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Piperacillin and Tazobactam Injection 2.25 gram Powder Vials by Apotex Corp
Piperacillin and Tazobactam Injection 2.25 gram Powder Vials by Apotex Corp

Piperacillin and Tazobactam Injection 2.25 gram Powder Vials 10 mL x 10/Box (RX)

by Apotex Corporation
Year End Sale 30%
$ 89.95
$ 63.00
SKU 60505-6156-04
*Mountainside Medical does not fill personal prescriptions Medical Professional License Required to Unlock Account

How to Order:

✔ Send an email request to: sales@mountainside-medical.com

You will receive instructions on how to create an account along with Rx Ordering Details.

(Note: Acceptable licenses must have Prescriptive Authority in the license issuing state.)

Piperacillin and tazobactam is a potent antibiotic combination administered intravenously to treat moderate to severe bacterial infections. It is available under the brand name Zosyn, among others.

Piperacillin and Tazobactam for Injection is a combination antibiotic used to treat a variety of bacterial infections. Piperacillin is a penicillin antibiotic that works by killing bacteria, and Tazobactam is a beta-lactamase inhibitor that helps prevent certain bacteria from becoming resistant to the effects of Piperacillin.

Piperacillin and Tazobactam for Injection, provided by Apotex Corporation, is a potent antibacterial treatment designed to combat a wide range of infections. This combination medication is delivered in powder form, contained in 2.25 g vials (10 mL), with each box containing ten vials. The product effectively targets infections caused by susceptible strains of bacteria, offering reliable and comprehensive treatment.

Indications and Usage: This combination is used primarily for the treatment of moderate to severe infections, including:

  • Intra-abdominal infections
  • Skin and soft tissue infections
  • Respiratory tract infections
  • Urinary tract infections

Dosage: The typical dosage varies depending on the severity of the infection, patient weight, and renal function. It is administered via intravenous infusion. Healthcare professionals should refer to specific dosing guidelines to ensure safe and effective use.

CDC Guidelines: According to the CDC, antibiotic stewardship is crucial. Prescribing Piperacillin and Tazobactam should be based on susceptibility patterns and clinical judgment. It is essential to reassess the need for continued use as culture results become available.

Details and Features:

  • Strength: 2.25 g per vial
  • Contents: Each vial contains Piperacillin sodium equivalent to 2 g of Piperacillin and Tazobactam sodium equivalent to 0.25 g of Tazobactam.
  • Format: Powder for reconstitution
  • Packaging: 10 vials per box

Mechanism of Action: Piperacillin is a broad-spectrum, beta-lactam antibiotic that inhibits bacterial cell wall synthesis. Tazobactam, a beta-lactamase inhibitor, prevents the degradation of Piperacillin by beta-lactamase enzymes, enhancing its effectiveness against resistant bacteria.

Directions:

  1. Reconstitute the powder with a compatible diluent as indicated in the prescribing information.
  2. Administer intravenously over a period of 30 minutes.
  3. Ensure compatibility with other IV medications and solutions.

Warnings:

  • Hypersensitivity Reactions: Patients with a history of allergic reactions to penicillins or cephalosporins may be at increased risk.
  • Renal Impairment: Dosage adjustments may be necessary.
  • Superinfection: Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.
  • Drug Interactions: Monitor for interactions with anticoagulants and other medications metabolized by the liver.

Side Effects:

  • Gastrointestinal disturbances (nausea, diarrhea)
  • Rash or allergic reactions
  • Electrolyte imbalances
  • Thrombocytopenia or neutropenia

Consultation with Healthcare Professionals: Always seek the advice of a healthcare provider for diagnosis and treatment options. The details provided herein do not substitute professional medical guidance.

Piperacillin and Tazobactam Injection 2.25 gram Powder Vials 10 mL x 10/Box (RX)
Piperacillin and Tazobactam Injection 2.25 gram Powder Vials 10 mL x 10/Box (RX)
$ 89.95 $ 63.00
🔒 Medical License Required
Piperacillin and Tazobactam Injection – Frequently Asked Questions (FAQs)
  • What is Piperacillin and Tazobactam Injection used for?

    This combination antibiotic is used to treat a variety of serious bacterial infections including pneumonia, intra-abdominal infections, skin and soft tissue infections, urinary tract infections, and sepsis, particularly those caused by susceptible Gram-positive and Gram-negative organisms (including Pseudomonas aeruginosa).

  • How does Piperacillin-Tazobactam work?

    Piperacillin is a broad-spectrum penicillin antibiotic that kills bacteria. Tazobactam is a beta-lactamase inhibitor, which protects piperacillin from being broken down by certain types of bacterial enzymes, making the drug more effective.

  • How is this medicine administered?

    It is given as an intravenous (IV) infusion in a hospital or healthcare setting by trained professionals. Dosages are based on the type and severity of infection, kidney function, and patient weight/age.

  • What are the most common side effects?

    The most common side effects are diarrhea, nausea, vomiting, rash, constipation, headache, and infusion site reactions. Serious but rare effects include allergic reactions, low potassium, blood count changes, and C. difficile-associated diarrhea.

  • Can Piperacillin-Tazobactam cause allergic reactions?

    Yes. Allergic reactions can range from rash and itching to serious reactions like anaphylaxis. People with a penicillin allergy should not receive this drug.

  • Can this medication be used in children?

    Yes, but dosages will be adjusted for weight and kidney function. Pediatric use should be closely monitored by a healthcare provider.

  • Are there any drug interactions?

    Yes. Piperacillin/Tazobactam can interact with certain antibiotics (aminoglycosides), methotrexate, anticoagulants, and other medications. Always inform your healthcare provider of all medicines you’re taking.

  • Is kidney function monitored during treatment?

    Yes. Piperacillin/Tazobactam is excreted by the kidneys, so kidney function is monitored and dosing may be adjusted in patients with impaired kidney function.

  • Can Piperacillin and Tazobactam Injection be used during pregnancy or breastfeeding?

    Use in pregnancy should only be if clearly needed and prescribed. It is generally considered safe during breastfeeding, but discuss risks and benefits with your provider.

  • How long does the treatment last?

    The duration of therapy depends on the type and severity of infection, typically ranging from 7–14 days or as directed by your doctor.

  • What should I do if I miss a dose?

    If administered in the hospital, your care team will manage the dosing schedule. If you're at home and miss a dose, contact your healthcare provider immediately.

  • Does it cover MRSA?

    No, Piperacillin-Tazobactam does not cover MRSA (methicillin-resistant Staphylococcus aureus); other antibiotics are needed for MRSA.

  • What should I tell my doctor before starting this medicine?

    Inform them about all allergies (especially to penicillins/cephalosporins), current medications, history of kidney disease, seizure disorder, pregnancy, or breastfeeding status

  • Can it cause C. difficile infection?

    Yes. As with all broad-spectrum antibiotics, this medicine can increase the risk for Clostridioides difficile (C. diff) infection and antibiotic-associated diarrhea.

  • How is Piperacillin and Tazobactam stored before use?

    Unmixed vials should be stored as directed—usually at room temperature in a dry place. After reconstitution (mixing with IV fluid), use promptly or follow your pharmacy’s guidelines.

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