Epinephrine Auto-Injector 0.3 mg Adult Strength Injection Pens (2-Pack) by Amneal (Rx)

An Epinephrine Auto-Injector 0.3 mg is a medical device used to quickly inject a measured dose (0.3 milligrams) of epinephrine (adrenaline) into the body. It is most commonly used for emergency treatment of severe allergic reactions (anaphylaxis) in adults and children who weigh above a certain threshold (typically over 30 kg or 66 lbs).

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Epinephrine Auto-Injector 0.3 mg is designed for the emergency treatment of severe allergic reactions (anaphylaxis) in adults and children weighing 30 kg (66 lbs) or more. This device delivers a precise dose of epinephrine to rapidly counteract symptoms of anaphylaxis, such as difficulty breathing, hives, swelling, or a significant drop in blood pressure. By stabilizing the cardiovascular and respiratory systems, it quickly reduces allergic symptoms and provides critical time for medical treatment.

Anneal Pharmaceuticals introduces the Epinephrine Auto-Injector 0.3 mg, a critical and reliable solution for the emergency treatment of anaphylaxis in adults and children weighing 30 kg (66 lbs) or more. This convenient two-pack ensures that individuals at risk for severe allergic reactions have immediate access to potentially life-saving medication. Engineered for simplicity and speed, each auto-injector offers a quick, precise dose of epinephrine to counteract life-threatening symptoms, providing peace of mind in emergency situations.

When is it Used?

• Anaphylaxis: Life-threatening allergic reactions from foods, bee stings, medications, latex, etc.
• Symptoms: Trouble breathing, swelling, hives, dizziness, low blood pressure, or loss of consciousness.
• First-line treatment: Epinephrine acts fast to reverse severe allergic symptoms.

How Does it Work?

• Epinephrine rapidly constricts blood vessels, relaxes airway muscles (bronchodilation), and reduces swelling.
• This helps improve breathing, raise blood pressure, and reduce hives/swelling.

How to Use? (General Steps)

1. Remove safety cap.
2. Press the tip firmly against the outer thigh, perpendicular to the leg (can be injected through clothing).
3. Hold in place for several seconds (usually around 3-10 seconds, depending on brand).
4. Call emergency services immediately after use, as further treatment may be needed.

Important Notes:

• 0.3 mg dose is intended for adults and children 30 kg (66 lbs) or more.
• A 0.15 mg auto-injector (often called "junior") is available for smaller children (15-30 kg).
• Always seek emergency care after using an auto-injector, even if symptoms improve.

Product Details and Features

• Dosage Strength: Each injection pen delivers 0.3 mg of epinephrine.
  
• Packaging: Includes two auto-injectors, offering a backup dose for persistent or repeat reactions.
  
• Design: Ergonomic and portable design for ease of access during emergencies.
  
• Activation: Automated needle mechanism with protective guard to avoid accidental contact.
  
• Manufacturer: Anneal Pharmaceuticals, a leader in emergency treatment solutions., known for ensuring product quality and efficacy.

Brand names: Common brands include EpiPen®, Auvi-Q®, Adrenaclick®, and generic versions.

Mechanism of Action

Epinephrine, a potent non-selective adrenergic agonist, activates both α- and β-adrenergic receptors. This results in vasoconstriction and bronchodilation, essential in reversing the symptoms of anaphylaxis such as low blood pressure, bronchospasm, and mucosal edema. Epinephrine also reduces vascular permeability, which helps prevent fluid from leaking into tissues, thus curtailing swelling and hives. This multifaceted action rapidly stabilizes the patient's respiratory and cardiovascular systems during an allergic emergency.

Directions for Use

1. Indication: Designed for intramuscular administration in the outer thigh at the first signs of anaphylaxis.
2. Instructions:

• Firmly grasp the injector with the orange tip pointing downward.
  
• Remove the safety cap.
  
• Press the auto-injector firmly against the thigh until a click is heard, indicating the injection has started.
  
• Hold in place for 3 seconds, then remove and massage the injection area for 10 seconds.

3. Repeat Use: If symptoms persist, administer the second auto-injector after 5 to 15 minutes. Seek emergency medical assistance immediately after use.

Training on the use of the auto-injector is essential, and practice devices should be used to familiarize individuals with its operation.

Warnings

• Medical Conditions: Notify healthcare providers about any pre-existing heart conditions or allergies.
  
• Storage: Store at room temperature, protected from light and moisture. Do not refrigerate or expose to extreme heat or cold.
  
• Device Inspection: Regularly check expiration dates and solution clarity. Replace if the fluid is discolored or contains particles.

Side Effects

Patients may experience side effects, though their occurrence is typically outweighed by the benefits during life-threatening situations:

• Common: Nervousness, anxiety, tremors, or palpitations due to its stimulatory effects.
  
• Cardiovascular: Potential for rapid heartbeat, arrhythmias, or hypertension.
  
• Neurological: Possible dizziness or headache.
  Injection Site Reactions: Mild pain, redness, or swelling may occur.

Serious adverse reactions are rare, particularly when used as directed in anaphylactic emergencies.

This summary provides essential information for healthcare professionals, caregivers, and patients in managing anaphylaxis with Epinephrine Auto-Injector 0.3 mg. It's imperative to consult comprehensive prescribing information and safety instructions provided by Anneal Pharmaceuticals. Always follow manufacturers' recommendations and seek advice from healthcare providers for proper usage tailored to specific medical needs.