Naltrexone Hydrochloride

Alcohol Use Disorder: Helps reduce cravings, prevent relapse, and support sobriety. Opioid Use Disorder: Blocks opioid receptors, preventing the euphoric effects of opioids and supporting recovery. Weight Loss (Low-Dose & Combo): Used in combination with bupropion (Contrave) for chronic weight management. Investigational Use: Studied for fibromyalgia, multiple sclerosis (MS), and autoimmune disorders (Low Dose Naltrexone or LDN).

Naltrexone hydrochloride is the full chemical name and salt form, but naltrexone and naltrexone hydrochloride are used interchangeably in medicine. Both refer to the same active substance used in naltrexone therapy.

Most patients do not feel “high” or sedated—rather, cravings and urges for alcohol or opioids are reduced. Some people notice clearer thinking, less compulsion, or more control over behaviors.

Reduces cravings for alcohol and opioids Lowers risk of relapse and overdose No addictive or sedative properties May support weight loss in certain formulations Possible mood stabilization and improved emotional control

Lack of awareness or training about medication-assisted therapies Concerns over patient adherence or motivation Some insurance plans require prior authorization Not effective in those unwilling to stop opioids or drinking

Naltrexone is not primarily an anti-anxiety drug, but some patients report less anxiety due to reduced compulsive urges or withdrawal symptoms. Always consult your provider for primary anxiety treatment options.

Effects begin within a few hours, with optimal results seen over weeks as cravings diminish. Extended-release injections last about 4 weeks per dose.

Yes, naltrexone is safe for most people when prescribed and monitored. Main risks: liver enzyme elevation, nausea, headache, insomnia, or allergic reactions. Not recommended for those with acute hepatitis, severe liver failure, or ongoing opioid use.

No, they are different medications: Naltrexone is a pure opioid antagonist (blocks receptors, no opioid effect). Suboxone (buprenorphine/naloxone) is a partial opioid agonist used for maintenance therapy.

You can experience normal “happiness,” but naltrexone blocks opioid-related euphoria. Many patients report more emotional stability and improved mood in recovery.

Adults with alcohol or opioid dependence who have detoxed (opioid-free for 7–10 days) People seeking medication-assisted treatment who don’t want or can’t use opioid agonists Individuals interested in adjunct weight management (Contrave)

Once daily, preferably at the same time each day (often morning). Take with food if stomach upset occurs; always follow your doctor’s instructions.

Naltrexone is not a stimulant and does not directly increase energy. Some people report better focus and alertness due to reduced cravings.

Side effects may include vivid dreams or insomnia in some users, especially during the first few weeks; most people adjust over time.

Yes, wearing a medical alert bracelet is recommended so emergency personnel know you are on naltrexone, as opioid pain medicines will not work normally.

As part of Contrave (naltrexone/bupropion), typical weight loss is 5–10% of body weight when combined with lifestyle changes.

Many patients report enhanced mood, stabilized emotions, and improved self-control. Not a traditional antidepressant, but often helps support mental wellbeing during recovery.

Can’t be taken with active opioid use (risk of withdrawal) Rare liver toxicity—monitor liver function GI side effects: nausea, vomiting, abdominal pain May not work for everyone; adherence and support are key

While not a “miracle drug,” naltrexone offers life-changing benefits for many in addiction recovery and is a cornerstone of modern MAT programs.

FDA-approved for alcohol and opioid dependence No addiction or abuse potential Available as daily tablets or monthly injections Supports recovery, weight loss, and possible mood benefits Pharmacy-direct, fast access with prescription