Vitamin K Injection Shot Phytonadione Emulsion 10 mg/1 mL 10/Box (RX)

High Potency Vitamin K Injection | Professional-Grade Phytonadione Injectable Solution for Rapid Correction of Vitamin K Deficiency and Blood Clotting Disorders

Vitamin K Injection (Phytonadione Injectable Emulsion 10 mg/mL) is a sterile, fat-soluble vitamin K1 preparation for intramuscular, subcutaneous, or intravenous administration. It is the gold-standard life-saving therapy used to reverse the effects of vitamin K deficiency, treat or prevent serious bleeding, and serve as an antidote to anticoagulant (warfarin) overdose. Phytonadione is the synthetic form of naturally occurring Vitamin K1, vital for activating clotting factors in blood coagulation.

Uses and Clinical Applications

• Rapid reversal of anticoagulant (warfarin) overdose
• Prevention and treatment of vitamin K deficiency bleeding (VKDB) in newborns
• Correction of hypoprothrombinemia due to:
  • Vitamin K deficiency (malnutrition, malabsorption, liver disease)
  • Antibiotic therapy (disrupting gut flora)
  • Prolonged parenteral nutrition without adequate vitamin K
• Support in liver disease-related coagulopathy
• Emergencies involving abnormal INR/prothrombin time (PT) prolongation

Healthcare settings include hospitals, ERs, surgical centers, and clinics; can also be physician-administered in home health situations.

Order Vitamin K Injection 10mg/mL by Caplin Steriles USA Now—Trusted by Healthcare Professionals for Critical Bleeding Disorders and Emergency Use

NDC: 65145-0151-10 UPC: 365145151100

Ensure life-saving readiness with Caplin Steriles high-strength phytonadione injectable emulsion. For hospital, medical clinic, surgical, pediatric, and emergency protocols.

Uses and Clinical Applications

• Rapid reversal of anticoagulant (warfarin) overdose
• Prevention and treatment of vitamin K deficiency bleeding (VKDB) in newborns
• Correction of hypoprothrombinemia due to:
  • Vitamin K deficiency (malnutrition, malabsorption, liver disease)
  • Antibiotic therapy (disrupting gut flora)
  • Prolonged parenteral nutrition without adequate vitamin K
• Support in liver disease-related coagulopathy
• Emergencies involving abnormal INR/prothrombin time (PT) prolongation

Healthcare settings include hospitals, ERs, surgical centers, and clinics; can also be physician-administered in home health situations.

Product Specifications

• Product: Vitamin K Injection Shot Phytonadione Injectable Emulsion
• Concentration: 10 mg/1 mL
• Packaging: 1 mL single-use vial, 10 vials per box
• NDC: 65145-0151-10
• UPC: 365145151100
• Presentation: Sterile, ready-to-use injectable emulsion (preservative-free)
• Manufacturer: Caplin Steriles USA
• Route of Administration: Intravenous (IV), Intramuscular (IM), or Subcutaneous (SC) – as directed by physician
• Storage: Refrigerate or store at 2° to 8°C (36°-46°F). Protect from light.

How to Use / Directions for Administration

IMPORTANT: Administer only under professional medical supervision. Emergency use may warrant hospital/clinic setting.

General Directions:

1. Inspect the vial: Ensure solution is clear, free of particulates, and not expired.
2. Aseptic Technique: Use sterile syringe and needle; prep injection site.
3. Administration Routes:
   • IV (intravenous): For urgent INR reversals/active major bleeding; infuse slowly to minimize rare hypersensitivity reactions.
   • IM (intramuscular): For non-urgent, non-bleeding situations; not recommended in patients with bleeding tendencies.
   • SC (subcutaneous): Alternative for patients at risk of bleeding with IM use.
4. Dosage: See below — always individualized and confirmed by prescriber.
5. After use: Dispose of syringe and vial safely in approved sharps container.

Typical Dosage Guidelines

• Warfarin (Coumadin) Overdose/INR correction:
  • 2.5–10 mg IV/IM/SC depending on INR and bleed severity.
• Prevention of VKDB in Neonates:
  • 1 mg IM (newborns at birth, per standard protocols)
• Treatment of Vitamin K Deficiency:
  • 5–10 mg IV/IM/SC, single dose or as prescribed until normalized PT/INR.
• Maximum adult dose: Individualize to minimum effective dose, avoid excessive dosing to prevent resistance to warfarin.

Dosages must be confirmed by qualified healthcare professionals!

Drug Interactions

ALERT: Always disclose all medicines and supplements to your healthcare provider.

• Anticoagulants (warfarin/coumadin): Vitamin K directly reverses effect; check INR frequently.
• Broad-spectrum antibiotics: May exacerbate vitamin K deficiency.
• Orlistat/mineral oils/bile acid sequestrants: May decrease vitamin K absorption.
• Other injectables: Avoid mixing in same syringe/IV tubing unless compatibility established.
• Cholestyramine, Colestipol: Can reduce vitamin K absorption.

Side Effects

Common:

• Pain, redness, or swelling at injection site
• Flushing sensation
• Unpleasant taste (after IV)

Rare/Serious:

• Allergic/hypersensitivity reactions: hives, itching, difficulty breathing, hypotension, shock—more likely with IV route if given too fast. Always infuse IV slowly.
• Severe anaphylactoid reactions (rare, most often with rapid IV injection)
• Hyperbilirubinemia in premature infants (rare, high doses)

Seek immediate medical care if you experience:

• Shortness of breath
• Severe rash, dizziness, or facial/throat swelling
• Sudden drop in blood pressure

Warnings & Precautions

• Use in Hospital Setting: Vitamin K injection should be given only by licensed healthcare professionals.
• IV Route: Risk of severe anaphylactoid reaction; infusion should be slow and monitored.
• Neonatal Use: IM injection is recommended for routine prophylaxis. IV use in infants only if medically indicated.
• Warfarin Patients: Re-administration may render the patient temporarily resistant to anticoagulation therapy.
• Liver Disease: Dosage may need adjustment, especially in chronic hepatic impairment.
• Pregnancy & Breastfeeding: Use only if clearly needed and prescribed; inform healthcare provider.
• Do Not Use for Hemolytic Disease in Newborns: Evaluate risk/benefit, especially in premature infants.