SM-C is a laboratory-characterized acellular secretome material prepared through controlled processing methods and documented through batch-specific analytical reporting.
Acellular secretome refers to the collection of bioactive molecules that are secreted by cells into their surrounding environment, but without the cells themselves being present ("acellular" = "without cells"). The secretome is typically collected from the conditioned medium in which cells have been cultured.
What is included in the Acellular Secretome?
The acellular secretome is rich in:
- Growth factors
- Cytokines
- Chemokines
- Extracellular vesicles (such as exosomes and microvesicles)
- Enzymes
- Lipids
- Proteins
- Nucleic acids (like mRNA and miRNA)
Major Sources
The acellular secretome is often derived from mesenchymal stem/stromal cells (MSCs), but it can come from other types of cells as well (immune cells, tumor cells, etc.).
Uses of Acellular Secretome
1. Regenerative Medicine
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Wound Healing: Promotes tissue repair and skin regeneration for chronic wounds, burns, ulcers, and surgical incisions.
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Bone & Cartilage Repair: Used to aid the regeneration of bone tissue (osteogenesis) and cartilage (chondrogenesis), especially for fractures and osteoarthritis.
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Cardiac Repair: Improves heart tissue healing after a myocardial infarction ("heart attack") by promoting angiogenesis and reducing inflammation and scar tissue.
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Nerve Repair: Supports regeneration in nerve injury, including peripheral nerve damage and some central nervous system conditions.
2. Anti-inflammatory Therapies
- Reduces inflammation and modulates immune responses, making it helpful in treating autoimmune diseases and inflammatory conditions.
3. Anti-fibrotic Effects
- May prevent excessive scar tissue formation (fibrosis) in organs like the liver, lung, heart, and kidney.
4. Cosmetic and Dermatology Applications
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Skin Rejuvenation: Used in creams or serums for anti-aging effects, promoting collagen production, and improving skin texture and tone.
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Hair Regrowth: Some products use secretomes for treating hair loss (alopecia) by stimulating hair follicle cells.
5. Diagnostics and Biomarker Discovery
- Analysis of the secretome’s composition can help detect disease-specific biomarkers, potentially enabling early diagnosis of certain diseases.
6. Anti-Cancer Research
- Studied for both supporting anti-tumor immune responses and understanding how tumor cells modulate their environment via their secretome.
7. Drug Delivery and Novel Drug Development
- Extracellular vesicles and exosomes within the secretome can be used as carriers for drug delivery.
Benefits over Cell-based Therapies
- Lower risk of immune rejection
- Reduced risk of tumorigenesis
- Easier storage and delivery
- No issues related to cell viability or ethical concerns of live cell use
Acellular secretome is the collection of active factors secreted by cells, harvested from cell cultures, and used for therapeutic or research purposes without any live cells present.
Product Specifications
- SKU: SM-C-2ML
- Material Type: Acellular secretome material
- Format: Sterile liquid preparation
- Volume: 2 mL
- Primary Material Components:
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- Secreted extracellular biomolecular fractions that may include:
- Extracellular vesicle populations
- Nanoparticle-associated biomolecules
- Soluble extracellular proteins and signaling factors
- Shelf Life: Up to 24 months when stored under recommended conditions
- Shipping: Temperature-controlled shipment
Scientific Characterization
SM-C is supplied as a laboratory-characterized acellular secretome material.
Laboratory documentation may include:
- Analytical characterization of extracellular vesicle and nanoparticle populations
- Batch identification and traceability records
- Laboratory-generated analytical measurements describing material composition
Each lot may include Certificates of Analysis (COAs) and supporting laboratory documentation describing analytical findings.
All specifications are provided for material identification, analytical reference, and documentation purposes only.
Documentation
Supporting documentation may include:
- Lot-specific Certificates of Analysis (COAs)
- Laboratory analytical reports
- Batch identification and traceability documentation
These materials provide transparency regarding the analytical characteristics associated with each production lot.
Storage & Handling
To maintain material stability, the following storage conditions are recommended:
- Short-Term Storage: −20 °C (freezer storage)
- Long-Term Storage: Maintain continuous frozen storage conditions
Avoid repeated freeze-thaw cycles and maintain appropriate cold-chain handling during transport and storage.
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