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Allopurinol Sodium 500 mg for Injection by Hikma
Allopurinol Sodium 500 mg for Injection by Hikma

Allopurinol Sodium Injection 500 mg, Single-Use Vial, Sterile (RX)

by Hikma Injectables
Year End Sale 21%
$ 8,595.00
$ 6,795.00
SKU 00143-9533-01
*Mountainside Medical does not fill personal prescriptions Medical Professional License Required to Unlock Account

How to Order:

✔ Send an email request to: sales@mountainside-medical.com

You will receive instructions on how to create an account along with Rx Ordering Details.

(Note: Acceptable licenses must have Prescriptive Authority in the license issuing state.)

Allopurinol sodium injection (brand name Aloprim) is a medication used to control elevated uric acid levels in the blood, particularly in patients undergoing chemotherapy who are unable to take oral allopurinol. It is administered intravenously in a hospital or clinical setting.

Allopurinol Sodium Injection is a medication used to manage and treat high levels of uric acid in the blood, commonly seen in conditions such as cancer therapy-induced tumor lysis syndrome. It works by inhibiting the enzyme xanthine oxidase, which is involved in the production of uric acid. This form is used when oral administration is not feasible, allowing for rapid intervention and management in an acute setting. It’s important to be administered under the guidance of a healthcare professional.

Allopurinol Sodium for Injection by Hikma Injectables is a sterile, high-quality formulation specifically designed for intravenous use. This 500 mg single-use vial is intended for the management of elevated uric acid levels associated with chemotherapy, ensuring rapid and effective control.

Uses:

This injectable form of Allopurinol is used to:

  • Prevent acute uric acid nephropathy in patients with leukemia, lymphoma, and solid tumor malignancies undergoing chemotherapy
  • Manage elevated uric acid levels in patients unable to take oral medication

Dosage:

Typically, the dosage is determined by the healthcare provider based on the patient’s specific needs and condition. It's crucial to follow the prescribed dosage to avoid complications.

CDC Guidelines:

While the CDC does not provide specific guidelines for Allopurinol, they emphasize the importance of managing uric acid levels to prevent complications in chemotherapy patients.

Details and Features:

  • Concentration: 500 mg of Allopurinol Sodium per vial
  • Formulation: Sterile, single-use vial for intravenous infusion
  • Brand: Hikma Injectables

Mechanism of Action:

Allopurinol acts by inhibiting xanthine oxidase, an enzyme involved in the conversion of hypoxanthine and xanthine to uric acid. This reduces uric acid production, helping prevent kidney damage and other complications associated with high uric acid levels.

Directions:

  1. For intravenous infusion only.
  2. Reconstitute the vial with appropriate diluent before administration.
  3. Administer under the supervision of a healthcare professional.
  4. Use immediately after preparation to ensure sterility.

Warnings:

  • Hypersensitivity reactions may occur; discontinue if any severe reactions appear.
  • For hospital and clinical settings only.
  • Not for use in patients who have demonstrated hypersensitivity to Allopurinol.
  • Monitor renal function regularly.

Side Effects:

Some potential side effects include:

  • Rash or allergic reactions
  • Gastrointestinal disturbances (nausea, vomiting)
  • Altered liver function tests
  • Infusion site reactions

Consult Healthcare Provider:

Always ensure that Allopurinol is administered under the guidance of a qualified healthcare professional. Monitor kidney and liver function regularly to detect any adverse effects promptly. Discontinue use and seek medical attention if serious side effects occur.

Allopurinol Sodium Injection 500 mg, Single-Use Vial, Sterile (RX)
Allopurinol Sodium Injection 500 mg, Single-Use Vial, Sterile (RX)
$ 8,595.00 $ 6,795.00
🔒 Medical License Required
Allopurinol Sodium Injection 500 mg – Frequently Asked Questions (FAQs)
  • What is Allopurinol Sodium Injection 500 mg used for?

    Allopurinol sodium injection is used to lower uric acid levels in the blood in patients who cannot take oral medications, especially during chemotherapy or radiation in cancer treatment to help prevent or treat tumor lysis syndrome (TLS).

  • How does Allopurinol work?

    Allopurinol works by inhibiting xanthine oxidase, an enzyme involved in converting purines to uric acid, which reduces the production of uric acid in the body.

  • Who needs Allopurinol Sodium Injection instead of oral tablets?

    Patients who cannot swallow tablets, have severe nausea or vomiting, or who need rapid control of uric acid (such as those at high risk for tumor lysis syndrome) may receive the injection.

  • How is Allopurinol Sodium Injection administered?

    It is given as an intravenous (IV) infusion in a hospital setting by healthcare professionals.

  • What are the common side effects of Allopurinol Injection?

    Common side effects include rash, nausea, vomiting, diarrhea, and changes in liver function tests. Rare but serious effects include severe skin reactions (Stevens-Johnson syndrome), kidney problems, and allergic reactions.

  • How long will I need Allopurinol injection?

    Duration depends on the clinical situation (for example, for the prevention of tumor lysis syndrome during cancer treatment), but it is usually used short-term until oral therapy is possible or risk subsides.

  • Are there any special precautions before receiving Allopurinol Injection?

    Let your healthcare provider know if you have a history of kidney or liver disease, allergies, or previous reactions to allopurinol.

  • Does Allopurinol interact with other medications?

    Yes. Allopurinol can interact with medications such as azathioprine, mercaptopurine, cyclosporine, certain antibiotics, and anticoagulants. Always tell your doctor about all medicines and supplements you are taking.

  • Can children receive Allopurinol Injection?

    Yes, allopurinol injection may be used in children for specific indications under medical supervision, with adjusted dosages.

  • Can Allopurinol Injection be given in patients with kidney problems?

    Caution is needed, and dosages may need adjustment based on kidney function. Kidney function is monitored during therapy.

  • What should I do if I develop a rash or allergic symptoms?

    Tell your healthcare provider immediately if you develop a rash, hives, swelling, difficulty breathing, or other signs of an allergic reaction, as some reactions can be severe.

  • How is the effect of Allopurinol monitored?

    Blood tests to check uric acid levels, kidney function, and liver function will be performed during treatment.

  • Is Allopurinol safe during pregnancy or breastfeeding?

    The safety of allopurinol in pregnancy and breastfeeding is not well established. Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

  • Can I eat normally while receiving Allopurinol Injection?

    There are no strict dietary restrictions, but staying hydrated is important. Sometimes, reduction of high-purine foods is recommended to lower uric acid levels further.

  • How should Allopurinol Injection be stored before use?

    It should be stored as directed by the manufacturer, typically at controlled room temperature and protected from light until prepared for use in the hospital or clinic.

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