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Promethazine HCL for Injection 25 mg vial on a sterile tray, essential for nausea control and allergy relief in medical treatments.
Promethazine HCL for Injection 25 mg vial on a sterile tray, essential for nausea control and allergy relief in medical treatments.

Promethazine HCL for Injection 25 mg Single-Dose Vials 1 mL x 25/Tray (Rx)

by Himka
Sold out
$ 129.95
$ 89.00
SKU 00641-0928-25

Promethazine HCL for Injection is a medication that is used to treat a variety of conditions. It works by blocking the action of histamine in the body. This helps to reduce the symptoms of conditions such as allergies, motion sickness, and nausea.

Himka Promethazine HCL for Injection 25mg Single-Dose 1mL Vials x 25/Tray, Promethazine is the generic equivalent of Phenadoz®, Phenergan® or Promethegan™. It is an antihistamine. This Promethazine comes in a 1mL single-dose vial. Promethazine hydrochloride is a phenothiazine derivative which possesses antihistaminic, sedative, antimotion-sickness, antiemetic, and anticholinergic effects. Promethazine is a competitive H1 receptor antagonist, but does not block the release of histamine. Structural differences from the neuroleptic phenothiazines result in its relative lack (1/10 that of chlorpromazine) of dopamine antagonist properties. Clinical effects are generally apparent within 5 minutes of an intravenous injection and within 20 minutes of an intramuscular injection. Duration of action is four to six hours, although effects may persist up to 12 hours. Promethazine hydrochloride is metabolized in the liver, with the sulfoxides of promethazine and N-desmethylpromethazine being the predominant metabolites appearing in the urine. Following intravenous administration in healthy volunteers, the plasma half-life for promethazine has been reported to range from 9 to 16 hours. The mean plasma half-life for promethazine after intramuscular administration in healthy volunteers has been reported to be 9.8 ± 3.4 hours.

Brand: Himka
NDC: 00641-0928-25
Size: 1 mL Single-dose vial x 25 Per Tray

Promethazine hydrochloride injection is indicated for the following conditions:

  1. Amelioration of allergic reactions to blood or plasma.
  2. In anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled.
  3. For other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated.
  4. For sedation and relief of apprehension and to produce light sleep from which the patient can be easily aroused.
  5. Active treatment of motion sickness.
  6. Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery.
  7. As an adjunct to analgesics for the control of postoperative pain.
  8. Preoperative, postoperative, and obstetric (during labor) sedation.
  9. Intravenously in special surgical situations, such as repeated bronchoscopy, ophthalmic surgery, and poor-risk patients, with reduced amounts of meperidine or other narcotic analgesic as an adjunct to anesthesia and analgesia.
Promethazine HCL for Injection 25 mg Single-Dose Vials 1 mL x 25/Tray (Rx)
Promethazine HCL for Injection 25 mg Single-Dose Vials 1 mL x 25/Tray (Rx)
$ 129.95 $ 89.00
Antihistamine Medicines Frequently Asked Questions (FAQs)
  • What are antihistamines used for?

    Antihistamines are primarily used to treat allergies, such as hay fever, hives, itching, and symptoms of allergic reactions (runny nose, sneezing, watery eyes). Some are also used for motion sickness, insomnia, or to relieve cold symptoms.

  • What are common examples of antihistamine medicines?

    Common antihistamines include: First-generation (sedating): Diphenhydramine (Benadryl), Chlorpheniramine, Clemastine Second-generation (non-sedating): Loratadine (Claritin), Cetirizine (Zyrtec), Fexofenadine (Allegra)

  • What is the difference between first-generation and second-generation antihistamines?

    First-generation antihistamines can cause more drowsiness and are shorter-acting. Second-generation antihistamines are less likely to cause drowsiness and usually last longer.

  • Are antihistamines safe during pregnancy or breastfeeding?

    Some antihistamines are considered safe, but it’s important to consult your healthcare provider before taking any, especially during pregnancy or while breastfeeding.

  • Can children take antihistamines?

    Many antihistamines are approved for use in children, but dosing depends on age and weight. Always consult a pediatrician before using antihistamines in young children.

  • What are the side effects of antihistamines?

    Common side effects include drowsiness (especially with first-generation types), dry mouth, dizziness, blurred vision, constipation, and urinary retention.

  • Can I take antihistamines and drink alcohol?

    It’s best to avoid alcohol with antihistamines, especially first-generation types like diphenhydramine, as both can increase drowsiness and impair coordination.

  • Can I take more than one type of antihistamine at the same time?

    Generally, you should not combine different oral antihistamines unless instructed by your healthcare provider, as this increases the risk of side effects without improving efficacy.

  • Do antihistamines work immediately?

    Most oral antihistamines start to work within 30–60 minutes, while nasal or eye antihistamines may work faster.

  • Can I use antihistamines long-term?

    Second-generation antihistamines are often safe for long-term use under medical supervision, but you should see a doctor if you need them daily for extended periods.

  • Do antihistamines interact with other medications?

    Yes, especially first-generation antihistamines, which may interact with sedatives, sleeping pills, muscle relaxants, and certain antidepressants. Check with your pharmacist or doctor if unsure.

  • What should I do if I miss a dose of my antihistamine?

    Take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose. Don’t double up unless instructed by your doctor.

  • Can antihistamines be used for itching not caused by allergies?

    Yes, antihistamines can sometimes relieve itching due to other causes, like insect bites or skin irritations, but always check with your provider for chronic or severe itching.

  • Are there non-drowsy antihistamines?

    Yes, second-generation antihistamines (e.g., loratadine, cetirizine, fexofenadine) are less likely to cause drowsiness than first-generation drugs.

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