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Filters
- anesthetic spray (6)
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Skin Refrigerant Sprays
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Sale 37%
Gebauer's Ethyl Chloride Skin Refrigerant Spray Mist Topical Anesthetic
4.9 (29) 4.9 out of 5 stars, 29 reviews37% OFFOriginal price $ 78.95Current price $ 49.95 -
Sale 25%
Gebauer's Pain Ease Aerosol Mist Spray Topical Anesthetic 118 mL
4.4 (27) 4.4 out of 5 stars, 27 reviews25% OFFOriginal price $ 64.95Current price $ 49.00 -
Sale 25%
Pain Ease Cold Topical Skin Refrigerant Spray 4 oz by Medi-First
5.0 (3) 5.0 out of 5 stars, 3 reviews25% OFFOriginal price $ 9.95Current price $ 7.50 -
Sale 23%
Ethyl Chloride Spray (Cold Spray for Skin) by Gebauer, Jet-Stream 3.5 oz
4.4 (9) 4.4 out of 5 stars, 9 reviews23% OFFOriginal price $ 75.00Current price $ 58.00 -
Sale 45%
Gebauer Pain Ease Topical Anesthetic Skin Refrigerant Spray Medium Stream 1 oz
3.0 (3) 3.0 out of 5 stars, 3 reviews45% OFFOriginal price $ 39.95Current price $ 22.00 -
Sale 34%
CryoDose TA Anesthetic Mist Spray 115 mL Size
5.0 (6) 5.0 out of 5 stars, 6 reviews34% OFFOriginal price $ 69.95Current price $ 45.95 -
Sale 41%
Americaine Benzocaine Topical Anesthetic Spray 2 oz
5.0 (1) 5.0 out of 5 stars, 1 review41% OFFOriginal price $ 11.85Current price $ 6.95 -
Sale 34%
CryoDose TA Topical Anesthetic Medium Stream Spray 115 mL Size
5.0 (2) 5.0 out of 5 stars, 2 reviews34% OFFOriginal price $ 67.95Current price $ 44.85 -
Sale 33%
HurriCaine Topical Anesthetic Pain Spray Kit with 200 Extension tubes
5.0 (1) 5.0 out of 5 stars, 1 review33% OFFOriginal price $ 78.95Current price $ 52.95 -
Sale 7%
🔒 Medical License Required
Cryosurgery Kit - Verruca Freeze 50 Freeze Kit (VFK50)
7% OFFOriginal price $ 429.95Current price $ 399.00 -
Sale 11%
Gebauer's Spray and Stretch Topical Anesthetic Vapocoolant Spray
11% OFFOriginal price $ 64.95Current price $ 57.90 -
Sale 7%
CryoDose Reusable Cryosurgical Treatment Kit with 162 mL Canister, 6 Cones, 20 Arrow Buds and 20 Round Buds
7% OFFOriginal price $ 429.95Current price $ 398.00 -
Sale 19%
CryoDose Cryotherapy Applicator Arrow Buds 30/Pack
5.0 (1) 5.0 out of 5 stars, 1 review19% OFFOriginal price $ 58.79Current price $ 47.85 -
Sale 29%
🔒 Medical License Required
Cetacaine Topical Anesthetic Spray Dental Anesthesia Oral Numbing Spray 5 gm Bottle (Rx)
29% OFFOriginal price $ 139.95Current price $ 99.95 -
Sale 20%
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Sale 36%
Cryosurgery Kit Cryo Professional System with (2) 80mL Cryogen Canisters, (50) 5mm Applicators, 6/Case
36% OFFOriginal price $ 459.95Current price $ 295.00 -
This item is sold out
CryoDose TA Topical Anesthetic Mist Spray 35 mL Size
27% OFFOriginal price $ 29.95Current price $ 22.00 -
This item is sold out
Histofreezer CryoConcepts H Kit Portable Cryosurgical System
14% OFFOriginal price $ 399.95Current price $ 345.00 -
Sale 27%
CryoTherapy DE Treatment Kit with 30 Round Tips, 20 Arrow Tips
27% OFFOriginal price $ 549.95Current price $ 399.95 -
Sale 18%
Histofreezer Flex Cryosurgery Kit with 30 Buds and 40 Cones
18% OFFOriginal price $ 799.95Current price $ 659.00 -
This item is sold out
Instant Ice Topical Skin Refrigerant Spray by Gebauer 3.9 oz
36% OFFOriginal price $ 38.95Current price $ 24.95 -
Sale 14%
🔒 Medical License Required
Cryosurgery Verruca Freeze Kit with 5 CryoCones (3, 5, 7, 9, 12 mm) 30 CryoBuds (10 Small, 10 Med, 10 Large)
14% OFFOriginal price $ 579.95Current price $ 499.95
People Also Searched For
Skin refrigerant sprays – also known as cold sprays or vapocoolant sprays – are topical aerosol sprays that rapidly cool the surface of the skin. They typically contain a liquefied gas under pressure, which is released as a fine mist onto the skin. Upon contact, this liquid quickly evaporates, absorbing heat from the skin and dropping the skin’s temperature dramatically. These sprays are designed to be safe for direct use on intact skin and are commonly used for first aid, sports injuries, and minor medical procedures to provide quick pain relief through cooling.
How Does Skin Refrigerant Spray Work?
Skin refrigerant sprays work on the principle of evaporative cooling. When the liquefied gas in the spray comes out and hits the warmer skin, it rapidly turns from liquid to gas, a process that takes away heat from the skin (much like how alcohol feels cool as it evaporates off the skin). This fast drop in skin temperature (often down to about 10-15°C in the area applied) causes a few useful effects:
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Local Anesthetic Effect (Pain Relief): The sudden cold numbs the superficial nerve endings. In extremely cold conditions, nerve fibers transmit pain signals more slowly or not at all. Thus, by “freezing” the skin surface for a short time, these sprays act as temporary topical anesthetics, making pain sensation less intense. People often feel immediate relief because the cold dulls the nerves that send pain signals to the brain.
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Reduction of Swelling and Inflammation: Cold causes blood vessels in the skin (and just under it) to constrict (a process called vasoconstriction). By narrowing the blood vessels, the spray can help reduce blood flow to the area, which in turn minimizes bruising or swelling (edema) from an injury. That’s why cold therapy is generally recommended for acute injuries – these sprays just provide a very rapid, localized way to apply cold.
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Fast and Short-Acting: One advantage of vapocoolant sprays is how quickly they act. They start cooling (and thus numbing) within seconds of application. The pain relief is almost immediate, which is why they’re popular right before a painful procedure (like a needle stick) or immediately after an injury. However, the effect is short-lived, typically lasting only a few minutes – often enough time to perform a quick procedure or initial first aid. For example, a sports cold spray might provide relief that lasts up to 10–15 minutes before the area returns to normal temperature.
It’s important to note that skin refrigerant sprays only affect the surface and near-surface of the skin. They do not cool deep tissues significantly, so their pain relief and anti-swelling effects are mostly superficial and temporary.



















