Lidocaine 1% with Epinephrine 1% Injection 1:100,000, 500 mg/50ml, 50 mL Multiple Dose 25/Tray (Rx)

Lidocaine 1% with Epinephrine 1:100,000 Injection is a local anesthetic solution used primarily in medical and dental procedures to numb a specific area and reduce bleeding.

Lidocaine 1% and Epinephrine 1:100,000 Injection (500 mg/50 mL, 50 mL) is used as a local anesthetic to manage pain and control bleeding during surgical, dental, and medical procedures. Lidocaine acts by blocking nerve signals, providing numbness and reducing discomfort. Epinephrine, as a vasoconstrictor, prolongs the anesthetic effect and decreases bleeding by constricting blood vessels. This combination is highly effective for procedures where extended anesthesia and minimal bleeding are critical, optimizing surgical field visibility and enhancing patient comfort.

Uses

• Local anesthesia in dental procedures (tooth extractions, fillings)
• Minor surgical, dermatological, or medical procedures needing local numbness and bloodless field

Breakdown of the Solution

1. Lidocaine 1%

• Lidocaine is a local anesthetic.
• 1% means 10 mg of lidocaine per mL of solution.
• Blocks sodium channels in nerves, preventing pain signals from traveling.

2. Epinephrine 1:100,000

• Epinephrine (adrenaline) is a vasoconstrictor.
• 1:100,000 means there is 0.01 mg (10 micrograms) of epinephrine per mL of solution (i.e., 1 gram in 100,000 mL).
• Constricts blood vessels, which:
  • Reduces bleeding at the site
  • Prolongs and enhances the numbing effect of lidocaine
  • Reduces systemic absorption, lowering risk of lidocaine toxicity

Concentration and Formulation:

Lidocaine Concentration: 1% (10 mg/mL)
Epinephrine Concentration: 1:100,000

Packaging:

Volume: 50 mL per vial
Type: Multiple-dose glass vial
Package Configuration: Available in trays, with 25 vials per tray.

Indications:

• Local or Regional Anesthesia: Used in various surgical and dental procedures to numb a specific area while decreasing blood flow to the site, aiding in field clarity and reducing systemic absorption.
  
• Prolongation of Effects: The addition of epinephrine helps in prolonging the anesthesia effect by slowing lidocaine absorption into the bloodstream.

Administration:

Typically administered via infiltration or nerve block techniques by healthcare professionals.

Safety and Precautions:

• Contraindications: Known hypersensitivity to amide-type local anesthetics and epinephrine-containing products.
  
• Warnings and Precautions: Careful monitoring is required to avoid systemic toxic reactions to lidocaine and cardiovascular reactions due to epinephrine. Use cautiously in patients with cardiovascular disease or those taking MAO inhibitors or tricyclic antidepressants.
  
• Adverse Reactions: Though generally well-tolerated, may cause localized reactions like redness or swelling, and rarely systemic responses like heart palpitations or serious allergic reactions.

Storage:

• Store at controlled room temperature and protect from light. Do not freeze.

This combination injectable is pivotal in ensuring effective local anesthesia with reduced bleeding and prolonged anesthesia duration, adding significantly to procedural success while prioritizing patient comfort and safety.