Regadenoson is an intravenous medication used as a pharmacologic stress agent for myocardial perfusion imaging (MPI) in patients who cannot undergo adequate exercise. As a coronary vasodilator, it increases blood flow to the heart, mimicking the effects of physical exercise for diagnostic evaluation.
Use:
Regadenoson is utilized during stress tests to help diagnose heart conditions by enhancing blood flow to the heart, allowing clinicians to detect coronary artery disease. It acts more rapidly and selectively compared to other stress agents such as adenosine, making it a preferred choice in many stress imaging procedures.
Regadenoson Injection 0.4 mg/5 mL, Prefilled Syringe, by Eugia US, is a sterile, single-use, prefilled syringe indicated for use as a pharmacologic stress agent in radionuclide myocardial perfusion imaging (MPI) studies. Each ready-to-administer 5 mL syringe delivers exactly 0.8 mg regadenoson for rapid, reliable preparation and administration, helping healthcare professionals streamline cardiac stress testing with consistent results and robust safety.
What It Is Used For
Regadenoson Injection is FDA-approved and utilized to:
- Induce coronary vasodilation in patients unable to undergo adequate exercise stress during myocardial perfusion imaging (MPI).
- Help diagnose coronary artery disease (CAD) by simulating the effects of exercise on the heart using radionuclide tracers.
Regadenoson is chosen especially for patients with respiratory risks, as it has lower bronchoconstrictive effects than other stress agents.
Details and Features
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Ready-to-use prefilled syringe: Simplifies dosing—no dilution or preparation required.
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Dose strength: 0.4 mg regadenoson in 5 mL solution, single-dose
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Sterile, preservative-free: Ensures safety and optimal patient care
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Rapid onset, short duration: Fast acting (starts in ~1-2 minutes, lasts ~6 minutes)
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Broad compatibility: Can be used in adults regardless of body weight or sex
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Latex-free materials: Safe for latex-sensitive patients
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Manufactured by Eugia US: Trusted quality for hospital and clinical use
Dosage
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Recommended Dose: 0.4 mg regadenoson as a rapid IV injection (administered over 10 seconds)
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Followed immediately by: 5 mL saline flush
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Single-dose only: Do not reuse or split the contents
CDC Guidelines
While the CDC does not issue specific regadenoson administration guidance, general CDC best practices for IV injection apply:
- Strictly follow aseptic technique
- Use a new sterile syringe and needle for each patient; never share prefilled syringes
- Monitor patient vital signs throughout administration and post-procedure
- Be prepared for immediate management of potential adverse reactions, including anaphylaxis.
Mechanism of Action
Regadenoson is a selective A2A adenosine receptor agonist. By activating these receptors in coronary artery smooth muscle, regadenoson causes coronary vasodilation, increasing coronary blood flow. This simulates the increased blood flow induced by exercise, helping identify areas of reduced perfusion during myocardial perfusion imaging.
Directions
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Preparation:
- Confirm the integrity of the prefilled syringe and check expiration date.
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Administration:
- Administer the entire 5 mL dose (0.4 mg) IV as a rapid injection (over 10 seconds)
- Immediately follow with a 5 mL saline flush
- Inject the radionuclide tracer 10–20 seconds after the saline flush
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Monitoring:
- Observe the patient for signs of hypotension, arrhythmia, bronchospasm, or hypersensitivity reactions
- Ensure emergency resuscitation equipment and medications are readily available.
Warnings
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Cardiac Risk: May cause serious or fatal cardiac events, particularly in patients with unstable angina or cardiovascular instability.
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Contraindications: Do not use in patients with 2nd or 3rd degree AV block, sinus node dysfunction (unless pacemaker present), or hypersensitivity to regadenoson.
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Bronchospasm Risk: Use cautiously in patients with asthma or COPD, though regadenoson is less likely than other agents to induce bronchospasm.
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Seizures: Use caution in patients with a history of seizures; may lower seizure threshold.
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Pregnancy: Use only if clearly needed and benefits outweigh potential risks.
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Not for repeated use or infusion. Single-use only.
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Emergency Preparedness: Emergency medications and airway support should be immediately available.
Side Effects
Common Side Effects:
- Flushing
- Chest discomfort or shortness of breath
- Headache
- Dizziness
- Abdominal discomfort or nausea
Serious/Rare Adverse Effects:
- Severe hypotension or hypertension
- Cardiac arrhythmias (e.g., AV block, supraventricular tachycardia)
- Seizures
- Bronchospasm or respiratory distress
- Allergic/anaphylactic reactions
If severe side effects occur, discontinue use and provide necessary emergency care immediately.
Choose Regadenoson Injection 0.4 mg/5 mL Prefilled Syringe by Eugia US for fast, effective, and reliable pharmacologic stress testing. Trusted for precision, safety, and ease-of-use in advanced cardiac care settings.
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