Regadenoson Injection Prefilled Syringe 0.4 mg per 5mL
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Regadenoson is an intravenous medication used as a pharmacologic stress agent in myocardial perfusion imaging (MPI) for patients who are unable to exercise sufficiently. Acting as a coronary vasodilator, it increases blood flow to the heart, mimicking the effects of physical activity for diagnostic evaluation.
Use Regadenoson is employed to help diagnose heart conditions by enhancing blood flow to the heart, aiding in the detection of coronary artery disease during a stress test. It works more quickly and selectively than other stress agents such as adenosine, making it a popular choice for stress testing procedures.
Regadenoson Injection by Hikma is a pharmacologic stress agent used in myocardial perfusion imaging (MPI) for patients unable to undergo adequate exercise stress. This prefilled syringe offers precise administration, enhancing diagnostic accuracy for cardiac assessments.
Usage: Regadenoson is used in radionuclide myocardial perfusion imaging to evaluate coronary artery disease in patients who cannot perform physical exercise stress tests.
Dosage:
- Standard Dose: 0.4 mg administered as a rapid intravenous injection (10 seconds) followed by a saline flush.
- Do not repeat the dose within 24 hours.
CDC Guidelines: While the CDC doesn't have specific regadenoson guidelines, it underscores the importance of using diagnostic agents in controlled environments with appropriate monitoring due to potential cardiac effects.
Details and Features:
- Concentration: 0.4 mg per 5 mL
- Volume: 5 mL prefilled syringe
- Ease of Use: Prefilled for precise and straightforward administration
- Rapid Action: Provides quick onset for effective MPI
- Selective A2A Receptor Agonist: Minimizes respiratory side effects
Mechanism of Action: Regadenoson selectively activates A2A adenosine receptors, causing coronary vasodilation and increased blood flow in the heart. This mimics the effects of exercise, enabling visualization of coronary blood flow and identifying coronary artery disease through imaging.
Directions for Use:
- Administer 0.488 mg intravenously over 10 seconds.
- Follow immediately with a 5 mL saline flush.
- Ensure appropriate monitoring and emergency equipment are available.
Warnings:
- Contraindicated in patients with certain cardiac conditions, such as unstable angina or severe hypotension.
- Exercise caution in patients with chronic obstructive pulmonary disease (COPD) or asthma.
- Monitor for potential arrhythmias and hypotension.
Side Effects: Possible side effects include:
- Dyspnea
- Headache
- Flushing
- Chest discomfort
- Dizziness In case of severe adverse effects, initiate appropriate medical interventions immediately.
Regadenoson Injection by Hikma delivers reliable, rapid-onset pharmacologic stress for accurate cardiac imaging, ensuring effective cardiovascular diagnostics in patients unable to exercise.