Powerful Life-Saving Alkali for Metabolic Acidosis, Cardiac Emergencies, and Toxicology Protocols
Sodium Bicarbonate Injection 8.4% by Exela Pharma Sciences delivers immediate, high-impact correction of acute, life-threatening metabolic acidosis, advanced cardiac arrest, drug overdose, renal failure, and electrolyte imbalances. This sterile, preservative-free 10 mL vial (8.4% concentration) offers exact, physician-preferred dosing—making it a crucial crash cart, ICU, ER, anesthesia, and EMS asset trusted by medical professionals nationwide.
Sodium Bicarbonate Injection 8.4% 10mL by Exela is a sterile, nonpyrogenic, and highly effective solution designed for the urgent management of life-threatening acid-base imbalances. Trusted by leading hospitals, emergency rooms, and critical care teams, this injectable sodium bicarbonate offers fast, safe, and predictable results when seconds count.
Rapid Correction of Acidosis – Emergency pH Balance for Critical Care
What is Sodium Bicarbonate Injection?
Sodium Bicarbonate Injection 8.4% is a concentrated, intravenous (IV) alkalinizing agent used to restore normal blood pH in severe metabolic acidosis, cardiac emergencies, and drug toxicity cases. This crucial medication is commonly administered during CPR, advanced cardiac life support (ACLS), acute renal failure, diabetic ketoacidosis (DKA), and certain poisonings and overdoses.
- Emergency treatment of severe metabolic acidosis
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Cardiac arrest and CPR protocols (ACLS)
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Drug overdose, poisoning, and toxicity management
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Hyperkalemia (high potassium) therapy
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Diabetic ketoacidosis (DKA) and acute/chronic renal failure
- Support during surgery, anesthesia, and critical care
Order Sodium Bicarbonate Injection 8.4% 10 mL IV Vial by Exela Pharma Sciences Now!
Equip your crash cart, ICU, ER, or EMS team with this vital, hospital-trusted buffer—the proven choice for immediate acidosis correction, poison antidote protocols, and advanced resuscitation.
NDC: 51754-5011-04 | UPC: 351754501146 Prescription required. Hospital/Professional use only.
Uses and Applications
Sodium Bicarbonate Injection 8.4% is indicated for:
- Immediate treatment of severe metabolic acidosis (renal failure, circulatory collapse, diabetic ketoacidosis, shock, cardiac arrest)
- Cardiac arrest/advanced cardiac life support (ACLS): Buffer for acidemia, refractory arrhythmias, asystole, PEA when indicated
- Drug overdose/toxicity support: Tricyclic antidepressant (TCA) overdose, barbiturates, salicylate poisoning (alkalinizing urine and serum)
- Adjunct in severe hyperkalemia (to stabilize myocardium and favor potassium shift)
- Correction of acid-base disturbances in surgery, trauma, burns, or sepsis
- Hospital code carts, emergency departments, intensive care units, anesthesia, EMS kits
Not for mild acidosis or chronic alkalinization—use exclusively by clinical professionals for acute indications.
How to Use
- Visually inspect vial for particulate matter and discoloration; use only if clear.
- Clean vial top and withdraw required dose with a sterile syringe.
- Administer by slow IV push or as part of rapid-sequence infusion via a large bore vein (peripheral or central), as clinically indicated.
- For pediatric or neonatal dilution, consult institutional protocol.
- Continuously monitor blood gases, chemistry, and ECG during administration and adjust subsequent doses as required.
- Use a dedicated IV line if possible—do not mix with calcium or acidic solutions.
Administer only by or under direct supervision of qualified healthcare professionals.
Dosage and Administration
Adults:
- Metabolic Acidosis/Cardiac Arrest:
- Usual dose: 1 mEq/kg IV (e.g., 70 kg = 70 mEq or 7 x 10 mL vials); titrate based on arterial blood gases and clinical response
- May repeat every 10 minutes as needed
- TCA Overdose or Drug-Induced Acidosis:
- 1–2 mEq/kg IV bolus, repeat as needed based on ECG and serum pH to maintain arterial pH > 7.45
- Hyperkalemia:
- 50–100 mEq IV over several minutes; use in conjunction with other treatments
Pediatrics:
- 1 mEq/kg IV push; dilute to 4.2% for neonates and infants
Never use IM/Subcut. Maximum doses and frequency depend on patient's status and response—always individualize and monitor.
Drug Interactions
- IV calcium (chloride or gluconate): Do not infuse together—precipitation/fatal embolism risk.
- Catecholamines (epinephrine, norepinephrine): May be inactivated by alkaline pH.
- Weak acids/alkaline sensitive drugs: Potential for pH-dependent pharmacokinetic changes (barbiturates, tetracyclines, salicylates).
- Potassium supplements: Carefully monitor for hypokalemia.
- Monitor electrolytes closely with diuretic or digoxin therapy; sodium overload risk.
Always use separate IV lines for incompatible drugs. Consult pharmacy for all drug compatibility questions.
Side Effects
Common Side Effects
- Local infusion site pain or irritation
- Transient hypokalemia
- Fluid overload, especially with repeated doses
- Alkalosis (especially after large or repeated doses)
Severe/Rare Side Effects
- Metabolic alkalosis (confusion, muscle twitching, seizures, hypoventilation)
- Tetany (secondary to hypocalcemia)
- Hypernatremia, sodium/fluid overload (heart failure, kidney disease patients)
- Tissue necrosis (extravasation risk—central line preferred for repeated administration or large doses)
- Pulmonary edema, cardiac arrhythmias (in severe overload/rapid bolus)
Discontinue and treat immediately if extravasation or severe side effects occur.
