Glycopyrrolate 1 mg Tablets

Glycopyrrolate (glycopyrronium) is a prescription anticholinergic medication (muscarinic receptor antagonist) that reduces bodily secretions and slows gastrointestinal motility. Each white to off-white round tablet (debossed “MCR 117” on one side contains 1 mg of glycopyrrolate. Packaged by American Health Packaging, this offering includes 10 blister cards of 100 tablets each (1000 tablets total). Glycopyrrolate is the generic equivalent of Robinul® (oral) and works by blocking acetylcholine signals, thereby decreasing stomach acid and saliva production. The active ingredient glycopyrrolate is identical to glycopyrronium (International Nonproprietary Name).

Uses and Applications

Glycopyrrolate 1 mg is FDA-approved to ease symptoms of peptic ulcer disease (as adjunct therapy) by reducing gastric acid and spasms. It can help relieve burning, abdominal pain, and heartburn associated with ulcers. By slowing digestive secretions and motility, it is used under physician supervision for gastrointestinal spasms and related disorders. Off-label, glycopyrrolate is commonly used to control excessive salivation (drooling, sialorrhea) in neurologic conditions and to reduce excessive sweating (hyperhidrosis) or respiratory secretions when needed. For example, glycopyrrolate oral solution (Cuvposa®) is FDA-approved for severe drooling in children. In surgical settings, injectable glycopyrrolate is routinely given preoperatively to dry secretions (note: our product is oral tablets). Because of its antisecretory effects, glycopyrrolate is also used in managing conditions where reduced saliva or mucus is desired.

Product Specifications:

• Dose & Form: 1 mg oral tablets (round, off-white, film-coated).
• Packaging: 10 blister packs × 100 tablets each (total 1000 tabs). Packaged by American Health Packaging.
• Imprint: Tablets are debossed “MCR 117” on one side (plain on the other). Scored for splitting if smaller doses needed.
• Strength: Each tablet contains 1 mg glycopyrrolate (glycopyrronium bromide form). Generic for Robinul®.
• NDC: 60687-0458-01.
• Storage: Store at room temperature (68–77°F, 20–25°C) in a dry place. Keep bottle/blister closed and protected from moisture. Keep out of reach of children and pets.

How to Use: Follow your healthcare provider’s instructions carefully. Swallow tablets whole with water; they can be taken with or without food. It’s often recommended to space doses evenly through the day (e.g. morning, early afternoon, bedtime). For best effect in ulcer treatment, doses are typically given before meals and at bedtime. Do not crush or chew the tablets (they are film-coated) unless told by a pharmacist. If you miss a dose and remember soon after, take it; otherwise skip and resume your schedule. Do not double up doses. Use this medication only as prescribed – it is not an over-the-counter drug.

Dosage and Administration:

• Typical Adult Dose (Peptic Ulcer): Start with 1 mg (one tablet) three times daily (morning, afternoon, and at bedtime). Some patients may need one dose increased to 2 mg at bedtime for overnight symptom control. After ulcer symptoms improve, maintenance dosing is often reduced (for example, 1 mg twice daily).
• Titration: Adjust dose gradually based on response and tolerability. Use the lowest effective dosage. Maximum total daily dose should not exceed 8 mg. If higher doses are needed, switch to 2 mg tablets rather than giving multiple 1 mg tabs.
• Pediatric Use: Oral tablets are generally dosed for adults. (Note: an oral liquid form is available for pediatric drooling, with weight-based dosing; tablets are rarely used in children.)
• Special Populations: Patients with significant liver or kidney disease may require dose adjustment (monitor closely). Glycopyrrolate is not usually recommended in elderly patients due to increased risk of side effects.
• Administration Tip: To control nighttime symptoms, a dose at bedtime is common. Do not take more than directed. If treating drooling, doses are often scheduled around meals.

Drug Interactions: Glycopyrrolate has significant interactions due to its anticholinergic effects. It should not be used with other strong anticholinergics (e.g. oxybutynin, tolterodine, dicyclomine, tricyclic antidepressants, some antihistamines) without medical guidance. Concomitant use with other medications that dry secretions can amplify side effects. Because glycopyrrolate slows gut transit, it can alter the absorption of oral drugs. For example, it may increase gut contact time of medications (raising side effect risk) or delay their absorption. Use caution if on drugs like potassium chloride tablets (solid KCl) – glycopyrrolate may prolong GI contact and worsen irritation. Antipsychotics and other CNS drugs may also interact, potentially worsening movement disorders (tardive dyskinesia). Always tell your doctor about ALL drugs and supplements you take to avoid harmful interactions.

Side Effects & Warnings: Glycopyrrolate’s side effects are typical of anticholinergic drugs. The most common side effects include: dry mouth (xerostomia) and thirst, blurry vision, drowsiness, headaches, flushing (warm/red face), and decreased sweating. Gastrointestinal effects such as nausea, vomiting or constipation are also described. Other frequent reactions can include tachycardia (fast heartbeat) and difficulty urinating (especially in men with prostate enlargement). Because glycopyrrolate reduces sweating, heat intolerance or overheating can occur (be cautious in hot weather or during exercise). Inform your doctor if any side effect is severe or persistent.

Serious Warnings/Contraindications: Do not take glycopyrrolate if you have known hypersensitivity to it or related anticholinergics. It is contraindicated in patients with narrow-angle (angle-closure) glaucoma, myasthenia gravis, severe ulcerative colitis or toxic megacolon, significant intestinal or urinary tract obstruction, or prostatic enlargement leading to urinary retention. Use is strongly discouraged in these conditions because glycopyrrolate can precipitate acute glaucoma attacks, worsen GI obstruction (paralytic ileus), or cause acute urinary retention.

Use extreme caution in the elderly or debilitated. Older adults are more prone to anticholinergic complications (confusion, delirium, falls, urinary retention, bowel obstruction). If you experience difficulty seeing at night, enlarged pupils, eye pain, or sudden vision changes, stop the drug and seek medical attention (signs of acute glaucoma risk. Because glycopyrrolate may cause drowsiness and blurred vision, avoid driving or hazardous tasks until you know how it affects you. Also avoid alcohol and avoid overheating (use caution in hot environments).

Glycopyrrolate can cause dry mouth, so good oral hygiene is advised. If dry mouth is very bothersome, sipping water or sucking sugar-free candy may help. Report any signs of allergic reaction (rash, itching, swelling, difficulty breathing) immediately. Do not use glycopyrrolate to treat acute conditions without doctor advice.

Pregnancy & Breastfeeding: There is limited data on use during pregnancy. Because of potential risk (anticholinergics may affect fetal development), only use if clearly needed and directed by a doctor. Sulfonamide component (in glycopyrrolate bromide) may have slight risk in pregnancy. It is not known whether glycopyrrolate passes into breast milk; breastfeeding women should consult their physician.

Summary: Glycopyrrolate 1 mg tablets are a generic anticholinergic medication for reducing stomach acid and secretions. They are indicated mainly as adjunctive therapy for peptic ulcer symptoms but also help manage drooling (off-label). Follow healthcare instructions carefully regarding dose and schedule. Monitor for common anticholinergic side effects (dry mouth, constipation, blurred vision, rapid heart rate). Always inform your doctor of all your medications to avoid interactions. Consult your physician or pharmacist with any questions. This information is not a substitute for professional medical advice – always seek the guidance of a qualified healthcare provider regarding medications, doses, and any health conditions.