Estradiol Vaginal Cream 0.01%, Unscented 42.5 grams (Rx)

Estradiol Vaginal Cream 0.01% is a hormone replacement medication that is used to treat symptoms of menopause, such as vaginal dryness, itching, and pain during intercourse. It contains estradiol, which is a form of estrogen, and is applied directly to the vagina using an applicator. This cream helps to replenish estrogen levels in the body and restore vaginal tissue, improving symptoms and overall quality of life. It is typically used for a short period of time and should be used as directed by a healthcare provider.

Estradiol Vaginal Cream 0.01% contains the active ingredient estradiol, which is a synthetic form of the female hormone estrogen. It works by replacing the body's natural levels of estrogen that decline during menopause. This hormonal imbalance can cause symptoms such as vaginal dryness, irritation, and painful intercourse.
Estradiol helps to restore the natural balance of hormones in the vaginal area, which can improve symptoms related to menopause and vulvar and vaginal atrophy. The cream is applied directly to the vaginal tissues, where it is absorbed and helps to increase blood flow and decrease inflammation.
By replenishing estrogen levels, Estradiol Vaginal Cream 0.01% helps to improve the health and function of the vaginal tissues, reducing symptoms of vaginal atrophy. It also helps to maintain mucosal integrity and improve vaginal moisture, making intercourse less painful and more comfortable. Additionally, estrogen can also help to increase vaginal elasticity and improve symptoms of urinary tract problems.

Estradiol Vaginal Cream 0.01% works by increasing estrogen levels and restoring the natural hormonal balance in the vagina to alleviate symptoms of menopause and vaginal atrophy.

Targeted Relief From Vaginal Dryness & Atrophy—Gentle, Hormone Replacement Therapy You Can Trust

Estradiol Vaginal Cream 0.01% Unscented by Encube Ethicals is a clinically proven hormone therapy designed to alleviate the uncomfortable symptoms of vaginal atrophy and dryness associated with menopause and hormonal changes. Delivering precise, low-dose estradiol directly where you need it, this unscented formula soothes irritation and restores intimate comfort—so you can feel like yourself again.

Uses

• Relieves vaginal dryness, itching, and burning due to menopause, chemotherapy, or surgical removal of ovaries.
• Treats vulvovaginal atrophy (thinning and inflammation of the vaginal wall) linked to estrogen deficiency.
• Reduces painful intercourse (dyspareunia) caused by menopausal symptoms.
• Helps restore healthy vaginal tissue for improved overall intimate wellness.

Benefits

• Low-Dose, Targeted Hormone Therapy: Delivers estrogen directly to vaginal tissues for maximum effectiveness and minimal systemic absorption.
• Fast-Acting Relief: Noticeable improvement in comfort, moisture, and tissue health in as little as a few weeks.
• Unscented & Gentle: Free from fragrances, dyes, and harsh additives for sensitive skin and intimate areas.
• Easy-To-Use Applicator: Ensures accurate dosing and convenient at-home use.
• Doctor Recommended: A proven and trusted solution for postmenopausal and surgically induced hormonal symptoms.

Specifications

• Product Name: Estradiol Vaginal Cream 0.01% Unscented
• Strength: 0.01% (0.1 mg estradiol per gram of cream)
• Net Weight: 42.5 grams per tube
• NDC: 21922-0085-06
• Manufacturer: Encube Ethicals
• Dosage Form: Topical vaginal cream (unscented)
• Applicator: Included for precise administration

Directions for Use

1. Wash hands thoroughly before and after application.
2. Using the applicator: Fill with the prescribed dose of cream as directed by your healthcare provider.
3. Gently insert the applicator into the vagina and press the plunger to release the cream.
4. Apply once daily for the initial weeks (as directed), then reduce to 1–3 times per week for maintenance, or as prescribed by your doctor.
5. Clean the applicator after each use with mild soap and warm water.

Always follow your healthcare provider’s instructions for dosage and application frequency.

Side Effects

Most women tolerate Estradiol Vaginal Cream well. Possible side effects may include:

• Local irritation or itching
• Vaginal discharge or spotting
• Headache or breast tenderness
• Nausea or abdominal discomfort

Rare but serious side effects:

• Blood clots, stroke, or heart attack (especially in women with a history of these conditions)
• Unusual vaginal bleeding
• Signs of allergic reaction (rash, swelling, difficulty breathing)

If you experience new or worsening symptoms, stop use and consult your healthcare provider immediately.

Warnings

• Prescription use only. Not for use without a doctor’s supervision.
• Do not use if you have a history of blood clots, breast cancer, or estrogen-dependent tumors unless specifically directed by your healthcare provider.
• Inform your doctor about your medical history before starting estradiol therapy.
• Regular check-ups, including pelvic exams and breast screenings, are strongly recommended during use.
• Not for use in children.
• For vaginal use only—do not ingest or use on other body parts.
• Discontinue use immediately if you experience unusual vaginal bleeding, chest pain, shortness of breath, or vision changes.
• Store at room temperature away from moisture and heat.
• Keep out of reach of children and pets.

Rediscover intimate comfort and confidence with Estradiol Vaginal Cream 0.01% Unscented by Encube Ethicals (NDC 21922-0085-06)—the clinically trusted solution for menopause-related vaginal symptoms. Order now for gentle, effective relief and renewed well-being!