Follistim AQ Cartridge (Follitropin Beta Injection) is a highly purified form of human follicle-stimulating hormone (FSH). This hormone is synthetically produced using recombinant DNA technology, making it a form of recombinant human FSH (r-hFSH). It is designed for subcutaneous administration.
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Potency: 300 International Units (IU) of Follitropin Beta per cartridge.
Indications:
Follistim AQ Cartridge is commonly used in fertility treatments. Its primary indications include:
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Controlled Ovarian Hyperstimulation (COH): Utilized in women undergoing assisted reproductive technologies (ART) such as in vitro fertilization (IVF) to stimulate the development of multiple follicles.
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Ovulation Induction: For anovulatory women where the underlying cause is functional but not anatomical or otherwise treatable.
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Hypogonadotropic Hypogonadism: In men, it is used to stimulate spermatogenesis.
Mechanism of Action:
Follitropin Beta mimics the natural FSH released by the pituitary gland, playing a crucial role in the regulation of the reproductive process. It promotes the growth and development of ovarian follicles in women and stimulates spermatogenesis in men.
Dosage and Administration:
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Dosage: The specific dosage varies based on the indication, response, and treatment protocol established by a fertility specialist. For COH and ovulation induction, the dosage is individualized and may begin with 75 IU per day, adjusted based on response.
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Administration: The Follistim AQ Cartridge is intended for subcutaneous injections and can be self-administered following proper training. It is typically injected into the abdomen or thigh.
Storage:
- Store refrigerated at 2°C to 8°C (36°F to 46°F).
- After opening, the cartridge may be kept at room temperature (up to 25°C or 77°F) for up to 28 days.
- Protect from light and do not freeze.
Precautions:
- Use under the supervision of a specialist in fertility treatment.
- Caution in patients with active or recent medical history of thromboembolic events.
- Regular monitoring with ultrasound and/or estradiol levels is recommended to prevent excessive ovarian response.
- Increased risk of multiple pregnancies or ovarian hyperstimulation syndrome (OHSS).
Side Effects:
Common side effects may include:
- Injection site reactions (pain, redness, swelling)
- Headache
- Abdominal pain or bloating
- Ovarian hyperstimulation syndrome
- Mood swings
Rare but severe side effects can include:
- Severe abdominal pain
- Rapid weight gain
- Shortness of breath
- Decreased urination
Contraindications:
- Hypersensitivity to Follitropin Beta or any component of the drug.
- Primary ovarian failure.
- Uncontrolled non-gonadal endocrinopathies (e.g., thyroid or adrenal disorders).
- Tumors of the hypothalamus or pituitary gland.
Pregnancy.
Follistim AQ Cartridge is a potent reproductive hormone therapy intended to support individuals undergoing fertility treatments. It must be used under close medical supervision to ensure efficacy and minimize potential risks. Always follow the dosage and administration instructions provided by your healthcare provider.
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