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Ibuprofen Liquid 100 mg / 5 mL Oral Suspension 473 mL

RDC10159911

$ 32.50 $ 49.95

Ibuprofen Liquid Oral Suspension 473 mL is used as an analgesic for relief of mild to moderate muscular pain, post-immunisation pyrexia, symptomatic relief of headache, earache, dental pain and backache. It can also be used in minor injuries such as sprains and strains.

The active ingredient in Ibuprofen Oral Suspension USP, 100 mg/5 mL is  ibuprofen,  which  is  a  member  of  the  propionic  acid  group  of  nonsteroidal  anti-inflammatory  drugs  (NSAIDs).  Ibuprofen  is  a  racemic  mixture  of  [+] S-  and  [-] R-enantiomers.  It  is  a  white  to  
off-white crystalline powder, with a melting point of 74º to 77ºC. It  is  practically  insoluble  in  water  (<0.1  mg/mL),  but  readily  soluble   in   organic   solvents   such   as   ethanol   and   acetone.   Ibuprofen has a pKa of 4.43±0.03 and an n-octanol/water
partition coefficient  of  11.7  at  pH  7.4.  The  chemical  name  for  ibuprofen  is  (±)-2-(p-isobutylphenyl)  propionic  acid.  The  molecular  weight  of  
ibuprofen is 206.28. Its molecular formula is C13H1802.

Ibuprofen is a nonsteroidal anti-inflammatory drug  (NSAID)  that  possesses  anti-inflammatory,  analgesic  and  antipyretic activity. Its mode of action, like that of other NSAIDs, is not completely understood, but may be related to prostaglandin
synthetase  inhibition.  After  absorption  of  the  racemic  ibuprofen, the [-]R-enantiomer undergoes interconversion to the [+]S-form. The  biological  activities  of  ibuprofen  are  associated  with  the  [+]S-enantiomer.Pharmacokinetics -
Ibuprofen is a racemic mixture of [-]R- and {+]S-isomers.
In  vivo and  in  vitro studies  indicate  that  the  [+]S-isomer  is  responsible  for  clinical  activity.  The  [-]R-form,  while  thought  to  be  pharmacologically  inactive,  is  slowly  and  incompletely  (~60%)  interconverted  into  the  active  [+]S  species  
in  adults.  The degree  of  interconversion  in  children  is  unknown,  but  is  thought  to  be  similar.  The  [-]R-isomer  serves  as  a  circulating  reservoir  to  maintain  levels  of  active  drug.  Ibuprofen  is  well  absorbed  orally,  with  less  than  1%  being  excreted  in  the  urine unchanged. It has a biphasic elimination time curve with a
plasma  half-life  of  approximately  2  hours.  Studies  in  febrile children  have  established  the  dose-proportionality  of  5  and  10  mg/kg doses of ibuprofen. Studies in adults have established the dose-proportionality  of  ibuprofen  as  a  single  oral  dose  from  50  to 600 mg for total drug and up to 1200 mg for free drug.

 

Buy Ibuprofen Liquid 100 mg / 5 mL Oral Suspension 473 mL online at Mountainside Medical Equipment.

Ibuprofen Liquid 100 mg / 5 mL Oral Suspension 473 mL Tags

ibuprofen | Ibuprofen Liquid | Liquid Pain Reliever | Relieve Pain |

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