Diphenhydramine Hydrochloride API Powder USP is the pharmaceutical-grade, high-purity form of diphenhydramine hydrochloride (the active ingredient in Benadryl and other allergy medicines), presented as a powder that meets the quality and purity specifications of the United States Pharmacopeia (USP). It serves as the Active Pharmaceutical Ingredient (API) in the manufacture of various medicinal products.
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Pharmaceutical-Grade Antihistamine for Custom Allergy, Sleep, and Topical Relief Compounding
What is Diphenhydramine Hydrochloride?
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Diphenhydramine hydrochloride is a first-generation antihistamine.
- It is commonly used to treat allergies, itching, hay fever, nausea, motion sickness, insomnia, and as a cough suppressant.
- It works by blocking the effects of histamine, a substance in the body that causes allergy symptoms.
Chemical Name: 2-(Diphenylmethoxy)-N,N-dimethylethylamine hydrochloride
Molecular Formula: C<sub>17</sub>H<sub>21</sub>NO · HCl
CAS Number: 147-24-0
Appearance: White, crystalline powder
Solubility: Freely soluble in water
Common Uses: API for allergy medications, sleep aids, anti-nausea formulations, topical anti-itch ointments, etc.
Standard: USP (meets all USP quality specifications)
Features & Health Benefits
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USP-Grade, High-Purity Diphenhydramine HCl: Rigorously batch-tested for identity, potency, and purity, ensuring consistency and safety in all compounding applications.
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Versatile Compounding Powerhouse: Create capsules, oral suspensions, syrups, rapid dissolve tablets, topical creams, gels, lotions, and suppositories tailored to specific patient needs.
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Allergy & Antihistamine Relief: The trusted active ingredient in BenadrylⓇ—controls symptoms of seasonal allergies, hay fever, urticaria, itching, and allergic reactions.
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Sleep Aid & Nighttime Soothing: Effectively compounded for use as a short-term sleeping aid in cases of occasional insomnia, per prescriber guidance.
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Topical Itch & Rash Solutions: Forms the backbone of custom anti-itch creams and gels for bug bites, minor skin irritations, eczema, and contact dermatitis.
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Pediatric, Adult, & Geriatric Customization: Precise dosing for age & need, from oral liquids for children to higher-potency formulas for adults and elderly patients.
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Medisca Quality Assurance: Trusted by expert pharmacists worldwide—cGMP-manufactured, batch-traceable, and USP-compliant.
Clinical & Compounding Applications
- Oral allergy relief: custom capsules, syrups, suspensions
- Sleep aid: compounded liquids, capsules, dissolvable tablets
- Itch/rash topical: creams, ointments, gels, lotions
- Allergic skin reactions: compounded suppositories and rectal forms
- Pediatric anti-allergy compounding and dose-titration
- Hospital, clinic, and at-home prescription use
Why Choose Diphenhydramine Hydrochloride API Powder USP
- Highest pharmaceutical-grade purity and safety
- Batch-to-batch reliability for professional compounding
- Multi-use versatility for allergy, skin, and sleep solutions
- Supports patient-centered dosing and custom medication formulas
- Widely trusted by compounding pharmacies, pediatricians, allergists, dermatologists, and sleep clinics
SDS Sheets for Diphenhydramine Hydrochloride, USP
Allergen BSE GMO Declaration
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Directions for Compounding & Use
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For Licensed Compounding Professionals Only: Not for direct consumer sale.
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Formulations: Capsule, syrup, suspension, topical cream/gel, lozenge, suppository, or per physician order.
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Dosing: Tailor to age, symptom, and indication—pediatric dosing typically 1–2 mg/kg; adult doses per condition, always per prescription.
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Storage: Store tightly sealed, away from moisture and light, at controlled room temperature as per USP and compounding best practices.
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Documentation: Maintain batch tracking, compounding logs, and prescription compliance per federal and state pharmacy laws.
Possible Side Effects (For Patient Counseling)
Common:
- Drowsiness or sedation
- Dry mouth, blurred vision
- Dizziness
- Mild stomach upset
Rare/Serious:
- Confusion (especially elderly)
- Rapid heartbeat or palpitations
- Allergic reaction (rash, swelling, trouble breathing)
- Urinary retention (watch in prostate disorders)
- Seizure (rare, overdose)
Use with caution in young children, elderly, or those with chronic medical conditions. Avoid combining with alcohol or other sedating drugs. Do not use for extended periods without medical supervision.
Precautions
- Professional compounding and prescription use only
- Avoid use in children under 2 years without provider order; monitor for paradoxical excitation in pediatric cases
- Screen for allergies to diphenhydramine or related antihistamines
- Provide patient instructions for safe, appropriate use; supply appropriate warning labels for sedative effects
- Comply with current USP <795> and pharmacy best practice guidelines
Deliver exceptional allergy, sleep, and topical relief solutions with Diphenhydramine Hydrochloride API Powder USP For Compounding by Medisca—the leading choice of compounding professionals and clinicians for precision, purity, and patient-centered care.
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