Hydroquinone Cream 4% Skin Bleaching Cream (Rx)

What it is used for

• Treatment of hyperpigmented conditions such as:
  • Melasma/chloasma
  • Post‑inflammatory hyperpigmentation (acne scars, trauma)
  • Solar/sun lentigines (age spots)
• Lightening of localized dark patches to improve cosmetic appearance
• Often used as part of a dermatologist‑supervised regimen (may be combined with sunscreen, retinoids, or topical corticosteroids per clinical guidance)

How it works (brief) Hydroquinone inhibits tyrosinase, an enzyme required for melanin synthesis, thereby reducing pigment production and allowing existing pigment to fade over time.

Details and features

• Active ingredient: Hydroquinone 4% (topical)
• Vehicle: cream base for easy application and distribution
• Tube: 1 oz (30 g) — single patient use, hygienic dispensing
• Compatible with standard dermatologic adjuncts when supervised by a clinician
• Suitable for targeted treatment of facial and body hyperpigmentation
• Store at room temperature, protect from light

Directions and administration

• Perform a patch test prior to widespread use: apply a small amount to an inconspicuous area (behind the ear or inside forearm) and observe for 24–48 hours for irritation or allergic reaction.
• Cleanse and dry the treatment area. Apply a thin film of cream to the affected area once or twice daily (follow prescriber instructions).
• Rub in gently and wash hands after application unless treating the hands.
• Use daily broad‑spectrum sunscreen (SPF 30 or higher) and sun‑protective measures while using hydroquinone and for several weeks after discontinuation.
• Avoid applying to irritated, broken, or eczematous skin. Do not apply to eyes, lips, mucous membranes, or genitalia.
• Reassess with your clinician after 8–12 weeks of therapy. Continue only under medical supervision.

Dosage and duration

• Typical regimen: apply a thin layer to affected areas once or twice daily as directed by your healthcare provider.
• Treatment effect: visible improvement may be seen within 4–8 weeks; maximal results often require 8–12 weeks.
• Limit continuous use: to reduce risk of adverse effects (including exogenous ochronosis), many clinicians recommend limiting continuous use to 3–4 months and then reassessing. Intermittent maintenance or supervised combination therapies are commonly used.
• Pediatric use: safety and dosing in children should follow a healthcare provider’s recommendation.

Allergies and contraindications

• Contraindicated in patients with known hypersensitivity to hydroquinone or any component of the cream.
• Avoid use if you have a history of allergic contact dermatitis to topical depigmenting agents or cream excipients.
• Use caution and consult your clinician if you have sensitive skin or a history of atopy.

Drug and topical interactions

• Benzoyl peroxide: can oxidize hydroquinone and may reduce effectiveness or discolor the product; avoid concurrent use unless supervised and guided by a clinician.
• Topical retinoids (e.g., tretinoin) and mild topical corticosteroids are commonly co‑prescribed to enhance penetration and results but can increase irritation — combination therapy should be directed by a prescriber.
• Other topical irritants (strong alpha‑ or beta‑hydroxy acids, physical exfoliants) can increase risk of irritation; avoid combined use unless recommended.
• Systemic drug interactions are unlikely due to minimal systemic absorption; nevertheless, report all current medications to your prescriber.

Side effects and adverse reactions Common/local and usually mild:

• Temporary redness, stinging, burning, dryness or irritation at the site of application
• Mild peeling or flaking as pigment fades

Less common/serious:

• Allergic contact dermatitis (rash, swelling, itching) — discontinue and seek medical care if suspected
• Hypopigmentation (over‑lightening) of treated or surrounding skin
• Paradoxical hyperpigmentation in rare cases
• Exogenous ochronosis: a rare but serious bluish‑black discoloration of treated skin associated with prolonged or excessive use of hydroquinone, more commonly reported with higher concentrations and in darker skin tones
• Photosensitivity: increased susceptibility to UV damage; strict photoprotection required

Warnings and precautions

• Risk of exogenous ochronosis: avoid prolonged continuous use without dermatologic supervision; monitor closely, especially in darker phototypes.
• Sun exposure: use broad‑spectrum sunscreen and protective clothing during treatment because UV exposure can reduce efficacy and increase irritation.
• Pregnancy and lactation: limited human data — consult your healthcare provider. Many clinicians avoid routine use during pregnancy; discuss risks/benefits.
• Not for use on mucous membranes, genitals, or broken skin.
• If severe irritation, blistering, swelling, or signs of allergic reaction occur, discontinue use immediately and seek medical attention.
• Keep out of reach of children.

Storage and handling

• Store at controlled room temperature (typically 20–25 °C / 68–77 °F) away from excessive heat and light. Keep tube tightly closed.
• Discard product if it changes color (darkens) or odor, which may indicate oxidation or degradation.

Regulatory and clinical notes

• Hydroquinone 4% is frequently prescribed and used under dermatologic supervision; follow your clinician’s instructions regarding combinations, duration, and follow‑up.
• For persistent pigmentation or lack of improvement after an appropriate trial, consult a dermatologist for alternative or adjunctive treatments (chemical peels, laser therapy, kojic acid, azelaic acid, tranexamic acid, etc.).

Hydroquinone 4% Cream by Westminster Pharmaceuticals is an effective topical therapy for targeted reduction of hyperpigmentation when used according to professional guidance. It offers a potent tyrosinase‑inhibiting formulation in a convenient 1 oz tube for localized treatment. To maximize benefits and minimize risks (irritation, hypopigmentation, or rare ochronosis), use under a healthcare provider’s direction, limit continuous duration as recommended, protect treated skin from sun exposure, and report any adverse reactions promptly. Consult your dermatologist or prescriber for individualized dosing, combination therapy options, and monitoring.