Ketorolac Tromethamine Injection 60 mg Per 2 mL Vials (Rx)

Ketorolac Tromethamine Injection 60 mg per 2 mL vials are used for the short-term management of moderate to severe pain, typically following surgery. As a nonsteroidal anti-inflammatory drug (NSAID), it works by inhibiting prostaglandin synthesis, which helps reduce inflammation and relieve pain. This injection is often employed as an alternative to opioid analgesics, providing effective pain control without the risk of opioid addiction. It is administered intramuscularly or intravenously in medical settings to ensure rapid and efficient pain relief.

Ketorolac Tromethamine Injection is a non-steroidal anti-inflammatory drug (NSAID) used for the short-term management of moderate to severe pain. It is particularly effective in postoperative settings, providing strong analgesic properties without the use of opioids. This formulation is presented in 60 mg per 2 mL vials, and Sagent Pharmaceuticals packages these in packs containing 25 vials.

Details and Features:

Dosage Form: 60 mg per 2 mL vial
Packaging: 25 vials per pack
Administration Route: Intended for intravenous (IV) or intramuscular (IM) injection
Use: Short-term management of moderate to severe acute pain, typically used for no more than five days
Non-Opioid Analgesic: Provides pain relief without the potential for opioid dependence

Mechanism of Action:

Ketorolac works by inhibiting the enzyme cyclooxygenase (COX), which is essential in the biosynthesis of prostaglandins from arachidonic acid. Prostaglandins play a pivotal role in the mediation of inflammation, pain, and fever. By reducing the production of these compounds, Ketorolac provides effective analgesic, anti-inflammatory, and antipyretic effects.

Warnings:

• Duration of Use: Intended for short-term use only; not to exceed five days due to the increased risk of serious side effects with longer use.
  
• Gastrointestinal Risk: Use cautiously due to risks of gastrointestinal irritation, ulceration, bleeding, and perforation.
  
• Renal Risk: May cause or exacerbate renal impairment, especially in dehydrated patients or those with pre-existing kidney problems.
  
• Cardiovascular Risk: NSAIDs, including Ketorolac, may increase the risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, particularly with prolonged use.
  
• Hypersensitivity Reactions: Contraindicated in patients with known hypersensitivity to Ketorolac or other NSAIDs.
  
• Avoid in Certain Populations: Contraindicated in active peptic ulcer disease, recent gastrointestinal bleeding, or perforation, advanced renal impairment, and concurrent use with other NSAIDs or aspirin.
  
• Pregnancy: Avoid use, especially in late pregnancy, due to the risk of fetal harm.

Side Effects:

Common side effects may include:

• Gastrointestinal: Nausea, dyspepsia, abdominal pain, diarrhea, or in severe cases, peptic ulcers or bleeding.
  
• Renal: Increased serum creatinine and, in rare cases, acute renal failure.
  
• Cardiovascular: Hypertension, palpitations, or edema.
  
• Hematologic: Prolonged bleeding time.
  
• Central Nervous System: Headache, dizziness, or somnolence.
  
• Hypersensitivity: Rash, pruritus, or, rarely, anaphylaxis.

Ketorolac Tromethamine Injection should be administered under medical supervision with careful monitoring of patient condition and response to therapy. It is critical to adhere to recommended dosing and duration guidelines to minimize the risk of adverse effects. Regular evaluations ensure the treatment remains necessary and beneficial.