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A vial labeled Depo-Medrol for Injection 40 mg, 1 mL, with a green cap.
A vial labeled Depo-Medrol for Injection 40 mg, 1 mL, with a green cap.

Depo-Medrol for Injection 40 mg, 1 mL x 25/Pack (Rx)

by Pfizer Injectables
Year End Sale 20%
$ 499.95
$ 399.95
SKU 00009-3073-03
*Mountainside Medical does not fill personal prescriptions Medical Professional License Required to Unlock Account

How to Order:

✔ Send an email request to: sales@mountainside-medical.com

You will receive instructions on how to create an account along with Rx Ordering Details.

(Note: Acceptable licenses must have Prescriptive Authority in the license issuing state.)

Depo-Medrol for Injection 40 mg, 1 mL is an anti-inflammatory medication used to relieve pain, swelling, redness, stiffness, and other symptoms of inflammation in various parts of the body. Depo-Medrol is a corticosteroid used to treat an extensive number of conditions, including asthma, chronic obstructive pulmonary disease, allergies, and dermatological disorders, as well as several types of rheumatic and autoimmune disorders. The drug combines methylprednisolone acetate with benzyl alcohol, both of which are anti-inflammatory drugs. Depo-Medrol helps reduce inflammation by reducing the activity of the immune system. Patients are typically provided with either a single intramuscular injection or multiple injections throughout a course of treatment. Depo-Medrol is considered both a mild and a safe option as an injectable anti-inflammatory medication and has been successfully used in millions of Depo-Medrol injections worldwide.

Benefits for Depo-Medrol for Injection 40 mg, 1 mL

  • Reduces swelling by suppressing the immune system
  • Provides effective, long lasting relief from the symptoms of allergies and arthritis
  • Relieves itching and reduces inflammation
  • Stimulates healing of broken down skin, muscle, and joint tissues
  • Used to manage disease-related pain, stiffness and inflammation
  • Minimizes flare-ups of chronic conditions and can be useful for reducing pain after exercise
  • May suppress certain types of cancer
  • Allows for a precise dosage and can be combined with other medicines for maximum benefit
  • Increases range of motion and joint function
  • Is injected directly into muscle or joint for a more reliable absorption rate
  • Delays the need for invasive procedures such as surgery

Depo-Medrol for Injection 40 mg, crafted by Pfizer Injectables, is a potent corticosteroid medication designed for the management of various inflammatory and autoimmune conditions. It is particularly useful in alleviating joint pain, such as that caused by arthritis, as well as other conditions responsive to glucocorticoids. This medication delivers rapid relief from inflammation, offering patients improved comfort and mobility.

Details and Features

Dosage Form: Injectable suspension
Strength: 40 mg/mL
Pack Size: 25 vials of 1 mL each
Manufacturer: Pfizer Injectables
Indications:  Used for conditions like arthritis, allergic reactions, skin conditions, and other inflammatory disorders
Storage: Store at controlled room temperature, protect from light

Mechanism of Action

Depo-Medrol contains methylprednisolone acetate, a glucocorticoid that suppresses the immune system and decreases inflammation. By inhibiting leukocyte infiltration at the site of inflammation, interfering with mediators of inflammatory response, and suppressing humoral immune responses, it reduces inflammation and modifies the body's immune response.

Side Effects

While Depo-Medrol is effective for reducing inflammation and pain, it may cause side effects, including:

  • Fluid retention
  • Hypertension
  • Mood changes, such as mood swings or depression
  • Increased blood sugar levels
  • Immune suppression leading to higher susceptibility to infections
  • Osteoporosis with long-term use
  • Stomach ulcers or gastrointestinal bleeding
  • Insomnia

Warnings

  • Medical Supervision: Administration should be performed under medical supervision. Regular monitoring is advisable, especially for long-term use.
  • Contraindications: Not suitable for those with systemic fungal infections or known hypersensitivity to ingredients.
  • Pregnancy and Nursing: Use cautiously in pregnant or breastfeeding women; consult a healthcare provider.
  • Interactions: Can interact with other medications like NSAIDs, anticoagulants, and certain vaccines. Inform your doctor about any other treatments or medications you’re using.
  • Abrupt Discontinuation: Do not discontinue abruptly; tapering off is necessary to prevent withdrawal symptoms.
  • Psychiatric Effects: Patients with a history of mood disorders should report any behavioral changes immediately.

This detailed guide is intended to provide a comprehensive understanding of Depo-Medrol for Injection 40 mg. Always rely on guidance from healthcare professionals and product labeling for safe and effective use.

Depo-Medrol for Injection 40 mg, 1 mL x 25/Pack (Rx)
Depo-Medrol for Injection 40 mg, 1 mL x 25/Pack (Rx)
$ 499.95 $ 399.95
🔒 Medical License Required
FAQs About Corticosteroid Shots
  • What Is a Corticosteroid Shot?

    A corticosteroid shot (or cortisone injection) is a minimally invasive procedure where synthetic steroid medication is injected directly into joints, tendons, or soft tissues to rapidly reduce inflammation, pain, and swelling. They are commonly used for knee arthritis, shoulder pain, bursitis, tendinitis, gout, and more.

  • Why Do Doctors Not Like to Give Cortisone Shots?

    While highly effective, many doctors limit cortisone or steroid shots because: Overuse can weaken cartilage and soft tissue Too many injections increase risk of joint damage, infection, or systemic side effects Potential for temporary pain flare or “cortisone flare” post-injection Thus, cortisone injections are reserved for the most appropriate cases.

  • What Is the Main Reason for Corticosteroid Use?

    The primary purpose is targeted inflammation control – reducing joint pain, improving mobility, and controlling diseases like rheumatoid arthritis, osteoarthritis, bursitis, and tendinopathies.

  • How Long Does a Cortisone Shot Injection Last?

    Relief can start within 24-72 hours and typically lasts from a few weeks to several months. Duration varies by condition, joint, and individual response.

  • Are Steroid Injections Good for Knee Arthritis?

    Yes, corticosteroid injections are a proven, effective short-term treatment for reducing pain and swelling in moderate to severe knee osteoarthritis. Though not a cure, they improve quality of life and function.

  • What Is an Alternative to a Cortisone Shot?

    Hyaluronic acid injections (viscosupplementation) Physical therapy NSAIDs (nonsteroidal anti-inflammatory drugs) PRP (platelet-rich plasma) injections Lifestyle modification and exercise These can be used alone or in combination depending on severity and patient needs.

  • What Is the Downside of Getting Cortisone Shots?

    Temporary pain or “cortisone flare” after injection Bruising or infection risk Tendon or cartilage weakening if overused Possible increase in blood sugar for diabetics Rarely: facial flushing, allergic reaction, or local fat loss (lipoatrophy)

  • What Is the Difference Between a Cortisone Shot and a Corticosteroid Injection?

    They are the same thing. " Corticosteroid" is the medical term; "cortisone shot" is the common term. Both refer to steroid-based injections used for inflammation.

  • What Is the Success Rate of Corticosteroid Injections?

    Success rates vary, but up to 75–80% of patients experience significant pain relief for weeks or months, especially when the cause is inflammation.

  • Do Steroid Shots Make You Gain Weight?

    While short-term, local injections rarely cause weight gain, repeated or high-dose steroid shots (especially into soft tissue or multiple joints) can increase risk of fluid retention and weight gain. Systemic steroid side effects are uncommon with occasional use.

  • How Many Cortisone Shots Will They Give You?

    Most doctors limit injections to 3–4 times per year per joint to prevent long-term damage. Frequency depends on the joint, diagnosis, and your overall health.

  • How Much Does a Cortisone Shot Cost?

    Corticosteroid injection cost ranges from $100–$300 per shot in the U.S., depending on clinic, location, and insurance coverage.

  • What Should I Avoid After a Cortisone Shot?

    Avoid strenuous activity for 24–48 hours Do not submerge joint in water (baths, pools, hot tubs) for 24 hours Monitor for infection signs (redness, swelling, fever) Follow your doctor’s post-injection instructions

  • What Next if a Cortisone Shot Doesn’t Work?

    Consider alternative injections (hyaluronic acid/PRP/biologics) Physical therapy or alternative medications Consult an orthopedic specialist for surgical options if pain persists

  • What Knee Injection Lasts 3 Years?

    Hyaluronic acid (gel) injections and some new-generation regenerative treatments (like stem cell therapy) may provide longer pain relief (sometimes up to 2–3 years), but results vary.

  • Key Health Benefits of Our Corticosteroid Shots:

    FDA-approved, medical-grade formulations Minimal discomfort with expert placement Rapid, targeted anti-inflammatory response Used for knee and joint pain, arthritis, bursitis, gout, tendonitis Trusted by orthopedic doctors, sports medicine clinics, and pain specialists worldwide

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