Flumazenil Injection 10 mL Multiple Dose Vials 1.0 mg/mL, 10/Box - Hikma (RX)
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Flumazenil Injection is a medication used in hospitals and emergency settings to reverse the effects of benzodiazepine drugs (such as diazepam/Valium, lorazepam/Ativan, midazolam/Versed, alprazolam/Xanax, etc.). It is an antidote to benzodiazepine overdose or sedation.
What is Flumazenil?
- Drug class: Benzodiazepine antagonist
- Brand name: Romazicon (in the US)
- How it works: Flumazenil quickly and competitively blocks benzodiazepine receptors in the brain, reversing the sedative and central nervous system (CNS) depressant effects of benzodiazepines.
Uses
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Reversal of Benzodiazepine Sedation and Overdose
- Used when a person has had too much benzodiazepine (accidental or intentional), causing dangerous sedation, respiratory depression, or coma.
- Used after procedures to reverse benzodiazepine-induced sedation or anesthesia.
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Diagnostic Use
- Sometimes used to help diagnose suspected benzodiazepine overdose in cases of unexplained decreased consciousness.
The Essential Benzodiazepine Overdose Antidote for Hospitals, Emergency Rooms, and Critical Care
Ensure rapid, targeted reversal of benzodiazepine sedation and overdose with Flumazenil Injection 1.0 mg/mL, 10 mL Multiple Dose Vials (10/Box) by Hikma Injectables—the gold-standard antidote trusted by hospitals, emergency departments, and critical care teams. Specially formulated for controlled, consistent IV dosing, Flumazenil provides fast reawakening and recovery from excessive benzodiazepine effects in both adult and pediatric patients.
Key Features & High-Impact Clinical Benefits
- Powerful Benzodiazepine Overdose Antidote: Clearly reverses CNS and respiratory depression from medications like midazolam, diazepam, lorazepam, alprazolam, and more.
- Rapid Action, Hospital-Grade Rescue: Onset within 1-2 minutes, making it crucial for code carts, procedural sedation recovery, and poison control readiness.
- Versatile, Multiple Dose Vials: Each 10 mL vial at 1.0 mg/mL ensures flexible, titratable IV dosing to meet each patient’s situation; box of 10 covers all resuscitation and acute care needs.
- Essential for All Critical Settings: Must-have medication for ED, ICU, operating rooms, surgical suites, anesthesia recovery, and EMS protocols.
- Trusted Hikma Injectables Quality: Produced to the highest standards for sterility, potency, and clinical reliability.
Top Uses & Emergency Indications
- Benzodiazepine overdose reversal (intentional or iatrogenic)
- Rapid arousal from procedural sedation or general anesthesia
- Overdose reversal in adults & pediatrics
- ICU and hospital drug toxicity management
- Poison control & acute care protocols
- Crash cart and code blue drug box essential
Why Choose Flumazenil by Hikma Injectables?
- Immediate patient rescue from benzodiazepine overdose
- Reduces need for invasive airway or ventilator support
- Flexible multi-dose vial for titration & redosing
- Critical addition to every hospital, surgical suite, ICU, and EMS agency
- Trusted by top medical professionals and pharmacy teams internationally
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Directions for Use
- Route: Intravenous (IV) administration only, as per hospital or poison control protocol.
- Adult dosing: Initial 0.2 mg IV over 15 seconds; repeat 0.2 mg every minute as needed to max 1 mg for initial reversal. May titrate further as clinically indicated.
- Pediatric dosing: 0.01 mg/kg IV over 15 seconds, repeat if necessary. Maximum 0.05 mg/kg or 1 mg total.
- Monitor for return of sedation or toxicity; may require redosing due to shorter half-life than some benzodiazepines.
Continuous cardiac and respiratory monitoring recommended during and after administration. Only for professional/clinical setting use.
Possible Side Effects
Common:
- Nausea, vomiting
- Dizziness, agitation, headache
- Flushing or injection site pain
Serious (Seek Immediate Help):
- Seizures, especially in chronic benzodiazepine or mixed overdose
- Arrhythmias or cardiac events
- Acute withdrawal symptoms (agitation, confusion, anxiety)
- Hypersensitivity reactions (rare)
Precautions
- Contraindicated in patients with cyclic antidepressant overdose or those at risk for seizures.
- Use extreme caution in benzodiazepine-dependent patients (may precipitate withdrawal, seizures).
- Not a substitute for airway or respiratory support if needed.
- Hospital and professional use only—do not use outside of a medical facility.
Stay prepared for any sedation emergency—choose Flumazenil Injection Antidote 1.0 mg/mL, 10 mL Multiple Dose Vials (10/Box) by Hikma Injectables. The premier, hospital-grade benzodiazepine reversal agent for lifesaving results in EDs, ICUs, surgery, anesthesia recovery, and EMS everywhere.
