Ketorolac Injection 30 mg/ mL, Preservative Free Single Dose 1 mL x 25/Tray (Rx)

Ketorolac Tromethamine Injection 30 mg/mL is a powerful, non-steroidal anti-inflammatory drug (NSAID) intended for short-term management of moderate to severe pain requiring analgesia at an opioid-level intensity. Specially packaged in preservative-free, single-dose 1 mL vials, this formulation is designed for maximum safety, sterility, and efficacy in hospital and procedural settings.

Uses

Ketorolac Tromethamine Injection is indicated for the short-term treatment (up to 5 days in adults) of moderate to severe acute pain that requires analgesia at the opioid level, typically administered postoperatively or when oral analgesics are not suitable. It is NOT indicated for minor or chronic pain conditions.

Ketorolac tromethamine injection is used for:

• Short-term management of moderate to severe acute pain
• Post-operative pain relief (e.g., after orthopedic, abdominal, dental surgeries)
• Musculoskeletal pain, including injury-related discomfort
• Pain in patients where opioid alternatives are required or preferred

Product Details & Features

• Strength/Concentration: 30 mg/mL
• Packaging: 1 mL single-dose vials, 25 vials per tray
• Preservative-Free: Reduces risk of hypersensitivity and ensures suitability for sensitive populations
• Sterile, Ready-to-Use: Reduces risks of contamination and dosimetric errors
• Manufacturer: Fosun Pharma USA, known for high-quality hospital pharmaceuticals
• Route: Intravenous (IV) or intramuscular (IM) injection

Features

• Opioid-Sparing Effect: Potent analgesic reduces or eliminates the need for opioids, minimizing addiction risk
• Rapid Onset: Provides quick pain relief post-surgery
• Convenient Dosing: Each vial is single-use, minimizing waste and dosing errors
• Preservative-Free: Safe for neonatal, pediatric, and allergic populations

Dosage & Administration:

• Adults: Initial dose is 30 mg intravenously (IV) or intramuscularly (IM) as single injection.
• Maintenance Dose: 30 mg IV or IM every 6 hours as needed, not to exceed 120 mg per day in adults.
• Elderly or Renal Impairment: Lower dose recommended (15 mg every 6 hours; max 60 mg/day).
• Max Duration: Not to exceed 5 days due to increased risk of serious adverse effects.

Always consult a healthcare professional for personalized dosing recommendations.

Drug Interactions:

Ketorolac tromethamine may interact with the following drugs—consult your pharmacist or doctor before use:

• Other NSAIDs: Increased risk of GI bleeding, ulcers
• Anticoagulants (Warfarin, Heparin): Enhanced bleeding risk
• SSRIs, SNRIs: Heightened gastrointestinal bleeding risk
• ACE inhibitors/ARBs/Diuretics: Reduced renal function, risk of acute kidney injury
• Corticosteroids: Increased risk of GI side effects
• Lithium: Elevated lithium serum concentrations and toxicity
• Methotrexate: Increased toxicity risk

Potential Side Effects:

Common side effects include:

• Gastrointestinal: Nausea, dyspepsia, abdominal pain, diarrhea
• CNS: Dizziness, headache, drowsiness
• Injection Site: Pain, swelling, erythema

Serious adverse effects:

• GI bleeding, ulceration
• Renal impairment, acute kidney injury
• Hypertension, fluid retention
• Severe allergic reactions (anaphylaxis, angioedema)
• Bleeding disorders/bruising easily

Warnings & Precautions:

• Not for use in children or nursing infants.
• Contraindicated in patients with active peptic ulcer, GI bleeding, or recent surgery with high bleeding risk.
• Avoid in patients with advanced renal impairment, and during labor and delivery due to risk of fetal harm.
• BLACK BOX WARNING: Increased risk of serious cardiovascular thrombotic events, myocardial infarction, stroke, GI bleeding, ulceration, and perforation.
• Avoid with other NSAIDs or in those with hypersensitivity to Ketorolac.
• Short-term use only (5 days).

Get hospital-strength pain management with Ketorolac Injection 30mg/mL, trusted by healthcare professionals for fast, non-opioid relief. Preservative-free and ready-to-use single dose vials – achieve next-level pain control.

Uses and Clinical Applications

Broadly indicated for:

• Short-Term Management of Moderate to Severe Acute Pain: For adults, especially after surgical procedures, orthopedic injuries, trauma, and dental surgeries
• Non-Opioid Alternative: Powerful non-narcotic analgesic for situations where opioid minimization is critical
• Perioperative Care: Acute pain control post-surgery, avoiding opioid-related side effects and dependency risks
• Hospital, ED, and Ambulatory Surgery Centers: First-line solution for acute pain episodes requiring strong, immediate intervention

Dosage & Administration

Adults (Under 65 years, normal renal function):

• IM Administration: 60 mg as a single dose, or 30 mg every 6 hours as needed. MAX 120 mg/24 hours.
• IV Administration: 30 mg as a single dose, or 30 mg every 6 hours as needed. MAX 120 mg/24 hours.
• Duration: Not to exceed 5 days in total.

Elderly (≥65 years), Renally Impaired, or <50 kg Body Weight:

• MAX Dose: 15 mg per administration, not to exceed 60 mg/24 hours.

Duration:

• Critical Limitation: Total therapy duration must NOT exceed 5 days (increases risk of serious adverse effects with extended use).
• Pediatric Use: Not routinely recommended unless directed by a pediatric specialist.

Note: Always follow the specific dosage and administration instructions provided by the prescribing healthcare professional.

How to Use: Professional Administration Only

1. Inspection & Preparation:

   • Confirm package integrity; solution must be clear and colorless.
   • Aseptically draw entire contents for single-use only; discard unused portion immediately after first use.

2. Administration:

   • Intramuscular (IM): Inject deep into a large muscle mass.
   • Intravenous (IV): Administer either as a slow IV bolus (≥15 seconds) or IV infusion, as clinically appropriate.

3. Storage:

   • Store at controlled room temperature, 20° to 25°C (68° to 77°F).
   • Protect from light; do not freeze.

Drug Interactions

• Other NSAIDs or Aspirin: Increases risk of gastrointestinal (GI) bleeding and renal toxicity.
• Anticoagulants (Warfarin, Heparin): Elevated bleeding risk; close monitoring required.
• SSRIs/SNRIs: Cumulative increase in GI bleeding potential.
• Diuretics, ACE Inhibitors: Higher risk of renal impairment.
• Methotrexate, Lithium: NSAIDs may elevate toxicity of these medications.
• Corticosteroids: Enhanced risk of GI ulcers and perforation.

Always perform complete medication review prior to administration.

Side Effects and Warnings

Common Side Effects:

• Nausea, vomiting, abdominal pain
• Headache, dizziness, drowsiness
• Injection site discomfort

Serious/Severe Adverse Effects:

• Gastrointestinal: GI bleeding, peptic ulcer, perforation (potentially fatal; even without prior symptoms)
• Renal: Kidney injury or failure
• Bleeding Risk: Increased bleeding (especially perioperatively or with coagulopathies)
• Hypersensitivity: Anaphylaxis, bronchospasm (especially in aspirin-sensitive asthma patients)
• Thrombotic Events: Myocardial infarction, stroke

Boxed Warnings/Contraindications:

• NOT for chronic pain use or minor pain conditions.
• DO NOT exceed 5 days of therapy.
• CONTRAINDICATED in patients with: active or recent GI bleeding/ulcers, advanced renal impairment, risk of bleeding, hypersensitivity to NSAIDs, labor and delivery, perioperative pain in CABG (coronary artery bypass graft) surgery.
• Avoid use in combination with other NSAIDs.