Ketorolac Tromethamine Injection (Toradol) – Short-term NSAID Pain Reliever

Ketorolac tromethamine is a potent nonsteroidal anti-inflammatory drug (NSAID) used as an injectable painkiller. It is the generic form of the prescription analgesic Toradol. Each 2 mL vial contains 60 mg (30 mg/mL) of ketorolac tromethamine for injection. This injectable form is typically given by healthcare providers in a hospital or clinic (intramuscular or intravenous) for acute pain control.

Uses and Indications

Ketorolac injection is indicated for short-term relief of moderately severe pain (often postoperative or injury-related) in adults and adolescents 17 years or older . It is not intended for mild pain, chronic conditions, or use beyond 5 days because of its risk profile. In practice, patients receive their first doses by injection, and in some cases may switch to oral ketorolac or other therapies once they can take pills.

• Acute pain management in adults
• Short-term pain control after surgical or dental procedures
• Trauma and orthopedic injuries
• Musculoskeletal and back pain
• Renal & biliary colic
• Non-opioid pain alternative in hospitals and clinics

Dosage:

The injection is given by a healthcare professional, either into a muscle (IM) or into a vein (IV). Dosing is generally every 4–6 hours as needed for pain, with typical single doses of 15 mg IV or 30 mg IM (accomplished by drawing from the 60 mg/2 mL vial). A maximum of 5 days total therapy is strictly observed; ketorolac is not used continuously beyond five days or for chronic pain. (After injection therapy, doctors may switch appropriate patients to oral NSAIDs.)

Mechanism of action: Ketorolac works like other NSAIDs by blocking the cyclooxygenase (COX) enzymes, which are needed to produce prostaglandins and other mediators of pain, fever, and inflammation. By inhibiting COX, ketorolac reduces prostaglandin synthesis, thereby diminishing pain and inflammation. It is a very effective non-opioid analgesic for acute pain; in fact, it is often used to supplement or reduce opioid requirements after surgery

Why Choose Ketorolac Tromethamine Injection by Sagent?

• High-Potency NSAID Formula: Delivers 60 mg of Ketorolac Tromethamine in a convenient 2 mL single-use vial for IV or IM administration.
• Opioid-Sparing Pain Relief: Proven to reduce or replace opioid use in acute and moderate-to-severe pain situations, lowering the risk of opioid-related side effects.
• Rapid Onset of Action: Starts providing effective pain relief within minutes for surgical pain, orthopedic trauma, musculoskeletal injuries, dental pain, and more.
• Broad Indications: Ideal for postoperative pain, renal colic, biliary colic, and in situations requiring powerful anti-inflammatory and analgesic effects.
• High Purity & Reliable Supply: Manufactured by Sagent Pharmaceuticals, a leader in hospital-grade injectable medications, ensuring safety, consistency, and reliability.

Ketorolac Tromethamine is a prescription-only NSAID designed for short-term management of severe acute pain that requires injectable administration. It inhibits prostaglandin synthesis, significantly reducing inflammation, swelling, and pain without the risks associated with addictive opioids. Frequently used for surgical pain, orthopedic pain, dental pain, renal colic, and musculoskeletal pain, it is trusted by medical professionals worldwide.

Directions for Use (Healthcare Professional Use Only):

• For intravenous or intramuscular administration as directed by the prescriber.
• Recommended only for short-term use (up to 5 days in adults).
• Do NOT use in pediatric patients or for minor/chronic pain.

Important Safety Information:

• Prescription only. For use under the supervision of healthcare professionals.
• Not for chronic pain, pediatric use, or prior to major surgery.
• Contraindicated in patients with peptic ulcer disease, active bleeding, advanced renal impairment, and during labor and delivery.
• May cause gastrointestinal, renal, or cardiovascular complications. Review contraindications and warnings before use.

Why Trust Sagent Pharmaceuticals?

Sagent Pharmaceuticals is a trusted leader in providing high-quality injectable medications for hospitals, clinics, and healthcare professionals. Every batch is manufactured to the strictest quality standards, ensuring efficacy and patient safety with each use.

Details and Features:

Dosage Form: 60 mg per 2 mL vial
Packaging: 25 vials per pack
Administration Route: Intended for intravenous (IV) or intramuscular (IM) injection
Use: Short-term management of moderate to severe acute pain, typically used for no more than five days
Non-Opioid Analgesic: Provides pain relief without the potential for opioid dependence

Warnings:

• Duration of Use: Intended for short-term use only; not to exceed five days due to the increased risk of serious side effects with longer use.
  
• Gastrointestinal Risk: Use cautiously due to risks of gastrointestinal irritation, ulceration, bleeding, and perforation.
  
• Renal Risk: May cause or exacerbate renal impairment, especially in dehydrated patients or those with pre-existing kidney problems.
  
• Cardiovascular Risk: NSAIDs, including Ketorolac, may increase the risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, particularly with prolonged use.
  
• Hypersensitivity Reactions: Contraindicated in patients with known hypersensitivity to Ketorolac or other NSAIDs.
  
• Avoid in Certain Populations: Contraindicated in active peptic ulcer disease, recent gastrointestinal bleeding, or perforation, advanced renal impairment, and concurrent use with other NSAIDs or aspirin.
  
• Pregnancy: Avoid use, especially in late pregnancy, due to the risk of fetal harm.

Side Effects:

Common side effects of ketorolac injection are related to its NSAID action. These include gastrointestinal upset (stomach pain, nausea, indigestion) and headache. Mild dizziness or drowsiness can also occur. Because ketorolac inhibits prostaglandins, it can irritate the stomach lining; some patients may experience indigestion or mild GI discomfort. Injection-site reactions (pain or swelling) may happen but are usually minor.Serious warnings and precautions: Ketorolac carries significant warnings. Like other NSAIDs, it can cause severe gastrointestinal bleeding or ulcers and kidney damage, especially with high doses or prolonged use. It also increases the risk of cardiovascular events; patients on NSAIDs (including ketorolac) have a higher risk of heart attack or stroke than those not on NSAIDs. Because of these risks, ketorolac is limited to very short courses and only for appropriate patients. It is contraindicated (should not be used) in patients with a known allergy to ketorolac or other NSAIDs, in those with active peptic ulcer/bleeding, or in people with advanced kidney disease. It should not be used around the time of major surgery (e.g. coronary bypass) or after 20 weeks of pregnancy (risking fetal harm). Patients receiving ketorolac are monitored carefully – for example, blood pressure and kidney function – and therapy is stopped immediately if serious adverse effects (like bleeding, liver problems, or signs of heart issues) occur.

Common side effects may include:

• Gastrointestinal: Nausea, dyspepsia, abdominal pain, diarrhea, or in severe cases, peptic ulcers or bleeding.
  
• Renal: Increased serum creatinine and, in rare cases, acute renal failure.
  
• Cardiovascular: Hypertension, palpitations, or edema.
  
• Hematologic: Prolonged bleeding time.
  
• Central Nervous System: Headache, dizziness, or somnolence.
  
• Hypersensitivity: Rash, pruritus, or, rarely, anaphylaxis.

Ketorolac Tromethamine Injection should be administered under medical supervision with careful monitoring of patient condition and response to therapy. It is critical to adhere to recommended dosing and duration guidelines to minimize the risk of adverse effects. Regular evaluations ensure the treatment remains necessary and beneficial.