Methotrexate Injection 250 mg/mL Vial 10 mL (RX)

Methotrexate Injection is a trusted treatment for cancer, rheumatoid arthritis, and psoriasis. Methotrexate Injection delivers fast relief, reduces inflammation, and slows disease progression. Choose Methotrexate Injection for effective care. Methotrexate Injection supports your health with proven results. Related keywords: chemotherapy, rheumatoid arthritis treatment, psoriasis therapy, cancer medication.

Methotrexate for Injection by Fresenius Kabi is a sterile, preservative-free solution formulated at 250 mg/mL, supplied in a 10 mL single-use vial. This high-potency antineoplastic agent is designed for intravenous (IV), intramuscular (IM), intra-arterial (IA), or intrathecal (IT) administration by experienced healthcare professionals. Methotrexate is widely trusted for its role in the treatment of various cancers and certain autoimmune diseases.

What It Is Used For

Methotrexate for Injection is indicated for the management of:

• Certain neoplastic diseases, including acute lymphoblastic leukemia (ALL), breast cancer, lung cancer, head and neck cancer, and osteosarcoma
• Severe, recalcitrant, disabling psoriasis unresponsive to other therapies
• Rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) when response to other treatments has been inadequate
• Other off-label autoimmune or inflammatory conditions as determined by your doctor

Dosage & CDC Guidelines

Dosage

• Oncologic Uses: Doses typically range from 10 mg/m² to 30 mg/m² weekly, or as continuous infusion, depending on the disease protocol.
• Psoriasis & Rheumatoid Arthritis: Lower doses, generally 7.5 mg to 25 mg total per week, adjusted according to clinical response.
• Always individualize dosage based on indication, patient status, and physician guidance.

CDC Guidelines

• The Centers for Disease Control and Prevention (CDC) and other authorities recommend methotrexate be administered only by healthcare professionals familiar with its uses, toxicities, and safety precautions.
• Rigorous monitoring (CBC, liver, and renal function tests) is required before and during therapy.

Details & Features

• Concentration: 250 mg/mL
• Volume: 10 mL single-use vial
• Manufacturer: Fresenius Kabi, renowned for its pharmaceutical quality and reliability
• Sterile, preservative-free formulation
• Easy-to-read labeling and tamper-evident packaging
• Suitable for multiple routes of administration (IV, IM, IT, IA)

Mechanism of Action

Methotrexate is an antimetabolite and antifolate drug. It inhibits dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. This blocks DNA synthesis, repair, and cellular replication, primarily targeting rapidly dividing cells, such as cancerous, psoriatic, and immune cells.

Directions for Use

1. To be administered only by qualified healthcare providers in a clinical setting.
2. Inspect vial, ensuring solution is clear and free from particles.
3. Dosage and route are prescribed based on patient’s condition and treatment protocol.
4. Use appropriate aseptic technique; avoid mixing with incompatible solutions.
5. Dispose of any unused portion; single-use only.

ALWAYS refer to the full prescribing information for detailed instructions.

Warnings

• Methotrexate can cause serious, life-threatening side effects: liver toxicity, lung disease, bone marrow suppression, infections, and gastrointestinal toxicity.
• Not for use in pregnancy; causes fetal death or congenital anomalies. Women of childbearing age should use effective contraception during and after therapy.
• Use with caution in patients with liver, renal, or pre-existing bone marrow impairment.
• May increase the risk of infections. Monitor closely.
• Not recommended for routine use in children unless specialized expertise is available.

Side Effects

Common side effects include:

• Nausea, vomiting, diarrhea
• Stomatitis (mouth sores)
• Fatigue
• Dizziness or headache

Serious side effects may involve:

• Severe bone marrow suppression (anemia, bleeding, infections)
• Hepatotoxicity (elevated liver enzymes, liver failure)
• Pulmonary toxicity (pneumonitis)
• Renal impairment
• Photosensitivity or rash
• Allergic reactions

If any severe or unusual symptoms occur, seek immediate medical attention.

Consult your healthcare provider for full prescribing information and before starting Methotrexate for Injection.