Amikacin Sulfate injection 250 mg/mL Single Dose Vials 2 mL x 10/Box Sagent (RX)

Amikacin Sulfate Injection is a prescription medication used to treat bacterial infections caused by susceptible strains of microorganisms. It contains the active ingredient amikacin sulfate, which belongs to a class of antibiotics called aminoglycosides. It is available in single-dose vials and is administered by injection (usually into a muscle or vein) under the supervision of a healthcare provider. This medication is typically used to treat severe or life-threatening infections, and its strength and dosage may vary depending on the specific condition being treated.

Amikacin Sulfate injection is an antibiotic medication that works by inhibiting the growth and spread of bacteria in the body. It does this by binding to the bacterial ribosomes, which are responsible for producing essential proteins needed for bacterial growth and survival. By interfering with this process, Amikacin disrupts the bacteria's ability to grow and reproduce, ultimately killing the bacteria and treating the infection.

Amikacin Sulfate Injection 250 mg/mL by Sagent is a powerful, broad-spectrum aminoglycoside antibiotic specifically formulated for hospital and clinical environments. Each box contains 10 sterile 2 mL single-dose vials, providing a consistent and high-concentration option for rapid and effective treatment of severe Gram-negative and select Gram-positive bacterial infections. Manufactured under stringent quality standards by Sagent, this injectable antibiotic is trusted by healthcare professionals for use in emergencies and critical care settings.

Uses

• Severe Gram-Negative Bacterial Infections: Including septicemia, bacteremia, and hospital-acquired pneumonia.
• Respiratory Tract Infections: Treatment of lower respiratory infections unresponsive to other antibiotics.
• Urinary Tract Infections (UTIs): For complicated or resistant UTIs.
• Bone, Joint, and Skin Infections: Particularly for osteomyelitis, septic arthritis, and complicated skin and soft tissue infections.
• Abdominal and Intra-Abdominal Infections: In conjunction with other agents for polymicrobial infections.
• Neonatal and Pediatric Infections: When indicated, with careful dosing adjustments.

Benefits

• Fast-Acting, High-Potency: Quickly achieves therapeutic levels for critical and life-threatening infections.
• Broad-Spectrum Efficacy: Effective against a wide array of multidrug-resistant Gram-negative organisms, including Pseudomonas and Acinetobacter.
• Accurate, Weight-Based Dosing: 2 mL single-dose vials (each containing 500 mg) offer dosing flexibility for all patient populations.
• Sterile & Convenient Packaging: Reduces risk of contamination and ensures ready-to-use medication for urgent care.
• Sagent Assurance: Produced with advanced track-and-trace technology for safety and reliability in hospital settings.

Specifications

• Active Ingredient: Amikacin Sulfate, USP
• Concentration/Strength: 250 mg/mL (500 mg per 2 mL vial)
• Dosage Form: Sterile injection, for IV or IM use
• Vial Size: 2 mL single-dose glass vials
• Box Quantity: 10 vials per box
• NDC: 25021-0173-02
• Manufacturer: Sagent Pharmaceuticals
• Storage: Store at 20°–25°C (68°–77°F), protect from light, do not freeze

Directions for Use

1. Determine Dosage:
   • Adult usual dose: 15 mg/kg/day divided every 8–12 hours, adjusted for infection severity and renal function
   • Pediatric dosing: 15–20 mg/kg/day in divided doses, per physician’s orders
2. Route of Administration:
   • May be administered intravenously (IV) or intramuscularly (IM)
   • For IV use, the solution should be diluted and infused over 30–60 minutes
3. Duration:
   • Typically 7–10 days, or as prescribed based on organism and patient response
4. Monitoring:
   • Close monitoring of renal function, auditory function, and peak/trough serum amikacin levels is essential

Administration should always follow physician’s orders and institutional protocols.

Side Effects

Common:

• Injection site discomfort or redness
• Headache
• Nausea or vomiting
• Rash or fever

Serious (Seek immediate medical attention):

• Nephrotoxicity: (Kidney damage) Signs include decreased urination, elevated blood urea nitrogen (BUN)/creatinine
• Ototoxicity: (Hearing or balance disturbances) Ringing in the ears, hearing loss, dizziness
• Neurotoxicity: (Tingling, seizures, muscular twitching)
• Severe allergic reaction: Rash, swelling, difficulty breathing

Warnings & Precautions

• Monitor Closely: Renal function and hearing must be checked regularly, as risk of toxicity increases with higher cumulative doses, prolonged therapy, or in patients with renal impairment.
• Use With Caution: In patients taking other nephrotoxic or ototoxic medications, or those with pre-existing kidney/hearing issues.
• Contraindications: Hypersensitivity to amikacin or other aminoglycosides.
• Pregnancy & Breastfeeding: Use only if clearly necessary and under healthcare supervision.
• For Hospital/Professional Use: Not for at-home use; keep out of reach of children.

Why Choose Amikacin Sulfate Injection by Sagent?

• High-concentration dosage and rapid action
• Trusted in critical, hospital, and ICU settings
• Sterile, ready-to-use single-dose vials for safety and convenience
• Produced to the highest pharmaceutical standards by Sagent

Order Amikacin Sulfate Injection 250 mg/mL, 2 mL Single Dose Vials x 10/Box by Sagent (NDC: 25021-0173-02) today for dependable, fast-acting, and powerful antibiotic therapy against severe infections!