MOTS-c is a small peptide (16 amino acids) naturally produced in the body, particularly within mitochondria—the “power plants” of cells. “MOTS-c” stands for Mitochondrial Open Reading Frame of the 12S rRNA type-c. It’s classified as a mitochondria-derived peptide.
How Does MOTS-c Work?
MOTS-c acts as a cell signaling molecule—especially in metabolic tissues.
- It influences mitochondrial function, energy production, and cellular metabolism.
- Enhances fat and glucose metabolism, increases insulin sensitivity, and stimulates production of AMP-activated protein kinase (AMPK), known as a “metabolic master switch.”
Benefits & Uses
-
Metabolic Health
- Improves insulin sensitivity and glucose utilization (helpful for prediabetes, type 2 diabetes).
- May reduce fat accumulation and favor weight loss/metabolic flexibility.
- Activates AMPK, which helps regulate energy expenditure.
-
Exercise Performance/Recovery
- Enhances exercise endurance and capacity in animal studies.
- Protects muscle from fatigue and age-related decline (“muscle longevity peptide”).
-
Anti-Aging & Longevity
- MOTS-c levels decline with age; supplementation may counteract aspects of age-related metabolic dysfunction.
- Improves mitochondrial function—considered a hallmark of healthy aging.
-
Cellular Stress Resistance
- May protect against oxidative and metabolic stress at the cellular level.
Emerging Areas of Research
- Fatty liver disease
- Osteoporosis protection
- Cardiovascular support
- Enhanced cognitive/brain metabolic function
Mechanism Summary
MOTS-c acts via:
- AMPK activation: Leading to improved energy metabolism and greater glucose uptake.
- Regulation of mitochondrial gene expression: Affecting metabolism and cellular energy.
- Improving insulin sensitivity: Lowering blood sugar and possibly reducing body fat.
Product Specifications
- Material Type: Synthetic peptide compound
- Peptide Name: MOTS-c
- Molecular Formula: C101H152N28O22S2
- CAS Number: 1627580-64-6
- Quantity: 10 mg
- Format: Lyophilized powder
- Storage Condition: 2–8 °C
- Shelf Life: Up to 24 months when stored under recommended conditions
- Shipping: Temperature-controlled shipping (overnight or standard options available)
MOTS-c injection is a synthetic version of a mitochondrial peptide intended to optimize metabolism, improve exercise performance, and possibly promote healthy aging. Major uses revolve around metabolic enhancement, anti-aging, and athletic optimization, but it remains an investigational therapy.
MOTS-c is a small peptide (16 amino acids) naturally produced in the body, particularly within mitochondria—the “power plants” of cells. “MOTS-c” stands for Mitochondrial Open Reading Frame of the 12S rRNA type-c. It’s classified as a mitochondria-derived peptide.
How Does MOTS-c Work?
MOTS-c acts as a cell signaling molecule—especially in metabolic tissues.
- It influences mitochondrial function, energy production, and cellular metabolism.
- Enhances fat and glucose metabolism, increases insulin sensitivity, and stimulates production of AMP-activated protein kinase (AMPK), known as a “metabolic master switch.”
Benefits & Uses
-
Metabolic Health
- Improves insulin sensitivity and glucose utilization (helpful for prediabetes, type 2 diabetes).
- May reduce fat accumulation and favor weight loss/metabolic flexibility.
- Activates AMPK, which helps regulate energy expenditure.
-
Exercise Performance/Recovery
- Enhances exercise endurance and capacity in animal studies.
- Protects muscle from fatigue and age-related decline (“muscle longevity peptide”).
-
Anti-Aging & Longevity
- MOTS-c levels decline with age; supplementation may counteract aspects of age-related metabolic dysfunction.
- Improves mitochondrial function—considered a hallmark of healthy aging.
-
Cellular Stress Resistance
- May protect against oxidative and metabolic stress at the cellular level.
Emerging Areas of Research
- Fatty liver disease
- Osteoporosis protection
- Cardiovascular support
- Enhanced cognitive/brain metabolic function
Mechanism Summary
MOTS-c acts via:
- AMPK activation: Leading to improved energy metabolism and greater glucose uptake.
- Regulation of mitochondrial gene expression: Affecting metabolism and cellular energy.
- Improving insulin sensitivity: Lowering blood sugar and possibly reducing body fat.
Product Specifications
- Material Type: Synthetic peptide compound
- Peptide Name: MOTS-c
- Molecular Formula: C101H152N28O22S2
- CAS Number: 1627580-64-6
- Quantity: 10 mg
- Format: Lyophilized powder
- Storage Condition: 2–8 °C
- Shelf Life: Up to 24 months when stored under recommended conditions
- Shipping: Temperature-controlled shipping (overnight or standard options available)
MOTS-c injection is a synthetic version of a mitochondrial peptide intended to optimize metabolism, improve exercise performance, and possibly promote healthy aging. Major uses revolve around metabolic enhancement, anti-aging, and athletic optimization, but it remains an investigational therapy.










