Naloxone Hydrochloride Injection 0.4 mg SIngle Dose 1 mL, 10/Box (RX)

Fast, Reliable Opioid Overdose Reversal – Hospital & Emergency-Grade Opioid Antidote

Naloxone Hydrochloride Injection 0.4 mg/mL by Lifestar Pharma offers immediate, powerful reversal of life-threatening opioid overdose. Designed for hospitals, EMS, first responders, clinics, and harm-reduction programs, these sterile single-dose vials deliver dependable, precise dosing for urgent intervention when seconds count. Naloxone is the proven opioid antagonist, now widely recommended for community and emergency use to combat the opioid crisis and save lives fast.

Naloxone Hydrochloride Injection is a prescription medication used to treat opioid overdose. Naloxone is an opioid antagonist, which means it can reverse the effects of opioid drugs such as morphine, heroin, and oxycodone. This medication is typically administered as an injection to quickly counter the effects of an overdose and prevent death. Lifestar Pharma is the manufacturer of the medication, and the 0.4 mg/mL concentration indicates the strength of the solution in each 1 mL vial. It is important to follow the instructions for use provided by your doctor or the medication label, as improper use may lead to serious side effects.

Naloxone Hydrochloride is a medication commonly used to reverse the effects of opioids, such as morphine, heroin, and prescription painkillers. It works by binding to the same receptors in the brain and body that opioids bind to, but without producing the same effects. This allows naloxone to effectively block the effects of opioids and reverse the symptoms of an overdose, including slowed breathing, lowered blood pressure, and loss of consciousness.

When administered as an injection, naloxone enters the bloodstream and quickly travels to the brain, where it binds to opioid receptors and displaces any opioids that may be present. This not only reverses the effects of the opioids but also prevents them from continuing to cause harm.

Naloxone is a competitive antagonist, meaning it competes with opioids for the same receptors in the body. It has a higher affinity for these receptors, meaning it has a stronger binding ability, which allows it to effectively displace opioids and reverse their effects.

Order Naloxone Hydrochloride Injection 0.4 mg/mL 1 mL x 10/Box by Lifestar Pharma – Be Ready to Save a Life

Don’t take chances in an opioid emergency. Arm your team, workplace, or home with the same antidote trusted by hospitals and emergency responders everywhere.

NDC: 70756-0658-10 | UPC: 370756658108 Prescription required. Use as directed by a clinician or as part of state-authorized rescue programs.

Uses and Applications

• Emergency treatment of known or suspected opioid overdose: Reversal of opioid-induced respiratory and central nervous system depression in settings like community, EMS, clinics, first responder units, hospitals, and at home.
• Opioid toxicity from drugs such as fentanyl, heroin, morphine, hydrocodone, oxycodone, codeine, tramadol, and methadone.
• Reversal of iatrogenic opioid overdose: Including post-surgical or procedural narcotic use.
• Opioid rescue kit for high-risk patients, caregivers, harm reduction, treatment centers, and public health initiatives.
• Works for adults, adolescents, children, and neonates (dosing varies by protocol and medical supervision).

Product Specifications

• Active Ingredient: Naloxone Hydrochloride 0.4 mg per 1 mL
• Concentration: 0.4 mg/mL
• Form: Preservative-free, sterile injectable solution
• Packaging: 1 mL single-dose glass vials, box of 10 vials
• Administration route: Intramuscular (IM), intravenous (IV), subcutaneous (SC)
• Manufacturer: Lifestar Pharma
• NDC: 70756-0658-10
• UPC: 370756658108
• Latex-free
• Storage: Store at 20° to 25°C (68°–77°F); protect from light; do not freeze

How to Use

1. Open the carton and select one single-dose vial (confirm colorless, clear solution).
2. Draw 1 mL (0.4 mg) from the vial using a sterile syringe and needle.
3. Inject naloxone 0.4 mg via intramuscular (IM), intravenous (IV), or subcutaneous (SC) route, per protocol. Common IM site: Outer thigh or upper arm.
4. If no response in 2–3 minutes, repeat injection using a new vial and syringe, up to medical/professional guidelines.
5. Call 911 or emergency services immediately after first administration.
6. Continue rescue breathing or CPR as needed until the patient is fully responsive or professional help arrives.

Always read full prescribing information and safety instructions before use.

Dosage and Administration

• Adults & Children:
  • Initial dose: 0.4 mg (1 mL) IM, IV, or SC; repeat every 2–3 minutes if needed using fresh vials/syringes.
• Neonates/newborns:
  • 0.01 mg/kg by IM or IV injection, repeated if necessary at 2–3 min intervals.
• Repeat doses may be required as naloxone may wear off before the opioid.
• Medical personnel may titrate dose based on patient response.
• Monitor closely after administration for recurrent respiratory depression.

ALWAYS seek emergency medical help immediately. Naloxone is a temporary antidote.

Drug Interactions

• Opioid drugs: Naloxone reverses effects of opioids (including pain relief and euphoria).
• Mixed agonist/antagonist analgesics: May cause withdrawal; not effective for non-opioid CNS depression.
• No clinically significant interactions with non-opioid emergency drugs (i.e., epinephrine, benzodiazepines, or CPR meds).
• May precipitate withdrawal in opioid-dependent individuals.
• Low risk of systemic interactions due to rapid metabolism.

Side Effects

Common Side Effects

• Acute opioid withdrawal symptoms: Body aches, nausea, vomiting, sweating, tachycardia, hypertension, agitation, restlessness, shivering, yawning, irritability.
• Injection site pain or redness.

Rare/Severe Side Effects

• Severe aggression, convulsions, seizures (rare)
• Cardiac arrhythmias
• Pulmonary edema (very rare)
• Allergic reaction (hives, difficulty breathing – extremely rare)

Monitor all patients after naloxone administration for serious side effects and recurrent overdose symptoms.

Warnings and Precautions

• Naloxone does NOT replace emergency medical care. Always call 911.
• Repeated dosing may be required, especially with long-acting or potent opioids (fentanyl, methadone).
• May induce severe opioid withdrawal—especially in those physically dependent; distressing but not life-threatening compared to uncorrected overdose.
• Use with caution in neonates, pregnancy, and cardiorespiratory illness.
• Discard any unused solution after opening. Use only once per vial.
• Store away from children.