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Allergic Reaction Medications
Medications for allergic reactions work by blocking histamine or other inflammatory mediators or by reducing immune responses. Common categories include:
-
Antihistamines (H₁ blockers): These prevent histamine from causing allergy symptoms. Examples include diphenhydramine (Benadryl) and chlorpheniramine (older, sedating antihistamines) as well as newer, non-drowsy agents like cetirizine (Zyrtec), loratadine (Claritin) and fexofenadine (Allegra). (Antihistamines are available as pills, liquids, nasal sprays or eye drops.)
-
Decongestants: These shrink swollen nasal tissues and ease congestion. For example, pseudoephedrine (Sudafed) or phenylephrine are oral decongestants, and oxymetazoline (Afrin) is a topical nasal spray. (Combo products also exist, e.g. Claritin®-D which contains loratadine + pseudoephedrine.)
-
Corticosteroids: These steroid medications suppress allergic inflammation. Intranasal corticosteroids like fluticasone (Flonase) or mometasone (Nasonex) are first-line for hay fever obstacles. Inhaled steroids (budesonide, fluticasone inhalers) treat allergic asthma, and powerful oral steroids (e.g. prednisone, methylprednisolone) are used for severe or systemic allergies.
-
Leukotriene inhibitors: These block another allergy mediator (leukotrienes). The main example is montelukast (Singulair), a daily pill used for allergic rhinitis and asthma).
-
Mast cell stabilizers: These prevent mast cells from releasing histamine. For instance, cromolyn sodium (available as a nasal spray or eye drops) is used prophylactically to reduce allergy symptoms when exposed to triggers.
-
Bronchodilators (beta-agonists): While not direct “anti-allergy” drugs, these inhalers relieve bronchospasm from allergic asthma. Short-acting inhaled beta-agonists like albuterol (ProAir, Ventolin) relax the airways when wheezing or tightness occurs.
-
Epinephrine (adrenaline): For life-threatening allergic reactions (anaphylaxis), injectable epinephrine is the drug of choice. Auto-injectors (e.g. EpiPen, Auvi-Q, Adrenaclick) deliver a fixed dose of epinephrine that rapidly opens airways and raises blood pressure. Patients with severe food, insect or drug allergies carry an epinephrine pen at all times.
Each of these medication types targets a different aspect of the allergic response. For example, antihistamines block histamine’s effects to reduce itching, sneezing and hives, whereas steroids reduce overall inflammation. In practice, mild to moderate allergy symptoms are managed with antihistamines, decongestants and nasal steroids, whereas epinephrine is reserved for anaphylaxis. Leukotriene modifiers and mast-cell stabilizers are additional options for chronic allergy control or asthma.
-
Sale 21%
Original price $ 499.95Current price $ 395.00Epinephrine Auto Injector Jr Pediatric Pen 0.15 mg (2 Pack) For Weight 33 lbs to 66 lbs (Rx)
Discover life-saving Epinephrine Auto Injector Jr 0.15 mg for pediatric use at Mountainside Medical. Perfect for emergency allergy reactions, it de...
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Sale 37%
Original price $ 475.00Current price $ 299.95Epinephrine Auto-Injector 0.15 mg Injection Syringe, 2-Pack (Rx)
Epinephrine Auto-Injector Jr, 0.15 mg Epinephrine (also called adrenaline) is the first-line treatment for life-threatening allergic reactions (ana...
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Sale 22%
Original price $ 32.99Current price $ 25.80Adrenalin Injection Epinephrine 1:1000, 1 mg Vial - Each (Rx)
7 reviewsAdrenalin Injection Adrenaline injection (the injectable form of epinephrine) is a clear, colorless solution (typically 1 mg/mL, often labeled 1:10...
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Sale
$ 4.29Diphenhydramine Injection 50 mg (Diphenhydramine 50 mg) (Rx)
5 reviewsDiphenhydramine 50 mg Diphenhydramine Injection 50 mg is a powerful, fast-acting solution for acute allergy relief. As an injectable form of the fa...
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Sale 29%
Original price $ 39.95Current price $ 28.20Epinephrine Prefilled Syringe 0.1 mg/mL (1 mg per 10 mL) Each (Rx)
3 reviewsAn Epinephrine Prefilled Syringe is a medical device containing a specific dose of epinephrine (also known as adrenaline), already loaded into a sy...
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Sale 14%
Original price $ 1,100.00Current price $ 945.00Neffy Epinephrine Nasal Spray 2 mg (Needle-Free Treatment) (2-Pack)
Neffy Epinephrine Nasal Spray 2 mg is an emergency treatment for severe allergic reactions, known as anaphylaxis. This nasal spray delivers epineph...
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Original price $ 210.00Current price $ 199.00Promethazine HCl for Injection 50 mg per mL Ampules 1 mL x 25-Pack (Rx)
Promethazine HCl for Injection 50 mg / mL Ampules 1 mL x 25/Tray. Promethazine hydrochloride is a phenothiazine derivative which possesses antihist...
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Sale 19%
Original price $ 215.95Current price $ 175.00Epinephrine for Injection 1 mL Ampules (1:1000), 10/Box (Rx)
2 reviewsEpinephrine Ampules are used to treat anaphylaxis, a severe allergic reaction. The medication works by narrowing the blood vessels and increasing h...
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Sale 23%
Original price $ 109.00Current price $ 83.95Dexamethasone Sodium Phosphate Injection 120 mg Per 30 mL (4 mg/mL) Multi-Dose Vials 30 mL (RX)
Dexamethasone Sodium Phosphate Injection 120 mg per 30 mL is a corticosteroid solution used for managing severe inflammation and modulating the imm...
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Sale 28%
Original price $ 159.95Current price $ 115.00Promethazine HCL for Injection 25 mg Single-Dose Vials 1 mL x 25/Tray (Rx)
Promethazine HCL for Injection is a medication that is used to treat a variety of conditions. It works by blocking the action of histamine in the b...
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Sale 26%
Original price $ 139.95Current price $ 103.85Epinephrine for Injection 1 mg/mL (1:1000) Professional Convenience Kit (Rx)
2 reviewsEpinephrine Professional Convenience Kit is a life-saving device that administers epinephrine to people who are experiencing anaphylactic shock. Th...
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Sale 8%
Original price $ 639.95Current price $ 589.00Teva Epinephrine Auto-Injector Pen (Epipen Generic) 0.3 mg (2-Pack + 1 Trainer)
The Teva Epinephrine Auto-Injector Pen 0.3 mg is a FDA-approved, easy-to-use emergency treatment for severe allergic reactions (anaphylaxis) in adu...
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Sale 23%
Original price $ 259.95Current price $ 199.95Epinephrine Snap-V Emergency Anaphylaxis Kit with Injection Vial (Rx)
Epinephrine Snap-V Emergency Anaphylaxis Kit with Injection Vial. Each Epinephrine Snap-V kit contains one 1 mL vial of epinephrine 1 mg/mL for inj...
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Sale 19%
Original price $ 129.95Current price $ 105.85Epinephrine Injection 10 mg/10 mL Multiple-dose Vial 10 mL by BPI Labs (RX)
Emergency & Critical Care Solution | Fast-Acting Cardiac, Anaphylaxis, & Resuscitation Support Ensure clinical readiness for life-threateni...
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Sale 21%
Original price $ 149.95Current price $ 119.00Diphenhydramine Hydrochloride Prefilled Syringes for Injection 50 mg/mL, 24 Pack (Rx)
Diphenhydramine Hydrochloride for Injection is a medication that is used to treat allergic reactions. It works by blocking the effects of histamine...
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Sale 23%
Original price $ 149.95Current price $ 115.00Promethegan Promethazine HCL Suppositories 25 mg, 12 Count **Refrigerated (Rx)
Promethegan Promethazine HCL Suppositories 25 mg are used to treat nausea, vomiting, and allergies. They are also effective for sedation before and...
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Sale 29%
Original price $ 525.00Current price $ 375.00Adrenalin Epinephrine Injection Multiple-Dose Vial 30 mL (Rx)
Adrenaline (Epinephrine) Injection Adrenaline (called epinephrine in the US) is a naturally occurring catecholamine hormone used as a critical emer...
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Original price $ 65.00Current price $ 49.50Lidocaine Hydrochloride 2% and Epinephrine 1:200,000 for Injection 20 mL, 5/Box (Rx) Exp 12/31/26
Lidocaine Hydrochloride 2% and Epinephrine 1:200,000 is used as a local anesthetic to provide pain relief and reduce bleeding during surgical and d...
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Sale 37%
Original price $ 475.00Current price $ 299.95Epinephrine Auto-Injector 0.3 mg Adult Epinephrine Pen (2-Pack) (Rx)
Epinephrine Auto-Injector 0.3 mg An Epinephrine Auto-Injector 0.3 mg (commonly known by brand names like EpiPen®, Auvi-Q®, or Adrenaclick®) is a pr...
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Sale 42%
Original price $ 189.00Current price $ 109.00Dexamethasone Sodium Phosphate Injection 10 mg/mL Multi-Dose Vials 10 mL x 10/Tray (Rx)
Dexamethasone Sodium Phosphate Injection 10 mg/mL Multi-Dose Vials 10 mL is a type of corticosteroid medication that is used to treat various condi...
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Sale 25%
Original price $ 129.95Current price $ 97.00Diphenhydramine Injection 50 mg/mL Benadryl Injection Vial 1 mL x 25/Tray (Rx)
Fast-Acting Antihistamine Injection for Severe Allergic Reactions, Anaphylaxis, and Acute Allergy Emergencies Get rapid, life-saving allergy relief...
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Sale 12%
Original price $ 295.95Current price $ 259.00Dexamethasone Sodium Phosphate Injection, 1 mL Prefilled Syringe, 10 mg/mL, 24/Box
Fresenius Kabi Dexamethasone Sodium Phosphate Injection 10 mg/mL Prefilled Syringes 1 mL x 24/Box. For Intravenous or Intramuscular Use Only. NDC: ...
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Sale 14%
Original price $ 145.95Current price $ 125.95Dexamethasone Sodium Phosphate Injection, 1 mL Prefilled Syringe, 4 mg/mL, 24/Box (Rx)
Fresenius Dexamethasone Sodium Phosphate Prefilled Syringes work by providing a high concentration of dexamethasone phosphate, a synthetic glucocor...
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Sale 19%
Original price $ 675.95Current price $ 549.00Dexamethasone Sodium Phosphate Injection 30 mL Multi-Dose Vials, 4mg/mL, 25/Tray (Rx)
Eugia Dexamethasone Sodium Phosphate Injection 4mg/mL Multi-Dose Vials 30 mL x 25/Tray. For Intravenous or Intramuscular Use Only. NDC: 55150-0239-...
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People Also Searched For
Allergic Reaction Medications
Medications for allergic reactions work by blocking histamine or other inflammatory mediators or by reducing immune responses. Common categories include:
-
Antihistamines (H₁ blockers): These prevent histamine from causing allergy symptoms. Examples include diphenhydramine (Benadryl) and chlorpheniramine (older, sedating antihistamines) as well as newer, non-drowsy agents like cetirizine (Zyrtec), loratadine (Claritin) and fexofenadine (Allegra). (Antihistamines are available as pills, liquids, nasal sprays or eye drops.)
-
Decongestants: These shrink swollen nasal tissues and ease congestion. For example, pseudoephedrine (Sudafed) or phenylephrine are oral decongestants, and oxymetazoline (Afrin) is a topical nasal spray. (Combo products also exist, e.g. Claritin®-D which contains loratadine + pseudoephedrine.)
-
Corticosteroids: These steroid medications suppress allergic inflammation. Intranasal corticosteroids like fluticasone (Flonase) or mometasone (Nasonex) are first-line for hay fever obstacles. Inhaled steroids (budesonide, fluticasone inhalers) treat allergic asthma, and powerful oral steroids (e.g. prednisone, methylprednisolone) are used for severe or systemic allergies.
-
Leukotriene inhibitors: These block another allergy mediator (leukotrienes). The main example is montelukast (Singulair), a daily pill used for allergic rhinitis and asthma).
-
Mast cell stabilizers: These prevent mast cells from releasing histamine. For instance, cromolyn sodium (available as a nasal spray or eye drops) is used prophylactically to reduce allergy symptoms when exposed to triggers.
-
Bronchodilators (beta-agonists): While not direct “anti-allergy” drugs, these inhalers relieve bronchospasm from allergic asthma. Short-acting inhaled beta-agonists like albuterol (ProAir, Ventolin) relax the airways when wheezing or tightness occurs.
-
Epinephrine (adrenaline): For life-threatening allergic reactions (anaphylaxis), injectable epinephrine is the drug of choice. Auto-injectors (e.g. EpiPen, Auvi-Q, Adrenaclick) deliver a fixed dose of epinephrine that rapidly opens airways and raises blood pressure. Patients with severe food, insect or drug allergies carry an epinephrine pen at all times.
Each of these medication types targets a different aspect of the allergic response. For example, antihistamines block histamine’s effects to reduce itching, sneezing and hives, whereas steroids reduce overall inflammation. In practice, mild to moderate allergy symptoms are managed with antihistamines, decongestants and nasal steroids, whereas epinephrine is reserved for anaphylaxis. Leukotriene modifiers and mast-cell stabilizers are additional options for chronic allergy control or asthma.
