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Box of Solu-Medrol injection vials, each labeled with 125 mg per vial, for intramuscular or intravenous use.
Box of Solu-Medrol injection vials, each labeled with 125 mg per vial, for intramuscular or intravenous use.

Solu-Medrol Injection 125 mg Methylprednisolone 2 ml Vials, 25/Pack (RX)

by Pfizer Injectables
Year End Sale 31%
$ 549.95
$ 379.00
SKU 00009-0047-22
*Mountainside Medical does not fill personal prescriptions Medical Professional License Required to Unlock Account

How to Order:

✔ Send an email request to: sales@mountainside-medical.com

You will receive instructions on how to create an account along with Rx Ordering Details.

(Note: Acceptable licenses must have Prescriptive Authority in the license issuing state.)

Solu-Medrol Injection is a brand name for an injectable form of methylprednisolone sodium succinate, which is a synthetic glucocorticoid (corticosteroid) medication. It is used for its potent anti-inflammatory and immunosuppressive effects.

Uses

Solu-Medrol is prescribed for:

  • Severe allergic reactions (anaphylaxis)
  • Asthma or COPD exacerbations
  • Autoimmune conditions (lupus, rheumatoid arthritis, etc.)
  • Severe inflammation caused by various conditions
  • Certain types of shock
  • Acute spinal cord injury (as part of some protocols)
  • Multiple sclerosis flare-ups
  • Some cancers, as part of chemotherapy regimens

Active Ingredient

  • Methylprednisolone sodium succinate

Forms and Strengths

  • Available in vials or single-use Act-O-Vials, typically in strengths such as 40 mg, 125 mg, 500 mg, and 1 gram per vial or kit.

Route of Administration

  • Intravenous (IV) injection
  • Intramuscular (IM) injection

Solu-Medrol is a corticosteroid medication used to reduce inflammation and suppress the immune system in various medical conditions. It is commonly prescribed for conditions such as severe allergic reactions, asthma, arthritis, lupus, and multiple sclerosis flare-ups. By decreasing inflammation, Solu-Medrol helps alleviate symptoms such as swelling, pain, and allergic responses. It can be administered intravenously or intramuscularly, providing rapid relief in acute settings. Healthcare providers may use it alongside other treatments to manage chronic conditions effectively.

Details and Features

Active Ingredient: Methylprednisolone Sodium Succinate
Concentration: 125 mg per 2 mL vial
Formulation: Powder for injection that must be reconstituted before use
Packaging: Available in multiple-use packs, typically containing 25 vials
Manufacturer: Pfizer Injectables
Usage: Primarily used for quick intervention in severe inflammation and immune-mediated conditions, in both inpatient and outpatient settings.
NDC: 00009-0047-22
UPC: 300090047221

Mechanism of Action

Methylprednisolone, the active ingredient in Solu-Medrol, exerts its effects by inhibiting multiple inflammatory pathways. It blocks the expression of inflammatory mediators such as cytokines and chemokines, reducing their ability to promote inflammation and immune response. The drug alters gene transcription, leading to decreased production of substances that promote inflammation and increased production of anti-inflammatory proteins.

Warnings

  • Increased Susceptibility to Infections: Can suppress the body’s immune response, increasing the risk of infections and masking existing infection symptoms.
  • Endocrine Effects: Prolonged use can lead to adrenal suppression, Cushing's syndrome, and hypothalamic-pituitary-adrenal (HPA) axis suppression.
  • Cardiovascular: May cause hypertension, fluid retention, and electrolyte imbalances.
  • Gastrointestinal Risks: Potential for peptic ulcers, GI bleeding, or perforation in susceptible individuals.
  • Bone Density: Long-term use can result in bone loss or osteoporosis.
  • Psychiatric Effects: Possible mood swings, depression, or other psychiatric symptoms.
  • Ophthalmic Concerns: Risk of cataracts, glaucoma, and exacerbation of eye infections.

Side Effects

Common Side Effects:

- Insomnia
- Increased appetite and weight gain
- Mood changes or irritability
- Edema (fluid retention)

Serious Side Effects:

  • Peptic ulcers and gastrointestinal bleeding
  • Osteoporosis with possible fracture risk in long-term use
  • Elevated blood sugar levels, problematic in diabetic patients
  • Severe infections due to immunosuppression
  • Hypertension and cardiovascular complications

Administration and Monitoring

Solu-Medrol should be administered by healthcare professionals familiar with corticosteroid therapy. Close monitoring is necessary to manage dosages and mitigate potential complications, especially during prolonged treatment courses. Monitoring might include periodic evaluation of blood pressure, blood sugar levels, and bone density. Adjustments in therapy should be guided by clinical response and the patient's condition, considering the lowest dosage for therapeutic efficacy to minimize side effects.

Solu-Medrol Injection 125 mg Methylprednisolone 2 ml Vials, 25/Pack (RX)
Solu-Medrol Injection 125 mg Methylprednisolone 2 ml Vials, 25/Pack (RX)
$ 549.95 $ 379.00
🔒 Medical License Required
FAQs About Corticosteroid Shots
  • What Is a Corticosteroid Shot?

    A corticosteroid shot (or cortisone injection) is a minimally invasive procedure where synthetic steroid medication is injected directly into joints, tendons, or soft tissues to rapidly reduce inflammation, pain, and swelling. They are commonly used for knee arthritis, shoulder pain, bursitis, tendinitis, gout, and more.

  • Why Do Doctors Not Like to Give Cortisone Shots?

    While highly effective, many doctors limit cortisone or steroid shots because: Overuse can weaken cartilage and soft tissue Too many injections increase risk of joint damage, infection, or systemic side effects Potential for temporary pain flare or “cortisone flare” post-injection Thus, cortisone injections are reserved for the most appropriate cases.

  • What Is the Main Reason for Corticosteroid Use?

    The primary purpose is targeted inflammation control – reducing joint pain, improving mobility, and controlling diseases like rheumatoid arthritis, osteoarthritis, bursitis, and tendinopathies.

  • How Long Does a Cortisone Shot Injection Last?

    Relief can start within 24-72 hours and typically lasts from a few weeks to several months. Duration varies by condition, joint, and individual response.

  • Are Steroid Injections Good for Knee Arthritis?

    Yes, corticosteroid injections are a proven, effective short-term treatment for reducing pain and swelling in moderate to severe knee osteoarthritis. Though not a cure, they improve quality of life and function.

  • What Is an Alternative to a Cortisone Shot?

    Hyaluronic acid injections (viscosupplementation) Physical therapy NSAIDs (nonsteroidal anti-inflammatory drugs) PRP (platelet-rich plasma) injections Lifestyle modification and exercise These can be used alone or in combination depending on severity and patient needs.

  • What Is the Downside of Getting Cortisone Shots?

    Temporary pain or “cortisone flare” after injection Bruising or infection risk Tendon or cartilage weakening if overused Possible increase in blood sugar for diabetics Rarely: facial flushing, allergic reaction, or local fat loss (lipoatrophy)

  • What Is the Difference Between a Cortisone Shot and a Corticosteroid Injection?

    They are the same thing. " Corticosteroid" is the medical term; "cortisone shot" is the common term. Both refer to steroid-based injections used for inflammation.

  • What Is the Success Rate of Corticosteroid Injections?

    Success rates vary, but up to 75–80% of patients experience significant pain relief for weeks or months, especially when the cause is inflammation.

  • Do Steroid Shots Make You Gain Weight?

    While short-term, local injections rarely cause weight gain, repeated or high-dose steroid shots (especially into soft tissue or multiple joints) can increase risk of fluid retention and weight gain. Systemic steroid side effects are uncommon with occasional use.

  • How Many Cortisone Shots Will They Give You?

    Most doctors limit injections to 3–4 times per year per joint to prevent long-term damage. Frequency depends on the joint, diagnosis, and your overall health.

  • How Much Does a Cortisone Shot Cost?

    Corticosteroid injection cost ranges from $100–$300 per shot in the U.S., depending on clinic, location, and insurance coverage.

  • What Should I Avoid After a Cortisone Shot?

    Avoid strenuous activity for 24–48 hours Do not submerge joint in water (baths, pools, hot tubs) for 24 hours Monitor for infection signs (redness, swelling, fever) Follow your doctor’s post-injection instructions

  • What Next if a Cortisone Shot Doesn’t Work?

    Consider alternative injections (hyaluronic acid/PRP/biologics) Physical therapy or alternative medications Consult an orthopedic specialist for surgical options if pain persists

  • What Knee Injection Lasts 3 Years?

    Hyaluronic acid (gel) injections and some new-generation regenerative treatments (like stem cell therapy) may provide longer pain relief (sometimes up to 2–3 years), but results vary.

  • Key Health Benefits of Our Corticosteroid Shots:

    FDA-approved, medical-grade formulations Minimal discomfort with expert placement Rapid, targeted anti-inflammatory response Used for knee and joint pain, arthritis, bursitis, gout, tendonitis Trusted by orthopedic doctors, sports medicine clinics, and pain specialists worldwide

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