), instill them at least \u003cstrong\u003e5 minutes apart\u003c\/strong\u003e. This prevents one drop from washing out another and ensures optimal absorption.\u003c\/li\u003e\n\u003cli\u003eVIZZ should not be used together with other miotic (pupil-constricting) eye drops unless directed by your doctor.\u003c\/li\u003e\n\u003cli\u003eTell your physician or pharmacist about all prescription and over-the-counter medications (eye drops, oral drugs, herbal products, vitamins) you are taking to check for any potential interactions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAlways inform your eye care professional of any new medications before starting VIZZ.\u003c\/p\u003e\n\u003ch2\u003eSide Effects\u003c\/h2\u003e\n\u003cp\u003eIn clinical trials, VIZZ was generally well tolerated. The most common adverse reactions included mild, transient symptoms shortly after instillation. These include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eInstillation-site irritation:\u003c\/strong\u003e Eye discomfort, stinging or burning sensation (~20% of users).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTemporary blurred or dimmed vision:\u003c\/strong\u003e Vision may appear slightly blurred or darkened immediately post-dose (~16%). Vision typically clears within minutes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHeadache:\u003c\/strong\u003e Mild headache (~13%) has been reported.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOcular redness:\u003c\/strong\u003e Mild redness or bloodshot eyes (conjunctival\/ocular hyperemia) in ~7–8% of patients.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThese side effects were mostly mild to moderate and resolved without stopping therapy. If any side effect is persistent or bothersome, contact your doctor. Less common effects (\u0026lt;5%) can include eye itching, foreign body sensation, tearing, or eye pigment changes. To report any suspected adverse reactions, contact Lenz Therapeutics or the FDA MedWatch program (info in package insert).\u003c\/p\u003e\n\u003ch2\u003eWarnings\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eBlurred\/Darkened Vision:\u003c\/strong\u003e Temporary visual dimming or spots are common right after applying VIZZ. Do not drive, operate machinery, or perform any hazardous activities until your vision is fully clear.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePupil Constriction:\u003c\/strong\u003e Because VIZZ causes pupil constriction (“pinhole effect”), vision at very low light may be dimmer. Use caution in poorly lit conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRetinal Detachment Risk:\u003c\/strong\u003e Miotic agents have been rarely associated with retinal tear or detachment. An eye doctor should perform a dilated retinal exam before starting VIZZ. If you experience sudden flashes of light, new floaters, or loss of peripheral vision, discontinue use and seek immediate ophthalmic evaluation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOcular Inflammation:\u003c\/strong\u003e Use with caution in patients with a history of uveitis or iritis. VIZZ may exacerbate anterior eye inflammation or adhesions of the iris or lens.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypersensitivity:\u003c\/strong\u003e VIZZ is contraindicated in patients with known hypersensitivity or allergy to aceclidine or any component of the product. Do not use if you have experienced allergic eye reactions to similar glaucoma\/presbyopia drops.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eContact Lenses:\u003c\/strong\u003e Remove soft contact lenses before instillation; wait at least 10 minutes after dosing before reinserting. If using contact lenses, ensure they are disinfected.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSterility\/Injury:\u003c\/strong\u003e Avoid touching the vial tip to your eye or any surface to keep the dropper sterile. Discard each single-dose vial promptly after use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOther:\u003c\/strong\u003e VIZZ is for ophthalmic use only. Avoid swallowing or touching it to skin\/other areas. Keep out of reach of children.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003ePatients should receive counseling on these precautions. Regular follow-ups with an eye care professional are recommended to monitor vision changes and ocular health during VIZZ treatment.\u003c\/p\u003e","brand":"LENZ Therapeutics","offers":[{"title":"Default Title","offer_id":53942101901680,"sku":"84226-0100-21","price":115.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0996\/0350\/files\/VIZZ-Eye-Drop-Aceclidine-1.44_-Ophthalmic-Solution.jpg?v=1782302472","url":"https:\/\/www.mountainside-medical.com\/products\/vizz-eye-drop-aceclidine-1-44-ophthalmic-solution","provider":"Mountainside Medical","version":"1.0","type":"link"}