Top-Rated Broad-Spectrum Antibiotic for Serious Infections

Ceftriaxone Sodium Injection 250 mg (1 mL Vials, 10-Pack) by Pfizer Injectables is the leading hospital-strength, broad-spectrum injectable antibiotic trusted worldwide for rapid and effective treatment of moderate to severe bacterial infections. This powerful third-generation cephalosporin antibiotic is ideal for ER, hospital, clinic, and outpatient use, delivering reliable infection control with industry-leading quality and safety.

Ceftriaxone Sodium Injection 250 mg 1 mL Vials are used to treat a variety of bacterial infections. As a broad-spectrum cephalosporin antibiotic, it works by inhibiting cell wall synthesis, effectively killing bacteria. It is often utilized for infections such as respiratory tract infections, urinary tract infections, skin infections, and sexually transmitted infections like gonorrhea. This injection provides a rapid therapeutic response, is administered intravenously or intramuscularly, and is crucial in managing severe and systemic bacterial infections.

Ceftriaxone Sodium for Injection is a sterile, broad-spectrum cephalosporin antibiotic used for the treatment of various bacterial infections. This formulation by Pfizer Injectables contains 250 mg of ceftriaxone sodium per 1 mL vial and is packaged in packs of 10 vials. It is designed for intravenous (IV) or intramuscular (IM) administration, and it is effective against a wide range of Gram-positive and Gram-negative bacteria.

Dosage Form: 250 mg of ceftriaxone per 1 mL vial
Packaging: 10 vials per pack
Administration Routes: Intravenous (IV) or intramuscular (IM)
Spectrum: Broad-spectrum antibiotic effective against various bacteria, including respiratory system, urinary tract, skin, and other types of infections
Use: Commonly used to treat infections such as bacterial meningitis, pneumonia, sepsis, and gonorrhea

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Uses & Applications

Ceftriaxone Sodium Injection 250 mg is indicated for:

• Serious bacterial infections: Pneumonia, sepsis, bacterial meningitis, intra-abdominal infections, joint infections, skin/soft tissue infections, bone infections (osteomyelitis)
• Gonorrhea: Single-dose treatment of uncomplicated gonorrhea
• Urinary tract infections (UTI)
• Pelvic inflammatory disease (PID)
• Lyme disease (neurological and cardiac involvement)
• Surgical prophylaxis: Prevention of postoperative infections
• Community-acquired and hospital-acquired infections requiring parenteral antibiotic therapy

Benefits & Features

• Powerful Broad-Spectrum Antibiotic: Effective against a wide variety of gram-positive and gram-negative organisms
• Rapid Bactericidal Action: High efficacy in eliminating severe infections
• Convenient 250 mg Dose: Allows accurate pediatric and adult dosing
• Versatile (IM/IV) Administration: For hospital, clinic, home care, or emergency settings
• 10 Single-Dose Vials per Pack: Ideal for multi-patient use, ER, or group practices
• Stable, Sterile, and Reliable: Pfizer quality assurance for every vial
• Minimal Dosing Frequency: Once or twice daily dosing for added convenience and compliance

Specifications

Instructions on How to Use

1. Preparation:

   • Inspect vial for integrity and expiration.
   • Reconstitute each 250 mg vial with 0.9 mL of sterile water for injection (for IV use) or 0.9 mL of 1% lidocaine (for IM injection).
   • Gently shake until dissolved and clear.
   • Use reconstituted solution immediately; follow guidelines if storing short-term.

2. Administration:

   • For IV injection: Administer slowly over 2-4 minutes.
   • For IM injection: Inject deep into large muscle (e.g. gluteal).

3. Aseptic Technique:

   • Always use sterile needles, syringes, and disinfect the site.

Administration should be performed by a qualified healthcare professional.

Dosage and Administration

• Adults: 1–2 g once daily or in divided doses (every 12 hours), maximum 4 g/day for life-threatening infections
• Children/Infants: 50–75 mg/kg once daily or in divided doses (max 2 g/day for non-meningitis, 4 g/day for meningitis)
• Gonorrhea: Single 250 mg IM dose for uncomplicated cases
• Surgical Prophylaxis: 1 g IV 30–90 min before surgery
• Duration: Determined by infection type, patient response, and provider instructions

Always individualize dosing per physician’s orders and clinical guidelines.

Drug Interactions

• Calcium-containing IV solutions: May form precipitate—do not mix or infuse simultaneously (esp. in neonates)
• Vitamin K antagonists (warfarin): Enhanced anticoagulant effect, monitor INR closely
• Aminoglycoside antibiotics: Risk of nephrotoxicity when co-administered
• Probenecid: May increase ceftriaxone levels, rarely used together
• Other antibiotics: If co-administered, monitor for additive or antagonistic effects

Consult provider for comprehensive drug interaction review.

Side Effects & Warnings

Common Side Effects

• Local: Pain, redness, or swelling at injection site
• Gastrointestinal: Diarrhea, nausea, vomiting
• Rash or mild allergic reaction

Serious Adverse Reactions

• Anaphylaxis/hypersensitivity reactions: Facial swelling, difficulty breathing, severe rash—seek emergency help
• Clostridioides difficile–associated diarrhea (CDAD)
• Hematologic: Neutropenia, thrombocytopenia, coagulopathy
• Renal or hepatic dysfunction: Rare, monitor with prolonged therapy
• Gallbladder pseudolithiasis (pediatrics)
• Serum sickness–like reactions
• Seizures: Rare in high or prolonged dosing

Warnings & Precautions

• Not for use in patients with known cephalosporin allergy
• Cautious use in patients with penicillin allergy—possible cross-reactivity
• Neonates: Avoid with calcium/mix with calcium-containing products
• Monitor for superinfection with fungal or non-susceptible bacteria during prolonged therapy
• Use with caution in patients with liver/kidney disease