Polymyxin B Sulfate USP (Micronized) For Compounding (API)

Polymyxin B Sulfate USP (Micronized) for compounding is used in the preparation of topical and ophthalmic formulations for the treatment of infections caused by susceptible bacteria. It is essentially used in pharmacy to compound different medication for the treatment of infections caused by Gram-negative organisms, particularly Pseudomonas species. However, it is important to note that Polymyxin B Sulfate should only be used under the guidance and direction of a healthcare professional.

Polymyxin B sulfate USP (micronized) is an active pharmaceutical ingredient (API) commonly used in topical and ophthalmic preparations. It belongs to the polymyxin class of antibiotics and is derived from the bacteria Bacillus polymyxa.

The API is composed of two components, polymyxin B1 and polymyxin B2, which work together to inhibit the growth and proliferation of susceptible bacteria by disrupting their cell membranes. It is primarily used to treat infections caused by Gram-negative bacteria, including Pseudomonas aeruginosa and Klebsiella pneumoniae.

In topical preparations, polymyxin B sulfate USP is commonly used in combination with other antibiotics and agents, such as bacitracin and neomycin, for the treatment of skin infections. In ophthalmic formulations, it is used to treat bacterial conjunctivitis and eye infections.

The API is available as a powder or a solution, and must be sterilized before use in formulations.

CAS Number: 1405-20-5
Property: Light Sensitive | Hygroscopic