Naloxone Prefilled Syringe (Opioid Antidote) 2 mg Dose (Rx)

Fast, Reliable Emergency Opioid Overdose Reversal – Easy-Use Lifesaving Solution

#1 Doctor-Trusted, Prescription-Grade Opioid Overdose Rescue Syringe

Be prepared to save a life—Naloxone Prefilled Syringe 2 mg by International Medication Systems delivers powerful, immediate opioid overdose reversal in a ready-to-use, pre-filled syringe. Naloxone (Narcan® alternative) is the gold standard opioid antidote, critical for reversing life-threatening respiratory depression due to opioid overdose. Trusted by EMS, hospitals, first responders, law enforcement, clinics, and caregivers nationwide, this injection is essential for combating the ongoing opioid crisis.

Current Expiration : October 2026

Uses:

• Life-Saving Opioid Overdose Treatment
• Crucial for Fentanyl, Heroin, Prescription Painkiller Overdose
• Restores Normal Breathing Until Emergency Help Arrives
• Prevents Fatalities and Severe Brain Injury
• Integral Part of Harm Reduction and Public Health Programs

Be Prepared. Naloxone Prefilled Syringe (Opioid Antidote) 2 mg (2 mL) by International Medication Systems Can Save a Life!

Order your prescription-grade opioid rescue kit today—trusted by first responders and public health programs nationwide.

NDC: 76329-3369-1 UPC: 376329336916 Product number: 3369 Prescription required in some locations. Ask your pharmacist or healthcare provider for supply and training.

Uses and Applications

• Emergency reversal of opioid overdose:
  • Suspected or confirmed opioid toxicity (heroin, fentanyl, oxycodone, morphine, hydrocodone, codeine, methadone, and more)
• Reversal of opioid-induced respiratory/CNS depression
• Layperson, bystander, first responder, EMS, clinic, hospital, law enforcement and community opioid rescue
• Harm reduction and take-home opioid rescue kits
• Post-surgical or post-anesthesia opioid monitoring (as directed)
• Ideal for home use in patients prescribed high-dose opioid pain medications or with addiction risk

Product Specifications

• Active Ingredient: Naloxone Hydrochloride 2 mg per 2 mL (1 mg/mL) in prefilled syringe
• Delivery: Ready-to-use sterile prefilled syringe with Luer Lock tip (needle not included—attach standard IM/SC injection needle as needed)
• Packaging: Individually sealed, single-use syringe
• Dose: 2 mg (2 mL) per syringe
• Manufacturer: International Medication Systems (IMS)
• NDC: 76329-3369-1
• UPC: 376329336916
• Product number: 3369
• Prescription required in some states; pharmacy, first responder, and community distribution
• Room temperature storage

How to Use

Naloxone Prefilled Syringe Administration (For Opioid Overdose)

1. Check unresponsiveness: Shake, shout, and check breathing.
2. Call emergency services (911) immediately.
3. Remove cap from syringe and attach needle (as directed). No mixing required.
4. Inject naloxone 2 mg (2 mL) into muscle (thigh, buttock, shoulder) or subcutaneously. May also administer intravenously if trained.
5. If using as an intranasal alternative, use an atomizer (not included).
6. Monitor breathing and responsiveness: If no response in 2–3 minutes, administer additional doses as necessary and continue rescue breathing or CPR until medical help arrives.
7. Stay with person until emergency help arrives—opioid effects can return as naloxone wears off.

Always read the included package insert and follow emergency protocols.

Dosage and Administration

• Adults and Children: Usual dose is 2 mg (2 mL) by intravenous (IV), intramuscular (IM), or subcutaneous (SC) injection.
  • If no response, repeat every 2–3 minutes, using new syringes as needed.
• Repeat dosing is often necessary as naloxone effects may wear off before opioid effects do.
• Pediatric dosing: Use same 2 mg/2 mL dose; may be titrated at a lower dose by medical professionals for smaller children/infants.
• Initial IM/SC/IV dose: 0.4 mg to 2 mg depending on professional protocol, but prefilled syringe delivers a standard 2 mg rescue dose.

DO NOT DELAY EMERGENCY HELP—call 911 even if naloxone is administered.

Drug Interactions

• Opioid medications: Fully or partially reverses effects, including pain control and euphoria.
• Mixed agonist/antagonist analgesics: May precipitate withdrawal.
• No known interactions with other emergency or resuscitation drugs.
• Other CNS depressants: No reported significant interaction, but monitor closely.
• Patients on long-term opioid therapy: Sudden reversal triggers acute withdrawal; medical supervision recommended.

Side Effects

Common Side Effects

• Acute opioid withdrawal (if physically dependent): sweating, nausea, vomiting, agitation, fast heart rate, blood pressure swings, muscle aches, anxiety
• Injection site reactions (pain, redness, swelling)

Severe/Rare Side Effects

• Severe hypertension
• Cardiac arrhythmias
• Seizures (rare)
• Pulmonary edema (very rare)
• Allergic reactions (rash, difficulty breathing: extremely rare)

Monitor all patients closely after naloxone administration.

Warnings and Precautions

• Naloxone is NOT a substitute for emergency medical care. Always call 911 and seek immediate help.
• May cause acute withdrawal symptoms in opioid-dependent individuals, which can be intense and distressing but are rarely life-threatening compared to untreated overdose.
• Use with caution in cardiac disease, newborns, and pregnancy—benefits generally outweigh risks in emergency overdose.
• Storage: Room temperature (68º–77ºF); protect from light. Do not freeze.
• Single use only; discard unused portion safely in sharps container.
• Keep out of reach of children.