Marcaine (Bupivacaine Hydrochloride) 125 mg/50 mL with Epinephrine 1:200,000 is used for local anesthesia and pain management during surgical, dental, and obstetric procedures. The addition of epinephrine prolongs the anesthetic effect by constricting blood vessels, minimizing bleeding, and reducing the rate of systemic absorption. This formulation provides prolonged muscle relaxation and sensory blockade, making it suitable for procedures requiring extended anesthesia. Bupivacaine is preferred for its long-lasting effects, ensuring effective patient comfort and control over pain during and post-procedure.
Marcaine (Bupivacaine Hydrochloride) with Epinephrine Injection is a long-lasting local anesthetic formulation designed for producing regional anesthesia or nerve block during surgical, dental, or diagnostic procedures. This specific formulation combines Bupivacaine, a potent amide-type anesthetic, with Epinephrine to extend the duration of anesthetic action by reducing local blood flow.
Key Features
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Active Ingredients: The formulation contains 125 mg of Bupivacaine Hydrochloride per 50 mL and Epinephrine at a concentration of 1:200,000, providing effective anesthesia with prolonged action.
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Concentration: This 0.25% solution offers a balanced potency suitable for a wide range of medical applications, ensuring effective nerve blockade while minimizing potential toxicity.
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Epinephrine Addition: The inclusion of Epinephrine helps to constrict blood vessels at the site of administration, thereby prolonging the anesthetic effect of Bupivacaine and reducing systemic absorption, which enhances the action and safety profile.
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Multi-Dose Vial: Packaged in a 50 mL multi-dose vial, it allows for multiple uses from the same vial when sterile technique is employed, making it a convenient cost-effective option for clinical settings.
Usage and Application
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Regional Anesthesia: Ideal for procedures where localized numbness is required, such as surgeries involving extremities, where spinal or epidural anesthesia may be applied.
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Nerve Block: Used in various nerve blocks to manage pain during and after surgical procedures.
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Epidural Anesthesia: Can be utilized in epidural blocks, especially when combined with analgesics for labor pain management.
Safety and Precautions
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Contraindications: Marcaine should not be used in patients with a known hypersensitivity to local anesthetics of the amide type or any component of the formulation.
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Monitoring: Continuous monitoring of cardiovascular and respiratory functions is recommended during administration due to potential systemic effects.
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Handling: Multi-dose vials should be handled under sterile conditions to prevent contamination.
Storage Information
Storage Conditions: Store at controlled room temperature and protect from light to maintain the stability of the formulation.
Manufacturer Information
Brand: Manufactured by Pfizer Injectables, a globally recognized leader in pharmaceutical solutions ensuring stringent quality control and reliability.
Marcaine with Epinephrine provides a reliable and effective anesthetic solution for a wide range of medical procedures, ensuring safety and efficacy in local anesthesia practices.
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