Solu-Medrol Injection 125 mg Methylprednisolone 2 ml Vials, 25/Pack (RX)

Solu-Medrol Injection is a brand name for an injectable form of methylprednisolone sodium succinate, which is a synthetic glucocorticoid (corticosteroid) medication. It is used for its potent anti-inflammatory and immunosuppressive effects.

Uses

Solu-Medrol is prescribed for:

• Severe allergic reactions (anaphylaxis)
• Asthma or COPD exacerbations
• Autoimmune conditions (lupus, rheumatoid arthritis, etc.)
• Severe inflammation caused by various conditions
• Certain types of shock
• Acute spinal cord injury (as part of some protocols)
• Multiple sclerosis flare-ups
• Some cancers, as part of chemotherapy regimens

Active Ingredient

• Methylprednisolone sodium succinate

Forms and Strengths

• Available in vials or single-use Act-O-Vials, typically in strengths such as 40 mg, 125 mg, 500 mg, and 1 gram per vial or kit.

Route of Administration

• Intravenous (IV) injection
• Intramuscular (IM) injection

Solu-Medrol is a corticosteroid medication used to reduce inflammation and suppress the immune system in various medical conditions. It is commonly prescribed for conditions such as severe allergic reactions, asthma, arthritis, lupus, and multiple sclerosis flare-ups. By decreasing inflammation, Solu-Medrol helps alleviate symptoms such as swelling, pain, and allergic responses. It can be administered intravenously or intramuscularly, providing rapid relief in acute settings. Healthcare providers may use it alongside other treatments to manage chronic conditions effectively.

Details and Features

Active Ingredient: Methylprednisolone Sodium Succinate
Concentration: 125 mg per 2 mL vial
Formulation: Powder for injection that must be reconstituted before use
Packaging: Available in multiple-use packs, typically containing 25 vials
Manufacturer: Pfizer Injectables
Usage: Primarily used for quick intervention in severe inflammation and immune-mediated conditions, in both inpatient and outpatient settings.
NDC: 00009-0047-22
UPC: 300090047221

Mechanism of Action

Methylprednisolone, the active ingredient in Solu-Medrol, exerts its effects by inhibiting multiple inflammatory pathways. It blocks the expression of inflammatory mediators such as cytokines and chemokines, reducing their ability to promote inflammation and immune response. The drug alters gene transcription, leading to decreased production of substances that promote inflammation and increased production of anti-inflammatory proteins.

Warnings

• Increased Susceptibility to Infections: Can suppress the body’s immune response, increasing the risk of infections and masking existing infection symptoms.
  
• Endocrine Effects: Prolonged use can lead to adrenal suppression, Cushing's syndrome, and hypothalamic-pituitary-adrenal (HPA) axis suppression.
  
• Cardiovascular: May cause hypertension, fluid retention, and electrolyte imbalances.
  
• Gastrointestinal Risks: Potential for peptic ulcers, GI bleeding, or perforation in susceptible individuals.
  
• Bone Density: Long-term use can result in bone loss or osteoporosis.
  
• Psychiatric Effects: Possible mood swings, depression, or other psychiatric symptoms.
  
• Ophthalmic Concerns: Risk of cataracts, glaucoma, and exacerbation of eye infections.

Side Effects

Common Side Effects:

- Insomnia
- Increased appetite and weight gain
- Mood changes or irritability
- Edema (fluid retention)

Serious Side Effects:

• Peptic ulcers and gastrointestinal bleeding
• Osteoporosis with possible fracture risk in long-term use
• Elevated blood sugar levels, problematic in diabetic patients
• Severe infections due to immunosuppression
• Hypertension and cardiovascular complications

Administration and Monitoring

Solu-Medrol should be administered by healthcare professionals familiar with corticosteroid therapy. Close monitoring is necessary to manage dosages and mitigate potential complications, especially during prolonged treatment courses. Monitoring might include periodic evaluation of blood pressure, blood sugar levels, and bone density. Adjustments in therapy should be guided by clinical response and the patient's condition, considering the lowest dosage for therapeutic efficacy to minimize side effects.